{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T01:05:04Z","timestamp":1778979904630,"version":"3.51.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["R-21 AR077565"],"award-info":[{"award-number":["R-21 AR077565"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"curejm foundation center of excellence"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>High-dose glucocorticoids (GC) remain the primary therapy to induce remission in Juvenile Dermatomyositis (JDM). Studies of the natural history of GC associated weight gain in children are very limited, especially in the JDM population. This study aims to measure BMI changes in a cohort of JDM subjects over 60\u2009months and to examine the changes in body composition by DXA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included all subjects with JDM who had 5\u00a0years of follow-up data and multiple DXA studies. BMI and total body fat (TBF) percentiles were calculated based on the CDC published percentile charts. To study the natural history of weight gain and TBF, we assessed the data at four-time points (T0\u2009=\u2009baseline, T1\u2009&gt;\u20091.5\u2009years, T2\u2009=\u20091.51\u20133.49\u2009years, T3\u2009=\u20093.5\u20135\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      68 subjects (78% female, 70% white) were included in this retrospective study. Paired T-test showed a significant increase in the mean BMI percentile by 17.5 points (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.004) after the initiation of medical treatment, followed by a gradual decrease over the study period. However, the TBF percentile did not change over the study period. TBF in the last visit (T3) had a strong correlation with the T1 BMI, and T1 TBF percentile (correlation coefficients 0.63, 0.56\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.001, 0.002 respectively). Also, there was a positive correlation (correlation coefficients 0.39,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.002) between the TBF percentile and muscle DAS but not the skin DAS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the BMI percentile decreased throughout the study, the TBF percentile remained high until the end of the study (60\u2009months). This finding raises the concern that some of the reduction in the BMI percentile could reflect a drop in the lean body mass from muscle wasting rather than actual fat loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12969-021-00622-1","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T06:04:04Z","timestamp":1628575444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in total body fat and body mass index among children with juvenile dermatomyositis treated with high-dose glucocorticoids"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-4863","authenticated-orcid":false,"given":"Amer","family":"Khojah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Shore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"622_CR1","doi-asserted-by":"publisher","unstructured":"Pachman LM, Nolan BE, DeRanieri D, Khojah AM. Juvenile Dermatomyositis: New Clues to Diagnosis and Therapy. Curr Treat Options in Rheum. 2021;7:39\u201362. https:\/\/doi.org\/10.1007\/s40674-020-00168-5.","DOI":"10.1007\/s40674-020-00168-5"},{"key":"622_CR2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jpeds.2017.12.053","volume":"195","author":"LM Pachman","year":"2018","unstructured":"Pachman LM, Khojah AM. Advances in juvenile dermatomyositis: myositis specific antibodies aid in understanding disease heterogeneity. J Pediatr. 2018;195:16\u201327. https:\/\/doi.org\/10.1016\/j.jpeds.2017.12.053.","journal-title":"J Pediatr"},{"issue":"2","key":"622_CR3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jpeds.2005.10.032","volume":"148","author":"LM Pachman","year":"2006","unstructured":"Pachman LM, Abbott K, Sinacore JM, Amoruso L, Dyer A, Lipton R, et al. Duration of illness is an important variable for untreated children with juvenile dermatomyositis. J Pediatr. 2006;148(2):247\u201353. https:\/\/doi.org\/10.1016\/j.jpeds.2005.10.032.","journal-title":"J Pediatr"},{"issue":"1","key":"622_CR4","doi-asserted-by":"publisher","first-page":"e0170259","DOI":"10.1371\/journal.pone.0170259","volume":"12","author":"F Aljebab","year":"2017","unstructured":"Aljebab F, Choonara I, Conroy S. Systematic review of the toxicity of long-course Oral corticosteroids in children. PLoS One. 2017;12(1):e0170259. https:\/\/doi.org\/10.1371\/journal.pone.0170259.","journal-title":"PLoS One"},{"issue":"1","key":"622_CR5","doi-asserted-by":"publisher","first-page":"A18","DOI":"10.1016\/j.clinthera.2012.12.014","volume":"35","author":"ER Pulgaron","year":"2013","unstructured":"Pulgaron ER. Childhood obesity: a review of increased risk for physical and psychological comorbidities. Clin Ther. 2013;35(1):A18\u201332. https:\/\/doi.org\/10.1016\/j.clinthera.2012.12.014.","journal-title":"Clin Ther"},{"issue":"3","key":"622_CR6","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/j.1442-200X.2009.02972.x","volume":"52","author":"A Levin","year":"2010","unstructured":"Levin A, Morad Y, Grotto I, Ravid M, Bar-Dayan Y. Weight disorders and associated morbidity among young adults in Israel 1990-2003. Pediatr Int. 2010;52(3):347\u201352. https:\/\/doi.org\/10.1111\/j.1442-200X.2009.02972.x.","journal-title":"Pediatr Int"},{"issue":"3","key":"622_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ijcard.2010.08.013","volume":"148","author":"R Gupta","year":"2011","unstructured":"Gupta R, Wayangankar SA, Targoff IN, Hennebry TA. Clinical cardiac involvement in idiopathic inflammatory myopathies: a systematic review. Int J Cardiol. 2011;148(3):261\u201370. https:\/\/doi.org\/10.1016\/j.ijcard.2010.08.013.","journal-title":"Int J Cardiol"},{"issue":"5","key":"622_CR8","first-page":"1075","volume":"30","author":"T Takken","year":"2003","unstructured":"Takken T, Spermon N, Helders PJ, Prakken AB, Van Der Net J. Aerobic exercise capacity in patients with juvenile dermatomyositis. J Rheumatol. 2003;30(5):1075\u201380.","journal-title":"J Rheumatol"},{"issue":"3","key":"622_CR9","first-page":"610","volume":"28","author":"C Huemer","year":"2001","unstructured":"Huemer C, Kitson H, Malleson PN, Sanderson S, Huemer M, Cabral DA, et al. Lipodystrophy in patients with juvenile dermatomyositis--evaluation of clinical and metabolic abnormalities. 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Arthritis Care Res. 2020. https:\/\/doi.org\/10.1002\/acr.24535.","DOI":"10.1002\/acr.24535"},{"issue":"2","key":"622_CR12","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1590\/S0100-879X2005000200020","volume":"38","author":"TC Castro","year":"2005","unstructured":"Castro TC, Terreri MT, Szejnfeld VL, Len C, Fonseca AS, Hilario MO. Bone mineral density of Brazilian girls with juvenile dermatomyositis. Braz J Med Biol Res. 2005;38(2):309\u201313. https:\/\/doi.org\/10.1590\/S0100-879X2005000200020.","journal-title":"Braz J Med Biol Res"},{"key":"622_CR13","unstructured":"Ogden CL, Li Y, Freedman DS, Borrud LG, Flegal KM. Smoothed percentage body fat percentiles for U.S. children and adolescents, 1999-2004. 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IRB# 2012\u201314858 at Ann & Robert H. Lurie Children\u2019s Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The final manuscript has been reviewed and approved by all the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There is no potential conflict of interest, real or perceived by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"118"}}