{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:37:50Z","timestamp":1792093070857,"version":"4.4.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"DOI":"10.1186\/s12969-024-01051-6","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T03:54:27Z","timestamp":1735876467000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Factors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-0783","authenticated-orcid":false,"given":"Katherine D.","family":"Nowicki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3841-5602","authenticated-orcid":false,"given":"Nathan D.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2709-7338","authenticated-orcid":false,"given":"Carson L.","family":"Keeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6595-804X","authenticated-orcid":false,"given":"Nathan J.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2346-741X","authenticated-orcid":false,"given":"Jennifer B.","family":"Soep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-1379","authenticated-orcid":false,"given":"Yongdong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"issue":"4","key":"1051_CR1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.pcl.2018.04.003","volume":"65","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Ferguson PJ. Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children. Pediatr Clin North Am. 2018;65(4):783\u2013800.","journal-title":"Pediatr Clin North Am"},{"issue":"1","key":"1051_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12969-016-0109-1","volume":"14","author":"MR Roderick","year":"2016","unstructured":"Roderick MR, Shah R, Rogers V, Finn A, Ramanan AV. Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. Pediatr Rheumatol Online J. 2016;14(1):47.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"2","key":"1051_CR3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s11926-012-0239-5","volume":"14","author":"PJ Ferguson","year":"2012","unstructured":"Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep. 2012;14(2):130\u201341.","journal-title":"Curr Rheumatol Rep"},{"issue":"7","key":"1051_CR4","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1093\/rheumatology\/key058","volume":"57","author":"H Girschick","year":"2018","unstructured":"Girschick H, Finetti M, Orlando F, Schalm S, Insalaco A, Ganser G, et al. The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. Rheumatology (Oxford). 2018;57(7):1203\u201311.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"1051_CR5","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1002\/art.39013","volume":"67","author":"J Wipff","year":"2015","unstructured":"Wipff J, Costantino F, Lemelle I, Pajot C, Duquesne A, Lorrot M, et al. A large national cohort of French patients with chronic recurrent multifocal osteitis. Arthritis Rheumatol. 2015;67(4):1128\u201337.","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"1051_CR6","doi-asserted-by":"publisher","first-page":"e1190","DOI":"10.1542\/peds.2011-3788","volume":"130","author":"A Borzutzky","year":"2012","unstructured":"Borzutzky A, Stern S, Reiff A, Zurakowski D, Steinberg EA, Dedeoglu F, et al. Pediatric chronic nonbacterial osteomyelitis. Pediatrics. 2012;130(5):e1190\u20137.","journal-title":"Pediatrics"},{"issue":"9","key":"1051_CR7","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1093\/rheumatology\/kev013","volume":"54","author":"P Walsh","year":"2015","unstructured":"Walsh P, Manners PJ, Vercoe J, Burgner D, Murray KJ. Chronic recurrent multifocal osteomyelitis in children: nine years\u2019 experience at a statewide tertiary paediatric rheumatology referral centre. Rheumatology (Oxford). 2015;54(9):1688\u201391.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"1051_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12969-018-0290-5","volume":"16","author":"CS Bhat","year":"2018","unstructured":"Bhat CS, Anderson C, Harbinson A, McCann LJ, Roderick M, Finn A, et al. Chronic non bacterial osteitis- a multicentre study. Pediatr Rheumatol Online J. 2018;16(1):74.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"1051_CR9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00296-018-4151-9","volume":"39","author":"MM Kostik","year":"2019","unstructured":"Kostik MM, Kopchak OL, Chikova IA, Isupova EA, Mushkin AY. Comparison of different treatment approaches of pediatric chronic non-bacterial osteomyelitis. Rheumatol Int. 2019;39(1):89\u201396.","journal-title":"Rheumatol Int"},{"issue":"1","key":"1051_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12969-021-00530-4","volume":"19","author":"D O'Leary","year":"2021","unstructured":"O\u2019Leary D, Wilson AG, MacDermott EJ, Lowry C, Killeen OG. Variability in phenotype and response to treatment in chronic nonbacterial osteomyelitis; the Irish experience of a national cohort. Pediatr Rheumatol Online J. 2021;19(1):45.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"2","key":"1051_CR11","doi-asserted-by":"publisher","first-page":"R74","DOI":"10.1186\/ar2992","volume":"12","author":"C Beck","year":"2010","unstructured":"Beck C, Morbach H, Beer M, Stenzel M, Tappe D, Gattenl\u00f6hner S, et al. Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment. Arthritis Res Ther. 2010;12(2):R74.","journal-title":"Arthritis Res Ther"},{"key":"1051_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2021.100095","volume":"4","author":"DY Zhao","year":"2021","unstructured":"Zhao DY, McCann L, Hahn G, Hedrich CM. Chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO). J Transl Autoimmun. 2021;4: 100095.","journal-title":"J Transl Autoimmun"},{"issue":"2","key":"1051_CR13","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1136\/ard.2004.023838","volume":"64","author":"HJ Girschick","year":"2005","unstructured":"Girschick HJ, Raab P, Surbaum S, Trusen A, Kirschner S, Schneider P, et al. Chronic non-bacterial osteomyelitis in children. Ann Rheum Dis. 2005;64(2):279\u201385.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1051_CR14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/rheumatology\/kel190","volume":"46","author":"A Jansson","year":"2007","unstructured":"Jansson A, Renner ED, Ramser J, Mayer A, Haban M, Meindl A, et al. Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford). 2007;46(1):154\u201360.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"1051_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00296-019-04400-x","volume":"40","author":"S Concha","year":"2020","unstructured":"Concha S, Hern\u00e1ndez-Ojeda A, Contreras O, Mendez C, Talesnik E, Borzutzky A. Chronic nonbacterial osteomyelitis in children: a multicenter case series. Rheumatol Int. 2020;40(1):115\u201320.","journal-title":"Rheumatol Int"},{"issue":"4","key":"1051_CR16","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/0049-0172(88)90011-X","volume":"17","author":"RM Laxer","year":"1988","unstructured":"Laxer RM, Shore AD, Manson D, King S, Silverman ED, Wilmot DM. Chronic recurrent multifocal osteomyelitis and psoriasis\u2013a report of a new association and review of related disorders. Semin Arthritis Rheum. 1988;17(4):260\u201370.","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"1051_CR17","first-page":"707","volume":"35","author":"H Gleeson","year":"2008","unstructured":"Gleeson H, Wiltshire E, Briody J, Hall J, Chaitow J, Sillence D, et al. Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. J Rheumatol. 2008;35(4):707\u201312.","journal-title":"J Rheumatol"},{"issue":"2","key":"1051_CR18","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.joms.2022.10.005","volume":"81","author":"NA Beck","year":"2023","unstructured":"Beck NA, Roudnitsky E, Nuzzi LC, Padwa BL, Dedeoglu F. How Have the Diagnosis and Treatment of Chronic Recurrent Multifocal Osteomyelitis Changed Over Time? J Oral Maxillofac Surg. 2023;81(2):238\u201347.","journal-title":"J Oral Maxillofac Surg"},{"key":"1051_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12969-015-0023-y","volume":"13","author":"D Kaiser","year":"2015","unstructured":"Kaiser D, Bolt I, Hofer M, Relly C, Berthet G, Bolz D, et al. Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study. Pediatr Rheumatol Online J. 2015;13:25.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"1051_CR20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12969-022-00698-3","volume":"20","author":"S Kaut","year":"2022","unstructured":"Kaut S, Van den Wyngaert I, Christiaens D, Wouters C, Noppe N, Herregods N, et al. Chronic nonbacterial osteomyelitis in children: a multicentre Belgian cohort of 30 children. Pediatr Rheumatol Online J. 2022;20(1):41.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"1051_CR21","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s13075-021-02658-w","volume":"23","author":"C Reiser","year":"2021","unstructured":"Reiser C, Klotsche J, Hospach A, Berendes R, Schnabel A, Jansson AF, et al. First-year follow-up of children with chronic nonbacterial osteomyelitis-an analysis of the German National Pediatric Rheumatologic Database from 2009 to 2018. Arthritis Res Ther. 2021;23(1):281.","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"1051_CR22","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3899\/jrheum.161255","volume":"44","author":"A Schnabel","year":"2017","unstructured":"Schnabel A, Range U, Hahn G, Berner R, Hedrich CM. Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis. J Rheumatol. 2017;44(7):1058\u201365.","journal-title":"J Rheumatol"},{"key":"1051_CR23","doi-asserted-by":"publisher","first-page":"7694942","DOI":"10.1155\/2017\/7694942","volume":"2017","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Dedeoglu F, Ferguson PJ, Lapidus SK, Laxer RM, Bradford MC, et al. Physicians\u2019 Perspectives on the Diagnosis and Treatment of Chronic Nonbacterial Osteomyelitis. Int J Rheumatol. 2017;2017:7694942.","journal-title":"Int J Rheumatol"},{"issue":"8","key":"1051_CR24","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1002\/acr.23462","volume":"70","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Wu EY, Oliver MS, Cooper AM, Basiaga ML, Vora SS, et al. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and\/or With Active Spinal Lesions. Arthritis Care Res (Hoboken). 2018;70(8):1228\u201337.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1051_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114147","volume":"180","author":"S Bindu","year":"2020","unstructured":"Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020;180: 114147.","journal-title":"Biochem Pharmacol"},{"key":"1051_CR26","unstructured":"Team RC. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria2018."},{"key":"1051_CR27","unstructured":"W. N. Venables BDR. Modern Applied Statistics with S. 4 ed. New York, NY: Springer; 2010. 498 p."},{"issue":"8","key":"1051_CR28","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/j.1651-2227.2011.02205.x","volume":"100","author":"AF Jansson","year":"2011","unstructured":"Jansson AF, Grote V. Nonbacterial osteitis in children: data of a German Incidence Surveillance Study. Acta Paediatr. 2011;100(8):1150\u20137.","journal-title":"Acta Paediatr"},{"issue":"1","key":"1051_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12969-021-00657-4","volume":"20","author":"L Ma","year":"2022","unstructured":"Ma L, Liu H, Tang H, Zhang Z, Zou L, Yu H, et al. Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series. Pediatr Rheumatol Online J. 2022;20(1):1.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"6","key":"1051_CR30","first-page":"974","volume":"31","author":"A Ziobrowska-Bech","year":"2013","unstructured":"Ziobrowska-Bech A, Fiirgaard B, Heuck C, Ramsgaard Hansen O, Herlin T. Ten-year review of Danish children with chronic non-bacterial osteitis. Clin Exp Rheumatol. 2013;31(6):974\u20139.","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"1051_CR31","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1148\/radiol.2523081335","volume":"252","author":"J Fritz","year":"2009","unstructured":"Fritz J, Tzaribatchev N, Claussen CD, Carrino JA, Horger MS. Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology. 2009;252(3):842\u201351.","journal-title":"Radiology"},{"issue":"2","key":"1051_CR32","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1067\/mpd.2002.126457","volume":"141","author":"AM Huber","year":"2002","unstructured":"Huber AM, Lam PY, Duffy CM, Yeung RS, Ditchfield M, Laxer D, et al. Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. J Pediatr. 2002;141(2):198\u2013203.","journal-title":"J Pediatr"},{"issue":"9","key":"1051_CR33","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1093\/rheumatology\/ken249","volume":"47","author":"C Catalano-Pons","year":"2008","unstructured":"Catalano-Pons C, Comte A, Wipff J, Quartier P, Faye A, Gendrel D, et al. Clinical outcome in children with chronic recurrent multifocal osteomyelitis. Rheumatology (Oxford). 2008;47(9):1397\u20139.","journal-title":"Rheumatology (Oxford)"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-024-01051-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-024-01051-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-024-01051-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T04:04:41Z","timestamp":1735877081000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-024-01051-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1051"],"URL":"https:\/\/doi.org\/10.1186\/s12969-024-01051-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5271182\/v1","asserted-by":"object"}]},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"15 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Institutional Review Board of record of records, the Colorado Multiple Institutional Review Board (COMIRB) approved the collection of data for this study (#12\u20131557 and #13\u20130099). Informed consent and assent were obtained from all individual participants enrolled in this study after January 1, 2018 as data was collected prospectively (although prospective data was not included in this report), but consent was waived for those patients enrolled prior to January 1, 2018 given the retrospective nature of data collection for these patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"YD received research funding from Bristol-Myers Squibb, Rheumatology Research Foundation, Consortium for Technology & Innovation in Pediatrics, Childhood Arthritis & Rheumatology Research Alliance, royalties from UpToDate and consulting fees from Novartis in 2020.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2"}}