{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:14:48Z","timestamp":1788142488805,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":73,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Rheumatol"],"DOI":"10.1186\/s12969-026-01236-1","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:34:28Z","timestamp":1781843668000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor necrosis factor inhibitor-related autoimmune disorders in pediatric rheumatology practice: a multicenter nationwide study"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-2076","authenticated-orcid":false,"given":"Deniz","family":"Gezgin Y\u0131ld\u0131r\u0131m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-8603","authenticated-orcid":false,"given":"Batuhan","family":"K\u00fc\u00e7\u00fckali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-4055","authenticated-orcid":false,"given":"Nergis","family":"Akay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-5972","authenticated-orcid":false,"given":"Sultan Nilay","family":"Yo\u011fun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-6605","authenticated-orcid":false,"given":"Eray","family":"Tunce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-9998","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Ta\u015ftano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-8417","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Do\u011fru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-6962","authenticated-orcid":false,"given":"Yunus Emre","family":"Bayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-8996","authenticated-orcid":false,"given":"Seher","family":"\u015eener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-5196","authenticated-orcid":false,"given":"Mehmet Orhan","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-0069","authenticated-orcid":false,"given":"R\u00fcya","family":"Torun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-0935","authenticated-orcid":false,"given":"Semra","family":"Ayduran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4233-5457","authenticated-orcid":false,"given":"Nesibe G\u00f6k\u00e7e","family":"Kocamaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1063-7459","authenticated-orcid":false,"given":"Elif","family":"K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-4919","authenticated-orcid":false,"given":"Ozan An\u0131l","family":"Ak\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6901-9944","authenticated-orcid":false,"given":"\u00c7isem","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-1356","authenticated-orcid":false,"given":"Ece","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9950-2489","authenticated-orcid":false,"given":"Fatma G\u00fcl","family":"Demirkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-3509","authenticated-orcid":false,"given":"Belde","family":"Kasap Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-822X","authenticated-orcid":false,"given":"Rabia Miray","family":"K\u0131\u015fla Ekinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-1640","authenticated-orcid":false,"given":"Sel\u00e7uk","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4700-1361","authenticated-orcid":false,"given":"Serkan","family":"T\u00fcrku\u00e7ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6542-2656","authenticated-orcid":false,"given":"Erdal","family":"Sa\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-6952","authenticated-orcid":false,"given":"Nihal","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-4410","authenticated-orcid":false,"given":"Elif","family":"\u00c7elikel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-0228","authenticated-orcid":false,"given":"K\u00fcbra","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-4595","authenticated-orcid":false,"given":"Semanur","family":"Ozdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-9922","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Pa\u00e7 K\u0131saarslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-7387","authenticated-orcid":false,"given":"Nuray","family":"Aktay Ayaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-6409","authenticated-orcid":false,"given":"Bet\u00fcl","family":"S\u00f6zeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8800-0800","authenticated-orcid":false,"given":"Erbil","family":"\u00dcnsal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-7720","authenticated-orcid":false,"given":"\u00d6zg\u00fcr","family":"Kasap\u00e7opur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6530-9672","authenticated-orcid":false,"given":"Sevcan A.","family":"Bakkalo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"issue":"4","key":"1236_CR1","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/art.42037","volume":"74","author":"KB Onel","year":"2022","unstructured":"Onel KB, Horton DB, Lovell DJ, Shenoi S, Cuello CA, Angeles-Han ST, et al. 2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2022;74(4):553\u201369.","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"1236_CR2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s10067-023-06740-3","volume":"43","author":"S Sener","year":"2024","unstructured":"Sener S, Cam V, Ozen S, Batu ED. Biologic drugs in the treatment of juvenile dermatomyositis: a literature review. Clin Rheumatol. 2024;43(2):591\u2013602.","journal-title":"Clin Rheumatol"},{"key":"1236_CR3","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.2147\/OPTH.S322445","volume":"15","author":"LF Norcia","year":"2021","unstructured":"Norcia LF, Kiappe OP, Jorge EC. Biological Therapy in Noninfectious Pediatric Uveitis: A Systematic Review. Clin Ophthalmol. 2021;15:3765\u201376.","journal-title":"Clin Ophthalmol"},{"key":"1236_CR4","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jpeds.2018.05.042","volume":"201","author":"G Horneff","year":"2018","unstructured":"Horneff G, Seyger MMB, Arikan D, Kalabic J, Anderson JK, Lazar A, et al. Safety of Adalimumab in Pediatric Patients with Polyarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Psoriasis, and Crohn\u2019s Disease. J Pediatr. 2018;201:166\u201375.","journal-title":"J Pediatr"},{"issue":"5","key":"1236_CR5","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s40272-025-00706-5","volume":"27","author":"ED Batu","year":"2025","unstructured":"Batu ED, Sener S. A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma. Paediatr Drugs. 2025;27(5):563\u201374.","journal-title":"Paediatr Drugs"},{"issue":"11","key":"1236_CR6","doi-asserted-by":"publisher","first-page":"e15377","DOI":"10.1111\/1756-185X.15377","volume":"27","author":"G Ayan","year":"2024","unstructured":"Ayan G, Basaran O, Firlatan B, Kilic L, Bilginer Y, Alikasifoglu M, et al. Long-term follow-up of anti-TNF treatment in adult and pediatric DADA2 patients: Insights from real-world data. Int J Rheum Dis. 2024;27(11):e15377.","journal-title":"Int J Rheum Dis"},{"issue":"1","key":"1236_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12969-023-00798-8","volume":"21","author":"G Horneff","year":"2023","unstructured":"Horneff G, Minden K, Rolland C, Daly ACH, Borlenghi C, Ruperto N. Efficacy and safety of TNF inhibitors in the treatment of juvenile idiopathic arthritis: a systematic literature review. Pediatr Rheumatol Online J. 2023;21(1):20.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"8","key":"1236_CR8","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/j.1398-9995.2006.01058.x","volume":"61","author":"WJ Pichler","year":"2006","unstructured":"Pichler WJ. Adverse side-effects to biological agents. Allergy. 2006;61(8):912\u201320.","journal-title":"Allergy"},{"issue":"4","key":"1236_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jaut.2011.08.002","volume":"37","author":"AT Borchers","year":"2011","unstructured":"Borchers AT, Leibushor N, Cheema GS, Naguwa SM, Gershwin ME. Immune-mediated adverse effects of biologicals used in the treatment of rheumatic diseases. J Autoimmun. 2011;37(4):273\u201388.","journal-title":"J Autoimmun"},{"issue":"11","key":"1236_CR10","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1080\/14740338.2017.1372421","volume":"16","author":"M P\u00e9rez-De-Lis","year":"2017","unstructured":"P\u00e9rez-De-Lis M, Retamozo S, Flores-Ch\u00e1vez A, Kostov B, Perez-Alvarez R, Brito-Zer\u00f3n P, et al. Autoimmune diseases induced by biological agents. A review of 12,731 cases (BIOGEAS Registry). Expert Opin Drug Saf. 2017;16(11):1255\u201371.","journal-title":"Expert Opin Drug Saf"},{"issue":"7","key":"1236_CR11","doi-asserted-by":"publisher","first-page":"103332","DOI":"10.1016\/j.autrev.2023.103332","volume":"22","author":"L De Stefano","year":"2023","unstructured":"De Stefano L, Pallavicini FB, Mauric E, Piccin V, Vismara EM, Montecucco C, et al. Tumor necrosis factor-\u03b1 inhibitor-related autoimmune disorders. Autoimmun Rev. 2023;22(7):103332.","journal-title":"Autoimmun Rev"},{"issue":"6","key":"1236_CR12","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.4049\/jimmunol.1500286","volume":"195","author":"PG Miller","year":"2015","unstructured":"Miller PG, Bonn MB, McKarns SC. Transmembrane TNF-TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression. J Immunol. 2015;195(6):2633\u201347.","journal-title":"J Immunol"},{"issue":"1","key":"1236_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41419-018-1266-6","volume":"10","author":"S Yang","year":"2019","unstructured":"Yang S, Xie C, Chen Y, Wang J, Chen X, Lu Z, et al. Differential roles of TNF\u03b1-TNFR1 and TNF\u03b1-TNFR2 in the differentiation and function of CD4\u2009+\u2009Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases. Cell Death Dis. 2019;10(1):27.","journal-title":"Cell Death Dis"},{"issue":"7","key":"1236_CR14","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/rheumatology\/keq031","volume":"49","author":"T Horiuchi","year":"2010","unstructured":"Horiuchi T, Mitoma H, Harashima S, Tsukamoto H, Shimoda T, Transmembrane. TNF-alpha: structure, function and interaction with anti-TNF agents. Rheumatology (Oxford). 2010;49(7):1215\u201328.","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"1236_CR15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1365-2796.2003.01298.x","volume":"255","author":"F D\u2019Auria","year":"2004","unstructured":"D\u2019Auria F, Rovere-Querini P, Giazzon M, Ajello P, Baldissera E, Manfredi AA, et al. Accumulation of plasma nucleosomes upon treatment with anti-tumour necrosis factor-alpha antibodies. J Intern Med. 2004;255(3):409\u201318.","journal-title":"J Intern Med"},{"issue":"3","key":"1236_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.semarthrit.2006.02.001","volume":"36","author":"DE Furst","year":"2006","unstructured":"Furst DE, Wallis R, Broder M, Beenhouwer DO. Tumor necrosis factor antagonists: different kinetics and\/or mechanisms of action may explain differences in the risk for developing granulomatous infection. Semin Arthritis Rheum. 2006;36(3):159\u201367.","journal-title":"Semin Arthritis Rheum"},{"issue":"3","key":"1236_CR17","doi-asserted-by":"publisher","first-page":"R125","DOI":"10.1186\/ar4582","volume":"16","author":"E Kaltsonoudis","year":"2014","unstructured":"Kaltsonoudis E, Zikou AK, Voulgari PV, Konitsiotis S, Argyropoulou MI, Drosos AA. Neurological adverse events in patients receiving anti-TNF therapy: a prospective imaging and electrophysiological study. Arthritis Res Ther. 2014;16(3):R125.","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"1236_CR18","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1002\/1529-0131(200011)43:11<2383::AID-ANR2>3.0.CO;2-D","volume":"43","author":"PJ Charles","year":"2000","unstructured":"Charles PJ, Smeenk RJ, De Jong J, Feldmann M, Maini RN. Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials. Arthritis Rheum. 2000;43(11):2383\u201390.","journal-title":"Arthritis Rheum"},{"issue":"7","key":"1236_CR19","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1002\/art.21190","volume":"52","author":"L De Rycke","year":"2005","unstructured":"De Rycke L, Baeten D, Kruithof E, Van den Bosch F, Veys EM, De Keyser F. Infliximab, but not etanercept, induces IgM anti-double-stranded DNA autoantibodies as main antinuclear reactivity: biologic and clinical implications in autoimmune arthritis. Arthritis Rheum. 2005;52(7):2192\u2013201.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"1236_CR20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1136\/ard.2004.024182","volume":"64","author":"C Eriksson","year":"2005","unstructured":"Eriksson C, Engstrand S, Sundqvist KG, Rantap\u00e4\u00e4-Dahlqvist S. Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF alpha. Ann Rheum Dis. 2005;64(3):403\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1236_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2174\/1573397115666190506152729","volume":"16","author":"MA Aghdashi","year":"2020","unstructured":"Aghdashi MA, Khadir M, Dinparasti-Saleh R. Antinuclear Antibodies and Lupus-like Manifestations in Rheumatoid Arthritis and Ankylosing Spondylitis Patients at 4 Months\u2019 Follow-up After Treatment with Infliximab and Etanercept. Curr Rheumatol Rev. 2020;16(1):61\u20136.","journal-title":"Curr Rheumatol Rev"},{"key":"1236_CR22","doi-asserted-by":"crossref","unstructured":"De Bandt M, Sibilia J, Le Lo\u00ebt X, Prouzeau S, Fautrel B, Marcelli C, et al. Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey. Arthritis Res Ther. 2005;7(3):545\u2009\u2013\u200951.","DOI":"10.1186\/ar1715"},{"key":"1236_CR23","doi-asserted-by":"crossref","unstructured":"Wetter DA, Davis MD. Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic. Mayo Clin Proc. 2009;84(11):979\u2009\u2013\u200984.","DOI":"10.1016\/S0025-6196(11)60668-X"},{"issue":"7","key":"1236_CR24","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3899\/jrheum.091413","volume":"37","author":"AM Brunasso","year":"2010","unstructured":"Brunasso AM, Scocco GL, Massone C. Dermatomyositis during adalimumab therapy for rheumatoid arthritis. J Rheumatol. 2010;37(7):1549\u201350.","journal-title":"J Rheumatol"},{"issue":"5","key":"1236_CR25","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1111\/pde.14712","volume":"38","author":"BM Cyrenne","year":"2021","unstructured":"Cyrenne BM, Parpia AS, Sibbald C. Paradoxical psoriasis in pediatric patients: A systematic review. Pediatr Dermatol. 2021;38(5):1086\u201393.","journal-title":"Pediatr Dermatol"},{"issue":"2","key":"1236_CR26","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s12016-011-8262-2","volume":"42","author":"I Pontikaki","year":"2012","unstructured":"Pontikaki I, Shahi E, Frasin LA, Gianotti R, Gelmetti C, Gerloni V, et al. Skin manifestations induced by TNF-alpha inhibitors in juvenile idiopathic arthritis. Clin Rev Allergy Immunol. 2012;42(2):131\u20134.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"4","key":"1236_CR27","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/pde.12576","volume":"32","author":"ES West","year":"2015","unstructured":"West ES, Nanda K, Ofodile O, Rutledge J, Brandling-Bennett HA. Adalimumab-Induced Cutaneous Lupus Erythematosus in a 16-Year-Old Girl with Juvenile Idiopathic Arthritis. Pediatr Dermatol. 2015;32(4):140\u20134.","journal-title":"Pediatr Dermatol"},{"issue":"5","key":"1236_CR28","first-page":"e84970","volume":"17","author":"T Aung","year":"2025","unstructured":"Aung T, Prasanpanich M, Kaplan A, Eblen K, Fishbein GA. Tumor Necrosis Factor-Alpha Inhibitor-Induced Sarcoid-Like Reaction in a Patient With Juvenile Idiopathic Arthritis: A Case Report. Cureus. 2025;17(5):e84970.","journal-title":"Cureus"},{"issue":"2","key":"1236_CR29","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s10067-023-06793-4","volume":"43","author":"B K\u00fc\u00e7\u00fckali","year":"2024","unstructured":"K\u00fc\u00e7\u00fckali B, Gezgin Y\u0131ld\u0131r\u0131m D, Esmeray \u015eenol P, \u00d6zdemir HB, Bakkalo\u011flu SA. Etanercept-associated episcleritis: a pediatric case report of a paradoxical adverse reaction and review of the literature. Clin Rheumatol. 2024;43(2):799\u2013808.","journal-title":"Clin Rheumatol"},{"key":"1236_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3899\/jrheum.080432","volume":"36","author":"A Bazso","year":"2009","unstructured":"Bazso A, Consolaro A, Ruperto N, Pistorio A, Viola S, Magni-Manzoni S, et al. Development and testing of reduced joint counts in juvenile idiopathic arthritis. J Rheumatol. 2009;36:183\u201390.","journal-title":"J Rheumatol"},{"issue":"2","key":"1236_CR31","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31(2):390\u20132.","journal-title":"J Rheumatol"},{"key":"1236_CR32","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"A Bohan","year":"1975","unstructured":"Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975;292:344\u20137.","journal-title":"N Engl J Med"},{"issue":"6","key":"1236_CR33","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1136\/annrheumdis-2015-208491","volume":"75","author":"I Kon\u00e9-Paut","year":"2016","unstructured":"Kon\u00e9-Paut I, Shahram F, Darce-Bello M, Cantarini L, Cimaz R, Gattorno M, et al. Consensus classification criteria for paediatric Beh\u00e7et\u2019s disease from a prospective observational cohort: PEDBD. Ann Rheum Dis. 2016;75(6):958\u201364.","journal-title":"Ann Rheum Dis"},{"key":"1236_CR34","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/rheumatology\/ken509","volume":"48","author":"F Yal\u00e7inkaya","year":"2009","unstructured":"Yal\u00e7inkaya F, Ozen S, Oz\u00e7akar ZB, Aktay N, Cakar N, D\u00fczova A, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology (Oxford). 2009;48:395\u20138.","journal-title":"Rheumatology (Oxford)"},{"key":"1236_CR35","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/art.34473","volume":"64","author":"M Petri","year":"2012","unstructured":"Petri M, Orbai AM, Alarcon GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64:2677\u201386.","journal-title":"Arthritis Rheum"},{"issue":"12","key":"1236_CR36","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1093\/rheumatology\/kead318","volume":"62","author":"B Yagiz","year":"2023","unstructured":"Yagiz B, Lermi N, Coskun BN, Dalkilic E, Kiraz S, Erden A, et al. The predictors of paradoxical reactions, especially psoriasis, to biologic therapy-findings from the TReasure database: a 5-year follow-up study. Rheumatology (Oxford). 2023;62(12):3962\u20137.","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"1236_CR37","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/apt.15370","volume":"50","author":"J Korzenik","year":"2019","unstructured":"Korzenik J, Larsen MD, Nielsen J, Kjeldsen J, N\u00f8rg\u00e5rd BM. Increased risk of developing Crohn\u2019s disease or ulcerative colitis in 17 018 patients while under treatment with anti-TNF\u03b1 agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease. Aliment Pharmacol Ther. 2019;50(3):289\u201394.","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"1236_CR38","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/bjd.21716","volume":"187","author":"P Bataille","year":"2022","unstructured":"Bataille P, Layese R, Claudepierre P, Paris N, Dubiel J, Amiot A, et al. Paradoxical reactions and biologic agents: a French cohort study of 9303 patients. Br J Dermatol. 2022;187(5):676\u201383.","journal-title":"Br J Dermatol"},{"issue":"4","key":"1236_CR39","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.jmii.2012.03.006","volume":"46","author":"CC Shen","year":"2013","unstructured":"Shen CC, Yeh KW, Ou LS, Yao TC, Chen LC, Huang JL. Clinical features of children with juvenile idiopathic arthritis using the ILAR classification criteria: a community-based cohort study in Taiwan. J Microbiol Immunol Infect. 2013;46(4):288\u201394.","journal-title":"J Microbiol Immunol Infect"},{"issue":"6","key":"1236_CR40","first-page":"88","volume":"119","author":"I Kremenevski","year":"2022","unstructured":"Kremenevski I, Sander O, Sticherling M, Raithel M, LastName FM. Paradoxical Reactions to Biologicals in Chronic Inflammatory Systemic Diseases. Dtsch Arztebl Int. 2022;119(6):88\u201395.","journal-title":"Dtsch Arztebl Int"},{"issue":"6","key":"1236_CR41","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.jaad.2016.01.018","volume":"74","author":"C Faivre","year":"2016","unstructured":"Faivre C, Villani AP, Aubin F, Lipsker D, Bottaro M, Cohen JD, et al. Hidradenitis suppurativa (HS): An unrecognized paradoxical effect of biologic agents (BA) used in chronic inflammatory diseases. J Am Acad Dermatol. 2016;74(6):1153\u20139.","journal-title":"J Am Acad Dermatol"}],"container-title":["Pediatric Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12969-026-01236-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-026-01236-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12969-026-01236-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:21:36Z","timestamp":1788139296000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12969-026-01236-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1236"],"URL":"https:\/\/doi.org\/10.1186\/s12969-026-01236-1","relation":{},"ISSN":["1546-0096"],"issn-type":[{"value":"1546-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The present study was approved by the Ethics Committee of Gazi University (2025, approval number: 806).","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent was obtained from the patients\u2019 legal guardians.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"56"}}