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This study was performed in accordance with the Declaration of Helsinki and all patients or parents\/guardians provided informed consent for both Registry enrollment and biosample collection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"CK has received consulting fees from Novartis and Swedish Orphan Biovitrum (SOBI) and received research support from Novartis. GS has received consulting fees from SOBI and Novartis, and research support from IpiNovyx. BV has received consultancy fees from Sobi and Novartis, as well as an unrestricted research grant from Sobi in a public-private grant mechanism. CW has been an iDMC member for SOBI, has received speakers\u2019 fee from SOBI, and has received speakers\u2019 fee from Novartis. CB has received consulting fees from Sobi and Novartis, as well as speaking fees from GSK. RAM is employed part-time by Pharming Healthcare, Warren, NJ, and has performed consulting for AB2Bio. CK is Senior Editor of Pediatric Rheumatology, GS is Associate Editor of Pediatric Rheumatology, and CB, FdB, BV, and DD are members of the journal\u2019s editorial board.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}