{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:29:13Z","timestamp":1757618953708,"version":"3.44.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"DOI":"10.1186\/s12969-025-01121-3","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T06:45:10Z","timestamp":1752561910000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying the characteristics of and developing a predictive model for differentiating cancer-related musculoskeletal symptoms from juvenile idiopathic arthritis"],"prefix":"10.1186","volume":"23","author":[{"given":"Khwanjira","family":"Archawanantakul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-9711","authenticated-orcid":false,"given":"Soamarat","family":"Vilaiyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-163X","authenticated-orcid":false,"given":"Samart","family":"Pakakasama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-4378","authenticated-orcid":false,"given":"Butsabong","family":"Lerkvaleekul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"1121_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1546-0096-11-20","volume":"11","author":"L Zombori","year":"2013","unstructured":"Zombori L, Kovacs G, Csoka M, Derfalvi B. Rheumatic symptoms in childhood leukaemia and lymphoma-a ten-year retrospective study. Pediatr Rheumatol Online J. 2013;11:20.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"8","key":"1121_CR2","first-page":"566","volume":"109","author":"C Kirubakaran","year":"2011","unstructured":"Kirubakaran C, Scott JX, Ebenezer S. Is this acute lymphoblastic leukaemia or juvenile rheumatoid arthritis. J Indian Med Assoc. 2011;109(8):566.","journal-title":"J Indian Med Assoc"},{"issue":"3","key":"1121_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00277-009-0826-3","volume":"89","author":"RK Marwaha","year":"2010","unstructured":"Marwaha RK, Kulkarni KP, Bansal D, Trehan A. Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. Ann Hematol. 2010;89(3):249\u201354.","journal-title":"Ann Hematol"},{"issue":"1","key":"1121_CR4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0022-3476(99)70372-0","volume":"134","author":"DA Cabral","year":"1999","unstructured":"Cabral DA, Tucker LB. Malignancies in children who initially present with rheumatic complaints. J Pediatr. 1999;134(1):53\u20137.","journal-title":"J Pediatr"},{"issue":"4","key":"1121_CR5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.rbr.2016.11.001","volume":"57","author":"MB Fonseca","year":"2017","unstructured":"Fonseca MB, Gomes FHR, Valera ET, Pileggi GS, Gonfiantini PB, Gonfiantini MB, et al. Signs and symptoms of rheumatic diseases as first manifestation of pediatric cancer: diagnosis and prognosis implications. Rev Bras Reumatol Engl Ed. 2017;57(4):330\u20137.","journal-title":"Rev Bras Reumatol Engl Ed"},{"issue":"6","key":"1121_CR6","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1053\/sarh.2000.5752","volume":"29","author":"S Trapani","year":"2000","unstructured":"Trapani S, Grisolia F, Simonini G, Calabri GB, Falcini F. Incidence of occult cancer in children presenting with musculoskeletal symptoms: a 10-year survey in a pediatric rheumatology unit. Semin Arthritis Rheum. 2000;29(6):348\u201359.","journal-title":"Semin Arthritis Rheum"},{"issue":"10","key":"1121_CR7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/archdischild-2016-311251","volume":"101","author":"RT Van den Clarke","year":"2016","unstructured":"Van den Clarke RT, Bankhead C, Mitchell CD, Phillips B, Thompson MJ. Clinical presentation of childhood leukaemia: a systematic review and meta-analysis. Arch Dis Child. 2016;101(10):894\u2013901.","journal-title":"Arch Dis Child"},{"issue":"9","key":"1121_CR8","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1007\/s10067-018-4034-1","volume":"37","author":"N Brix","year":"2018","unstructured":"Brix N, Hasle H, Rosthoj S, Herlin T. Characteristics of children with acute lymphoblastic leukemia presenting with arthropathy. Clin Rheumatol. 2018;37(9):2455\u201363.","journal-title":"Clin Rheumatol"},{"issue":"3","key":"1121_CR9","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/BPB.0b013e32835d731c","volume":"22","author":"I Riccio","year":"2013","unstructured":"Riccio I, Marcarelli M, Del Regno N, Fusco C, Di Martino M, Savarese R, et al. Musculoskeletal problems in pediatric acute leukemia. J Pediatr Orthop B. 2013;22(3):264\u20139.","journal-title":"J Pediatr Orthop B"},{"issue":"4","key":"1121_CR10","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1440-1754.2011.02230.x","volume":"48","author":"WY Teo","year":"2012","unstructured":"Teo WY, Chan MY, Ng KC, Tan AM. Bony presentations of childhood haematological malignancy to the emergency room. J Paediatr Child Health. 2012;48(4):311\u20136.","journal-title":"J Paediatr Child Health"},{"key":"1121_CR11","doi-asserted-by":"crossref","unstructured":"Civino A, Bovis F, Ponzano M, Alighieri G, Prete E, Sorrentino S et al. Development and initial validation of the ONCOREUM score to differentiate childhood cancer with arthropathy from juvenile idiopathic arthritis. J Pediatr. 2023;253:219\u201324 e3.","DOI":"10.1016\/j.jpeds.2022.09.046"},{"issue":"9","key":"1121_CR12","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1136\/archdischild-2014-307751","volume":"100","author":"N Brix","year":"2015","unstructured":"Brix N, Rosthoj S, Herlin T, Hasle H. Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children. Arch Dis Child. 2015;100(9):821\u20135.","journal-title":"Arch Dis Child"},{"issue":"8","key":"1121_CR13","doi-asserted-by":"publisher","first-page":"e0237530","DOI":"10.1371\/journal.pone.0237530","volume":"15","author":"N Brix","year":"2020","unstructured":"Brix N, Rosthoj S, Glerup M, Hasle H, Herlin T. Identifying acute lymphoblastic leukemia mimicking juvenile idiopathic arthritis in children. PLoS ONE. 2020;15(8):e0237530.","journal-title":"PLoS ONE"},{"issue":"5","key":"1121_CR14","doi-asserted-by":"publisher","first-page":"e840","DOI":"10.1542\/peds.2005-1515","volume":"117","author":"OY Jones","year":"2006","unstructured":"Jones OY, Spencer CH, Bowyer SL, Dent PB, Gottlieb BS, Rabinovich CE. A multicenter case-control study on predictive factors distinguishing childhood leukemia from juvenile rheumatoid arthritis. Pediatrics. 2006;117(5):e840\u20134.","journal-title":"Pediatrics"},{"issue":"7","key":"1121_CR15","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1002\/cncr.20910","volume":"103","author":"E Steliarova-Foucher","year":"2005","unstructured":"Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International classification of childhood cancer, third edition. Cancer. 2005;103(7):1457\u201367.","journal-title":"Cancer"},{"issue":"2","key":"1121_CR16","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, edmonton, 2001. J Rheumatol. 2004;31(2):390\u20132.","journal-title":"J Rheumatol"},{"issue":"7","key":"1121_CR17","doi-asserted-by":"publisher","first-page":"e507","DOI":"10.1016\/S2665-9913(21)00086-2","volume":"3","author":"A Civino","year":"2021","unstructured":"Civino A, Alighieri G, Prete E, Caroleo AM, Magni-Manzoni S, Vinti L, et al. Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sectional study. Lancet Rheumatol. 2021;3(7):e507\u201316.","journal-title":"Lancet Rheumatol"},{"key":"1121_CR18","doi-asserted-by":"crossref","unstructured":"Brix N, Amstrup J, Norgaard M, Hagstrom S, Hasle H, Herlin T. Musculoskeletal diagnoses before cancer in children: a Danish registry-based cohort study. J Pediatr. 2022;242:32\u20138 e2.","DOI":"10.1016\/j.jpeds.2021.11.024"},{"issue":"1\u20132","key":"1121_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3109\/10428199609054810","volume":"23","author":"T Kai","year":"1996","unstructured":"Kai T, Ishii E, Matsuzaki A, Okamura J, Ikuno Y, Tasaka E, et al. Clinical and prognostic implications of bone lesions in childhood leukemia at diagnosis. Leuk Lymphoma. 1996;23(1\u20132):119\u201323.","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"1121_CR20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2223\/JPED.903","volume":"78","author":"CM Barbosa","year":"2002","unstructured":"Barbosa CM, Nakamura C, Terreri MT, Lee ML, Petrilli AS, Hilario MO. Musculoskeletal manifestations as the onset of acute leukemias in childhood. J Pediatr (Rio J). 2002;78(6):481\u20134.","journal-title":"J Pediatr (Rio J)"},{"issue":"3","key":"1121_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/01202412-200505000-00003","volume":"14","author":"D Kobayashi","year":"2005","unstructured":"Kobayashi D, Satsuma S, Kamegaya M, Haga N, Shimomura S, Fujii T, et al. Musculoskeletal conditions of acute leukemia and malignant lymphoma in children. J Pediatr Orthop B. 2005;14(3):156\u201361.","journal-title":"J Pediatr Orthop B"},{"issue":"9","key":"1121_CR22","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1097\/MPH.0b013e3181468c55","volume":"29","author":"TC Robazzi","year":"2007","unstructured":"Robazzi TC, Barreto JH, Silva LR, Santiago MB, Mendonca N. Osteoarticular manifestations as initial presentation of acute leukemias in children and adolescents in Bahia, Brazil. J Pediatr Hematol Oncol. 2007;29(9):622\u20136.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"1","key":"1121_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/BPO.0b13e31815ff350","volume":"28","author":"R Sinigaglia","year":"2008","unstructured":"Sinigaglia R, Gigante C, Bisinella G, Varotto S, Zanesco L, Turra S. Musculoskeletal manifestations in pediatric acute leukemia. J Pediatr Orthop. 2008;28(1):20\u20138.","journal-title":"J Pediatr Orthop"},{"issue":"10","key":"1121_CR24","first-page":"1665","volume":"66","author":"MS Tamashiro","year":"2011","unstructured":"Tamashiro MS, Aikawa NE, Campos LM, Cristofani LM, Odone-Filho V, Silva CA. Discrimination of acute lymphoblastic leukemia from systemic-onset juvenile idiopathic arthritis at disease onset. Clin (Sao Paulo). 2011;66(10):1665\u20139.","journal-title":"Clin (Sao Paulo)"},{"issue":"1","key":"1121_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12969-019-0376-8","volume":"18","author":"M Louvigne","year":"2020","unstructured":"Louvigne M, Rakotonjanahary J, Goumy L, Tavenard A, Brasme JF, Rialland F, et al. Persistent osteoarticular pain in children: early clinical and laboratory findings suggestive of acute lymphoblastic leukemia (a multicenter case-control study of 147 patients). Pediatr Rheumatol Online J. 2020;18(1):1.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"6","key":"1121_CR26","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00296-009-1064-7","volume":"30","author":"D Gupta","year":"2010","unstructured":"Gupta D, Singh S, Suri D, Ahluwalia J, Das R, Varma N. Arthritic presentation of acute leukemia in children: experience from a tertiary care centre in North India. Rheumatol Int. 2010;30(6):767\u201370.","journal-title":"Rheumatol Int"},{"issue":"1","key":"1121_CR27","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12969-023-00836-5","volume":"21","author":"AR Torres Jimenez","year":"2023","unstructured":"Torres Jimenez AR, Solis Vallejo E, Cespedes Cruz AI, Ramirez Miramontes JV, Cortina Olvera GDC, Velazquez Cruz A, et al. Differences between leukemic arthritis and juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2023;21(1):50.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"11","key":"1121_CR28","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1007\/s10067-024-07141-w","volume":"43","author":"F Albayrak","year":"2024","unstructured":"Albayrak F, Kisacik B, Gunduz I, Kudas O, Koc E, Zengin O, et al. Inflammatory low back pain-associated malignancies mimicking spondylarthritis. Clin Rheumatol. 2024;43(11):3345\u201350.","journal-title":"Clin Rheumatol"},{"key":"1121_CR29","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jor.2020.05.022","volume":"22","author":"BKA Raj","year":"2020","unstructured":"Raj BKA, Singh KA, Shah H. Orthopedic manifestation as the presenting symptom of acute lymphoblastic leukemia. J Orthop. 2020;22:326\u201330.","journal-title":"J Orthop"},{"issue":"3","key":"1121_CR30","first-page":"185","volume":"88","author":"I Fragkandrea","year":"2013","unstructured":"Fragkandrea I, Nixon JA, Panagopoulou P. Signs and symptoms of childhood cancer: a guide for early recognition. Am Fam Physician. 2013;88(3):185\u201392.","journal-title":"Am Fam Physician"},{"issue":"1","key":"1121_CR31","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12969-022-00692-9","volume":"20","author":"S Kittivisuit","year":"2022","unstructured":"Kittivisuit S, Sripornsawan P, Songthawee N, Chavananon S, McNeil EB, Chotsampancharoen T. Musculoskeletal involvement in childhood leukemia: characteristics and survival outcomes. Pediatr Rheumatol Online J. 2022;20(1):34.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"1121_CR32","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1001\/archpedi.1996.02170260074012","volume":"150","author":"M Wallendal","year":"1996","unstructured":"Wallendal M, Stork L, Hollister JR. The discriminating value of serum lactate dehydrogenase levels in children with malignant neoplasms presenting as joint pain. Arch Pediatr Adolesc Med. 1996;150(1):70\u20133.","journal-title":"Arch Pediatr Adolesc Med"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-025-01121-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-025-01121-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-025-01121-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T09:59:23Z","timestamp":1757239163000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-025-01121-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1121"],"URL":"https:\/\/doi.org\/10.1186\/s12969-025-01121-3","relation":{},"ISSN":["1546-0096"],"issn-type":[{"type":"electronic","value":"1546-0096"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"1 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the Faculty of Medicine Ramathibodi Hospital, and was carried out in accordance with the Declaration of Helsinki (number MURA2025\/31). The informed consent was waived due to retrospective study design.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"73"}}