{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:41:43Z","timestamp":1788309703047,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R-21 AR077565"],"award-info":[{"award-number":["R-21 AR077565"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The CureJM Foundation","award":["The CureJM Foundation"],"award-info":[{"award-number":["The CureJM Foundation"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Juvenile Dermatomyositis (JDM) is a rare autoimmune disease characterized by skin and muscle inflammation. The loss of nail fold capillary end row loops (ERL) is evidence of small vessel involvement in JDM. This study aimed to examine the specific association of ERL over the disease course with evidence of JDM disease damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 68 initially treatment-na\u00efve JDM children who had been observed for at least five years with multiple ERL density assessments. The JDM disease course were categorized into monocyclic short, monocyclic long, polycyclic, and chronic. The ERL capillary count was cumulatively evaluated using the area under the curve (AUC) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean ERL density for the treatment-naive JDM was significantly lower than that of their healthy age-matched controls (4.8\u2009\u00b1\u20091.6 \/mm vs. 7.9\u2009\u00b1\u20090.9 \/mm; p\u2009&lt;\u20090.0001). The ERL AUC was significantly lower in children with a chronic disease course compared to those with a monocyclic short (p\u2009=\u20090.001) or monocyclic long disease course (p\u2009=\u20090.013). JDM patients with lipodystrophy had lower ERL AUC than those without lipodystrophy (p\u2009=\u20090.04). There was no association between ERL AUC and calcifications or fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistently decreased ERL capillary density, reflected by low ERL AUC, is associated with a chronic disease course and lipodystrophy in JDM. Despite medical therapy, the mean ERL count remained below normal even after five years, particularly in polycyclic and chronic cases. It is not clear that restoring normal capillary density is currently feasible in children with JDM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12969-023-00919-3","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T07:01:48Z","timestamp":1699858908000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Juvenile dermatomyositis: association between nail fold capillary end row loop\u2013 area under the curve\u2013 and disease damage indicators"],"prefix":"10.1186","volume":"21","author":[{"given":"Amer","family":"Khojah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa S.","family":"Klein-Gitelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-574X","authenticated-orcid":false,"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"issue":"1","key":"919_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s40674-020-00168-5","volume":"7","author":"LM Pachman","year":"2021","unstructured":"Pachman LM, Nolan BE, DeRanieri D, Khojah AM. Juvenile Dermatomyositis: New clues to diagnosis and therapy. Curr Treatm Opt Rheumatol. 2021;7(1):39\u201362.","journal-title":"Curr Treatm Opt Rheumatol"},{"issue":"3","key":"919_CR2","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/art.11122","volume":"49","author":"EP Mendez","year":"2003","unstructured":"Mendez EP, Lipton R, Ramsey-Goldman R, Roettcher P, Bowyer S, Dyer A, et al. US incidence of juvenile dermatomyositis, 1995\u20131998: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Registry. Arthritis Rheum. 2003;49(3):300\u20135.","journal-title":"Arthritis Rheum"},{"key":"919_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jpeds.2017.12.053","volume":"195","author":"LM Pachman","year":"2018","unstructured":"Pachman LM, Khojah AM. Advances in Juvenile Dermatomyositis: Myositis specific antibodies aid in understanding Disease Heterogeneity. 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Lurie Children\u2019s Hospital of Chicago (IRB# 2012\u201314,858). Signed informed consent was obtained from all subjects involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication was obtained from all study subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No potential conflict of interest is real or perceived by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"137"}}