{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:26:12Z","timestamp":1790421972242,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Juvenile spondyloarthritis (JSpA) represents a group of inflammatory arthritides with several distinctive features (enthesitis, involvement of spine and sacroiliac joint, HLA-B27 association and development of uveitis). There are limited data on the course of uveitis in children with JSpA.<\/jats:p>\n                    <jats:p>This study aims to estimate the prevalence of uveitis and to look at the presence of HLA-B27 in relation to uveitis occurrence and ocular symptoms in a cohort of JSpA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>This is a cross sectional\/retrospective study involving patients with JSpA followed in a tertiary referral hospital.<\/jats:p>\n                    <jats:p>Two hundred twenty-three patients were enrolled in the study. The prevalent diagnosis was enthesitis-related arthritis (ERA) (62%) followed by juvenile psoriatic arthritis (PsA), undifferentiated arthritis (UA), and the arthropathies associated with inflammatory bowel disease (IBD-A) (18, 14, 6%, respectively).<\/jats:p>\n                    <jats:p>Uveitis was reported in twenty-four patients (11%) of the JSpA cohort (JSpA-U). ERA patients had the highest uveitis prevalence (ERA-U) (13%) with similar prevalences in UA, PsA and in IBD-A (7% each).<\/jats:p>\n                    <jats:p>\n                      The prevalence of HLA-B27 positivity was similar amongst the entire JSpA-U cohort (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u200922, 45%) and those with ERA-U (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u20098, 44%). The overall prevalence of symptomatic uveitis was 79%. Neither the likelihood of uveitis, nor of symptomatic uveitis, varied by HLA-B27 status either in the entire cohort nor in those with ERA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>About one-tenth of patients developed uveitis, the majority of which was symptomatic. Fewer than half of the patients with uveitis were HLA-B27 positive. HLA-B27 status was not statistically associated with either the development of uveitis or symptomaticity of uveitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12969-020-00463-4","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T07:04:10Z","timestamp":1599721450000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Juvenile Spondyloarthritis: focus on uveitis"],"prefix":"10.1186","volume":"18","author":[{"given":"Achille","family":"Marino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela F.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Brandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-5292","authenticated-orcid":false,"given":"Melissa A.","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"issue":"4","key":"463_CR1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.pcl.2018.03.006","volume":"65","author":"PF Weiss","year":"2018","unstructured":"Weiss PF, Colbert RA. Juvenile Spondyloarthritis: a distinct form of juvenile arthritis. PediatrClin North Am. 2018;65(4):675\u201390.","journal-title":"PediatrClin North Am"},{"issue":"2","key":"463_CR2","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31(2):390\u20132.","journal-title":"J Rheumatol"},{"issue":"6","key":"463_CR3","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/acr.21616","volume":"64","author":"F Canou\u00ef-Poitrine","year":"2012","unstructured":"Canou\u00ef-Poitrine F, Lekpa FK, Farrenq V, Viallette C, Gabison G, Pouget F, et al. Prevalence and factors associated with uveitis in spondylarthritis patients in France: results from an observational survey. Arthritis Care Res (Hoboken). 2012;64(6):919\u201324.","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"7","key":"463_CR4","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1136\/ard.2007.075754","volume":"67","author":"N Zeboulon","year":"2008","unstructured":"Zeboulon N, Dougados M, Gossec L. Prevalence and characteristics of uveitis in the spondyloarthropathies: a systematic literature review. Ann Rheum Dis. 2008;67(7):955\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"463_CR5","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1053\/berh.2002.0247","volume":"16","author":"R Burgos-Vargas","year":"2002","unstructured":"Burgos-Vargas R, Pacheco-Tena C, Vazquez-Mellado J. The juvenile-onset spondyloarthritides: rationale for clinical evaluation. Best Pract Res Clin Rheumatol. 2002;16(4):551\u201372.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"1","key":"463_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12969-018-0238-9","volume":"16","author":"M Goirand","year":"2018","unstructured":"Goirand M, Breton S, Chevallier F, Duong NP, Uettwiller F, Melki I, et al. Clinical features of children with enthesitis-related juvenile idiopathic arthritis \/ juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology Centre. Pediatr Rheumatol Online J. 2018;16(1):21.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"463_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2016-000366","volume":"3","author":"A Wei\u00df","year":"2017","unstructured":"Wei\u00df A, Minden K, Listing J, Foeldvari I, Sieper J, Rudwaleit M. Course of patients with juvenile spondyloarthritis during 4 years of observation, juvenile part of GESPIC. RMD Open. 2017;3(1):e000366.","journal-title":"RMD Open"},{"issue":"3","key":"463_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.5114\/reum.2015.53133","volume":"53","author":"Z \u017buber","year":"2015","unstructured":"\u017buber Z, Turowska-Heydel D, Sobczyk M, Chudek J. Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis. Reumatologia. 2015;53(3):125\u201330.","journal-title":"Reumatologia"},{"issue":"2","key":"463_CR9","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/art.22381","volume":"56","author":"RK Saurenmann","year":"2007","unstructured":"Saurenmann RK, Levin AV, Feldman BM, Rose JB, Laxer RM, Schneider R, et al. Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis: a long-term followup study. Arthritis Rheum. 2007;56(2):647\u201357.","journal-title":"Arthritis Rheum"},{"issue":"6","key":"463_CR10","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1093\/rheumatology\/kem053","volume":"46","author":"A Heiligenhaus","year":"2007","unstructured":"Heiligenhaus A, Niewerth M, Ganser G, Heinz C, Minden K. Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nationwide study in Germany: suggested modification of the current screening guidelines. Rheumatology (Oxford). 2007;46(6):1015\u20139.","journal-title":"Rheumatology (Oxford)"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-020-00463-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-020-00463-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-020-00463-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T19:29:07Z","timestamp":1631215747000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-020-00463-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["463"],"URL":"https:\/\/doi.org\/10.1186\/s12969-020-00463-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.23979\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.23979\/v2","asserted-by":"object"}]},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"17 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was reviewed and approved by the institutional review board of the Children\u2019s Hospital of Philadelphia.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"70"}}