{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:53:05Z","timestamp":1784364785019,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001412"],"award-info":[{"award-number":["UL1TR001412"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 16K10045"],"award-info":[{"award-number":["JP 16K10045"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001703","name":"JM Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100001703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12969-019-0347-0","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T12:02:51Z","timestamp":1562932971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells"],"prefix":"10.1186","volume":"17","author":[{"given":"Kaiyu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"O\u2019Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1878-0717","authenticated-orcid":false,"given":"James N.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"issue":"8","key":"347_CR1","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1002\/art.1780250807","volume":"25","author":"G Spencer-Green","year":"1982","unstructured":"Spencer-Green G, Crowe WE, Levinson JE. Nailfold capillary abnormalities and clinical outcome in childhood dermatomyositis. Arthritis Rheum. 1982;25(8):954\u20138.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"347_CR2","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/art.1780250203","volume":"25","author":"WE Crowe","year":"1982","unstructured":"Crowe WE, Bove KE, Levinson JE, Hilton PK. Clinical and pathogenetic implications of histopathology in childhood polydermatomyositis. Arthritis Rheum. 1982;25(2):126\u201339.","journal-title":"Arthritis Rheum"},{"issue":"4","key":"347_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/00005792-196607000-00001","volume":"45","author":"BQ Banker","year":"1966","unstructured":"Banker BQ, Victor M. Dermatomyositis (systemic angiopathy) of childhood. Medicine (Baltimore). 1966;45(4):261\u201389.","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"347_CR4","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s11926-010-0101-6","volume":"12","author":"SA Greenberg","year":"2010","unstructured":"Greenberg SA. Dermatomyositis and type 1 interferons. Curr Rheumatol Rep. 2010;12(3):198\u2013203.","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"347_CR5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/art.30161","volume":"63","author":"MJ Kaplan","year":"2011","unstructured":"Kaplan MJ, Salmon JE. How does interferon-alpha insult the vasculature? Let me count the ways. Arthritis Rheum. 2011;63(2):334\u20136.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"347_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.21037\/atm.2016.12.68","volume":"5","author":"B De Paepe","year":"2017","unstructured":"De Paepe B. Vascular changes and perifascicular muscle fiber damage in dermatomyositis: another question of the chicken or the egg that is on our mind. Ann Transl Med. 2017;5(1):22.","journal-title":"Ann Transl Med"},{"issue":"4","key":"347_CR7","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/rheumatology\/kex468","volume":"57","author":"R Karasawa","year":"2018","unstructured":"Karasawa R, Tamaki M, Sato T, Tanaka M, Nawa M, Yudoh K, Jarvis JN. Multiple target autoantigens on endothelial cells identified in juvenile dermatomyositis using proteomics. Rheumatology (Oxford). 2018;57(4):671\u20136.","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"347_CR8","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1002\/art.21350","volume":"52","author":"JH Distler","year":"2005","unstructured":"Distler JH, Pisetsky DS, Huber LC, Kalden JR, Gay S, Distler O. Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases. Arthritis Rheum. 2005;52(11):3337\u201348.","journal-title":"Arthritis Rheum"},{"key":"347_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13059-015-0613-5","volume":"16","author":"M Tewari","year":"2015","unstructured":"Tewari M. A functional extracellular transcriptome in animals? Implications for biology, disease and medicine. Genome Biol. 2015;16:47.","journal-title":"Genome Biol"},{"issue":"3","key":"347_CR10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nri3622","volume":"14","author":"PD Robbins","year":"2014","unstructured":"Robbins PD, Morelli AE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14(3):195\u2013208.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"347_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1586\/14737159.2014.893828","volume":"14","author":"S Jia","year":"2014","unstructured":"Jia S, Zocco D, Samuels ML, Chou MF, Chammas R, Skog J, Zarovni N, Momen-Heravi F, Kuo WP. Emerging technologies in extracellular vesicle-based molecular diagnostics. Expert Rev Mol Diagn. 2014;14(3):307\u201321.","journal-title":"Expert Rev Mol Diagn"},{"issue":"5","key":"347_CR12","doi-asserted-by":"publisher","first-page":"769","DOI":"10.2217\/bmm.13.63","volume":"7","author":"F Properzi","year":"2013","unstructured":"Properzi F, Logozzi M, Fais S. Exosomes: the future of biomarkers in medicine. Biomark Med. 2013;7(5):769\u201378.","journal-title":"Biomark Med"},{"issue":"12","key":"347_CR13","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ncb1800","volume":"10","author":"J Skog","year":"2008","unstructured":"Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS, Krichevsky AM, Breakefield XO. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10(12):1470\u20136.","journal-title":"Nat Cell Biol"},{"key":"347_CR14","first-page":"55","volume":"8","author":"K Jiang","year":"2015","unstructured":"Jiang K, Sun X, Chen Y, Shen Y, Jarvis JN. RNA sequencing from human neutrophils reveals distinct transcriptional differences associated with chronic inflammatory states. BMC Med Genet. 2015;8:55.","journal-title":"BMC Med Genet"},{"issue":"2","key":"347_CR15","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/nar\/gks1187","volume":"41","author":"J An","year":"2013","unstructured":"An J, Lai J, Lehman ML, Nelson CC. miRDeep*: an integrated application tool for miRNA identification from RNA sequencing data. Nucleic Acids Res. 2013;41(2):727\u201337.","journal-title":"Nucleic Acids Res"},{"key":"347_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.14806\/ej.17.1.200","volume":"17","author":"M Martin","year":"2011","unstructured":"Martin M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. 2011;17:3.","journal-title":"EMBnet J"},{"issue":"4","key":"347_CR17","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 2013;14(4):R36.","journal-title":"Genome Biol"},{"issue":"2","key":"347_CR18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W. HTSeq--a Python framework to work with high-throughput sequencing data. Bioinformatics. 2015;31(2):166\u20139.","journal-title":"Bioinformatics"},{"issue":"1","key":"347_CR19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139\u201340.","journal-title":"Bioinformatics"},{"issue":"1","key":"347_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15\u201320.","journal-title":"Cell"},{"key":"347_CR21","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1186\/1471-2164-10-594","volume":"10","author":"Z Hu","year":"2009","unstructured":"Hu Z. Insight into microRNA regulation by analyzing the characteristics of their targets in humans. BMC Genomics. 2009;10:594.","journal-title":"BMC Genomics"},{"issue":"3","key":"347_CR22","first-page":"333","volume":"24","author":"JC Wargula","year":"2006","unstructured":"Wargula JC, Lovell DJ, Passo MH, Bove KE, Santangelo JD, Levinson JE. What more can we learn from muscle histopathology in children with dermatomyositis\/polymyositis? Clin Exp Rheumatol. 2006;24(3):333\u201343.","journal-title":"Clin Exp Rheumatol"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-019-0347-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12969-019-0347-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-019-0347-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T23:10:47Z","timestamp":1594422647000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-019-0347-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,12]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["347"],"URL":"https:\/\/doi.org\/10.1186\/s12969-019-0347-0","relation":{},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,12]]},"assertion":[{"value":"28 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Patient samples were acquired under the auspices of Institutional Review Board (IRB)-approved protocols at the University of Oklahoma Health Sciences Center and the University at Buffalo Jacobs School of Medicine and Biomedical Sciences. Informed consent was obtained from the parents of the participating subjects and, where required, assent was also obtained from the subjects themselves.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients\/parents consented to publication of data in de-identified form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}