{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:30:26Z","timestamp":1786419026696,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Municipal Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12024623"],"award-info":[{"award-number":["SHDC12024623"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Hospital Association","award":["MZ2024008"],"award-info":[{"award-number":["MZ2024008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"DOI":"10.1186\/s12969-026-01234-3","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:04:08Z","timestamp":1780725848000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical correlates and predictors of thrombocytopenia in childhood-onset systemic lupus erythematosus: a retrospective cohort study"],"prefix":"10.1186","volume":"24","author":[{"given":"Yang","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"1234_CR1","doi-asserted-by":"crossref","unstructured":"Yuan W, Guan F. Thrombosis and anticoagulation therapy in systemic lupus erythematosus. Autoimmune Dis. 2022;2022:3208037.","DOI":"10.1155\/2022\/3208037"},{"issue":"21","key":"1234_CR2","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.2169\/internalmedicine.4964-20","volume":"59","author":"H Akebo","year":"2020","unstructured":"Akebo H, et al. Lupus Aortitis Successfully Treated with Moderate-dose Glucocorticoids: A Case Report and Review of the Literature. Intern Med. 2020;59(21):2789\u201395.","journal-title":"Intern Med"},{"key":"1234_CR3","doi-asserted-by":"crossref","unstructured":"Melchior M et al. Decreased expression of aquaporins as a feature of tubular damage in lupus nephritis. Cells. 2025;14(5).","DOI":"10.3390\/cells14050380"},{"key":"1234_CR4","doi-asserted-by":"crossref","unstructured":"van Vollenhoven R et al. Conceptual framework for defining disease modification in systemic lupus erythematosus: a call for formal criteria. Lupus Sci Med. 2022;9(1).","DOI":"10.1136\/lupus-2021-000634"},{"key":"1234_CR5","doi-asserted-by":"publisher","first-page":"1473190","DOI":"10.3389\/fimmu.2025.1473190","volume":"16","author":"X Li","year":"2025","unstructured":"Li X, et al. Successful treatment of refractory systemic lupus erythematosus-associated immune thrombocytopenia with drug-induced liver injury with telitacicept: a case report and review. Front Immunol. 2025;16:1473190.","journal-title":"Front Immunol"},{"issue":"3","key":"1234_CR6","first-page":"280","volume":"148","author":"SM Ahn","year":"2025","unstructured":"Ahn SM, et al. Prognostic Factors for Chronic Thrombocytopenia in Systemic Lupus Erythematosus with Immune Thrombocytopenia. Acta Haematol. 2025;148(3):280\u20138.","journal-title":"Acta Haematol"},{"issue":"8","key":"1234_CR7","doi-asserted-by":"publisher","first-page":"e29146","DOI":"10.1002\/pbc.29146","volume":"68","author":"S Kittivisuit","year":"2021","unstructured":"Kittivisuit S, et al. Childhood-onset systemic lupus erythematosus and immune thrombocytopenia: Prevalence and risk factors. Pediatr Blood Cancer. 2021;68(8):e29146.","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"1234_CR8","doi-asserted-by":"publisher","first-page":"2194433","DOI":"10.1080\/0886022X.2023.2194433","volume":"45","author":"P Pan","year":"2023","unstructured":"Pan P, et al. Significance of platelets in the early warning of new-onset AKI in the ICU by using supervise learning: a retrospective analysis. Ren Fail. 2023;45(1):2194433.","journal-title":"Ren Fail"},{"issue":"1","key":"1234_CR9","doi-asserted-by":"publisher","first-page":"8211","DOI":"10.1038\/s41598-022-11926-x","volume":"12","author":"A Garc\u00eda-N\u00fa\u00f1ez","year":"2022","unstructured":"Garc\u00eda-N\u00fa\u00f1ez A, et al. Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients. Sci Rep. 2022;12(1):8211.","journal-title":"Sci Rep"},{"key":"1234_CR10","doi-asserted-by":"publisher","first-page":"1093213","DOI":"10.3389\/fmed.2022.1093213","volume":"9","author":"B Lerkvaleekul","year":"2022","unstructured":"Lerkvaleekul B, et al. Evaluating performance of the 2019 EULAR\/ACR, 2012 SLICC, and 1997 ACR criteria for classifying adult-onset and childhood-onset systemic lupus erythematosus: A systematic review and meta-analysis. Front Med (Lausanne). 2022;9:1093213.","journal-title":"Front Med (Lausanne)"},{"issue":"6","key":"1234_CR11","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3899\/jrheum.200871","volume":"48","author":"ED Batu","year":"2021","unstructured":"Batu ED, et al. The Performances of the ACR 1997, SLICC 2012, and EULAR\/ACR 2019 Classification Criteria in Pediatric Systemic Lupus Erythematosus. J Rheumatol. 2021;48(6):907\u201314.","journal-title":"J Rheumatol"},{"issue":"2","key":"1234_CR12","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3904\/kjim.2015.070","volume":"34","author":"CH Kim","year":"2019","unstructured":"Kim CH, et al. Methylprednisolone versus intravenous immune globulin as an initial therapy in adult primary immune thrombocytopenia. Korean J Intern Med. 2019;34(2):383\u20139.","journal-title":"Korean J Intern Med"},{"issue":"2","key":"1234_CR13","doi-asserted-by":"publisher","first-page":"180","DOI":"10.4103\/njcp.njcp_41_23","volume":"27","author":"MK Tuna","year":"2024","unstructured":"Tuna MK, Erkek ET. Is Immune Thrombocytopenia and its Treatment Associated with Sarcopenia? Niger J Clin Pract. 2024;27(2):180\u20137.","journal-title":"Niger J Clin Pract"},{"issue":"6","key":"1234_CR14","first-page":"e86574","volume":"17","author":"H Tassine","year":"2025","unstructured":"Tassine H, Allaoui A, Naitlhou A. Erythema Multiforme-Like Lesions Revealing Systemic Lupus Erythematosus Cureus. 2025;17(6):e86574.","journal-title":"Erythema Multiforme-Like Lesions Revealing Systemic Lupus Erythematosus Cureus"},{"key":"1234_CR15","doi-asserted-by":"crossref","unstructured":"Ma J et al. Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study. Lupus Sci Med. 2024;11(1).","DOI":"10.1136\/lupus-2024-001196"},{"issue":"1","key":"1234_CR16","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12969-025-01068-5","volume":"23","author":"T Buranapattama","year":"2025","unstructured":"Buranapattama T, et al. Mortality in children and adolescents with autoimmune inflammatory rheumatic diseases admitted to the pediatric intensive care unit. Pediatr Rheumatol Online J. 2025;23(1):20.","journal-title":"Pediatr Rheumatol Online J"},{"key":"1234_CR17","doi-asserted-by":"crossref","unstructured":"Pesqueda-Cendejas K et al. Nutritional approaches to modulate cardiovascular disease risk in systemic lupus erythematosus: a literature review. Nutrients. 2023;15(4).","DOI":"10.3390\/nu15041036"},{"issue":"2","key":"1234_CR18","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.clim.2015.07.001","volume":"160","author":"Y Liu","year":"2015","unstructured":"Liu Y, et al. Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus. Clin Immunol. 2015;160(2):319\u201327.","journal-title":"Clin Immunol"},{"key":"1234_CR19","doi-asserted-by":"publisher","first-page":"e932959","DOI":"10.12659\/AJCR.932959","volume":"22","author":"K Kuroda","year":"2021","unstructured":"Kuroda K, Itagane M, Kinjo M. Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy. Am J Case Rep. 2021;22:e932959.","journal-title":"Am J Case Rep"},{"issue":"11","key":"1234_CR20","doi-asserted-by":"publisher","first-page":"102395","DOI":"10.1016\/j.autrev.2019.102395","volume":"18","author":"YP Chock","year":"2019","unstructured":"Chock YP, et al. Antiphospholipid antibodies and the risk of thrombocytopenia in patients with systemic lupus erythematosus: A systematic review and meta-analysis. Autoimmun Rev. 2019;18(11):102395.","journal-title":"Autoimmun Rev"},{"issue":"1","key":"1234_CR21","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s10238-024-01438-5","volume":"24","author":"A Zinellu","year":"2024","unstructured":"Zinellu A, Paliogiannis P, Mangoni AA. A systematic review and meta-analysis of the diagnostic accuracy of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in systemic lupus erythematosus. Clin Exp Med. 2024;24(1):170.","journal-title":"Clin Exp Med"},{"issue":"3","key":"1234_CR22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/ajh.20408","volume":"80","author":"MS Kravitz","year":"2005","unstructured":"Kravitz MS, Shoenfeld Y. Thrombocytopenic conditions-autoimmunity and hypercoagulability: commonalities and differences in ITP, TTP, HIT, and APS. Am J Hematol. 2005;80(3):232\u201342.","journal-title":"Am J Hematol"},{"key":"1234_CR23","doi-asserted-by":"publisher","first-page":"1343896","DOI":"10.3389\/fphar.2024.1343896","volume":"15","author":"C Feely","year":"2024","unstructured":"Feely C, et al. Modifying platelets at their birth: anti-thrombotic therapy without haemorrhage. Front Pharmacol. 2024;15:1343896.","journal-title":"Front Pharmacol"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-026-01234-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-026-01234-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-026-01234-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:04:15Z","timestamp":1786417455000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12969-026-01234-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1234"],"URL":"https:\/\/doi.org\/10.1186\/s12969-026-01234-3","relation":{},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"13 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board at Children\u2019s Hospital of Fudan University (Approval No. 2025\u2009\u2212\u2009344). As a retrospective analysis of anonymized data from the Hospital Information System, the requirement for informed consent was waived by the Institutional Review Board. For participants under the age of 16, written informed consent for inclusion in the registry and research use of anonymized data was obtained from their parents or legal guardians during their admission for hospital.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"52"}}