{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:31:00Z","timestamp":1761168660402,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":334,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["NA7233"],"award-info":[{"award-number":["NA7233"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiovascular Magnetic Resonance"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1186\/s12968-015-0197-y","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T20:23:54Z","timestamp":1448915034000},"page":"106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Distal coronary embolization following acute myocardial infarction increases early infarct size and late left ventricular wall thinning in a porcine model"],"prefix":"10.1016","volume":"17","author":[{"given":"Reuben M.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yup","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiping","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azriel B.","family":"Osherov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh R.","family":"Ghugre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Noyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuling","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ladouceur-Wodzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Berk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdish","family":"Butany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansoor","family":"Husain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham A.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley H.","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1186\/s12968-015-0197-y_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0140-6736(03)12113-7","article-title":"Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials","volume":"361","author":"Keeley","year":"2003","journal-title":"Lancet"},{"key":"10.1186\/s12968-015-0197-y_bib2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S0735-1097(00)00865-2","article-title":"Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction","volume":"36","author":"Morishima","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib3","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1161\/CIRCULATIONAHA.107.742312","article-title":"Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention","volume":"117","author":"Jaffe","year":"2008","journal-title":"Circulation"},{"key":"10.1186\/s12968-015-0197-y_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jacc.2009.03.054","article-title":"Myocardial no-reflow in humans","volume":"54","author":"Niccoli","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.yjmcc.2011.06.009","article-title":"Coronary no reflow","volume":"52","author":"Schwartz","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib6","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1161\/CIRCULATIONAHA.108.814640","article-title":"Reperfusion injury, microvascular dysfunction, and cardioprotection: the \u201cdark side\u201d of reperfusion","volume":"120","author":"Prasad","year":"2009","journal-title":"Circulation"},{"key":"10.1186\/s12968-015-0197-y_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jcin.2008.03.015","article-title":"Clinical implications of distal embolization during coronary interventional procedures in patients with acute myocardial infarction: quantitative study with Doppler guidewire","volume":"1","author":"Okamura","year":"2008","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1186\/s12968-015-0197-y_bib8","first-page":"e362","article-title":"2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"127","author":"O'Gara","year":"2013","journal-title":"Circulation"},{"key":"10.1186\/s12968-015-0197-y_bib9","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(08)60833-8","article-title":"Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study","volume":"371","author":"Vlaar","year":"2008","journal-title":"Lancet"},{"key":"10.1186\/s12968-015-0197-y_bib10","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1001\/jama.2012.421","article-title":"Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction: the INFUSE-AMI randomized trial","volume":"307","author":"Stone","year":"2012","journal-title":"JAMA"},{"key":"10.1186\/s12968-015-0197-y_bib11","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1056\/NEJMoa1308789","article-title":"Thrombus aspiration during ST-segment elevation myocardial infarction","volume":"369","author":"Frobert","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1186\/s12968-015-0197-y_bib12","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehs434","article-title":"Coronary microembolization during early reperfusion: infarct extension, but protection by ischaemic postconditioning","volume":"34","author":"Skyschally","year":"2013","journal-title":"Euro Heart J"},{"key":"10.1186\/s12968-015-0197-y_bib13","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/mrm.22855","article-title":"Quantitative tracking of edema, hemorrhage, and microvascular obstruction in subacute myocardial infarction in a porcine model by MRI","volume":"66","author":"Ghugre","year":"2011","journal-title":"Magn Reson Med"},{"key":"10.1186\/s12968-015-0197-y_bib14","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/mrm.24531","article-title":"Quantitative magnetic resonance imaging can distinguish remodeling mechanisms after acute myocardial infarction based on the severity of ischemic insult","volume":"70","author":"Ghugre","year":"2012","journal-title":"Magn Reson Med"},{"key":"10.1186\/s12968-015-0197-y_bib15","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.acra.2008.09.002","article-title":"Intracoronary injection of contrast media maps the territory of the coronary artery: an MRI technique for assessing the effects of locally delivered angiogenic therapies","volume":"15","author":"Carlsson","year":"2008","journal-title":"Acad Radiol"},{"key":"10.1186\/s12968-015-0197-y_bib16","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2004.09.020","article-title":"Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model","volume":"44","author":"Amado","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1186\/s12968-015-0197-y_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1532-429X-11-38","article-title":"Infarct evolution in man studied in patients with first-time coronary occlusion in comparison to different species - implications for assessment of myocardial salvage","volume":"11","author":"Hedstrom","year":"2009","journal-title":"J Cardiovasc Magn Res"},{"key":"10.1186\/s12968-015-0197-y_bib19","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.jacc.2009.08.024","article-title":"Impact of primary coronary angioplasty delay on myocardial salvage, infarct size, and microvascular damage in patients with ST-segment elevation myocardial infarction: insight from cardiovascular magnetic resonance","volume":"54","author":"Francone","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib20","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/hc0502.102867","article-title":"No-Reflow Phenomenon","volume":"105","author":"Rezkalla","year":"2002","journal-title":"Circulation"},{"key":"10.1186\/s12968-015-0197-y_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/MCA.0b013e3282c1fdb6","article-title":"Temporal changes in TIMI myocardial perfusion grade in relation to epicardial flow, ST-resolution and left ventricular function after primary percutaneous coronary intervention","volume":"18","author":"Aasa","year":"2007","journal-title":"Coron Artery Dis"},{"key":"10.1186\/s12968-015-0197-y_bib22","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.amjcard.2003.08.056","article-title":"Prognostic significance of transient no-reflow during primary percutaneous coronary intervention for ST-elevation acute myocardial infarction","volume":"92","author":"Mehta","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.amjcard.2011.09.037","article-title":"Usefulness of transient and persistent no reflow to predict adverse clinical outcomes following percutaneous coronary intervention","volume":"109","author":"Chan","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1532-429X-14-68","article-title":"CMR of microvascular obstruction and hemorrhage in myocardial infarction","volume":"14","author":"Wu","year":"2012","journal-title":"J Cardiovasc Magn Res"},{"key":"10.1186\/s12968-015-0197-y_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/CIRCIMAGING.112.973222","article-title":"Characterizing myocardial edema and hemorrhage using quantitative T2 and T2* mapping at multiple time intervals post ST-segment elevation myocardial infarction","volume":"5","author":"Zia","year":"2012","journal-title":"Circulat Cardiovasc Img"},{"issue":"13","key":"10.1186\/s12968-015-0197-y_bib26","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/eurheartj\/ehr064","article-title":"Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodelling","volume":"32","author":"Masci","year":"2011","journal-title":"Euro Heart J"},{"key":"10.1186\/s12968-015-0197-y_bib27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jcmg.2011.04.014","article-title":"Prediction of life-threatening arrhythmic events in patients with chronic myocardial infarction by contrast-enhanced CMR","volume":"4","author":"Boye","year":"2011","journal-title":"JACC Cardiovasc Img"},{"key":"10.1186\/s12968-015-0197-y_bib28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.thromres.2010.03.012","article-title":"Effects of distal embolization on the timing of platelet and inflammatory cell activation in interventional coronary no-reflow","volume":"126","author":"Charron","year":"2010","journal-title":"Thromb Res"},{"key":"10.1186\/s12968-015-0197-y_bib29","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.yjmcc.2010.12.021","article-title":"Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction","volume":"50","author":"Vilahur","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib30","doi-asserted-by":"crossref","first-page":"H1229","DOI":"10.1152\/ajpheart.00207.2003","article-title":"Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction","volume":"285","author":"Hayashidani","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1186\/s12968-015-0197-y_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijcard.2005.01.011","article-title":"Circulating level of gelatinase activity predicts ventricular remodeling in patients with acute myocardial infarction","volume":"105","author":"Matsunaga","year":"2005","journal-title":"Intl J Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib32","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1152\/physrev.00024.2010","article-title":"Myocardial AKT: the omnipresent nexus","volume":"91","author":"Sussman","year":"2011","journal-title":"Physiol Rev"},{"key":"10.1186\/s12968-015-0197-y_bib33","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.CIR.101.6.660","article-title":"Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart","volume":"101","author":"Fujio","year":"2000","journal-title":"Circulation"},{"key":"10.1186\/s12968-015-0197-y_bib34","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2337\/db08-1193","article-title":"GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice","volume":"58","author":"Noyan-Ashraf","year":"2009","journal-title":"Diabetes"},{"key":"10.1186\/s12968-015-0197-y_bib35","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/01.RES.0000138303.76488.fe","article-title":"Postconditioning: a form of \u201cmodified reperfusion\u201d protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway","volume":"95","author":"Tsang","year":"2004","journal-title":"Circ Res"},{"key":"10.1186\/s12968-015-0197-y_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/jmcc.2001.1489","article-title":"Coronary microembolization: the role of TNF-alpha in contractile dysfunction","volume":"34","author":"Dorge","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jcmg.2008.10.011","article-title":"Systematic analysis of functional and structural changes after coronary microembolization: a cardiac magnetic resonance imaging study","volume":"2","author":"Breuckmann","year":"2009","journal-title":"JACC Cardiovasc Img"},{"key":"10.1186\/s12968-015-0197-y_bib38","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/CIRCULATIONAHA.109.888784","article-title":"Coronary microembolization: from bedside to bench and back to bedside","volume":"120","author":"Heusch","year":"2009","journal-title":"Circulation"},{"key":"10.1186\/s12968-015-0197-y_bib39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00395-009-0067-6","article-title":"Blockade of NF-kappaB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in rats","volume":"105","author":"Li","year":"2010","journal-title":"Bas Res Cardiol"},{"key":"10.1186\/s12968-015-0197-y_bib40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa0706416","article-title":"Thrombus aspiration during primary percutaneous coronary intervention","volume":"358","author":"Svilaas","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1186\/s12968-015-0197-y_bib41","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1056\/NEJMoa1405707","article-title":"Outcomes 1 year after thrombus aspiration for myocardial infarction","volume":"371","author":"Lagerqvist","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1186\/s12968-015-0197-y_bib42","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1056\/NEJMoa1415098","article-title":"Randomized trial of primary PCI with or without routine manual thrombectomy","volume":"372","author":"Jolly","year":"2015","journal-title":"N Engl J Med"}],"container-title":["Journal of Cardiovascular Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723009316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723009316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12968-015-0197-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:03:41Z","timestamp":1761095021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097664723009316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1097664723009316"],"URL":"https:\/\/doi.org\/10.1186\/s12968-015-0197-y","relation":{},"ISSN":["1097-6647"],"issn-type":[{"type":"print","value":"1097-6647"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distal coronary embolization following acute myocardial infarction increases early infarct size and late left ventricular wall thinning in a porcine model","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiovascular Magnetic Resonance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s12968-015-0197-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 THE AUTHORS. Published by Elsevier Inc on behalf of the Society for Cardiovascular Magnetic Resonance","name":"copyright","label":"Copyright"}],"article-number":"106"}}