{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:19:43Z","timestamp":1791670783286,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/14\/13\/30619"],"award-info":[{"award-number":["FS\/14\/13\/30619"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiovascular Magnetic Resonance"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1186\/s12968-021-00720-9","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T11:03:07Z","timestamp":1615201387000},"page":"26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cardiovascular magnetic resonance predictors of heart failure in hypertrophic cardiomyopathy: the role of myocardial replacement fibrosis and the microcirculation"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-0413","authenticated-orcid":false,"given":"Claire E.","family":"Raphael","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajen Sunthar","family":"Kanaganayagam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphonsus C.","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Di Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Silva","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Kanapeckaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Newsome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gregson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yueh","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Vassiliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir Ali","family":"MRCP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevfik F.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gatehouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Firmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frenneaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"O'Hanlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudley J.","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1186\/s12968-021-00720-9_bib1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/0002-9149(93)91136-6","article-title":"Clinicopathologic features of hypertrophic cardiomyopathy managed by cardiac transplantation","volume":"72","author":"Shirani","year":"1993","journal-title":"Am J Cardiol"},{"issue":"11","key":"10.1186\/s12968-021-00720-9_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJM199703133361107","article-title":"The management of hypertrophic cardiomyopathy","volume":"336","author":"Spirito","year":"1997","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1186\/s12968-021-00720-9_bib3","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy: a systematic review","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"issue":"6","key":"10.1186\/s12968-021-00720-9_bib4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cardfail.2011.01.015","article-title":"Risk of sudden death in end-stage hypertrophic cardiomyopathy","volume":"17","author":"Kawarai","year":"2011","journal-title":"J Card Fail"},{"issue":"17","key":"10.1186\/s12968-021-00720-9_bib5","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1093\/eurheartj\/ehq136","article-title":"Clinicopathological profiles of progressive heart failure in hypertrophic cardiomyopathy","volume":"31","author":"Melacini","year":"2010","journal-title":"Eur Heart J"},{"issue":"9","key":"10.1186\/s12968-021-00720-9_bib6","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jacc.2009.04.072","article-title":"The case for myocardial ischemia in hypertrophic cardiomyopathy","volume":"54","author":"Maron","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1186\/s12968-021-00720-9_bib7","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMoa025050","article-title":"Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy","volume":"349","author":"Cecchi","year":"2003","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1186\/s12968-021-00720-9_bib8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jacc.2005.10.050","article-title":"Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy","volume":"47","author":"Olivotto","year":"2006","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1186\/s12968-021-00720-9_bib9","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.113.007094","article-title":"Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy","volume":"130","author":"Chan","year":"2014","journal-title":"Circulation"},{"issue":"11","key":"10.1186\/s12968-021-00720-9_bib10","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jacc.2010.05.010","article-title":"Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy","volume":"56","author":"O'Hanlon","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"9814","key":"10.1186\/s12968-021-00720-9_bib11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(11)61335-4","article-title":"Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial","volume":"379","author":"Greenwood","year":"2012","journal-title":"Lancet"},{"issue":"24","key":"10.1186\/s12968-021-00720-9_bib12","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1161\/CIR.0b013e318223e230","article-title":"2011 ACCF\/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"124","author":"Gersh","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"10.1186\/s12968-021-00720-9_bib13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ahj.2005.02.050","article-title":"Prognostic utility of single-photon emission computed tomography in adult patients with hypertrophic cardiomyopathy","volume":"151","author":"Sorajja","year":"2006","journal-title":"Am Heart J"},{"issue":"4","key":"10.1186\/s12968-021-00720-9_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jacc.2014.12.018","article-title":"2014 ACC\/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials","volume":"66","author":"Hicks","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1186\/s12968-021-00720-9_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/jmri.25285","article-title":"Myocardial infarct sizing by late gadolinium-enhanced MRI: Comparison of manual, full-width at half-maximum, and n-standard deviation methods","author":"Zhang","year":"2016","journal-title":"J Magn Reson Imaging"},{"issue":"6","key":"10.1186\/s12968-021-00720-9_bib16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/eurjhf\/hft019","article-title":"Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy","volume":"15","author":"Gulati","year":"2013","journal-title":"Eur J Heart Fail"},{"issue":"14","key":"10.1186\/s12968-021-00720-9_bib17","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1161\/CIRCULATIONAHA.108.812503","article-title":"Complementary prognostic values of stress myocardial perfusion and late gadolinium enhancement imaging by cardiac magnetic resonance in patients with known or suspected coronary artery disease","volume":"120","author":"Steel","year":"2009","journal-title":"Circulation"},{"issue":"6","key":"10.1186\/s12968-021-00720-9_bib18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCULATIONAHA.113.001430","article-title":"Stress cardiac magnetic resonance imaging provides effective cardiac risk reclassification in patients with known or suspected stable coronary artery disease","volume":"128","author":"Shah","year":"2013","journal-title":"Circulation"},{"issue":"4","key":"10.1186\/s12968-021-00720-9_bib19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1186\/s12968-021-00720-9_bib20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcmg.2011.07.013","article-title":"A quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans","volume":"5","author":"Hsu","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1186\/s12968-021-00720-9_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12968-014-0049-1","article-title":"Coronary microvascular ischemia in hypertrophic cardiomyopathy - a pixel-wise quantitative cardiovascular magnetic resonance perfusion study","volume":"16","author":"Ismail","year":"2014","journal-title":"J Cardiovasc Magn Reson"},{"issue":"3","key":"10.1186\/s12968-021-00720-9_bib22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCULATIONAHA.105.583500","article-title":"Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy","volume":"114","author":"Harris","year":"2006","journal-title":"Circulation"},{"issue":"8","key":"10.1186\/s12968-021-00720-9_bib23","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.jacc.2005.04.062","article-title":"Dilated-hypokinetic evolution of hypertrophic cardiomyopathy: prevalence, incidence, risk factors, and prognostic implications in pediatric and adult patients","volume":"46","author":"Biagini","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1186\/s12968-021-00720-9_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/CIRCULATIONAHA.110.985812","article-title":"Mitral valve abnormalities identified by cardiovascular magnetic resonance represent a primary phenotypic expression of hypertrophic cardiomyopathy","volume":"124","author":"Maron","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1186\/s12968-021-00720-9_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12968-020-00623-1","article-title":"Prevalence and clinical significance of cardiovascular magnetic resonance adenosine stress-induced myocardial perfusion defect in hypertrophic cardiomyopathy","volume":"22","author":"Kim","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"issue":"2","key":"10.1186\/s12968-021-00720-9_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCIMAGING.112.000170","article-title":"Stress hypoperfusion and tissue injury in hypertrophic cardiomyopathy: spatial characterization using high-resolution 3-tesla magnetic resonance imaging","volume":"6","author":"Tyan","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"issue":"5","key":"10.1186\/s12968-021-00720-9_bib27","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/heart.84.5.476","article-title":"Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease","volume":"84","author":"Varnava","year":"2000","journal-title":"Heart"},{"issue":"11","key":"10.1186\/s12968-021-00720-9_bib28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jacc.2012.12.024","article-title":"Blunted myocardial oxygenation response during vasodilator stress in patients with hypertrophic cardiomyopathy","volume":"61","author":"Karamitsos","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1186\/s12968-021-00720-9_bib29","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1016\/j.jtcvs.2011.10.020","article-title":"2011 ACCF\/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"142","author":"Gersh","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"10.1186\/s12968-021-00720-9_bib30","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1053\/euhj.1997.0769","article-title":"Dipyridamole stress thallium-201 perfusion abnormalities in patients with hypertrophic cardiomyopathy. Relationship to clinical presentation and outcome","volume":"19","author":"Yamada","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1186\/s12968-021-00720-9_bib31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0735-1097(91)90869-B","article-title":"coronary vasodilation is impaired in HCM more so in patients with chest pain","volume":"17","author":"Camici","year":"1991","journal-title":"JACC"},{"issue":"18","key":"10.1186\/s12968-021-00720-9_bib32","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.jacc.2015.02.061","article-title":"Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies","volume":"65","author":"Maron","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"14","key":"10.1186\/s12968-021-00720-9_bib33","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/eurheartj\/ehs150","article-title":"Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence","volume":"33","author":"Spoladore","year":"2012","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1186\/s12968-021-00720-9_bib34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1056\/NEJMoa021332","article-title":"Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy","volume":"348","author":"Maron","year":"2003","journal-title":"N Engl J Med"}],"container-title":["Journal of Cardiovascular Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12968-021-00720-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12968-021-00720-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723003678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664723003678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12968-021-00720-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:58:04Z","timestamp":1761094684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097664723003678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1097664723003678"],"URL":"https:\/\/doi.org\/10.1186\/s12968-021-00720-9","relation":{},"ISSN":["1097-6647"],"issn-type":[{"value":"1097-6647","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular magnetic resonance predictors of heart failure in hypertrophic cardiomyopathy: the role of myocardial replacement fibrosis and the microcirculation","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiovascular Magnetic Resonance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s12968-021-00720-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 THE AUTHORS. Published by Elsevier Inc on behalf of the Society for Cardiovascular Magnetic Resonance","name":"copyright","label":"Copyright"}],"article-number":"26"}}