{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:35:56Z","timestamp":1787020556881,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autoinflammatory diseases are rare disorders of the innate immune system characterized by fever and other signs of inflammation. A feared complication of autoinflammatory diseases is the development of AA amyloidosis. AA amyloidosis is caused by extracellular deposition of soluble serum amyloid A (SAA) proteins as insoluble amyloid fibrils leading to organ damage. Prolonged high levels of SAA are a prerequisite to develop AA amyloidosis. Since measurement of SAA is relatively expensive and sometimes unavailable, C-reactive protein (CRP) is often used as a surrogacy marker to test for inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this research is to evaluate the possible relation between CRP and SAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort of patients with autoinflammatory diseases (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200999) where SAA and CRP blood testing was performed in the period between 2015 and 2021 in the University Medical Centre in Groningen was used to investigate the correlation between CRP and SAA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRP and SAA have a high correlation (rho\u2009=\u20090.755,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A CRP value below 0.45\u2009mg\/L results in 100% sensitivity for SAA below 4\u2009mg\/L. CRP below 5\u2009mg\/L is a good predictor of SAA below 4\u2009mg\/L with 85.4% sensitivity and 83.6% specificity. Only prednisone and erythrocyte sedimentation rate (ESR) significantly influence the relation between CRP and log\n                      <jats:sub>10<\/jats:sub>\n                      <jats:italic>SAA<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a significant correlation between CRP and SAA in our retrospective cohort. CRP levels below 5\u2009mg\/L proved to be highly predictive of SAA levels below 4\u2009mg\/L. This may not be true for patients on steroids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12969-022-00757-9","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T16:31:03Z","timestamp":1669393863000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The relation between C-reactive protein and serum amyloid A in patients with autoinflammatory diseases"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-0904","authenticated-orcid":false,"given":"G. E.","family":"Legger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W. E.","family":"Dermer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Brunger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L. A.","family":"van Daele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L. A.","family":"Nienhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"issue":"6","key":"757_CR1","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1056\/NEJM199902113400607","volume":"340","author":"C Gabay","year":"1999","unstructured":"Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448\u201354 Cited 2021 Dec 21. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/9971870\/.","journal-title":"N Engl J Med"},{"issue":"1","key":"757_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13506129.2019.1693359","volume":"27","author":"AF Brunger","year":"2020","unstructured":"Brunger AF, Nienhuis HL, Bijzet J, Hazenberg BP. Causes of AA amyloidosis: a systematic review. Amyloid. 2020;27(1):1\u201312 Cited 2021 Oct 14. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31766892\/.","journal-title":"Amyloid"},{"issue":"1","key":"757_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10020-018-0047-0","volume":"24","author":"GH Sack","year":"2018","unstructured":"Sack GH. Serum amyloid A \u2013 a review. Mol Med. 2018;24(1):1\u201327 Cited 2021 Sep 7. Available from: https:\/\/molmed.biomedcentral.com\/articles\/10.1186\/s10020-018-0047-0.","journal-title":"Mol Med"},{"issue":"23","key":"757_CR4","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1056\/NEJMoa070265","volume":"356","author":"HJ Lachmann","year":"2007","unstructured":"Lachmann HJ, Goodman HJ, Gilbertson JA, Gallimore JR, Sabin CA, Gillmore JD, et al. Natural history and outcome in systemic AA amyloidosis. N Engl J Med. 2007;356(23):2361\u201371 Cited 2021 Oct 14, Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/17554117\/.","journal-title":"N Engl J Med"},{"issue":"6","key":"757_CR5","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/rheumatology\/kei279","volume":"45","author":"HJ Lachmann","year":"2006","unstructured":"Lachmann HJ, \u015eeng\u00fcl B, Yavuz\u015fen TU, Booth DR, Booth SE, Bybee A, et al. Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford). 2006;45(6):746\u201350 Cited 2021 Dec 13. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/16403826\/.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"757_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/RHU.0000000000001134","volume":"27","author":"M \u00c7akan","year":"2021","unstructured":"\u00c7akan M, Karadag SG, Tanatar A, S\u00f6nmez HE, Ayaz NA. The value of serum amyloid A levels in familial Mediterranean fever to identify occult inflammation during asymptomatic periods. J Clin Rheumatol. 2021;27(1):1\u20134 Cited 2021 Oct 14. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31524848\/.","journal-title":"J Clin Rheumatol"},{"issue":"4\u20135","key":"757_CR7","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.clinbiochem.2016.11.008","volume":"50","author":"KS Stojanovic","year":"2017","unstructured":"Stojanovic KS, Hentgen V, Fellahi S, Georgin-Lavialle S, Amselem S, Grateau G, et al. Concordance between CRP and SAA in familial Mediterranean fever during attack-free period: A study of 218 patients. Clin Biochem. 2017;50(4\u20135):206\u20139 Cited 2021 Oct 14. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/27838405\/.","journal-title":"Clin Biochem"},{"key":"757_CR8","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00296-006-0265-6","volume":"27","author":"F Yal\u00e7\u00e2nkaya","year":"2007","unstructured":"Yal\u00e7\u00e2nkaya F, \u00c7akar N, Acar B, Tutar E, G\u00fcriz H, Elhan AH, et al. The value of the levels of acute phase reactants for the prediction of familial Mediterranean fever associated amyloidosis: a case control study. Rheumatol Int. 2007;27:517\u201322.","journal-title":"Rheumatol Int"},{"key":"757_CR9","doi-asserted-by":"crossref","unstructured":"Blank N, Schonland SO. Autoinflammatory syndromes and AA amyloidosis. Z Rheumatol.\u00a02020;79(7):649\u201359. Available from:\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/32253511\/.\u00a0Cited 2021\u00a0Oct 14.","DOI":"10.1007\/s00393-020-00778-3"},{"issue":"1","key":"757_CR10","first-page":"1","volume":"84","author":"M Tunca","year":"2005","unstructured":"Tunca M, Ozdogan H, Kasapcopur O, Yalcinkaya F, Ozen S, Topaloglu R, et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Med Int. 2005;84(1):1\u201311 Cited 2021 Dec 2. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/15643295\/.","journal-title":"Med Int"},{"issue":"11","key":"757_CR11","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1136\/annrheumdis-2013-204991","volume":"74","author":"R Levy","year":"2015","unstructured":"Levy R, G\u00e9rard L, Kuemmerle-Deschner J, Lachmann HJ, Kon\u00e9-Paut I, Cantarini L, et al. Phenotypic and genotypic characteristics of cryopyrin-associated periodic syndrome: a series of 136 patients from the Eurofever registry. Ann Rheum Dis. 2015;74(11):2043\u20139 Cited 2021 Dec 2. Available from: https:\/\/ard.bmj.com\/content\/74\/11\/2043.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"757_CR12","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1002\/art.37827","volume":"65","author":"T Lane","year":"2013","unstructured":"Lane T, Loeffler JM, Rowczenio DM, Gilbertson JA, Bybee A, Russell TL, et al. Brief report: AA amyloidosis complicating the hereditary periodic fever syndromes. Arthritis Rheum. 2013;65(4):1116\u201321 Cited 2021 Dec 2. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/art.37827.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"757_CR13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.semarthrit.2007.03.005","volume":"37","author":"Y Berkun","year":"2007","unstructured":"Berkun Y, Padeh S, Reichman B, Zaks N, Rabinovich E, Lidar M, et al. A single testing of serum amyloid A levels as a tool for diagnosis and treatment dilemmas in familial Mediterranean fever. Semin Arthritis Rheum. 2007;37(3):182\u20138.","journal-title":"Semin Arthritis Rheum"},{"key":"757_CR14","doi-asserted-by":"publisher","unstructured":"Lannerg\u00e5rd A, Larsson A, Kragsbjerg P, Friman G, Rd AL, Kragsbjerg P, et al. Correlations between serum amyloid A protein and C-reactive protein in infectious diseases. 2009;63(4):267\u201372. https:\/\/doi.org\/10.1080\/00365510310001636 Cited 2021 Dec 21. Available from: https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/00365510310001636.","DOI":"10.1080\/00365510310001636"},{"issue":"2","key":"757_CR15","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1042\/cs0680233","volume":"68","author":"CPJ Maury","year":"1985","unstructured":"Maury CPJ. Comparative study of serum amyloid A protein and C-reactive protein in disease. Clin Sci. 1985;68(2):233\u20138 Cited 2021 Dec 21. Available from: \/clinsci\/article\/68\/2\/233\/73655\/Comparative-Study-of-Serum-Amyloid-A-Protein-and-C.","journal-title":"Clin Sci"},{"key":"757_CR16","doi-asserted-by":"crossref","unstructured":"Wu B, Xu T, Li Y, Yin X. Interventions for reducing inflammation in familial Mediterranean fever. Cochrane Database Syst Rev. 2018;2018(10) Cited 2021 Nov 24. Available from: https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD010893.pub3\/full.","DOI":"10.1002\/14651858.CD010893.pub3"},{"issue":"6","key":"757_CR17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00296-006-0265-6","volume":"27","author":"F Yal\u00e7inkaya","year":"2007","unstructured":"Yal\u00e7inkaya F, \u00c7akar N, Acar B, Tutar E, G\u00fcriz H, Elhan AH, et al. The value of the levels of acute phase reactants for the prediction of familial Mediterranean fever associated amyloidosis: a case control study. Rheumatol Int. 2007;27(6):517\u201322 Cited 2021 Dec 13. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/17103173\/.","journal-title":"Rheumatol Int"},{"key":"757_CR18","unstructured":"Consensus of a group of professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standardization against the IFCC\/BCR\/CAP Reference Material (CRM 470). International Federation of Clinical Chemistry. Community Bureau of Reference of the Commission of the European Communities. College of American Pathologists - PubMed. Cited 2022 Mar 1. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/8831057\/"},{"issue":"5","key":"757_CR19","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3109\/00365519709084584","volume":"57","author":"S Hallan","year":"1997","unstructured":"Hallan S, \u00c5sberg A. The accuracy of C-reactive protein in diagnosing acute appendicitis--a meta-analysis. Scand J Clin Lab Invest. 1997;57(5):373\u201380 Cited 2022 Apr 20. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/9279962\/.","journal-title":"Scand J Clin Lab Invest"},{"issue":"4","key":"757_CR20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/13506129.2018.1549825","volume":"25","author":"MD Benson","year":"2018","unstructured":"Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, et al. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018;25(4):215\u20139 Cited 2022 Oct 23. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30614283\/.","journal-title":"Amyloid"},{"issue":"24","key":"757_CR21","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.1182\/blood-2009-07-230722","volume":"114","author":"JA Vrana","year":"2009","unstructured":"Vrana JA, Gamez JD, Madden BJ, Theis JD, Bergen HR, Dogan A. Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens. Blood. 2009;114(24):4957\u20139 Cited 2022 Oct 23. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/19797517\/.","journal-title":"Blood"},{"issue":"2","key":"757_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.proghi.2012.03.001","volume":"47","author":"RP Linke","year":"2012","unstructured":"Linke RP. On typing amyloidosis using immunohistochemistry. Detailled illustrations, review and a note on mass spectrometry. Prog Histochem Cytochem. 2012;47(2):61\u2013132 Cited 2022 Oct 23. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/22819384\/.","journal-title":"Prog Histochem Cytochem"},{"issue":"12","key":"757_CR23","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1136\/annrheumdis-2013-203666","volume":"73","author":"M Piram","year":"2014","unstructured":"Piram M, Kon\u00e9-Paut I, Lachmann HJ, Frenkel J, Ozen S, Kuemmerle-Deschner J, et al. Validation of the auto-inflammatory diseases activity index (AIDAI) for hereditary recurrent fever syndromes. Ann Rheum Dis. 2014;73(12):2168\u201373 Cited 2022 Oct 23. Available from: https:\/\/ard.bmj.com\/content\/73\/12\/2168.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"757_CR24","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s10067-020-05249-3","volume":"40","author":"S Can Sandikci","year":"2021","unstructured":"Can Sandikci S, Omma A, Yucel C, Omma T. Is there a relationship between serum omentin level and acute phase response in patients with familial Mediterranean fever? Clin Rheumatol. 2021;40(2):669\u201374 Cited 2022 Mar 1. Available from: https:\/\/link.springer.com\/article\/10.1007\/s10067-020-05249-3.","journal-title":"Clin Rheumatol"},{"issue":"4","key":"757_CR25","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00403-019-02014-8","volume":"312","author":"N Akdogan","year":"2019","unstructured":"Akdogan N, Dogan S, Incel-Uysal P, Karabulut E, Topcuoglu C, Yalcin B, et al. Serum amyloid A and C-reactive protein levels and erythrocyte sedimentation rate are important indicators in hidradenitis suppurativa. Arch DermatolRes. 2019;312(4):255\u201362 Cited 2021 Sep 7. Available from: https:\/\/link.springer.com\/article\/10.1007\/s00403-019-02014-8.","journal-title":"Arch DermatolRes"},{"issue":"5","key":"757_CR26","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1159\/000497375","volume":"65","author":"T F\u00fcl\u00f6p","year":"2019","unstructured":"F\u00fcl\u00f6p T, Larbi A, Witkowski JM. Human Inflammaging. Gerontology. 2019;65(5):495\u2013504 Cited 2022 Oct 23. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31055573\/.","journal-title":"Gerontology"},{"issue":"1","key":"757_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/21551197.2018.1564200","volume":"38","author":"KN Porter Starr","year":"2019","unstructured":"Porter Starr KN, Orenduff M, McDonald SR, Mulder H, Sloane R, Pieper CF, et al. Influence of weight reduction and enhanced protein intake on biomarkers of inflammation in older adults with obesity. J Nutr Gerontol Geriatr. 2019;38(1):33\u201349 Cited 2022 Mar 1. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30810500\/.","journal-title":"J Nutr Gerontol Geriatr"},{"issue":"4","key":"757_CR28","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1084\/jem.140.4.1102","volume":"140","author":"T Shirahama","year":"1974","unstructured":"Shirahama T, Cohen AS. Blockage of amyloid induction by colchicine in an animal model. J Exp Med. 1974;140(4):1102\u20137 Cited 2022 Mar 16. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/4427088\/.","journal-title":"J Exp Med"},{"issue":"4","key":"757_CR29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nri.2017.1","volume":"17","author":"DW Cain","year":"2017","unstructured":"Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017;17(4):233\u201347 Cited 2022 Mar 16. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/28192415\/.","journal-title":"Nat Rev Immunol"},{"issue":"26","key":"757_CR30","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1136\/vr.154.26.814","volume":"154","author":"S Mart\u00ednez-Subiela","year":"2004","unstructured":"Mart\u00ednez-Subiela S, Ginel PJ, Cer\u00f3n JJ. Effects of different glucocorticoid treatments on serum acute phase proteins in dogs. Vet Record. 2004;154(26):814\u20137 Cited 2022 Mar 1. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1136\/vr.154.26.814.","journal-title":"Vet Record"},{"issue":"6","key":"757_CR31","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3109\/1354750X.2011.607189","volume":"16","author":"S Takata","year":"2011","unstructured":"Takata S, Wada H, Tamura M, Koide T, Higaki M, Mikura SI, et al. Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community-acquired pneumonia (CAP), as presented with biologic half-life times. Biomarkers. 2011;16(6):530\u20135 Cited 2022 Oct 23. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/21854219\/.","journal-title":"Biomarkers"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-022-00757-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-022-00757-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-022-00757-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T19:33:51Z","timestamp":1669404831000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-022-00757-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["757"],"URL":"https:\/\/doi.org\/10.1186\/s12969-022-00757-9","relation":{},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]},"assertion":[{"value":"29 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval was obtained from the Medical Ethics Committee of the UMCG (2021\/050). All subjects, and\/or their parents, provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"106"}}