{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:54:13Z","timestamp":1792601653489,"version":"4.5.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ19H030005"],"award-info":[{"award-number":["LQ19H030005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Henoch\u2013Sch\u00f6nlein purpura (HSP) is a systemic small-vessel vasculitis also named IgA vasculitis that commonly affects the gastrointestinal tract. The video capsule endoscopy (VCE) characteristics of pediatric HSP patients are rarely reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with HSP and analyzed by VCE examination at our hospital from February 2010 to January 2020\u00a0are enrolled. The clinical features, laboratory findings, and the characteristics of VCE findings are studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There are 30 patients enrolled in this investigation from February 2010 to January 2020. The mean age of these patients is 96.9\u2009\u00b1\u200935.8\u2009months, and the most frequent finding of VCE is mucosal erosion, which account for 79.3% of the patients, and followed by mucosal erythema or petechia accounted for 69% of the patients. Regarding the disease location detected by endoscopy, jejunum is the most common involved part of the gastrointestinal tract in pediatric HSP patients. All the patients had the jejunum involved except in one patient the VCE did not pass through the pylorus. One third of the patients involved the descending portion of duodenum. No side effect is observed in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VCE may be an excellent adjust tool for evaluation of the gastrointestinal tract in children with abdominal symptoms without typical purpura in suspected pediatric HSP patients. VCE appears to be superior to esophagogastroduodenoscopy in detecting small intestinal lesions of HSP and has an excellent safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12969-020-00471-4","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T08:02:42Z","timestamp":1603872162000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The characteristics of video capsule endoscopy in pediatric Henoch\u2013Sch\u00f6nlein purpura with gastrointestinal symptoms"],"prefix":"10.1186","volume":"18","author":[{"given":"Youhong","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-7262","authenticated-orcid":false,"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"471_CR1","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.3748\/wjg.v11.i15.2354","volume":"11","author":"MJ Chen","year":"2005","unstructured":"Chen MJ, Wang TE, Chang WH, Tsai SJ, Liao WS. Endoscopic findings in a patient with Henoch-Schonlein purpura. World J Gastroenterol. 2005;11:2354\u20136.","journal-title":"World J Gastroenterol"},{"key":"471_CR2","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1055\/s-0034-1377757","volume":"46","author":"EJ Nam","year":"2014","unstructured":"Nam EJ, Kim GW, Kang JW, et al. Gastrointestinal bleeding in adult patients with Henoch-Schonlein purpura. Endoscopy. 2014;46:981\u20136.","journal-title":"Endoscopy"},{"key":"471_CR3","doi-asserted-by":"crossref","unstructured":"Dupont-Lucas C, Bellaiche M, Mouterde O, et al. Capsule endoscopy in children: which are the best indications? Arch Pediatr. 2010;17:1264\u201372.","DOI":"10.1016\/j.arcped.2010.04.026"},{"key":"471_CR4","doi-asserted-by":"crossref","unstructured":"Vadamalayan B, Hii M, Kark J, Bjarnason I. Feasibility of small bowel capsule endoscopy in children under the age of 4 years: a single centre experience. Frontline Gastroenterol. 2012;3:267\u201371.","DOI":"10.1136\/flgastro-2012-100163"},{"key":"471_CR5","first-page":"714","volume":"107","author":"F Arguelles-Arias","year":"2015","unstructured":"Arguelles-Arias F, Donat E, Fernandez-Urien I, et al. Guideline for wireless capsule endoscopy in children and adolescents: a consensus document by the SEGHNP (Spanish Society for Pediatric Gastroenterology, Hepatology, and nutrition) and the SEPD (Spanish Society for Digestive Diseases). Rev Esp Enferm Dig. 2015;107:714\u201331.","journal-title":"Rev Esp Enferm Dig"},{"key":"471_CR6","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.2169\/internalmedicine.2097-18","volume":"58","author":"T Tanaka","year":"2019","unstructured":"Tanaka T, Hiramatsu K, Saito Y, et al. The usefulness of video capsule endoscopy in evaluating gastrointestinal manifestations of immunoglobulin a vasculitis. Intern Med. 2019;58:1979\u201385.","journal-title":"Intern Med"},{"key":"471_CR7","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/ard.2009.116657","volume":"69","author":"S Ozen","year":"2010","unstructured":"Ozen S, Pistorio A, Iusan SM, et al. EULAR\/PRINTO\/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria. Ann Rheum Dis. 2010;69:798\u2013806.","journal-title":"Ann Rheum Dis"},{"key":"471_CR8","doi-asserted-by":"publisher","first-page":"e12036","DOI":"10.1097\/MD.0000000000012036","volume":"97","author":"B Lu","year":"2018","unstructured":"Lu B, Niu LL, Xu XG, Yao SL, Tan XY. Ulcerative colitis in an adult patient mimicking Henoch-Schonlein purpura: A case report. Medicine (Baltimore). 2018;97:e12036.","journal-title":"Medicine (Baltimore)"}],"updated-by":[{"DOI":"10.1186\/s12969-022-00683-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000}}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-020-00471-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-020-00471-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-020-00471-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T09:20:17Z","timestamp":1651483217000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-020-00471-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["471"],"URL":"https:\/\/doi.org\/10.1186\/s12969-020-00471-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-25324\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-25324\/v2","asserted-by":"object"}]},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"23 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12969-022-00683-w","URL":"https:\/\/doi.org\/10.1186\/s12969-022-00683-w","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of the Children\u2019s Hospital of Zhejiang University School of Medicine.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the parents of the patient for the publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"84"}}