{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:19:52Z","timestamp":1790245192189,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiovascular Magnetic Resonance"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1186\/s12968-019-0545-4","type":"journal-article","created":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T19:02:24Z","timestamp":1563130944000},"page":"39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Increased extracellular volume in the liver of pediatric Fontan patients"],"prefix":"10.1016","volume":"21","author":[{"given":"Charlotte","family":"de Lange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein J.E.","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Pagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Seed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Joon","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Broberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Z.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-3805","authenticated-orcid":false,"given":"Lars","family":"Grosse-Wortmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s12968-019-0545-4_bib1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1161\/CIRCULATIONAHA.105.592378","article-title":"Univentricular heart","volume":"115","author":"Khairy","year":"2007","journal-title":"Circulation."},{"key":"10.1186\/s12968-019-0545-4_bib2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/thx.26.3.240","article-title":"Surgical repair of tricuspid atresia","volume":"26","author":"Fontan","year":"1971","journal-title":"Thorax."},{"key":"10.1186\/s12968-019-0545-4_bib3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00246-014-0881-y","article-title":"Beyond a broken heart: circulatory dysfunction in the failing Fontan","volume":"35","author":"Mori","year":"2014","journal-title":"Pediatr Cardiol"},{"key":"10.1186\/s12968-019-0545-4_bib4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/j.pcsu.2010.02.006","article-title":"Forty years of the Fontan operation: a failed strategy","volume":"13","author":"Rychik","year":"2010","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"10.1186\/s12968-019-0545-4_bib5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/CIRCIMAGING.108.842096","article-title":"Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease","volume":"3","author":"Broberg","year":"2010","journal-title":"Circ Cardiovasc Imaging."},{"key":"10.1186\/s12968-019-0545-4_bib6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/CIRCULATIONAHA.105.548727","article-title":"Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of fallot and its relationship to adverse markers of clinical outcome","volume":"113","author":"Babu-Narayan","year":"2006","journal-title":"Circulation."},{"issue":"2","key":"10.1186\/s12968-019-0545-4_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.114.002504","article-title":"Myocardial T1 mapping in pediatric and congenital heart disease","volume":"8","author":"Riesenkampff","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1186\/s12968-019-0545-4_bib8","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.jacc.2013.11.066","article-title":"Myocardial extracellular remodeling is associated with ventricular diastolic dysfunction in children and young adults with congenital aortic stenosis","volume":"63","author":"Dusenbery","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-019-0545-4_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijcard.2017.04.073","article-title":"Pediatric Fontan patients are at risk for myocardial fibrotic remodeling and dysfunction","volume":"240","author":"Kato","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1186\/s12968-019-0545-4_bib10","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.ejrad.2015.05.019","article-title":"MR relaxometry in chronic liver diseases: comparison of T1 mapping, T2 mapping, and diffusion-weighted imaging for assessing cirrhosis diagnosis and severity","volume":"84","author":"Cassinotto","year":"2015","journal-title":"Eur J Radiol"},{"key":"10.1186\/s12968-019-0545-4_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jhep.2013.09.002","article-title":"Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease","volume":"60","author":"Banerjee","year":"2014","journal-title":"J Hepatol"},{"key":"10.1186\/s12968-019-0545-4_bib12","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00330-015-3994-7","article-title":"Quantitative assessment of hepatic function: modified look-locker inversion recovery (MOLLI) sequence for T1 mapping on Gd-EOB-DTPA-enhanced liver MR imaging","volume":"26","author":"Yoon","year":"2016","journal-title":"Eur Radiol"},{"key":"10.1186\/s12968-019-0545-4_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/srep41429","article-title":"Gd-EOB-DTPA-enhanced MR relaxometry for the detection and staging of liver fibrosis","volume":"7","author":"Haimerl","year":"2017","journal-title":"Sci Rep"},{"key":"10.1186\/s12968-019-0545-4_bib14","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1007\/s00261-018-1528-x","article-title":"Using T1 mapping in cardiovascular magnetic resonance to assess congestive hepatopathy","volume":"43","author":"Kazour","year":"2018","journal-title":"Abdom Radiol (NY)"},{"key":"10.1186\/s12968-019-0545-4_bib15","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/mrm.24793","article-title":"Adiabatic inversion pulses for myocardial T1 mapping","volume":"71","author":"Kellman","year":"2014","journal-title":"Magn Reson Med"},{"key":"10.1186\/s12968-019-0545-4_bib16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet."},{"key":"10.1186\/s12968-019-0545-4_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.healun.2015.10.015","article-title":"Fontan-associated liver disease: implications for heart transplantation","volume":"35","author":"Greenway","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"10.1186\/s12968-019-0545-4_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/j.pcsu.2015.11.006","article-title":"The relentless effects of the Fontan paradox","volume":"19","author":"Rychik","year":"2016","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu."},{"key":"10.1186\/s12968-019-0545-4_bib19","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1016\/j.jacc.2017.10.045","article-title":"Fontan-associated liver disease: proceedings from the American College of Cardiology Stakeholders Meeting, October 1 to 2, 2015, Washington DC","volume":"70","author":"Daniels","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-019-0545-4_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1067\/j.cpradiol.2017.04.002","article-title":"Abdominal imaging surveillance in adult patients after Fontan procedure: risk of chronic liver disease and hepatocellular carcinoma","volume":"47","author":"Nandwana","year":"2018","journal-title":"Curr Probl Diagn Radiol"},{"key":"10.1186\/s12968-019-0545-4_bib21","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.mayocp.2015.04.020","article-title":"Magnetic resonance Elastography: a novel technique for the detection of hepatic fibrosis and hepatocellular carcinoma after the Fontan operation","volume":"90","author":"Poterucha","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"10.1186\/s12968-019-0545-4_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/17474124.2017.1271710","article-title":"Multiparametric or practical quantitative liver MRI: towards millisecond, fat fraction, kilopascal and function era","volume":"11","author":"Unal","year":"2017","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1186\/s12968-019-0545-4_bib23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cgh.2012.01.023","article-title":"Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis","volume":"10","author":"Poynard","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1186\/s12968-019-0545-4_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/chd.12144","article-title":"Magnetic resonance elastography of the liver in patients status-post fontan procedure: feasibility and preliminary results","volume":"9","author":"Serai","year":"2014","journal-title":"Congen Heart Dis"},{"key":"10.1186\/s12968-019-0545-4_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/2150135114530172","article-title":"Fontan circulation in adult patients: acoustic radiation force impulse Elastography as a useful tool for liver assessment","volume":"5","author":"Melero-Ferrer","year":"2014","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"10.1186\/s12968-019-0545-4_bib26","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1007\/s00330-016-4614-x","article-title":"Effect of Fontan operation on liver stiffness in children with single ventricle physiology","volume":"27","author":"DiPaola","year":"2017","journal-title":"Eur Radiol"},{"key":"10.1186\/s12968-019-0545-4_bib27","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1148\/radiol.2018172099","article-title":"Diagnostic performance of MR Elastography for liver fibrosis in children and Young adults with a Spectrum of liver diseases","volume":"287","author":"Trout","year":"2018","journal-title":"Radiology."},{"key":"10.1186\/s12968-019-0545-4_bib28","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/s00330-012-2378-5","article-title":"MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis","volume":"22","author":"Heye","year":"2012","journal-title":"Eur Radiol"},{"key":"10.1186\/s12968-019-0545-4_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jmri.23620","article-title":"Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation","volume":"36","author":"Kim","year":"2012","journal-title":"J Magn Reson Imaging"},{"key":"10.1186\/s12968-019-0545-4_bib30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jhep.2015.10.009","article-title":"Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease","volume":"64","author":"Pavlides","year":"2016","journal-title":"J Hepatol"},{"key":"10.1186\/s12968-019-0545-4_bib31","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1136\/hrt.2010.201772","article-title":"Late hepatic complications after Fontan operation; non-invasive markers of hepatic fibrosis and risk factors","volume":"96","author":"Baek","year":"2010","journal-title":"Heart."},{"key":"10.1186\/s12968-019-0545-4_bib32","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jtcvs.2007.09.039","article-title":"Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers","volume":"135","author":"Friedrich-Rust","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1186\/s12968-019-0545-4_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/chd.12446","article-title":"Surveillance for liver complications after the Fontan procedure","volume":"12","author":"Hilscher","year":"2017","journal-title":"Congenit Heart Dis"},{"key":"10.1186\/s12968-019-0545-4_bib34","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.jtcvs.2011.08.038","article-title":"Hepatic pathology may develop before the Fontan operation in children with functional single ventricle: an autopsy study","volume":"143","author":"Schwartz","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1186\/s12968-019-0545-4_bib35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/jmri.25424","article-title":"Comparison of T2, T1rho, and diffusion metrics in assessment of liver fibrosis in rats","volume":"45","author":"Zhang","year":"2017","journal-title":"J Magn Reson Imaging"},{"key":"10.1186\/s12968-019-0545-4_bib36","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3348\/kjr.2017.18.6.898","article-title":"Impact of liver fibrosis and fatty liver on T1rho measurements: a prospective study","volume":"18","author":"Xie","year":"2017","journal-title":"Korean J Radiol"},{"key":"10.1186\/s12968-019-0545-4_bib37","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1148\/radiol.2016141802","article-title":"State of the art: clinical applications of cardiac T1 mapping","volume":"278","author":"Schelbert","year":"2016","journal-title":"Radiology."},{"key":"10.1186\/s12968-019-0545-4_bib38","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1148\/rg.2016150207","article-title":"Imaging findings of congestive Hepatopathy","volume":"36","author":"Wells","year":"2016","journal-title":"Radiographics."},{"key":"10.1186\/s12968-019-0545-4_bib39","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s10554-014-0424-x","article-title":"MR assessment of abdominal circulation in Fontan physiology","volume":"30","author":"Yoo","year":"2014","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1186\/s12968-019-0545-4_bib40","doi-asserted-by":"crossref","unstructured":"Yim D, Riesenkampff E, Caro-Dominguez P, Yoo SJ, Seed M, Grosse-Wortmann L. Assessment of Diffuse Ventricular Myocardial Fibrosis Using Native T1 in Children With Repaired Tetralogy of Fallot. Circ Cardiovasc Imaging 2017;10 pii: e005695. https:\/\/doi.org\/10.1161\/CIRCIMAGING.116.005695.","DOI":"10.1161\/CIRCIMAGING.116.005695"},{"key":"10.1186\/s12968-019-0545-4_bib41","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/mrm.26231","article-title":"Relaxation properties of human umbilical cord blood at 1.5 tesla","volume":"77","author":"Portnoy","year":"2017","journal-title":"Magn Reson Med"},{"key":"10.1186\/s12968-019-0545-4_bib42","volume":"19","author":"Messroghli","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1186\/s12968-019-0545-4_bib43","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jhep.2016.07.021","article-title":"Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging","volume":"65","author":"Palaniyappan","year":"2016","journal-title":"J Hepatol"}],"container-title":["Journal of Cardiovascular Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12968-019-0545-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12968-019-0545-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723002120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723002120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12968-019-0545-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:59:34Z","timestamp":1761094774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097664723002120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1097664723002120"],"URL":"https:\/\/doi.org\/10.1186\/s12968-019-0545-4","relation":{},"ISSN":["1097-6647"],"issn-type":[{"value":"1097-6647","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased extracellular volume in the liver of pediatric Fontan patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiovascular Magnetic Resonance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s12968-019-0545-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 THE AUTHORS. Published by Elsevier Inc on behalf of the Society for Cardiovascular Magnetic Resonance","name":"copyright","label":"Copyright"}],"article-number":"39"}}