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Imaging data were evaluated by blinded paediatric radiologists.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean age at onset was 10.3\u2009years and mean age at diagnosis was 11.7\u2009years. Bone pain was the leading symptom (29\/30 patients). Out of 180 symptomatic lesions, 131 were confirmed on MRI as hyperintense geographic lesions on STIR images at the metaphysis and epiphysis adjacent to growth plates of tubular bones. The most common sites of involvement were the lower limbs, spine, sternoclavicular joint and humerus. For nearly half of the patients (14\/30) monotherapy with NSAIDs was sufficient to obtain remission. The remaining 16 patients received second-line therapy: bisphosphonates (<jats:italic>n<\/jats:italic>\u2009=\u200915\/30), disease-modifying antirheumatic drugs (<jats:italic>n<\/jats:italic>\u2009=\u20097\/30), etanercept (<jats:italic>n<\/jats:italic>\u2009=\u20094\/30) and tocilizumab (<jats:italic>n<\/jats:italic>\u2009=\u20091\/30). Remission was reached after a mean time of 37.6\u2009months in 26\/30 patients. The prognosis was worse for patients with spinal involvement, resulting in more long-term sequelae.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We present a multicentre paediatric cohort of 30 CNO patients. A typical pattern of bone involvement could be found on MRI. NSAIDs were administered as first-line treatment. Second-line strategies included bisphosphonates, corticosteroids, methotrexate, etanercept and tocilizumab.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Retrospectively registered.\u00a0Registratienummer EC KUL: MP018023<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12969-022-00698-3","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T12:23:32Z","timestamp":1655123012000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Chronic nonbacterial osteomyelitis in children: a multicentre Belgian cohort of 30 children"],"prefix":"10.1186","volume":"20","author":[{"given":"Sara","family":"Kaut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ine","family":"Van den Wyngaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davy","family":"Christiaens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Noppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Herregods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"Dehoorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8488-5090","authenticated-orcid":false,"given":"Lien","family":"De Somer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"issue":"3","key":"698_CR1","first-page":"329","volume":"15","author":"A Giedion","year":"1972","unstructured":"Giedion A, Holthusen W, Masel LF, Vischer D. 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This means that the committee has acknowledged that your project, as described in the protocol, is scientifically relevant and in line with prevailing ethical standards. This favourable advice does not entail the committee\u2019s responsibility for the planned project, however. You remain solely responsible. If you intend to publish your master\u2019s thesis, this e-mail may be used as proof of the committee\u2019s consent.\u201dUZ Ghent: \u201cThe above mentioned documents have been reviewed by the ethics committee. A positive advice was given fort his protocol on 23\/03\/2018.\u201d","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No financial support.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}