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Demographic, clinical (anthropometric), and serological (including hormonal) evaluations were assessed at baseline. Growth velocity was recorded after one year. Mann-Whitney U test, chi-square test, and Fisher\u2019s exact t test were applied during statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      107 JIA patients were enrolled with a M: F ratio of 2.06:1 (72 boys &amp; 35 girls) with ERA being the most frequent subtype (51.4%). Mean age was 13 (\u00b1\u20094) years with a disease duration of 33 (\u00b1\u200924) months. Mean glucocorticoid intake was 2.17 (\u00b1\u20095.41) mg\/day at baseline. 20.6% children were stunted, 22.4% were underweight and 25.2% had low BMI. Stunted children were more likely to have early onset (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) &amp; high GH level (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Underweight children had longer disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and more damage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Children with weight z &lt; -2 have high GH and low IGFBP3. Low BMI group had high disease activity, damage, and poor quality of life &amp; functional state (p\u2009=\u2009&lt;\u20090.01). Delayed puberty was noticed only in 2.8% of children. Girls with low Estradiol level had longer exposure to corticosteroids. Slower growth velocity was observed in 22.4% of children without any identifiable cause.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One third of JIA patients experience growth and pubertal disturbances, primarily due to altered GH-IGF1 axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12969-025-01058-7","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:50:05Z","timestamp":1745484605000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endocrine dysfunction in patients with juvenile idiopathic arthritis"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1694-7795","authenticated-orcid":false,"given":"Sayan","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-5803","authenticated-orcid":false,"given":"Abilash Krishnan","family":"Vijayakumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh Kumar","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-0149","authenticated-orcid":false,"given":"Nishant Gautam","family":"Kamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9042-2578","authenticated-orcid":false,"given":"Ankush","family":"PM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-2583","authenticated-orcid":false,"given":"Puneet","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahid","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankti","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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