{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:14:36Z","timestamp":1764180876556,"version":"3.46.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"the Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["25ek0410112h0003"],"award-info":[{"award-number":["25ek0410112h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"DOI":"10.1186\/s12969-025-01164-6","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:48:22Z","timestamp":1763984902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of clinical practices during the transitional and young adult phases between patients with oligoarticular\/polyarticular juvenile idiopathic arthritis and those with rheumatoid arthritis in Japan"],"prefix":"10.1186","volume":"23","author":[{"given":"Sho","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Shabana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomo","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Tomiita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Nakagishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Umebayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Yashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Yasumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Wakiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Takezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Okura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadafumi","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Tohma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"1164_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jbspin.2013.09.003","volume":"81","author":"S Thierry","year":"2014","unstructured":"Thierry S, Fautrel B, Lemelle I, Guillemin F. Prevalence and incidence of juvenile idiopathic arthritis: a systematic review. Joint Bone Spine. 2014;81:112\u20137.","journal-title":"Joint Bone Spine"},{"key":"1164_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1546-0096-8-20","volume":"8","author":"LN Moorthy","year":"2010","unstructured":"Moorthy LN, Peterson MG, Hassett AL, Lehman TJ. Burden of childhood-onset arthritis. Pediatr Rheumatol Online J. 2010;8:20.","journal-title":"Pediatr Rheumatol Online J"},{"key":"1164_CR3","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1136\/annrheumdis-2016-210112","volume":"76","author":"HE Foster","year":"2017","unstructured":"Foster HE, Minden K, Clemente D, Leon L, McDonagh JE, Kamphuis S, et al. EULAR\/PReS standards and recommendations for the transitional care of young people with juvenile-onset rheumatic diseases. Ann Rheum Dis. 2017;76:639\u201346.","journal-title":"Ann Rheum Dis"},{"key":"1164_CR4","first-page":"1991","volume":"25","author":"RE Petty","year":"1998","unstructured":"Petty RE, Southwood TR, Baum J, Bhettay E, Glass DN, Manners P. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol. 1998;25:1991\u20134.","journal-title":"J Rheumatol"},{"key":"1164_CR5","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1093\/rheumatology\/keu257","volume":"53","author":"EJ Coulson","year":"2014","unstructured":"Coulson EJ, Hanson HJ, Foster HE. What does an adult rheumatologist need to know about juvenile idiopathic arthritis? Rheumatology (Oxford). 2014;53:2155\u201366.","journal-title":"Rheumatology (Oxford)"},{"key":"1164_CR6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1002\/art.21857","volume":"55","author":"PA Nigrovic","year":"2006","unstructured":"Nigrovic PA, White PH. Care of the adult with juvenile rheumatoid arthritis. Arthritis Rheum. 2006;55:208\u201316.","journal-title":"Arthritis Rheum"},{"key":"1164_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1586\/eci.12.35","volume":"8","author":"Y Saeki","year":"2012","unstructured":"Saeki Y, Matsui T, Saisho K, Tohma S. Current treatments of rheumatoid arthritis: from the \u2018NinJa\u2019 registry. Expert Rev Clin Immunol. 2012;8:455\u201365.","journal-title":"Expert Rev Clin Immunol"},{"key":"1164_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s41927-023-00328-9","volume":"7","author":"T Nishino","year":"2023","unstructured":"Nishino T, Hashimoto A, Tohma S, Matsui T. Comprehensive evaluation of the influence of sex differences on composite disease activity indices for rheumatoid arthritis: results from a nationwide observational cohort study. BMC Rheumatol. 2023;7:4.","journal-title":"BMC Rheumatol"},{"key":"1164_CR9","doi-asserted-by":"crossref","first-page":"S214","DOI":"10.1080\/14397595.2018.1548089","volume":"29","author":"T Matsui","year":"2019","unstructured":"Matsui T, Shabana K, Tohma S, Mori M. Development of a nationwide database of JIA: CoNinJa (Children\u2019s version of NinJa). Mod Rheumatol. 2019;29:S214.","journal-title":"Mod Rheumatol"},{"key":"1164_CR10","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31:390\u20132.","journal-title":"J Rheumatol"},{"key":"1164_CR11","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3, et al. 2010 rheumatoid arthritis classification criteria: an American college of Rheumatology\/European league against rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569\u201381.","journal-title":"Arthritis Rheum"},{"key":"1164_CR12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315\u201324.","journal-title":"Arthritis Rheum"},{"key":"1164_CR13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"ML Prevoo","year":"1995","unstructured":"Prevoo ML, van \u2018t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:44\u20138.","journal-title":"Arthritis Rheum"},{"key":"1164_CR14","first-page":"151","volume":"62","author":"J Fransen","year":"2004","unstructured":"Fransen J, Welsing PM, de Keijzer RM, van Riel PL. Disease activity scores using C-reactive protein: CRP May replace ESR in the assessment of RA disease activity (abstract). Ann Rheum Dis. 2004;62:151.","journal-title":"Ann Rheum Dis"},{"key":"1164_CR15","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/rheumatology\/keg072","volume":"42","author":"JS Smolen","year":"2003","unstructured":"Smolen JS, Breedveld FC, Schiff MH, Kalden JR, Emery P, Eberl G, et al. A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology (Oxford). 2003;42:244\u201357.","journal-title":"Rheumatology (Oxford)"},{"key":"1164_CR16","doi-asserted-by":"publisher","first-page":"R796","DOI":"10.1186\/ar1740","volume":"7","author":"D Aletaha","year":"2005","unstructured":"Aletaha D, Nell VP, Stamm T, Uffmann M, Pflugbeil S, Machold K, et al. Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther. 2005;7:R796\u2013806.","journal-title":"Arthritis Res Ther"},{"key":"1164_CR17","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/art.30129","volume":"63","author":"DT Felson","year":"2011","unstructured":"Felson DT, Smolen JS, Wells G, Zhang B, van Tuyl LH, Funovits J, et al. American college of Rheumatology\/European league against rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum. 2011;63:573\u201386.","journal-title":"Arthritis Rheum"},{"key":"1164_CR18","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1136\/annrheumdis-2018-213030","volume":"77","author":"A Ravelli","year":"2018","unstructured":"Ravelli A, Consolaro A, Horneff G, Laxer RM, Lovell DJ, Wulffraat NM, et al. Treating juvenile idiopathic arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2018;77:819\u201328.","journal-title":"Ann Rheum Dis"},{"key":"1164_CR19","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/ard.2009.123919","volume":"69","author":"JS Smolen","year":"2010","unstructured":"Smolen JS, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas D, Burmester G, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010;69:631\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1164_CR20","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/art.24516","volume":"61","author":"A Consolaro","year":"2009","unstructured":"Consolaro A, Ruperto N, Bazso A, Pistorio A, Magni-Manzoni S, Filocamo G, et al. Development and validation of a composite disease activity score for juvenile idiopathic arthritis. Arthritis Rheum. 2009;61:658\u201366.","journal-title":"Arthritis Rheum"},{"key":"1164_CR21","first-page":"2290","volume":"31","author":"CA Wallace","year":"2004","unstructured":"Wallace CA, Ruperto N, Giannini E. Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol. 2004;31:2290\u20134.","journal-title":"J Rheumatol"},{"key":"1164_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/RHU.0000000000000819","volume":"25","author":"DM Feger","year":"2019","unstructured":"Feger DM, Longson N, Dodanwala H, Ostrov BE, Olsen NJ, June RR. Comparison of adults with polyarticular juvenile idiopathic arthritis to adults with rheumatoid arthritis: A Cross-sectional analysis of clinical features and medication use. J Clin Rheumatol. 2019;25:163\u201370.","journal-title":"J Clin Rheumatol"},{"key":"1164_CR23","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/acr.22477","volume":"67","author":"CY Chang","year":"2015","unstructured":"Chang CY, Meyer RM, Reiff AO. Impact of medication withdrawal method on flare-free survival in patients with juvenile idiopathic arthritis on combination therapy. Arthritis Care Res (Hoboken). 2015;67:658\u201366.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1164_CR24","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1002\/art.20288","volume":"50","author":"N Ruperto","year":"2004","unstructured":"Ruperto N, Murray KJ, Gerloni V, Wulffraat N, de Oliveira SK, Falcini F, et al. A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum. 2004;50:2191\u2013201.","journal-title":"Arthritis Rheum"},{"key":"1164_CR25","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/1529-0131(199805)41:5<808::AID-ART6>3.0.CO;2-T","volume":"41","author":"MA van Rossum","year":"1998","unstructured":"van Rossum MA, Fiselier TJ, Franssen MJ, Zwinderman AH, ten Cate R, van Suijlekom-Smit LW, et al. Sulfasalazine in the treatment of juvenile chronic arthritis: a randomized, double-blind, placebo-controlled, multicenter study. Dutch juvenile chronic arthritis study group. Arthritis Rheum. 1998;41:808\u201316.","journal-title":"Arthritis Rheum"},{"key":"1164_CR26","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/art.20861","volume":"52","author":"E Silverman","year":"2005","unstructured":"Silverman E, Spiegel L, Hawkins D, Petty R, Goldsmith D, Schanberg L, et al. Long-term open-label preliminary study of the safety and efficacy of Leflunomide in patients with polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum. 2005;52:554\u201362.","journal-title":"Arthritis Rheum"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-025-01164-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-025-01164-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-025-01164-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:11:13Z","timestamp":1764180673000},"score":1,"resource":{"primary":{"URL":"https:\/\/ped-rheum.biomedcentral.com\/articles\/10.1186\/s12969-025-01164-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1164"],"URL":"https:\/\/doi.org\/10.1186\/s12969-025-01164-6","relation":{},"ISSN":["1546-0096"],"issn-type":[{"type":"electronic","value":"1546-0096"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"19 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The CoNinJa study protocol was reviewed and approved by the Ethics Review Board of Institute of Science Tokyo (Tokyo Medical and Dental University), the primary study center (approval No: M2016-256). Additional approvals were obtained from the ethics committees of the 15 other participating medical institutions. Guardians and patients were informed through an opt-out procedure. The NinJa study protocol was reviewed and approved by the Ethics Committee of the NHO Sagamihara National Hospital (approval No: 2014031816) and the ethics committees of all participating institutions. In accordance with the decisions of the respective ethics committees, the study was conducted either with written informed consent obtained from patients or through an opt-out approach. All authors approved the final version of the manuscript for publication and agree to take responsibility for any part of the work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"S.M. and K.S. have no conflict of interest to disclose. T.M. has received speaking fees and\/or honoraria from Abbvie Japan Co., Ltd., AsahiKASEI Co., Ltd., Ayumi Pharmaceutical, Chugai Pharmaceutical Co., Ltd., Eli Lilly Japan K.K., Mitsubishi-Tanabe Pharma Co., Ono Pharmaceutical, Pfizer Japan Inc., Taisho Pharmaceutical Co. Ltd., and UCB Japan Co. Ltd. and has received research grant from Asahi KASEI Co., Ltd., Chugai Pharmaceutical Co., Ltd., and Mitsubishi-Tanabe Pharma Co. N.I. received a lecture fee from Mitsubishi Tanabe Pharma Corporation, Glaxo Smith Kline plc, AbbVie GK, Ono Pharmaceutical co. M.S. has received speaking fees from Novartis Phama Co., Ltd. and has received research grant from MBL Co. Ltd. N.O. received speaker fee and\/or honoraria from AbbVie, Bristol-Myers Squib, Eli Lilly, GlaxoSmithKline, Mitsubishi Tanabe, Ono, Ayumi, Novartis and UCB. M.M has received unrestricted research grants for the previous Department of Lifetime Clinical Immunology from AbbVie GK, Ayumi Pharmaceutical Corporation, Chugai Pharmaceutical Co., Ltd., CSL Behring K.K., Japan Blood Products Organization, Nippon Kayaku Co., Ltd., UCB Japan Co. Ltd., Asahikasei Pharmaceutical Corporation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"120"}}