{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:16:20Z","timestamp":1777619780476,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["POWR.05.02.00-00-0149\/15"],"award-info":[{"award-number":["POWR.05.02.00-00-0149\/15"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POPC.02.02.00-00-0015\/18-00"],"award-info":[{"award-number":["POPC.02.02.00-00-0015\/18-00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diagnostic pathways for patients with juvenile idiopathic arthritis (JIA) have gradually improved over time. Provider practice has also shifted towards goal-oriented treatment with disease-modifying drugs (DMARDs) that together may have changed the epidemiologic landscape of JIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Public healthcare utilization records from the National Health Fund (NHF) were screened between 2010 and 2022. For individuals aged\u2009&lt;\u200916 years, we utilized a narrow JIA case definition combining repeat ICD-10 encoding with DMARDs prescription based on ATC codes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 2022, we identified 1,625 incident and 29,758 prevalent JIA cases (&lt;\u200916 years), which corresponds to incidence (IRs) and prevalence rates of 4.30 and 78.80 per 100,000 persons of the general population. For the pediatric population, annual IRs for JIA (&lt;\u200916 years) ranged between 24.0 (95% CI 22.8, 25.2) and 38.7 (95% CI 37.2\u201340.3) per 100,000. Greater susceptibility among females was also consistently observed with the annual IR ratio ranging between 1.16 and 1.53. The most common concurrent disorders based on medical care services were allergic rhinitis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20095,200, 17.5%), bronchial asthma (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20093,661, 12.3%) and chronic tonsillitis\/pharyngitis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20093641, 12.2%). Analysis of 214,285 outpatient care visits revealed a median (IQR, range) annual healthcare cost of 37.8\u20ac (35.8\u201347.4\u20ac, 30.3\u201386.1\u20ac) per JIA patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This comprehensive, nationwide study provides a contemporary estimate of JIA burden in Poland. Our findings indicate that both the occurrence of new cases and overall burden of JIA in the past ten years align with the lower end of projected figures for our geographical area, especially when compared with Scandinavian nations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12969-025-01065-8","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:48:14Z","timestamp":1743209294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epidemiology and comorbidity of juvenile idiopathic arthritis in Poland\u2013 a nationwide study"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-0601","authenticated-orcid":false,"given":"Zbigniew","family":"\u017buber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Podw\u00f3jcic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Szel\u0105g","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Krajewska-W\u0142odarczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Batko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Orlea\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Sowi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"\u015awiderek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"\u015amiglewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Maluchnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Brzosko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brygida","family":"Kwiatkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Stajszczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Batko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"1065_CR1","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31:390\u20132.","journal-title":"J Rheumatol"},{"key":"1065_CR2","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.berh.2018.10.004","volume":"32","author":"J Palman","year":"2018","unstructured":"Palman J, Shoop-Worrall S, Hyrich K, McDonagh JE. Update on the epidemiology, risk factors and disease outcomes of juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol. 2018;32:206\u201322.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"1065_CR3","first-page":"2460","volume":"30","author":"E Savolainen","year":"2003","unstructured":"Savolainen E, Kaipiainen-Sepp\u00e4nen O, Kr\u00f6ger L, Luosuj\u00e4rvi R. Total incidence and distribution of inflammatory joint diseases in a defined population: results from the Kuopio 2000 arthritis survey. J Rheumatol. 2003;30:2460\u20138.","journal-title":"J Rheumatol"},{"key":"1065_CR4","first-page":"217","volume":"5","author":"AM Prieur","year":"1987","unstructured":"Prieur AM, Le Gall E, Karman F, Edan C, Lasserre O, Goujard J. Epidemiologic survey of juvenile chronic arthritis in France. Comparison of data obtained from two different regions. Clin Exp Rheumatol. 1987;5:217\u201323.","journal-title":"Clin Exp Rheumatol"},{"key":"1065_CR5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jbspin.2013.09.003","volume":"81","author":"S Thierry","year":"2014","unstructured":"Thierry S, Fautrel B, Lemelle I, Guillemin F. Prevalence and incidence of juvenile idiopathic arthritis: a systematic review. Joint bone Spine. 2014;81:112\u20137.","journal-title":"Joint bone Spine"},{"key":"1065_CR6","doi-asserted-by":"publisher","first-page":"704","DOI":"10.5604\/12321966.1185780","volume":"22","author":"M T\u0142ustochowicz","year":"2015","unstructured":"T\u0142ustochowicz M, \u015aliwczy\u0144ski A, Iltchev P, Brzozowska M, Sierocka A, Marczak M, et al. Juvenile idiopathic arthritis morbidity rate in rural and urban areas of Poland 2008\u20132012. Ann Agric Environ Med. 2015;22:704\u20137.","journal-title":"Ann Agric Environ Med"},{"key":"1065_CR7","unstructured":"Simon TA, Harikrishnan GP, Kawabata H, Singhal S, Brunner HI, Lovell DJ. Prevalence of co-existing autoimmune disease in juvenile idiopathic arthritis: a cross-sectional study. Pediatric rheumatology online journal [Internet]. 2020 [cited 2023 Aug 19];18. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32503658\/"},{"key":"1065_CR8","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/rheumatology\/keh531","volume":"44","author":"S Stagi","year":"2005","unstructured":"Stagi S, Giani T, Simonini G, Falcini F. Thyroid function, autoimmune thyroiditis and coeliac disease in juvenile idiopathic arthritis. Rheumatology (Oxford). 2005;44:517\u201320.","journal-title":"Rheumatology (Oxford)"},{"key":"1065_CR9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13052-017-0373-9","volume":"43","author":"E Tronconi","year":"2017","unstructured":"Tronconi E, Miniaci A, Pession A. The autoimmune burden in juvenile idiopathic arthritis. Ital J Pediatr. 2017;43:56.","journal-title":"Ital J Pediatr"},{"key":"1065_CR10","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/art.10370","volume":"46","author":"S Prahalad","year":"2002","unstructured":"Prahalad S, Shear ES, Thompson SD, Giannini EH, Glass DN. Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritis. Arthritis Rheum. 2002;46:1851\u20136.","journal-title":"Arthritis Rheum"},{"key":"1065_CR11","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1002\/art.24618","volume":"60","author":"S Prahalad","year":"2009","unstructured":"Prahalad S, Hansen S, Whiting A, Guthery SL, Clifford B, McNally B, et al. Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. Arthritis Rheum. 2009;60:2124\u201330.","journal-title":"Arthritis Rheum"},{"key":"1065_CR12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/imj.15509","volume":"53","author":"J Tan","year":"2023","unstructured":"Tan J, Tiller G, Gowdie P, Cox A, Munro J, Allen R, et al. Patterns and rates of confirmed transfer of care of patients with juvenile idiopathic arthritis at a tertiary paediatric rheumatology centre. Intern Med J. 2023;53:46\u201350.","journal-title":"Intern Med J"},{"key":"1065_CR13","first-page":"1086","volume":"36","author":"F Conti","year":"2018","unstructured":"Conti F, Pontikaki I, D\u2019Andrea M, Ravelli A, De Benedetti F. Patients with juvenile idiopathic arthritis become adults: the role of transitional care. Clin Exp Rheumatol. 2018;36:1086\u201394.","journal-title":"Clin Exp Rheumatol"},{"key":"1065_CR14","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3899\/jrheum.180456","volume":"46","author":"J Guzman","year":"2019","unstructured":"Guzman J, Henrey A, Loughin T, Berard RA, Shiff NJ, Jurencak R, et al. Predicting which children with juvenile idiopathic arthritis will not attain early remission with Conventional Treatment: results from the ReACCh-Out cohort. J Rheumatol. 2019;46:628\u201335.","journal-title":"J Rheumatol"},{"key":"1065_CR15","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1136\/annrheumdis-2017-212104","volume":"77","author":"JF Swart","year":"2018","unstructured":"Swart JF, van Dijkhuizen EHP, Wulffraat NM, de Roock S. Clinical juvenile arthritis disease activity score proves to be a useful tool in treat-to-target therapy in juvenile idiopathic arthritis. Ann Rheum Dis. 2018;77:336\u201342.","journal-title":"Ann Rheum Dis"},{"key":"1065_CR16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1136\/annrheumdis-2018-213030","volume":"77","author":"A Ravelli","year":"2018","unstructured":"Ravelli A, Consolaro A, Horneff G, Laxer RM, Lovell DJ, Wulffraat NM, et al. Treating juvenile idiopathic arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2018;77:819\u201328.","journal-title":"Ann Rheum Dis"},{"key":"1065_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/acr.23853","volume":"72","author":"M Glerup","year":"2020","unstructured":"Glerup M, Rypdal V, Arnstad ED, Ekelund M, Peltoniemi S, Aalto K, et al. Long-term outcomes in juvenile idiopathic arthritis: eighteen years of Follow-Up in the Population-based nordic Juvenile Idiopathic Arthritis Cohort. Arthritis Care Res (Hoboken). 2020;72:507\u201316.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1065_CR18","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1080\/14397595.2020.1813369","volume":"31","author":"T Matsumoto","year":"2021","unstructured":"Matsumoto T, Mori M. Questionnaire survey on transitional care for patients with juvenile idiopathic arthritis (JIA) and families. Mod Rheumatol. 2021;31:691\u20136.","journal-title":"Mod Rheumatol"},{"key":"1065_CR19","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1365-2214.2006.00698.x","volume":"33","author":"KL Shaw","year":"2007","unstructured":"Shaw KL, Southwood TR, McDonagh JE. British Society of Paediatric and adolescent rheumatology. Young people\u2019s satisfaction of transitional care in adolescent rheumatology in the UK. Child Care Health Dev. 2007;33:368\u201379.","journal-title":"Child Care Health Dev"},{"key":"1065_CR20","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.5114\/aoms.2019.84092","volume":"17","author":"B Batko","year":"2021","unstructured":"Batko B, Korkosz M, Ju\u015b A, Wiland P. Management of rheumatoid arthritis in Poland - where daily practice might not always meet evidence-based guidelines. Arch Med Sci. 2021;17:1286\u201393.","journal-title":"Arch Med Sci"},{"key":"1065_CR21","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00296-019-04287-8","volume":"39","author":"M Ma\u015bli\u0144ska","year":"2019","unstructured":"Ma\u015bli\u0144ska M, Dobrzy\u0144ski T, Kwiatkowska B. Rheumatology in Poland. Rheumatol Int. 2019;39:757\u201367.","journal-title":"Rheumatol Int"},{"key":"1065_CR22","first-page":"1","volume":"13","author":"A Sagan","year":"2011","unstructured":"Sagan A, Panteli D, Borkowski W, Dmowski M, Domanski F, Czyzewski M, et al. Poland health system review. Health Syst Transit. 2011;13:1\u2013193.","journal-title":"Health Syst Transit"},{"key":"1065_CR23","unstructured":"Zuber Z, Kania U, Kr\u00f3l-Zdechlikiewicz A, Morawska A, Pilch B, Rajska E et al. Analysis of clinical symptoms and Laboratory profiles in children with juvenile idiopathic arthritis in Malopolska Region (Poland) in the years 2007\u20132010. Open Access Macedonian J Med Sci. 2014;2."},{"key":"1065_CR24","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1093\/rheumatology\/keab714","volume":"61","author":"R Costello","year":"2021","unstructured":"Costello R, McDonagh J, Hyrich KL, Humphreys JH. Incidence and prevalence of juvenile idiopathic arthritis in the United Kingdom, 2000\u20132018: results from the Clinical Practice Research Datalink. Rheumatology (Oxford). 2021;61:2548\u201354.","journal-title":"Rheumatology (Oxford)"},{"key":"1065_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12969-022-00755-x","volume":"20","author":"G Horneff","year":"2022","unstructured":"Horneff G, Borchert J, Heinrich R, Kock S, Klaus P, Dally H, et al. Incidence, prevalence, and comorbidities of juvenile idiopathic arthritis in Germany: a retrospective observational cohort health claims database study. Pediatr Rheumatol. 2022;20:1\u201313.","journal-title":"Pediatr Rheumatol"},{"key":"1065_CR26","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1542\/peds.98.1.84","volume":"98","author":"PJ Manners","year":"1996","unstructured":"Manners PJ, Diepeveen DA. Prevalence of juvenile chronic arthritis in a population of 12-year-old children in urban Australia. Pediatrics. 1996;98:84\u201390.","journal-title":"Pediatrics"},{"key":"1065_CR27","unstructured":"Uusitupa E, Rahikkala H, Sard S, Pokka T, Salo H, K\u00e4rki J et al. Incidence of juvenile idiopathic arthritis in Finland, 2000\u20132020. Rheumatology. 2024;keae322."},{"key":"1065_CR28","first-page":"2275","volume":"30","author":"L Berntson","year":"2003","unstructured":"Berntson L, Andersson G\u00e4re B, Fasth A, Herlin T, Kristinsson J, Lahdenne P, et al. Incidence of juvenile idiopathic arthritis in the nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria. J Rheumatol. 2003;30:2275\u201382.","journal-title":"J Rheumatol"},{"key":"1065_CR29","first-page":"379","volume":"29","author":"D Kurahara","year":"2002","unstructured":"Kurahara D, Tokuda A, Grandinetti A, Najita J, Ho C, Yamamoto K, et al. Ethnic differences in risk for pediatric rheumatic illness in a culturally diverse population. J Rheumatol. 2002;29:379\u201383.","journal-title":"J Rheumatol"},{"key":"1065_CR30","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1186\/1471-2407-14-634","volume":"14","author":"VC Kok","year":"2014","unstructured":"Kok VC, Horng J-T, Huang J-L, Yeh K-W, Gau J-J, Chang C-W, et al. Population-based cohort study on the risk of malignancy in east Asian children with juvenile idiopathic arthritis. BMC Cancer. 2014;14:634.","journal-title":"BMC Cancer"},{"key":"1065_CR31","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1002\/art.22709","volume":"56","author":"RK Saurenmann","year":"2007","unstructured":"Saurenmann RK, Rose JB, Tyrrell P, Feldman BM, Laxer RM, Schneider R, et al. Epidemiology of juvenile idiopathic arthritis in a multiethnic cohort: ethnicity as a risk factor. Arthritis Rheum. 2007;56:1974\u201384.","journal-title":"Arthritis Rheum"},{"key":"1065_CR32","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1002\/art.30426","volume":"63","author":"E Nordal","year":"2011","unstructured":"Nordal E, Zak M, Aalto K, Berntson L, Fasth A, Herlin T, et al. Ongoing disease activity and changing categories in a long-term nordic cohort study of juvenile idiopathic arthritis. Arthritis Rheum. 2011;63:2809\u201318.","journal-title":"Arthritis Rheum"},{"key":"1065_CR33","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s13075-023-03166-9","volume":"25","author":"F Oliveira Ramos","year":"2023","unstructured":"Oliveira Ramos F, Rodrigues AM, Melo AT, Aguiar F, Brites L, Azevedo S, et al. Influence of the timing of biological treatment initiation on juvenile idiopathic arthritis long-term outcomes. Arthritis Res Ther. 2023;25:177.","journal-title":"Arthritis Res Ther"},{"key":"1065_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12969-023-00811-0","volume":"21","author":"S Kirchner","year":"2023","unstructured":"Kirchner S, Klotsche J, Liedmann I, Niewerth M, Feldman D, Dressler F, et al. Adherence, helpfulness and barriers to treatment in juvenile idiopathic arthritis - data from a German inception cohort. Pediatr Rheumatol Online J. 2023;21:31.","journal-title":"Pediatr Rheumatol Online J"},{"key":"1065_CR35","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1093\/rheumatology\/kev398","volume":"55","author":"AF Mour\u00e3o","year":"2016","unstructured":"Mour\u00e3o AF, Santos MJ, Melo Gomes JA, Martins FM, Mendon\u00e7a SC, Oliveira Ramos F, et al. Effectiveness and long-term retention of anti-tumour necrosis factor treatment in juvenile and adult patients with juvenile idiopathic arthritis: data from Reuma.pt. Rheumatology (Oxford). 2016;55:697\u2013703.","journal-title":"Rheumatology (Oxford)"},{"key":"1065_CR36","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s00296-023-05293-7","volume":"43","author":"A Felis-Giemza","year":"2023","unstructured":"Felis-Giemza A, Chmurzy\u0144ska K, Ko\u0142odziejczyk B, Gazda A. Revising diagnosis of juvenile idiopathic arthritis in adults: a single-center retrospective study. Rheumatol Int. 2023;43:1307\u201311.","journal-title":"Rheumatol Int"},{"key":"1065_CR37","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12969-016-0088-2","volume":"14","author":"SLN Clarke","year":"2016","unstructured":"Clarke SLN, Sen ES, Ramanan AV. Juvenile idiopathic arthritis-associated uveitis. Pediatr Rheumatol. 2016;14:27.","journal-title":"Pediatr Rheumatol"},{"key":"1065_CR38","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.ophtha.2020.08.024","volume":"128","author":"V Rypdal","year":"2021","unstructured":"Rypdal V, Glerup M, Songstad NT, Bertelsen G, Christoffersen T, Arnstad ED, et al. Uveitis in Juvenile Idiopathic Arthritis: 18-Year outcome in the Population-based Nordic Cohort Study. Ophthalmology. 2021;128:598\u2013608.","journal-title":"Ophthalmology"},{"key":"1065_CR39","doi-asserted-by":"publisher","first-page":"212","DOI":"10.5152\/TurkArchPediatr.2023.22303","volume":"58","author":"F Ha\u015flak","year":"2023","unstructured":"Ha\u015flak F, Guliyeva V, Hotaman B, Duman \u00c7, Y\u0131ld\u0131z M, G\u00fcnalp A, et al. Non-rheumatic chronic comorbidities in children with juvenile idiopathic arthritis. Turkish Archives Pediatr. 2023;58:212\u20139.","journal-title":"Turkish Archives Pediatr"},{"key":"1065_CR40","first-page":"796","volume":"31","author":"A Raab","year":"2013","unstructured":"Raab A, Sengler C, Niewerth M, Klotsche J, Horneff G, Zink A, et al. Comorbidity profiles among adult patients with juvenile idiopathic arthritis: results of a biologic register. Clin Exp Rheumatol. 2013;31:796\u2013802.","journal-title":"Clin Exp Rheumatol"},{"key":"1065_CR41","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1093\/rheumatology\/keaa118","volume":"59","author":"A Chhabra","year":"2020","unstructured":"Chhabra A, Robinson C, Houghton K, Cabral DA, Morishita K, Tucker LB, et al. Long-term outcomes and disease course of children with juvenile idiopathic arthritis in the ReACCh-Out cohort: a two-centre experience. Rheumatology (Oxford). 2020;59:3727\u201330.","journal-title":"Rheumatology (Oxford)"},{"key":"1065_CR42","first-page":"508","volume":"37","author":"MS Kyll\u00f6nen","year":"2019","unstructured":"Kyll\u00f6nen MS, Kautiainen H, Puolakka K, V\u00e4h\u00e4salo P. The mortality rate and causes of death among juvenile idiopathic arthritis patients in Finland. Clin Exp Rheumatol. 2019;37:508\u201311.","journal-title":"Clin Exp Rheumatol"},{"key":"1065_CR43","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1136\/ard.2003.008516","volume":"63","author":"K Minden","year":"2004","unstructured":"Minden K, Niewerth M, Listing J, Biedermann T, Sch\u00f6ntube M, Zink A. Burden and cost of illness in patients with juvenile idiopathic arthritis. Ann Rheum Dis. 2004;63:836\u201342.","journal-title":"Ann Rheum Dis"},{"key":"1065_CR44","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1007\/s00296-011-1894-y","volume":"32","author":"IK Yucel","year":"2012","unstructured":"Yucel IK, Seyahi E, Kasapcopur O, Arisoy N. Economic impact of juvenile idiopathic arthritis and familial Mediterranean fever. Rheumatol Int. 2012;32:1955\u201362.","journal-title":"Rheumatol Int"},{"key":"1065_CR45","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s40273-020-00940-4","volume":"38","author":"G de Broucker","year":"2020","unstructured":"de Broucker G, Sim SY, Brenzel L, Gross M, Patenaude B, Constenla DO. Cost of Nine Pediatric Infectious Illnesses in low- and Middle-Income countries: a systematic review of cost-of-illness studies. PharmacoEconomics. 2020;38:1071\u201394.","journal-title":"PharmacoEconomics"},{"key":"1065_CR46","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1186\/s12889-019-6820-3","volume":"19","author":"I Spronk","year":"2019","unstructured":"Spronk I, Korevaar JC, Poos R, Davids R, Hilderink H, Schellevis FG, et al. Calculating incidence rates and prevalence proportions: not as simple as it seems. BMC Public Health. 2019;19:512.","journal-title":"BMC Public Health"},{"key":"1065_CR47","doi-asserted-by":"publisher","first-page":"11964","DOI":"10.3390\/ijerph191911964","volume":"19","author":"C Maciejewski","year":"2022","unstructured":"Maciejewski C, Oziera\u0144ski K, Basza M, Lodzi\u0144ski P, \u015aliwczy\u0144ski A, Kraj L, et al. Administrative Data in Cardiovascular Research-A Comparison of Polish National Health Fund and CRAFT Registry Data. Int J Environ Res Public Health. 2022;19:11964.","journal-title":"Int J Environ Res Public Health"},{"key":"1065_CR48","first-page":"16704","volume":"134","author":"C Maciejewski","year":"2024","unstructured":"Maciejewski C, Oziera\u0144ski K, Basza M, Barwio\u0142ek A, Ciurla M, Bo\u017cym A, et al. Practical use case of natural language processing for observational clinical research data retrieval from electronic health records: AssistMED project. Pol Arch Intern Med. 2024;134:16704.","journal-title":"Pol Arch Intern Med"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-025-01065-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-025-01065-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-025-01065-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T09:27:48Z","timestamp":1743413268000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-025-01065-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1065"],"URL":"https:\/\/doi.org\/10.1186\/s12969-025-01065-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4650683\/v1","asserted-by":"object"}]},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"27 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Under local regulations, ethical approval is not required due to the retrospective and secondary nature of the data. Data were also anonymized prior to analysis with subgroup size\u2009>\u20095 cases. This analysis relies solely on data obtained from the National Health Fund electronic databases. Obtaining institutional ethical approval was not required. Data utilized for this analysis was fully anonymized, which precludes the ability to reliably identify individuals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"none to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"33"}}