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Specific cytokine profiles could play a pivotal role in this inflammatory response. Gram-negative bacteremia, bacterial pneumonia, Kawasaki disease, and active SJIA exhibited similar cytokine profiles with elevated interleukin-6 (IL-6) and\/or IL-10, further suggesting a correlation between them. Only when JIA is complicated by MAS can increased interferon-\u03b3 (IFN-\u03b3) levels be observed. Therefore, increased serum IFN-\u03b3 levels could contribute to early diagnosing MAS in patients with SJIA in combination with other variables such as serum ferritin. A prospective multi-center study will be performed to further confirm the role of IFN-\u03b3 in the early recognition of MAS in SJIA.<\/jats:p>","DOI":"10.1186\/s12969-023-00907-7","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T09:02:18Z","timestamp":1697101338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis"],"prefix":"10.1186","volume":"21","author":[{"given":"Meiping","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7148-846X","authenticated-orcid":false,"given":"Xuefeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"issue":"52","key":"907_CR1","doi-asserted-by":"publisher","first-page":"15785","DOI":"10.1073\/pnas.1521837113","volume":"112","author":"PA Nigrovic","year":"2015","unstructured":"Nigrovic PA. 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