{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:23:34Z","timestamp":1740147814257,"version":"3.37.3"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074246"],"award-info":[{"award-number":["82074246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease with osteoarticular and cutaneous involvements as its main manifestations. Acne conglobata as a severe acne form may affect adolescent patients. Tumor necrosis factor inhibitors are usually used as a second-line therapy for refractory SAPHO syndrome and has been reported to treat acne conglobata successfully. We herein report three cases of adolescent patients with SAPHO syndrome associated with acne conglobata who were successfully treated with TNFi therapy.<\/jats:p>","DOI":"10.1186\/s12969-022-00749-9","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T11:23:56Z","timestamp":1665573836000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata"],"prefix":"10.1186","volume":"20","author":[{"given":"Shengyan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-1680","authenticated-orcid":false,"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"749_CR1","volume-title":"StatPearls","author":"W Hafsi","year":"2021","unstructured":"Hafsi W, Badri T. Acne Conglobata. In:  StatPearls. Treasure Island: StatPearls Publishing; 2021."},{"issue":"1","key":"749_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11832-014-0627-7","volume":"9","author":"I Rukavina","year":"2015","unstructured":"Rukavina I. SAPHO syndrome: a review. J Child Orthop. 2015;9(1):19\u201327. https:\/\/doi.org\/10.1007\/s11832-014-0627-7.","journal-title":"J Child Orthop"},{"issue":"11","key":"749_CR3","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1001\/jamadermatol.2013.6678","volume":"149","author":"FL Sand","year":"2013","unstructured":"Sand FL, Thomsen SF. Adalimumab for the treatment of refractory acne conglobata. JAMA Dermatol. 2013;149(11):1306\u20137. https:\/\/doi.org\/10.1001\/jamadermatol.2013.6678.","journal-title":"JAMA Dermatol"},{"issue":"1","key":"749_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00431-018-3263-2","volume":"178","author":"P Zimmermann","year":"2019","unstructured":"Zimmermann P, Curtis N. The role of Cutibacterium acnes in auto-inflammatory bone disorders. Eur J Pediatr. 2019;178(1):89\u201395. https:\/\/doi.org\/10.1007\/s00431-018-3263-2.","journal-title":"Eur J Pediatr"},{"issue":"4","key":"749_CR5","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.semarthrit.2018.04.003","volume":"48","author":"D Daoussis","year":"2019","unstructured":"Daoussis D, Konstantopoulou G, Kraniotis P, Sakkas L, Liossis SN. Biologics in SAPHO syndrome: a systematic review. Semin Arthritis Rheum. 2019;48(4):618\u201325. https:\/\/doi.org\/10.1016\/j.semarthrit.2018.04.003.","journal-title":"Semin Arthritis Rheum"},{"issue":"6","key":"749_CR6","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jfma.2013.10.001","volume":"114","author":"YS Su","year":"2015","unstructured":"Su YS, Chang CH. SAPHO syndrome associated with acne conglobata successfully treated with etanercept. J Formos Med Assoc. 2015;114(6):562\u20134. https:\/\/doi.org\/10.1016\/j.jfma.2013.10.001.","journal-title":"J Formos Med Assoc"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-022-00749-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-022-00749-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-022-00749-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T11:27:06Z","timestamp":1665574026000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-022-00749-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["749"],"URL":"https:\/\/doi.org\/10.1186\/s12969-022-00749-9","relation":{},"ISSN":["1546-0096"],"issn-type":[{"type":"electronic","value":"1546-0096"}],"subject":[],"published":{"date-parts":[[2022,10,12]]},"assertion":[{"value":"22 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the patients and their legal guardians have signed the written informed consents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"88"}}