{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:37:09Z","timestamp":1787020629930,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["GA 2621\/1-1"],"award-info":[{"award-number":["GA 2621\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiovascular Magnetic Resonance"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1186\/s12968-019-0519-6","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T19:04:55Z","timestamp":1548875095000},"page":"10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Myocardial triglycerides in cardiac amyloidosis assessed by proton cardiovascular magnetic resonance spectroscopy"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-8418","authenticated-orcid":false,"given":"Mareike","family":"Gastl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie M.","family":"Peereboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gotschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Fuetterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"von Deuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Boenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahel","family":"Schwotzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Flammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Manka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kozerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s12968-019-0519-6_bib1","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.2214\/AJR.04.0871","article-title":"MR findings in Cardiac Amyloidosis","volume":"186","author":"vanden Driesen","year":"2006","journal-title":"Am J Roentgenol"},{"key":"10.1186\/s12968-019-0519-6_bib2","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1161\/CIRCULATIONAHA.111.069195","article-title":"Cardiac Amyloidosis","volume":"126","author":"Quarta","year":"2012","journal-title":"Circulation"},{"key":"10.1186\/s12968-019-0519-6_bib3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/eurheartj\/ehu444","article-title":"T1 mapping and survival in systemic light-chain amyloidosis","volume":"36","author":"Banypersad","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1186\/s12968-019-0519-6_bib4","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1161\/CIRCULATIONAHA.104.489187","article-title":"Diagnosis and management of the cardiac amyloidoses","volume":"112","author":"Falk","year":"2005","journal-title":"Circulation"},{"key":"10.1186\/s12968-019-0519-6_bib5","doi-asserted-by":"crossref","unstructured":"Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, et al. Nonbiopsy diagnosis of Cardiac transthyretin Amyloidosis. Circulation. 2016;133:2404\u201312.","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"10.1186\/s12968-019-0519-6_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmg.2013.08.015","article-title":"CMR-based differentiation of AL and ATTR Cardiac Amyloidosis","volume":"7","author":"Dungu","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1186\/s12968-019-0519-6_bib7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jacc.2017.05.053","article-title":"Magnetic resonance in transthyretin Cardiac Amyloidosis","volume":"70","author":"Martinez-Naharro","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-019-0519-6_bib8","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart \u2014 An engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1186\/s12968-019-0519-6_bib9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/nbm.3320","article-title":"MRS: a noninvasive window into cardiac metabolism","volume":"28","author":"van Ewijk","year":"2015","journal-title":"NMR Biomed"},{"key":"10.1186\/s12968-019-0519-6_bib10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10741-012-9341-z","article-title":"1H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism","volume":"18","author":"Faller","year":"2012","journal-title":"Heart Fail Rev"},{"key":"10.1186\/s12968-019-0519-6_bib11","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cardfail.2010.05.006","article-title":"Clinical features of myocardial triglyceride in different types of cardiomyopathy assessed by proton magnetic resonance spectroscopy: comparison with myocardial creatine","volume":"16","author":"Nakae","year":"2010","journal-title":"J Card Fail"},{"key":"10.1186\/s12968-019-0519-6_bib12","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/CIRCIMAGING.113.000559","article-title":"Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis","volume":"6","author":"Mahmod","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1186\/s12968-019-0519-6_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12872-016-0382-4","article-title":"Myocardial lipid content in Fabry disease: a combined 1H-MR spectroscopy and MR imaging study at 3 tesla","volume":"16","author":"Petritsch","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1186\/s12968-019-0519-6_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/srep29096","article-title":"In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study","volume":"6","author":"Ami","year":"2016","journal-title":"Sci Rep"},{"key":"10.1186\/s12968-019-0519-6_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jprot.2017.10.003","article-title":"Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis","volume":"172","author":"Miyahara","year":"2017","journal-title":"J Proteome"},{"key":"10.1186\/s12968-019-0519-6_bib16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ajh.20381","article-title":"Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th international symposium on amyloid and Amyloidosis","volume":"79","author":"Gertz","year":"2005","journal-title":"Am J Hematol"},{"key":"10.1186\/s12968-019-0519-6_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijcard.2016.04.175","article-title":"Quantitative comparison of 2D and 3D late gadolinium enhancement MR imaging in patients with Fabry disease and hypertrophic cardiomyopathy","volume":"217","author":"Morsbach","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1186\/s12968-019-0519-6_bib18","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/mrm.25028","article-title":"Compensation of signal loss due to cardiac motion in point-resolved spectroscopy of the heart","volume":"72","author":"Weiss","year":"2014","journal-title":"Magn Reson Med"},{"key":"10.1186\/s12968-019-0519-6_bib19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1088\/0031-9155\/30\/4\/008","article-title":"1H NMR chemical shift selective (CHESS) imaging","volume":"30","author":"Haase","year":"1985","journal-title":"Phys Med Biol"},{"key":"10.1186\/s12968-019-0519-6_bib20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/nbm.2845","article-title":"Cardiac proton spectroscopy using large coil arrays","volume":"26","author":"Weiss","year":"2013","journal-title":"NMR Biomed"},{"key":"10.1186\/s12968-019-0519-6_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/mrm.26099","article-title":"Second-order motion compensated PRESS for cardiac spectroscopy","volume":"77","author":"Fuetterer","year":"2017","journal-title":"Magn Reson Med"},{"key":"10.1186\/s12968-019-0519-6_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02668096","article-title":"Java-based graphical user interface for the MRUI quantitation package","volume":"12","author":"Naressi","year":"2001","journal-title":"MAGMA"},{"key":"10.1186\/s12968-019-0519-6_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2463\/mrms.3.19","article-title":"Assessment of myocardial creatine concentration in dysfunctional human heart by proton magnetic resonance spectroscopy","volume":"3","author":"Nakae","year":"2004","journal-title":"Magn Reson Med Sci"},{"key":"10.1186\/s12968-019-0519-6_bib24","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2004.09.020","article-title":"Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model","volume":"44","author":"Amado","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-019-0519-6_bib25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1186\/s12968-019-0519-6_bib26","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/01.CIR.0000023531.22727.C1","article-title":"Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure","volume":"106","author":"Osorio","year":"2002","journal-title":"Circulation"},{"key":"10.1186\/s12968-019-0519-6_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ Res"},{"key":"10.1186\/s12968-019-0519-6_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11547-016-0718-2","article-title":"1H- and 31P-myocardial magnetic resonance spectroscopy in non-obstructive hypertrophic cardiomyopathy patients and competitive athletes","volume":"122","author":"Secchi","year":"2017","journal-title":"Radiol Med"},{"key":"10.1186\/s12968-019-0519-6_bib29","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1096\/fj.04-2263com","article-title":"Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart","volume":"18","author":"Sharma","year":"2004","journal-title":"FASEB J"},{"key":"10.1186\/s12968-019-0519-6_bib30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/mrm.10372","article-title":"Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging","volume":"49","author":"Szczepaniak","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1186\/s12968-019-0519-6_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jchf.2013.11.004","article-title":"Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction","volume":"2","author":"Mohammed","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1186\/s12968-019-0519-6_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.carpath.2015.07.008","article-title":"Cardiac amyloidosis: pathology, nomenclature, and typing","volume":"24","author":"Maleszewski","year":"2015","journal-title":"Cardiovasc Pathol"},{"key":"10.1186\/s12968-019-0519-6_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12968-016-0308-4","article-title":"Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: a comprehensive review","volume":"18","author":"Haaf","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1186\/s12968-019-0519-6_bib34","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/circ.104.14.1594","article-title":"Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfunction in isolated mouse hearts","volume":"104","author":"Liao","year":"2001","journal-title":"Circulation"},{"key":"10.1186\/s12968-019-0519-6_bib35","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/01.RES.0000126569.75419.74","article-title":"Human Amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress","volume":"94","author":"Brenner","year":"2004","journal-title":"Circ Res"},{"key":"10.1186\/s12968-019-0519-6_bib36","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1096\/fj.15-272179","article-title":"Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis","volume":"29","author":"Lavatelli","year":"2015","journal-title":"FASEB J"},{"key":"10.1186\/s12968-019-0519-6_bib37","doi-asserted-by":"crossref","first-page":"e1002266","DOI":"10.1371\/journal.pmed.1002266","article-title":"Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: a nontargeted metabolomic study","volume":"14","author":"Snowden","year":"2017","journal-title":"PLoS Med"},{"key":"10.1186\/s12968-019-0519-6_bib38","first-page":"1016","article-title":"Age dependency of myocardial triglyceride content: a 3T high-field 1H-MR spectroscopy study","volume":"187","author":"Petritsch","year":"2015","journal-title":"R\u00f6Fo"},{"key":"10.1186\/s12968-019-0519-6_bib39","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/eurheartj\/ehn207","article-title":"The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function","volume":"29","author":"van der Meer","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1186\/s12968-019-0519-6_bib40","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/nbm.3186","article-title":"Cardiac lipid levels show diurnal changes and long-term variations in healthy human subjects","volume":"27","author":"Ith","year":"2014","journal-title":"NMR Biomed"},{"key":"10.1186\/s12968-019-0519-6_bib41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/13506120600877136","article-title":"Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?","volume":"13","author":"Rapezzi","year":"2006","journal-title":"Amyloid"},{"key":"10.1186\/s12968-019-0519-6_bib42","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/j.crvasa.2012.11.018","article-title":"Cardiac amyloidosis: a comprehensive review","volume":"55","author":"Fikrle","year":"2013","journal-title":"Cor Vasa"},{"key":"10.1186\/s12968-019-0519-6_bib43","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/02841850701280809","article-title":"Creatine depletion and altered fatty acid metabolism in diseased human hearts: clinical investigation using 1 h magnetic resonance spectroscopy and 123 I BMIPP myocardial scintigraphy","volume":"48","author":"Nakae","year":"2007","journal-title":"Acta Radiol"},{"key":"10.1186\/s12968-019-0519-6_bib44","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jcmg.2012.11.013","article-title":"Noncontrast T1 mapping for the diagnosis of Cardiac Amyloidosis","volume":"6","author":"Karamitsos","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1186\/s12968-019-0519-6_bib45","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1148\/radiol.2015141744","article-title":"Differential myocyte responses in patients with Cardiac transthyretin Amyloidosis and light-chain Amyloidosis: a Cardiac MR imaging study","volume":"277","author":"Fontana","year":"2015","journal-title":"Radiology"},{"key":"10.1186\/s12968-019-0519-6_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16318-0","article-title":"Non-water-suppressed 1H MR spectroscopy with Orientational prior knowledge shows potential for separating intra- and Extramyocellular lipid signals in human myocardium","volume":"7","author":"Fillmer","year":"2017","journal-title":"Sci Rep"}],"container-title":["Journal of Cardiovascular Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12968-019-0519-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12968-019-0519-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723001837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723001837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12968-019-0519-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:02:17Z","timestamp":1761094937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097664723001837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1097664723001837"],"URL":"https:\/\/doi.org\/10.1186\/s12968-019-0519-6","relation":{},"ISSN":["1097-6647"],"issn-type":[{"value":"1097-6647","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial triglycerides in cardiac amyloidosis assessed by proton cardiovascular magnetic resonance spectroscopy","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiovascular Magnetic Resonance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s12968-019-0519-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 THE AUTHORS. Published by Elsevier Inc on behalf of the Society for Cardiovascular Magnetic Resonance","name":"copyright","label":"Copyright"}],"article-number":"10"}}