{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:44Z","timestamp":1791201764548,"version":"4.2.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Institut National pour la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM) funds"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["R06282DS"],"award-info":[{"award-number":["R06282DS"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12974-016-0509-7","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T04:50:15Z","timestamp":1455943815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat"],"prefix":"10.1186","volume":"13","author":[{"given":"Ana\u00efs","family":"Sapienza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Raveu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Reboussin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Roubeix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"D\u00e9gardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Godefroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Rost\u00e8ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Reaux-Le Goazigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Baudouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-9591","authenticated-orcid":false,"given":"St\u00e9phane","family":"Melik Parsadaniantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,20]]},"reference":[{"issue":"90","key":"509_CR1","first-page":"262","volume":"2006","author":"HA Quigley","year":"2010","unstructured":"Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2010;2006(90):262\u20137.","journal-title":"Br J Ophthalmol"},{"key":"509_CR2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ajo.2004.04.054","volume":"138","author":"RN Weinreb","year":"2004","unstructured":"Weinreb RN, Friedman DS, Fechtner RD, Cioffi GA, Coleman AL, Girkin CA, et al. Risk assessment in the management of patients with ocular hypertension. Am J Ophthalmol. 2004;138:458\u201367.","journal-title":"Am J Ophthalmol"},{"key":"509_CR3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1600-0420.1997.tb00391.x","volume":"75","author":"J Caprioli","year":"1997","unstructured":"Caprioli J. Neuroprotection of the optic nerve in glaucoma. Acta Ophthalmol Scand. 1997;75:364\u20137.","journal-title":"Acta Ophthalmol Scand"},{"key":"509_CR4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3129\/i07-051","volume":"42","author":"N Gupta","year":"2007","unstructured":"Gupta N, Yucel YH. Should we treat the brain in glaucoma? Can J Ophthalmol. 2007;42:409\u201313.","journal-title":"Can J Ophthalmol"},{"key":"509_CR5","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1523\/JNEUROSCI.3200-08.2008","volume":"28","author":"MB Wax","year":"2008","unstructured":"Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, et al. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci. 2008;28:12085\u201396.","journal-title":"J Neurosci"},{"key":"509_CR6","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1172\/JCI61135","volume":"122","author":"GR Howell","year":"2012","unstructured":"Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, et al. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest. 2012;122:1246\u201361.","journal-title":"J Clin Invest"},{"key":"509_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.neuro.051508.135728","volume":"35","author":"RW Nickells","year":"2012","unstructured":"Nickells RW, Howell GR, Soto I, John SW. Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annu Rev Neurosci. 2012;35:153\u201379.","journal-title":"Annu Rev Neurosci"},{"key":"509_CR8","doi-asserted-by":"crossref","unstructured":"Soto I, Howell GR. The complex role of neuroinflammation in glaucoma. Cold Spring Harb Perspect Med. 2014;4. doi: 10.1101\/cshperspect.a017269 .","DOI":"10.1101\/cshperspect.a017269"},{"key":"509_CR9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coph.2012.09.013","volume":"13","author":"G Tezel","year":"2013","unstructured":"Tezel G. Immune regulation toward immunomodulation for neuroprotection in glaucoma. Curr Opin Pharmacol. 2013;13:23\u201331.","journal-title":"Curr Opin Pharmacol"},{"key":"509_CR10","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1167\/iovs.07-1337","volume":"49","author":"A Bosco","year":"2008","unstructured":"Bosco A, Inman DM, Steele MR, Wu G, Soto I, Marsh-Armstrong N, et al. Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA\/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2008;49:1437\u201346.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"509_CR11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.22516","volume":"519","author":"A Bosco","year":"2011","unstructured":"Bosco A, Steele MR, Vetter ML. Early microglia activation in a mouse model of chronic glaucoma. J Comp Neurol. 2011;519:599\u2013620.","journal-title":"J Comp Neurol"},{"key":"509_CR12","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/bjo.2005.086769","volume":"90","author":"N Gupta","year":"2006","unstructured":"Gupta N, Ang LC, Noel de Tilly L, Bidaisee L, Yucel YH. Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol. 2006;90:674\u20138.","journal-title":"Br J Ophthalmol"},{"key":"509_CR13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/ICU.0b013e3280895aea","volume":"18","author":"N Gupta","year":"2007","unstructured":"Gupta N, Yucel YH. Glaucoma as a neurodegenerative disease. Curr Opin Ophthalmol. 2007;18:110\u20134.","journal-title":"Curr Opin Ophthalmol"},{"key":"509_CR14","doi-asserted-by":"crossref","unstructured":"Chiu K, Lau WM, Yeung SC, Chang RC, So KF. Retrograde labeling of retinal ganglion cells by application of fluoro-gold on the surface of superior colliculus. J Vis Exp. 2008. doi: 10.3791\/819 .","DOI":"10.3791\/819"},{"key":"509_CR15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/214245a0","volume":"214","author":"J Forrester","year":"1967","unstructured":"Forrester J, Peters A. Nerve fibres in optic nerve of rat. Nature. 1967;214:245\u20137.","journal-title":"Nature"},{"key":"509_CR16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.visres.2008.09.029","volume":"49","author":"M Salinas-Navarro","year":"2009","unstructured":"Salinas-Navarro M, Mayor-Torroglosa S, Jimenez-Lopez M, Aviles-Trigueros M, Holmes TM, Lund RD, et al. A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats. Vision Res. 2009;49:115\u201326.","journal-title":"Vision Res"},{"key":"509_CR17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.brainres.2009.09.029","volume":"1303","author":"S Zhang","year":"2009","unstructured":"Zhang S, Wang H, Lu Q, Qing G, Wang N, Wang Y, et al. Detection of early neuron degeneration and accompanying glial responses in the visual pathway in a rat model of acute intraocular hypertension. Brain Res. 2009;1303:131\u201343.","journal-title":"Brain Res"},{"key":"509_CR18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12974-015-0399-0","volume":"12","author":"GN Wilson","year":"2015","unstructured":"Wilson GN, Inman DM, Dengler Crish CM, Smith MA, Crish SD. Early pro-inflammatory cytokine elevations in the DBA\/2J mouse model of glaucoma. J Neuroinflammation. 2015;12:176.","journal-title":"J Neuroinflammation"},{"key":"509_CR19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-2094-9-92","volume":"9","author":"BI Gallego","year":"2012","unstructured":"Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramirez AI, Salinas-Navarro M, et al. IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma. J Neuroinflammation. 2012;9:92.","journal-title":"J Neuroinflammation"},{"key":"509_CR20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1742-2094-11-133","volume":"11","author":"B Rojas","year":"2014","unstructured":"Rojas B, Gallego BI, Ramirez AI, Salazar JJ, de Hoz R, Valiente-Soriano FJ, et al. Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers. J Neuroinflammation. 2014;11:133.","journal-title":"J Neuroinflammation"},{"key":"509_CR21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neulet.2015.02.033","volume":"591","author":"VK Avellaneda-Chevrier","year":"2015","unstructured":"Avellaneda-Chevrier VK, Wang X, Hooper ML, Chauhan BC. The retino-retinal projection: tracing retinal ganglion cells projecting to the contralateral retina. Neurosci Lett. 2015;591:105\u20139.","journal-title":"Neurosci Lett"},{"key":"509_CR22","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/BF00248754","volume":"71","author":"M Muller","year":"1988","unstructured":"Muller M, Hollander H. An experimental study in the rat and the rabbit. Exp Brain Res. 1988;71:611\u20137.","journal-title":"Exp Brain Res"},{"key":"509_CR23","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.eye.6701576","volume":"18","author":"H Levkovitch-Verbin","year":"2004","unstructured":"Levkovitch-Verbin H. Animal models of optic nerve diseases. Eye (Lond). 2004;18:1066\u201374.","journal-title":"Eye (Lond)"},{"key":"509_CR24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-3940(89)90326-1","volume":"104","author":"P Toth","year":"1989","unstructured":"Toth P, Straznicky C. Retino-retinal projections in three anuran species. Neurosci Lett. 1989;104:43\u20137.","journal-title":"Neurosci Lett"},{"key":"509_CR25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.exer.2015.03.015","volume":"134","author":"FM Nadal-Nicolas","year":"2015","unstructured":"Nadal-Nicolas FM, Valiente-Soriano FJ, Salinas-Navarro M, Jimenez-Lopez M, Vidal-Sanz M, Agudo-Barriuso M. Retino-retinal projection in juvenile and young adult rats and mice. Exp Eye Res. 2015;134:47\u201352.","journal-title":"Exp Eye Res"},{"key":"509_CR26","doi-asserted-by":"crossref","first-page":"e37873","DOI":"10.1371\/journal.pone.0037873","volume":"7","author":"A Denoyer","year":"2012","unstructured":"Denoyer A, Godefroy D, Celerier I, Frugier J, Degardin J, Harrison JK, et al. CXCR3 antagonism of SDF-1(5\u201367) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension. PLoS One. 2012;7:e37873.","journal-title":"PLoS One"},{"key":"509_CR27","first-page":"3451","volume":"41","author":"TW Mittag","year":"2000","unstructured":"Mittag TW, Danias J, Pohorenec G, Yuan HM, Burakgazi E, Chalmers-Redman R, et al. Retinal damage after 3 to 4\u00a0months of elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci. 2000;41:3451\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"509_CR28","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/mt.2014.44","volume":"22","author":"C Lechauve","year":"2014","unstructured":"Lechauve C, Augustin S, Cwerman-Thibault H, Reboussin E, Roussel D, Lai-Kuen R, et al. Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice. Mol Ther. 2014;22:1096\u2013109.","journal-title":"Mol Ther"},{"key":"509_CR29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676\u201382.","journal-title":"Nat Methods"},{"key":"509_CR30","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","volume":"117","author":"CL Tsou","year":"2007","unstructured":"Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest. 2007;117:902\u20139.","journal-title":"J Clin Invest"},{"key":"509_CR31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0079-6123(05)51011-2","volume":"151","author":"PJ May","year":"2006","unstructured":"May PJ. The mammalian superior colliculus: laminar structure and connections. Prog Brain Res. 2006;151:321\u201378.","journal-title":"Prog Brain Res"},{"key":"509_CR32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13287-015-0168-0","volume":"6","author":"C Roubeix","year":"2015","unstructured":"Roubeix C, Godefroy D, Mias C, Sapienza A, Riancho L, Degardin J, et al. Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma. Stem Cell Res Ther. 2015;6:177.","journal-title":"Stem Cell Res Ther"},{"key":"509_CR33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.preteyeres.2004.08.003","volume":"24","author":"JC Morrison","year":"2005","unstructured":"Morrison JC, Johnson EC, Cepurna W, Jia L. Understanding mechanisms of pressure-induced optic nerve damage. Prog Retin Eye Res. 2005;24:217\u201340.","journal-title":"Prog Retin Eye Res"},{"key":"509_CR34","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1167\/iovs.12-10581","volume":"54","author":"BJ Frankfort","year":"2013","unstructured":"Frankfort BJ, Khan AK, Tse DY, Chung I, Pang JJ, Yang Z, et al. Elevated intraocular pressure causes inner retinal dysfunction before cell loss in a mouse model of experimental glaucoma. Invest Ophthalmol Vis Sci. 2013;54:762\u201370.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"509_CR35","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1167\/iovs.14-15691","volume":"56","author":"H Chen","year":"2015","unstructured":"Chen H, Zhao Y, Liu M, Feng L, Puyang Z, Yi J, et al. Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension. Invest Ophthalmol Vis Sci. 2015;56:1971\u201384.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"509_CR36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1006\/exer.1999.0732","volume":"69","author":"A Sawada","year":"1999","unstructured":"Sawada A, Neufeld AH. Confirmation of the rat model of chronic, moderately elevated intraocular pressure. Exp Eye Res. 1999;69:525\u201331.","journal-title":"Exp Eye Res"},{"key":"509_CR37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-3940(01)01830-4","volume":"305","author":"ML Ko","year":"2001","unstructured":"Ko ML, Hu DN, Ritch R, Sharma SC, Chen CF. Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats. Neurosci Lett. 2001;305:139\u201342.","journal-title":"Neurosci Lett"},{"key":"509_CR38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0006-8993(01)02759-7","volume":"913","author":"FA Ahmed","year":"2001","unstructured":"Ahmed FA, Hegazy K, Chaudhary P, Sharma SC. Neuroprotective effect of alpha(2) agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure. Brain Res. 2001;913:133\u20139.","journal-title":"Brain Res"},{"key":"509_CR39","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1167\/iovs.02-1136","volume":"44","author":"G Tezel","year":"2003","unstructured":"Tezel G, Chauhan BC, LeBlanc RP, Wax MB. Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma. Invest Ophthalmol Vis Sci. 2003;44:3025\u201333.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"509_CR40","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/jnr.1104","volume":"64","author":"L Yuan","year":"2001","unstructured":"Yuan L, Neufeld AH. Activated microglia in the human glaucomatous optic nerve head. J Neurosci Res. 2001;64:523\u201332.","journal-title":"J Neurosci Res"},{"key":"509_CR41","first-page":"2217","volume":"15","author":"D Lam","year":"2009","unstructured":"Lam D, Jim J, To E, Rasmussen C, Kaufman PL, Matsubara J. Astrocyte and microglial activation in the lateral geniculate nucleus and visual cortex of glaucomatous and optic nerve transected primates. Mol Vis. 2009;15:2217\u201329.","journal-title":"Mol Vis"},{"key":"509_CR42","doi-asserted-by":"crossref","first-page":"e40065","DOI":"10.1371\/journal.pone.0040065","volume":"7","author":"M Roh","year":"2012","unstructured":"Roh M, Zhang Y, Murakami Y, Thanos A, Lee SC, Vavvas DG, et al. Etanercept, a widely used inhibitor of tumor necrosis factor-alpha (TNF-alpha), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS One. 2012;7:e40065.","journal-title":"PLoS One"},{"key":"509_CR43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.exer.2009.10.003","volume":"90","author":"M Salinas-Navarro","year":"2010","unstructured":"Salinas-Navarro M, Alarcon-Martinez L, Valiente-Soriano FJ, Jimenez-Lopez M, Mayor-Torroglosa S, Aviles-Trigueros M, et al. Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration. Exp Eye Res. 2010;90:168\u201383.","journal-title":"Exp Eye Res"},{"key":"509_CR44","first-page":"290","volume":"8","author":"CM Dengler-Crish","year":"2014","unstructured":"Dengler-Crish CM, Smith MA, Inman DM, Wilson GN, Young JW, Crish SD. Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA\/2J mouse model of glaucoma. Front Neurosci. 2014;8:290.","journal-title":"Front Neurosci"},{"key":"509_CR45","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3109\/02713683.2014.990983","volume":"40","author":"E Dekeyster","year":"2015","unstructured":"Dekeyster E, Aerts J, Valiente-Soriano FJ, De Groef L, Vreysen S, Salinas-Navarro M, et al. Ocular hypertension results in retinotopic alterations in the visual cortex of adult mice. Curr Eye Res. 2015;40:1269\u201383.","journal-title":"Curr Eye Res"},{"key":"509_CR46","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.freeradbiomed.2005.03.025","volume":"39","author":"ML Ko","year":"2005","unstructured":"Ko ML, Peng PH, Ma MC, Ritch R, Chen CF. Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma. Free Radic Biol Med. 2005;39:365\u201373.","journal-title":"Free Radic Biol Med"},{"key":"509_CR47","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.preteyeres.2006.07.003","volume":"25","author":"G Tezel","year":"2006","unstructured":"Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res. 2006;25:490\u2013513.","journal-title":"Prog Retin Eye Res"},{"key":"509_CR48","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.freeradbiomed.2004.06.001","volume":"37","author":"MC Moreno","year":"2004","unstructured":"Moreno MC, Campanelli J, Sande P, Sanez DA, Keller Sarmiento MI, Rosenstein RE. Retinal oxidative stress induced by high intraocular pressure. Free Radic Biol Med. 2004;37:803\u201312.","journal-title":"Free Radic Biol Med"},{"key":"509_CR49","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","volume":"31","author":"M Almasieh","year":"2012","unstructured":"Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res. 2012;31:152\u201381.","journal-title":"Prog Retin Eye Res"},{"key":"509_CR50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0301-0082(96)00021-4","volume":"50","author":"DG Herrera","year":"1996","unstructured":"Herrera DG, Robertson HA. Activation of c-fos in the brain. Prog Neurobiol. 1996;50:83\u2013107.","journal-title":"Prog Neurobiol"},{"key":"509_CR51","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/cdd.2012.122","volume":"20","author":"T Katome","year":"2013","unstructured":"Katome T, Namekata K, Guo X, Semba K, Kittaka D, Kawamura K, et al. Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury. Cell Death Differ. 2013;20:270\u201380.","journal-title":"Cell Death Differ"},{"key":"509_CR52","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1523\/JNEUROSCI.20-13-05037.2000","volume":"20","author":"M Kikuchi","year":"2000","unstructured":"Kikuchi M, Tenneti L, Lipton SA. Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells. J Neurosci. 2000;20:5037\u201344.","journal-title":"J Neurosci"},{"key":"509_CR53","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1167\/iovs.02-1101","volume":"44","author":"J Danias","year":"2003","unstructured":"Danias J, Lee KC, Zamora MF, Chen B, Shen F, Filippopoulos T, et al. Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA\/2NNia glaucomatous mice: comparison with RGC loss in aging C57\/BL6 mice. Invest Ophthalmol Vis Sci. 2003;44:5151\u201362.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"509_CR54","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1155\/NP.1991.141","volume":"2","author":"GM Friehs","year":"1991","unstructured":"Friehs GM, Parker RG, He LS, Haines SJ, Turner DA, Ebner TJ. Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of Parkinsonism. J Neural Transplant Plast. 1991;2:141\u201356.","journal-title":"J Neural Transplant Plast"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0509-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T16:31:00Z","timestamp":1567614660000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jneuroinflammation.com\/content\/13\/1\/44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,20]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["509"],"URL":"https:\/\/doi.org\/10.1186\/s12974-016-0509-7","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,20]]},"article-number":"44"}}