{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:20:46Z","timestamp":1788535246363,"version":"build-2803163510"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08834-3","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:55:07Z","timestamp":1787388907000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FMRP promotes gastric cancer progression via m6A-dependent stabilization of DVL2 and activation of the Wnt\/PCP-JNK pathway"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaoyu","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesha","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"issue":"3","key":"8834_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clinicians. 2024;74(3):229\u201363. https:\/\/doi.org\/10.3322\/caac.21834.","journal-title":"CA Cancer J Clinicians"},{"issue":"2","key":"8834_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/bfgp\/ely019","volume":"18","author":"Q Zhao","year":"2019","unstructured":"Zhao Q, Cao L, Guan L, Bie L, Wang S, Xie B, et al. Immunotherapy for gastric cancer: dilemmas and prospect. Brief Funct Genomics. 2019;18(2):107\u201312. https:\/\/doi.org\/10.1093\/bfgp\/ely019.","journal-title":"Brief Funct Genomics"},{"issue":"4","key":"8834_CR3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/CCO.0000000000000289","volume":"28","author":"R Obermannova","year":"2016","unstructured":"Obermannova R, Lordick F. Insights into next developments in advanced gastric cancer. Curr Opin Oncol. 2016;28(4):367\u201375. https:\/\/doi.org\/10.1097\/CCO.0000000000000289.","journal-title":"Curr Opin Oncol"},{"issue":"12","key":"8834_CR4","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1056\/NEJMoa1708423","volume":"378","author":"IJ Choi","year":"2018","unstructured":"Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, et al. Helicobacter pylori therapy for the prevention of metachronous gastric cancer. N Engl J Med. 2018;378(12):1085\u201395. https:\/\/doi.org\/10.1056\/NEJMoa1708423.","journal-title":"N Engl J Med"},{"key":"8834_CR5","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1056\/NEJMoa1909666","volume":"382","author":"GM Rodriguez","year":"2020","unstructured":"Rodriguez GM, Hernandez MC, Lin AY. Family history of gastric cancer and Helicobacter pylori treatment. N Engl J Med. 2020;382:2170\u201371. https:\/\/doi.org\/10.1056\/NEJMoa1909666.","journal-title":"N Engl J Med"},{"issue":"3","key":"8834_CR6","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1053\/j.gastro.2019.10.019","volume":"158","author":"S Kumar","year":"2020","unstructured":"Kumar S, Metz DC, Ellenberg S, Kaplan DE, Goldberg DS. Risk factors and incidence of gastric cancer after detection of Helicobacter pylori infection: a large cohort study. Gastroenterology. 2020;158(3):527\u201336.e7. https:\/\/doi.org\/10.1053\/j.gastro.2019.10.019.","journal-title":"Gastroenterology"},{"key":"8834_CR7","doi-asserted-by":"publisher","first-page":"108613","DOI":"10.1016\/j.biopha.2019.108613","volume":"112","author":"T Sun","year":"2019","unstructured":"Sun T, Wu R, Ming L. The role of m6A RNA methylation in cancer. Biomed Pharmacother. 2019;112:108613. https:\/\/doi.org\/10.1016\/j.biopha.2019.108613.","journal-title":"Biomed Pharmacother"},{"key":"8834_CR8","doi-asserted-by":"publisher","unstructured":"Tang Y, Chen K, Song B, Ma J, Wu X, Xu Q, et al. m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome. Nucleic Acids Res. 2021;49(D1):D134\u201343. https:\/\/doi.org\/10.1093\/nar\/gkaa692.","DOI":"10.1093\/nar\/gkaa692"},{"issue":"1","key":"8834_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13045-019-0805-7","volume":"12","author":"S Ma","year":"2019","unstructured":"Ma S, Chen C, Ji X, Liu J, Zhou Q, Wang G, et al. The interplay between m6A RNA methylation and noncoding RNA in cancer. J Hematol Oncol. 2019;12(1):121. https:\/\/doi.org\/10.1186\/s13045-019-0805-7.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"8834_CR10","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12943-019-1119-7","volume":"18","author":"L Liu","year":"2019","unstructured":"Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, et al. m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma. Mol Cancer. 2019;18(1):188. https:\/\/doi.org\/10.1186\/s12943-019-1119-7.","journal-title":"Mol Cancer"},{"issue":"1","key":"8834_CR11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12943-021-01447-y","volume":"21","author":"W Wan","year":"2022","unstructured":"Wan W, Ao X, Chen Q, Yu Y, Ao L, Xing W, et al. METTL3\/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer. Mol Cancer. 2022;21(1):60. https:\/\/doi.org\/10.1186\/s12943-021-01447-y.","journal-title":"Mol Cancer"},{"issue":"1","key":"8834_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12943-022-01522-y","volume":"21","author":"Y Hu","year":"2022","unstructured":"Hu Y, Gong C, Li Z, Liu J, Chen Y, Huang Y, et al. Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol Cancer. 2022;21(1):34. https:\/\/doi.org\/10.1186\/s12943-022-01522-y.","journal-title":"Mol Cancer"},{"issue":"1","key":"8834_CR13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s13046-020-01714-8","volume":"39","author":"Z Yang","year":"2020","unstructured":"Yang Z, Wang T, Wu D, Min Z, Tan J, Yu B. RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer. J Exp Clin Cancer Res. 2020;39(1):203. https:\/\/doi.org\/10.1186\/s13046-020-01714-8.","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"8834_CR14","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1158\/2159-8290.CD-20-0331","volume":"11","author":"D Dixit","year":"2021","unstructured":"Dixit D, Prager BC, Gimple RC, Poh HX, Wang Y, Wu Q, et al. The RNA m6A Reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells. Cancer Discov. 2021;11(2):480\u201399. https:\/\/doi.org\/10.1158\/2159-8290.CD-20-0331.","journal-title":"Cancer Discov"},{"issue":"1","key":"8834_CR15","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1186\/s12935-020-01554-8","volume":"20","author":"Z Lv","year":"2020","unstructured":"Lv Z, Sun L, Xu Q, Xing C, Yuan Y. Joint analysis of lncRNA m6A methylome and lncRNA\/mRNA expression profiles in gastric cancer. Cancer Cell Int. 2020;20(1):464. https:\/\/doi.org\/10.1186\/s12935-020-01554-8.","journal-title":"Cancer Cell Int"},{"issue":"10","key":"8834_CR16","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/s41419-020-03049-w","volume":"11","author":"Y Sun","year":"2020","unstructured":"Sun Y, Li S, Yu W, Zhao Z, Gao J, Chen C, et al. N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN\/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020;11(10):836. https:\/\/doi.org\/10.1038\/s41419-020-03049-w.","journal-title":"Cell Death Dis"},{"issue":"1","key":"8834_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/ajmg.a.38504","volume":"176","author":"AF Sitzmann","year":"2018","unstructured":"Sitzmann AF, Hagelstrom RT, Tassone F, Hagerman RJ, Butler MG. Rare FMR1 gene mutations causing fragile X syndrome: a review. Am J Med Genet Pt A. 2018;176(1):11\u201318. https:\/\/doi.org\/10.1002\/ajmg.a.38504.","journal-title":"Am J Med Genet Pt A"},{"issue":"4","key":"8834_CR18","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.celrep.2019.06.072","volume":"28","author":"BM Edens","year":"2019","unstructured":"Edens BM, Vissers C, Su J, Arumugam S, Xu Z, Shi H, et al. FMRP modulates neural differentiation through m6A-Dependent mRNA nuclear export. Cell Rep. 2019;28(4):845\u201354.e5. https:\/\/doi.org\/10.1016\/j.celrep.2019.06.072.","journal-title":"Cell Rep"},{"issue":"7429","key":"8834_CR19","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nature11737","volume":"492","author":"M Ascano","year":"2012","unstructured":"Ascano M, Mukherjee N, Bandaru P, Miller JB, Nusbaum JD, Corcoran DL, et al. FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature. 2012;492(7429):382\u201386. https:\/\/doi.org\/10.1038\/nature11737.","journal-title":"Nature"},{"issue":"48","key":"8834_CR20","doi-asserted-by":"publisher","first-page":"30400","DOI":"10.1073\/pnas.2009161117","volume":"117","author":"H Shu","year":"2020","unstructured":"Shu H, Donnard E, Liu B, Jung S, Wang R, Richter JD. FMRP links optimal codons to mRNA stability in neurons. Proc Natl Acad Sci USA. 2020;117(48):30400\u201311. https:\/\/doi.org\/10.1073\/pnas.2009161117.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"52","key":"8834_CR21","doi-asserted-by":"publisher","first-page":"19889","DOI":"10.1074\/jbc.AC119.010078","volume":"294","author":"PJ Hsu","year":"2019","unstructured":"Hsu PJ, Shi H, Zhu AC, Lu Z, Miller N, Edens BM, et al. The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine\u2013containing mRNAs. J Biol Chem. 2019;294(52):19889\u201395. https:\/\/doi.org\/10.1074\/jbc.AC119.010078.","journal-title":"J Biol Chem"},{"issue":"1","key":"8834_CR22","doi-asserted-by":"publisher","first-page":"10781","DOI":"10.1038\/s41598-020-66394-y","volume":"10","author":"CJ Westmark","year":"2020","unstructured":"Westmark CJ, Maloney B, Alisch RS, Sokol DK, Lahiri DK. FMRP regulates the nuclear export of Adam9 and Psen1 mRNAs: secondary analysis of an N6-methyladenosine dataset. Sci Rep. 2020;10(1):10781. https:\/\/doi.org\/10.1038\/s41598-020-66394-y.","journal-title":"Sci Rep"},{"issue":"6","key":"8834_CR23","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/j.cell.2014.08.035","volume":"158","author":"E Pasciuto","year":"2014","unstructured":"Pasciuto E, Bagni C. SnapShot: FMRP mRNA targets and diseases. Cell. 2014;158(6):1446\u20131446.e1. https:\/\/doi.org\/10.1016\/j.cell.2014.08.035.","journal-title":"Cell"},{"issue":"1","key":"8834_CR24","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s42003-021-02071-8","volume":"4","author":"Z Shen","year":"2021","unstructured":"Shen Z, Liu B, Wu B, Zhou H, Wang X, Cao J, et al. FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis. Commun Biol. 2021;4(1):540. https:\/\/doi.org\/10.1038\/s42003-021-02071-8.","journal-title":"Commun Biol"},{"issue":"24","key":"8834_CR25","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1038\/s41388-021-01833-2","volume":"40","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Wang Z, Ying C, Hu J, Zeng T, Gao L. FMR1\/circCHAF1A\/miR-211-5p\/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs. Oncogene. 2021;40(24):4094\u2013110. https:\/\/doi.org\/10.1038\/s41388-021-01833-2.","journal-title":"Oncogene"},{"issue":"10","key":"8834_CR26","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1002\/emmm.201302847","volume":"5","author":"R Luca","year":"2013","unstructured":"Luca R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, et al. The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation. EMBO Mol Med. 2013;5(10):1523\u201336. https:\/\/doi.org\/10.1002\/emmm.201302847.","journal-title":"EMBO Mol Med"},{"issue":"2","key":"8834_CR27","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.jcmgh.2020.10.009","volume":"11","author":"A Di Grazia","year":"2021","unstructured":"Di Grazia A, Marafini I, Pedini G, Di Fusco D, Laudisi F, Dinallo V, et al. The fragile X mental retardation protein regulates RIPK1 and colorectal cancer resistance to Necroptosis. Cellular Mol Gastroenterol Hepatol. 2021;11(2):639\u201358. https:\/\/doi.org\/10.1016\/j.jcmgh.2020.10.009.","journal-title":"Cellular Mol Gastroenterol Hepatol"},{"key":"8834_CR28","doi-asserted-by":"publisher","unstructured":"Wang X, Spandidos A, Wang H, Seed B. PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic Acids Res. 2012;40(D1):D1144\u201349. https:\/\/doi.org\/10.1093\/nar\/gkr1013.","DOI":"10.1093\/nar\/gkr1013"},{"issue":"4","key":"8834_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods. 2001;25(4):402\u201308. https:\/\/doi.org\/10.1006\/meth.2001.1262.","journal-title":"Methods"},{"key":"8834_CR30","doi-asserted-by":"publisher","unstructured":"Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, et al. Multiplexing siRNAs to compress RNAi-based screen size in human cells. Nucleic Acids Res. 2007;35(8):e57. https:\/\/doi.org\/10.1093\/nar\/gkm141.","DOI":"10.1093\/nar\/gkm141"},{"key":"8834_CR31","doi-asserted-by":"publisher","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98\u2013102. https:\/\/doi.org\/10.1093\/nar\/gkx247.","DOI":"10.1093\/nar\/gkx247"},{"issue":"5","key":"8834_CR32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ijms22052622","volume":"22","author":"\u00c1 Bartha","year":"2021","unstructured":"Bartha \u00c1, Gyorffy B. TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues. Int J Mol Sci. 2021;22(5):22. https:\/\/doi.org\/10.3390\/ijms22052622.","journal-title":"Int J Mol Sci"},{"key":"8834_CR33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","volume":"25","author":"DS Chandrashekar","year":"2022","unstructured":"Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, et al. UALCAN: an update to the integrated cancer data analysis platform. Neoplasia. 2022;25:18\u201327. https:\/\/doi.org\/10.1016\/j.neo.2022.01.001.","journal-title":"Neoplasia"},{"key":"8834_CR34","doi-asserted-by":"publisher","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, et al. NCBI GEO: archive for functional genomics data sets\u2014update. Nucleic Acids Res. 2012;41(D1):D991\u201395. https:\/\/doi.org\/10.1093\/nar\/gks1193.","DOI":"10.1093\/nar\/gks1193"},{"issue":"4","key":"8834_CR35","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1093\/nar\/gkq960","volume":"39","author":"J Cui","year":"2011","unstructured":"Cui J, Chen Y, Chou WC, Sun L, Chen L, Suo J, et al. An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer. Nucleic Acids Res. 2011;39(4):1197\u2013207. https:\/\/doi.org\/10.1093\/nar\/gkq960.","journal-title":"Nucleic Acids Res"},{"key":"8834_CR36","doi-asserted-by":"publisher","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioportal. Sci Signal. 2013;6(269):l1. https:\/\/doi.org\/10.1126\/scisignal.2004088.","DOI":"10.1126\/scisignal.2004088"},{"issue":"9","key":"8834_CR37","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1074\/mcp.TIR119.001673","volume":"18","author":"P Wu","year":"2019","unstructured":"Wu P, Heins ZJ, Muller JT, Katsnelson L, de Bruijn I, Abeshouse AA, et al. Integration and analysis of CPTAC Proteomics Data in the context of cancer genomics in the cBioportal. Mol Cellular Proteomics. 2019;18(9):1893\u201398. https:\/\/doi.org\/10.1074\/mcp.TIR119.001673.","journal-title":"Mol Cellular Proteomics"},{"key":"8834_CR38","doi-asserted-by":"publisher","unstructured":"Li JH, Liu S, Zhou H, Qu LH, Yang JH. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein\u2013RNA interaction networks from large-scale CLIP-Seq data. Nucl Acids Res. 2014;42(D1):D92\u201397. https:\/\/doi.org\/10.1093\/nar\/gkt1248.","DOI":"10.1093\/nar\/gkt1248"},{"issue":"6","key":"8834_CR39","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/s41592-026-03105-x","volume":"23","author":"K Zhou","year":"2026","unstructured":"Zhou K, Huang J, Liu S, Zheng W, Liu S, Xing Y, et al. An encyclopedic regulatory and functional atlas of RNA interactomes. Nat Methods. 2026;23(6):1109\u201314. https:\/\/doi.org\/10.1038\/s41592-026-03105-x.","journal-title":"Nat Methods"},{"issue":"7397","key":"8834_CR40","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485(7397):201\u201306. https:\/\/doi.org\/10.1038\/nature11112.","journal-title":"Nature"},{"key":"8834_CR41","doi-asserted-by":"publisher","first-page":"3936","DOI":"10.1093\/hmg\/ddy292","volume":"27","author":"F Zhang","year":"2018","unstructured":"Zhang F, Kang Y, Wang M, Li Y, Xu T, Yang W, et al. Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets. Hum Mol Genet. 2018;27:3936\u201350. https:\/\/doi.org\/10.1093\/hmg\/ddy292.","journal-title":"Hum Mol Genet"},{"issue":"5","key":"8834_CR42","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1158\/1055-9965.EPI-13-1057","volume":"23","author":"P Karimi","year":"2014","unstructured":"Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidem Biomar. 2014;23(5):700\u201313. https:\/\/doi.org\/10.1158\/1055-9965.EPI-13-1057.","journal-title":"Cancer Epidem Biomar"},{"issue":"10251","key":"8834_CR43","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth EC, Nilsson M, Grabsch HI, van Grieken NCT, Lordick F. Gastric cancer. Lancet. 2020;396(10251):635\u201348. https:\/\/doi.org\/10.1016\/S0140-6736(20)31288-5.","journal-title":"Lancet"},{"issue":"5","key":"8834_CR44","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/10409238.2020.1810621","volume":"55","author":"M Majumder","year":"2020","unstructured":"Majumder M, Johnson RH, Palanisamy V. Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer. Crit Rev Biochem Mol Biol. 2020;55(5):409\u201324. https:\/\/doi.org\/10.1080\/10409238.2020.1810621.","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"9","key":"8834_CR45","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1136\/adc.2006.103382","volume":"92","author":"R Kalkunte","year":"2007","unstructured":"Kalkunte R, Macarthur D, Morton R. Glioblastoma in a boy with fragile X: an unusual case of neuroprotection. Arch Dis Child. 2007;92(9):795\u201396. https:\/\/doi.org\/10.1136\/adc.2006.103382.","journal-title":"Archives Disease Child"},{"issue":"8","key":"8834_CR46","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41419-022-05019-w","volume":"13","author":"G Pedini","year":"2022","unstructured":"Pedini G, Buccarelli M, Bianchi F, Pacini L, Cencelli G, D\u2019Alessandris QG, et al. FMRP modulates the Wnt signalling pathway in glioblastoma. Cell Death Dis. 2022;13(8):719. https:\/\/doi.org\/10.1038\/s41419-022-05019-w.","journal-title":"Cell Death Dis"},{"key":"8834_CR47","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.cellsig.2018.03.004","volume":"47","author":"M Sharma","year":"2018","unstructured":"Sharma M, Castro-Piedras I, Simmons GE Jr, Pruitt K. Dishevelled: a masterful conductor of complex wnt signals. Cell Signal. 2018;47:52\u201364. https:\/\/doi.org\/10.1016\/j.cellsig.2018.03.004.","journal-title":"Cellular Signalling"},{"issue":"5","key":"8834_CR48","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.cellsig.2009.11.021","volume":"22","author":"C Gao","year":"2010","unstructured":"Gao C, Chen YG. Dishevelled: the hub of wnt signaling. Cell Signal. 2010;22(5):717\u201327. https:\/\/doi.org\/10.1016\/j.cellsig.2009.11.021.","journal-title":"Cellular Signalling"},{"issue":"1","key":"8834_CR49","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13041-020-00706-1","volume":"13","author":"CR Casingal","year":"2020","unstructured":"Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N. Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras\/MAPK, Wnt\/\u03b2-catenin, and mTOR signaling during corticogenesis. Mol Brain. 2020;13(1):167. https:\/\/doi.org\/10.1186\/s13041-020-00706-1.","journal-title":"Mol Brain"},{"issue":"11","key":"8834_CR50","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/onc.2016.304","volume":"36","author":"T Zhan","year":"2017","unstructured":"Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017;36(11):1461\u201373. https:\/\/doi.org\/10.1038\/onc.2016.304.","journal-title":"Oncogene"},{"issue":"1","key":"8834_CR51","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12943-020-01276-5","volume":"19","author":"X Xu","year":"2020","unstructured":"Xu X, Zhang M, Xu F, Jiang S. Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities. Mol Cancer. 2020;19(1):165. https:\/\/doi.org\/10.1186\/s12943-020-01276-5.","journal-title":"Mol Cancer"},{"issue":"1","key":"8834_CR52","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5230\/jgc.2024.24.e6","volume":"24","author":"I-H Kim","year":"2024","unstructured":"Kim I-H. Emerging targets for systemic treatment of gastric cancer: HER2 and beyond. J Gastric Cancer. 2024;24(1):29\u201356. https:\/\/doi.org\/10.5230\/jgc.2024.24.e6.","journal-title":"J Gastric Cancer"},{"key":"8834_CR53","doi-asserted-by":"publisher","first-page":"1565999","DOI":"10.3389\/fbioe.2025.1565999","volume":"13","author":"S Wang","year":"2025","unstructured":"Wang S, Li J, Zhang Z, Cao S, Zhang Z, Bian Y, et al. Advances in nanomedicine and delivery systems for gastric cancer research. Front Bioeng Biotechnol. 2025;13:1565999. https:\/\/doi.org\/10.3389\/fbioe.2025.1565999.","journal-title":"Front Bioeng Biotechnol"},{"issue":"2","key":"8834_CR54","doi-asserted-by":"publisher","first-page":"9420025","DOI":"10.26599\/FMH.2024.9420025","volume":"1","author":"J Wang","year":"2024","unstructured":"Wang J, Liao Z-X. Research progress of microrobots in tumor drug delivery. Food Med Homol. 2024;1(2):9420025. https:\/\/doi.org\/10.26599\/FMH.2024.9420025.","journal-title":"Food Med Homol"},{"issue":"2","key":"8834_CR55","doi-asserted-by":"publisher","first-page":"9420022","DOI":"10.26599\/FMH.2025.9420022","volume":"2","author":"Y-H Miao","year":"2025","unstructured":"Miao Y-H, Wang X, Zhao X-M, Hu Y-W, Liu X, Deng D-W. Co-assembly strategies of natural plant compounds for improving their bioavailability. Food Med Homol. 2025;2(2):9420022. https:\/\/doi.org\/10.26599\/FMH.2025.9420022.","journal-title":"Food Med Homol"},{"issue":"1","key":"8834_CR56","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1186\/s12967-025-07140-8","volume":"23","author":"Y Han","year":"2025","unstructured":"Han Y, Mao C, Zhou K, Liang M, Zhao L, Hong Y, et al. Fragile X mental retardation 1 gene FMR1 promotes proliferation, migration, and invasion of gastric cancer cells via c-MYC. J Transl Med. 2025;23(1):1210. https:\/\/doi.org\/10.1186\/s12967-025-07140-8.","journal-title":"J Transl Med"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08834-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08834-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08834-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:47:08Z","timestamp":1788533228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08834-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8834"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08834-3","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"1 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were conducted in compliance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. All animal protocols were performed in accordance with the institutional guidelines for the care and use of laboratory animals and were approved by the Institutional Animal Care and Use Committee of China Medical University (Approval Nos. CMU2021517 and CMU2021518). The human tissue microarray (Cat. No. STC1602) was commercially obtained from Shanghai Superbiotek Pharmaceutical Technology Co., Ltd. (Shanghai, China). According to the supplier\u2019s documentation, written informed consent was obtained from the original tissue donors. All tissue specimens and associated clinicopathological data were fully de-identified, and the authors had no access to patient-identifying information. The use of human tissues in this study was approved by the Institutional Ethics Committee of China Medical University (Approval No. [2026]165) and conducted in accordance with the principles of the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. The manuscript contains no individual person\u2019s data (including any individual details, images, or videos).","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that no competing interest exists.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1139"}}