{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:03:52Z","timestamp":1776909832359,"version":"3.51.2"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Kasr El-Aini Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Familial Mediterranean fever (FMF) is an autoinflammatory disease that can have conduction disturbances and cardiac rhythm disorders as manifestations of cardiac involvement. The aim of the study is to assess the susceptibility of children with FMF to cardiac repolarization abnormalities and therefore arrhythmia in children with FMF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A cross sectional study conducted on 60 children had FMF and 40 age and sex matched healthy controls. Cardiac repolarization markers, cardiac dimensions and functions were assessed by electrocardiogram (ECG) and conventional echocardiography in patients and controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean\u2009\u00b1\u2009SD age of the patients was 10.43\u2009\u00b1\u20093.472\u2009years, corrected QT (QTc) and the ratio of peak to end T wave (Tpe) over QTc interval (Tpe \/QTc) increased significantly in FMF patients more than healthy control (<jats:italic>p<\/jats:italic> value 0.023 and 0.022 respectively). P wave dispersion (Pd) was significantly higher in FMF patients with amyloidosis (<jats:italic>p<\/jats:italic> value 0.030). No significant difference was found in cardiac dimensions and functions between the two groups. We found a statistically negative correlation between Pd and age of patients at time of study, age of disease onset and age at diagnosis. On the other hand, we found a statistically significant positive correlation between Pd with number of attacks per year and disease severity score. Furthermore, Tpe\/QTc ratio correlated with FMF 50 score, QTc correlated with 24\u2009hours proteinuria. QT, JT intervals correlated with fibrinogen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>FMF Patients may have increased risk of arrhythmia and should be monitored on regular basis. Compliance to colchicine therapy and better disease control might play a role in decreasing this risk.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12969-022-00696-5","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:04:14Z","timestamp":1653311054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac repolarization abnormalities in children with familial Mediterranean fever"],"prefix":"10.1186","volume":"20","author":[{"given":"Yomna","family":"Farag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-165X","authenticated-orcid":false,"given":"Shaimaa","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Alzhraa","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Marzouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghda H.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodina","family":"Sobhy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"696_CR1","first-page":"1","volume":"2016","author":"HM Lotfy","year":"2016","unstructured":"Lotfy HM, Marzouk H, Farag Y, Nabih M, Khalifa IS, Mostafa N, et al. Serum amyloid a level in Egyptian children with familial Mediterranean fever. Inter Jour Rheum. 2016;2016:1\u20136.","journal-title":"Inter Jour Rheum"},{"key":"696_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4103\/0971-6866.132755","volume":"20","author":"MS Al-Haggar","year":"2014","unstructured":"Al-Haggar MS, Yahia S, Abdel-Hady D, Al-Saied A, Al-Kenawy R, Abo-El-Kasem R. Phenotype-genotype updates from familial Mediterranean fever database registry of Mansoura University children hospital, Mansoura. Egypt Indian J of Hum Genet. 2014;20:43\u201350.","journal-title":"Egypt Indian J of Hum Genet"},{"key":"696_CR3","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/1756-185X.12482","volume":"19","author":"S Salah","year":"2016","unstructured":"Salah S, El-Shabrawi M, Lotfy HM, Shiba HF, Abou-Zekri M, Farag Y. Detection of Mediterranean fever gene mutations in Egyptian children with inflammatory bowel disease. Int J Rheum Dis. 2016;19:806\u201313.","journal-title":"Int J Rheum Dis"},{"key":"696_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.berh.2012.01.004","volume":"26","author":"O Feld","year":"2012","unstructured":"Feld O, Yahalom G, Livneh A. Neurologic and other systemic manifestations in FMF: published and own experience. Best Pract Res Clin Rheumatol. 2012;26:119\u201333.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"696_CR5","doi-asserted-by":"publisher","unstructured":"Twig G, Livneh A, Vivante A, Afek A, Shamiss A, Derazne E, et al. Mortality risk factors associated with familial Mediterranean fever among a cohort of 1.25 million adolescents. Ann Rheum Dis. 2013. https:\/\/doi.org\/10.1136\/annrheumdis-2012-202932.","DOI":"10.1136\/annrheumdis-2012-202932"},{"key":"696_CR6","first-page":"1","volume":"8","author":"M Kozan","year":"2019","unstructured":"Kozan M, Ozan ZT, Demir V, Ede H. The relation of novel cardiovascular risk parameters in patients with familial Mediterranean fever. JRSM Cardiovasc Dis. 2019;8:1\u20136.","journal-title":"JRSM Cardiovasc Dis"},{"key":"696_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.4103\/ajm.AJM_78_17","volume":"7","author":"A Alsarah","year":"2017","unstructured":"Alsarah A, Alsara O. Cardiac manifestations of familial Mediterranean fever. Avicenna J Med. 2017;7:158\u201363.","journal-title":"Avicenna J Med"},{"key":"696_CR8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.autneu.2011.11.001","volume":"1","author":"U Canpolat","year":"2012","unstructured":"Canpolat U, Dural M, Aytemir K. Evaluation of various cardiac autonomic indices in patients with familial Mediterranean fever on colchicine treatment. Auton Neurosci. 2012;1:70\u20134.","journal-title":"Auton Neurosci"},{"key":"696_CR9","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1007\/s00467-013-2517-5","volume":"28","author":"DO Hacihamdioglu","year":"2013","unstructured":"Hacihamdioglu DO, Fidanci K, Kilic A, Gok F, Topaloglu R. QT and JT dispersion and cardiac performance in children with neonatal Bartter syndrome: a pilot study. Pediatr Nephrol. 2013;28:1969\u201374.","journal-title":"Pediatr Nephrol"},{"key":"696_CR10","doi-asserted-by":"publisher","first-page":"705","DOI":"10.12998\/wjcc.v3.i8.705","volume":"3","author":"Y Castro-Torres","year":"2015","unstructured":"Castro-Torres Y, Carmona-Puerta R, Katholi RE. Ventricular repolarization markers for predicting malignant arrhythmias in clinical practice. World J Clin Cases. 2015;3:705\u201320.","journal-title":"World J Clin Cases"},{"key":"696_CR11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.carcor.2013.01.007","volume":"49","author":"Y Castro-Torres","year":"2014","unstructured":"Castro-Torres Y. Tpeak-Tend\/QT: un nuevo predictor electrocardiogr\u00e1fico de muerte s\u00fabita card\u00edaca. Cardiocore. 2014;49:86\u20137.","journal-title":"Cardiocore"},{"key":"696_CR12","first-page":"3427","volume":"20","author":"A Kirbas","year":"2016","unstructured":"Kirbas A, K Daglar K, O Kirbas O, C Koseoglu O, Kara O, Biberoglu E, et al. P wave and QT dispersion in familial mediterranean fever. Eur Rev Med Pharmacol Sci. 2016;20:3427\u201333.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"696_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/rheumatology\/ken509","volume":"48","author":"F Yalcinkaya","year":"2009","unstructured":"Yalcinkaya F, Ozen S, Ozcakar ZB, Aktay N, Cakar N, D\u00fczova A. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology. 2009;48:395\u20138.","journal-title":"Rheumatology"},{"key":"696_CR14","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.semarthrit.2005.02.002","volume":"35","author":"A Mor","year":"2005","unstructured":"Mor A, Shinar Y, Zaks N. Evaluation of disease severity in familial Mediterranean fever. Semin Arthritis Rheum. 2005;35:57\u201364.","journal-title":"Semin Arthritis Rheum"},{"key":"696_CR15","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1136\/annrheumdis-2013-204719","volume":"73","author":"S Ozen","year":"2014","unstructured":"Ozen S, Demirkaya E, Duzova A, Erdogan O, Erken E, Gul A, et al. Acikel C, for the FMF arthritis Vasculitis and orphan disease research in pediatric rheumatology (FAVOR) and Turkish FMF study group. FMF50: a score for assessing outcome in familial Mediterranean fever. Ann Rheum Dis. 2014;73:897\u2013901.","journal-title":"Ann Rheum Dis"},{"key":"696_CR16","first-page":"343","volume":"30","author":"F Mk","year":"2015","unstructured":"Mk F, Kili A, Gulgun M, Ba\u015fbozkurt G, AcIkel C, \u015eim\u015fek D, et al. QT and JT dispersion in children with familial Mediterranean fever. Arch. Rheumatol. 2015;30:343\u20138.","journal-title":"Rheumatol"},{"key":"696_CR17","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","volume":"58","author":"DJ Sahn","year":"1978","unstructured":"Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58:1072\u201383.","journal-title":"Circulation"},{"key":"696_CR18","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1017\/S1047951111001867","volume":"22","author":"B Koca","year":"2012","unstructured":"Koca B, Kasap\u00e7opur O, Bakari S, S\u00f6nmez E, Oztun\u00e7 F, Eroglu AG, et al. QT dispersion and cardiac involvement in children with familial Mediterranean fever. Cardiol Young. 2012;22:404\u20139.","journal-title":"Cardiol Young"},{"key":"696_CR19","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.4067\/S0034-98872015001200009","volume":"143","author":"E Ahbap","year":"2015","unstructured":"Ahbap E, Sakaci T, Kara E, Sahutoglu T, Ozturk S, Basturk T, et al. Familial Mediterranean fever is associated with abnormal ventricular repolarization indices. Rev Med Chile. 2015;143:1560\u20138.","journal-title":"Rev Med Chile"},{"key":"696_CR20","doi-asserted-by":"publisher","unstructured":"Fidanci K, Kilic A, Gulgun M, Acikel C, Basbozkurt G, Demirkaya E, et al. FMF Arthritis Vasculitis and Orphan disease Research in Pediatric Rheumatology (FAVOR). QT and JT dispersion in children with FMF. From 7th Congress of International Society of Systemic Auto-Inflammatory Diseases (ISSAID) Lausanne, Switerland. Pediatr Rheumatol. 2013. https:\/\/doi.org\/10.1186\/1546-0096-11-S1-A42.","DOI":"10.1186\/1546-0096-11-S1-A42"},{"key":"696_CR21","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/s10067-011-1745-y","volume":"30","author":"U Nussinovitch","year":"2011","unstructured":"Nussinovitch U, Livneh A, Nussinovitch M, Volovitz B, Ben-Zvi I, Lidar M, et al. P-wave dispersion in systemic AA amyloidosis of familial Mediterranean fever. Clin Rheumatol. 2011;30:1295\u20138.","journal-title":"Clin Rheumatol"},{"key":"696_CR22","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.3109\/s10165-012-0815-6","volume":"23","author":"D Arslan","year":"2013","unstructured":"Arslan D, Oran B, Yaz\u0131l\u0131tas F, Peru H, Cimen D, Vatansev H. P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever. Mod Rheumatol. 2013;23:1166\u201371.","journal-title":"Mod Rheumatol"},{"key":"696_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1546-0096-12-41","volume":"12","author":"S Salah","year":"2014","unstructured":"Salah S, Rizk S, Lotfy HM, Houchi EL, S, MarzoukH and Farag Y. MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura. Pediatr Rheumatol. 2014;12:41.","journal-title":"Pediatr Rheumatol"},{"key":"696_CR24","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1097\/RHU.0000000000001465","volume":"26","author":"U Nussinovitch","year":"2020","unstructured":"Nussinovitch U, Stahi T, Livneh A. Evaluation of a Proarrhythmic repolarization marker (Total cosine R to T) in patients with uncomplicated familial Mediterranean fever. J Clin Rheumatol. 2020;26:334\u20137.","journal-title":"J Clin Rheumatol"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-022-00696-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-022-00696-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-022-00696-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:08:35Z","timestamp":1653311315000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-022-00696-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["696"],"URL":"https:\/\/doi.org\/10.1186\/s12969-022-00696-5","relation":{},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]},"assertion":[{"value":"1 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study had been approval by the ethical committee of Cairo University and a written informed consent was obtained from the parents or legal guardians of the children.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"38"}}