{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:58:58Z","timestamp":1793109538550,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH096625"],"award-info":[{"award-number":["MH096625"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12974-016-0510-1","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T11:36:02Z","timestamp":1456918562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS"],"prefix":"10.1186","volume":"13","author":[{"given":"Joan W.","family":"Berman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Carvallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisa M.","family":"Buckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9e","family":"Luers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Prevedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliseo A.","family":"Eugenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"510_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1007\/s13365-011-0032-7","volume":"17","author":"TL Jernigan","year":"2011","unstructured":"Jernigan TL, Archibald SL, Fennema-Notestine C, Taylor MJ, Theilmann RJ, Julaton MD, et al. Clinical factors related to brain structure in HIV: the CHARTER study. J Neurovirol. 2011;17:248\u201357.","journal-title":"J Neurovirol"},{"key":"510_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s13365-010-0006-1","volume":"17","author":"RK Heaton","year":"2011","unstructured":"Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17:3\u201316.","journal-title":"J Neurovirol"},{"key":"510_CR3","first-page":"137","volume":"19","author":"S Letendre","year":"2011","unstructured":"Letendre S. Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder. Top Antiviral Med. 2011;19:137\u201342.","journal-title":"Top Antiviral Med"},{"key":"510_CR4","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.febslet.2014.01.030","volume":"588","author":"EA Eugenin","year":"2014","unstructured":"Eugenin EA. Role of Connexin\/Pannexin containing channels in infectious diseases. FEBS Lett. 2014;588:1389\u201395.","journal-title":"FEBS Lett"},{"issue":"3","key":"510_CR5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s11481-012-9352-5","volume":"7","author":"EA Eugenin","year":"2012","unstructured":"Eugenin EA, Basilio D, Saez JC, Orellana JA, Raine CS, Bukauskas F, et al. The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol. 2012;7(3):499\u2013518.","journal-title":"J Neuroimmune Pharmacol"},{"issue":"Suppl 1","key":"510_CR6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/753312749","volume":"10","author":"Z Wang","year":"2004","unstructured":"Wang Z, Trillo-Pazos G, Kim SY, Canki M, Morgello S, Sharer LR, et al. Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. J Neurovirol. 2004;10 Suppl 1:25\u201332.","journal-title":"J Neurovirol"},{"key":"510_CR7","doi-asserted-by":"publisher","first-page":"9456","DOI":"10.1523\/JNEUROSCI.1460-11.2011","volume":"31","author":"EA Eugenin","year":"2011","unstructured":"Eugenin EA, Clements JE, Zink MC, Berman JW. Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism. J Neurosci. 2011;31:9456\u201365.","journal-title":"J Neurosci"},{"key":"510_CR8","doi-asserted-by":"publisher","first-page":"12844","DOI":"10.1523\/JNEUROSCI.4154-07.2007","volume":"27","author":"EA Eugenin","year":"2007","unstructured":"Eugenin EA, Berman JW. Gap junctions mediate human immunodeficiency virus-bystander killing in astrocytes. J Neurosci. 2007;27:12844\u201350.","journal-title":"J Neurosci"},{"key":"510_CR9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/ana.1011","volume":"49","author":"KA Thompson","year":"2001","unstructured":"Thompson KA, McArthur JC, Wesselingh SL. Correlation between neurological progression and astrocyte apoptosis in HIV-associated dementia. Ann Neurol. 2001;49:745\u201352.","journal-title":"Ann Neurol"},{"key":"510_CR10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1128\/JVI.73.2.897-906.1999","volume":"73","author":"A Ohagen","year":"1999","unstructured":"Ohagen A, Ghosh S, He J, Huang K, Chen Y, Yuan M, et al. Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope. J Virol. 1999;73:897\u2013906.","journal-title":"J Virol"},{"key":"510_CR11","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/jnc.12492","volume":"128","author":"JA Orellana","year":"2014","unstructured":"Orellana JA, Saez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA. HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism. J Neurochem. 2014;128:752\u201363.","journal-title":"J Neurochem"},{"key":"510_CR12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0248-4900(02)00016-3","volume":"94","author":"N Rouach","year":"2002","unstructured":"Rouach N, Avignone E, Meme W, Koulakoff A, Venance L, Blomstrand F, et al. Gap junctions and connexin expression in the normal and pathological central nervous system. Biol Cell. 2002;94:457\u201375.","journal-title":"Biol Cell"},{"key":"510_CR13","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1046\/j.1471-4159.2003.01775.x","volume":"85","author":"EA Eugenin","year":"2003","unstructured":"Eugenin EA, D'Aversa TG, Lopez L, Calderon TM, Berman JW. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem. 2003;85:1299\u2013311.","journal-title":"J Neurochem"},{"key":"510_CR14","doi-asserted-by":"publisher","first-page":"3438","DOI":"10.1073\/pnas.0611699104","volume":"104","author":"EA Eugenin","year":"2007","unstructured":"Eugenin EA, King JE, Nath A, Calderon TM, Zukin RS, Bennett MV, et al. HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes. Proc Natl Acad Sci U S A. 2007;104:3438\u201343.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"510_CR15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/glia.20137","volume":"49","author":"EA Eugenin","year":"2005","unstructured":"Eugenin EA, Dyer G, Calderon TM, Berman JW. HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS. Glia. 2005;49:501\u201310.","journal-title":"Glia"},{"key":"510_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S1046-2023(02)00359-6","volume":"29","author":"EA Eugenin","year":"2003","unstructured":"Eugenin EA, Berman JW. Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier. Methods. 2003;29:351\u201361.","journal-title":"Methods"},{"key":"510_CR17","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1099\/jmm.0.081091-0","volume":"63","author":"S Subbian","year":"2014","unstructured":"Subbian S, Eugenin E, Kaplan G. Detection of Mycobacterium tuberculosis in latently infected lungs by immunohistochemistry and confocal microscopy. J Med Microbiol. 2014;63:1432\u20135.","journal-title":"J Med Microbiol"},{"issue":"3","key":"510_CR18","first-page":"167","volume":"72","author":"CE Rella","year":"2014","unstructured":"Rella CE, Ruel N, Eugenin EA. Development of imaging techniques to study the pathogenesis of biosafety level 2\/3 infectious agents. Pathog Dis. 2014;72(3):167\u201373.","journal-title":"Pathog Dis"},{"key":"510_CR19","doi-asserted-by":"publisher","first-page":"G991","DOI":"10.1152\/ajpgi.00298.2001","volume":"282","author":"HE Gonzalez","year":"2002","unstructured":"Gonzalez HE, Eugenin EA, Garces G, Solis N, Pizarro M, Accatino L, et al. Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators. Am J Physiol Gastrointest Liver Physiol. 2002;282:G991\u2013G1001.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"510_CR20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248\u201354.","journal-title":"Anal Biochem"},{"key":"510_CR21","first-page":"G1109","volume":"274","author":"EA Eugenin","year":"1998","unstructured":"Eugenin EA, Gonzalez H, Saez CG, Saez JC. Gap junctional communication coordinates vasopressin-induced glycogenolysis in rat hepatocytes. Am J Physiol. 1998;274:G1109\u20131116.","journal-title":"Am J Physiol"},{"key":"510_CR22","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/jcp.21267","volume":"214","author":"L Carvallo","year":"2008","unstructured":"Carvallo L, Henriquez B, Paredes R, Olate J, Onate S, van Wijnen AJ, et al. 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. J Cell Physiol. 2008;214:740\u20139.","journal-title":"J Cell Physiol"},{"key":"510_CR23","doi-asserted-by":"publisher","first-page":"23667","DOI":"10.1074\/jbc.271.39.23667","volume":"271","author":"E Geimonen","year":"1996","unstructured":"Geimonen E, Jiang W, Ali M, Fishman GI, Garfield RE, Andersen J. Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence. J Biol Chem. 1996;271:23667\u201374.","journal-title":"J Biol Chem"},{"key":"510_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.gene.2004.12.048","volume":"350","author":"GM Essenfelder","year":"2005","unstructured":"Essenfelder GM, Larderet G, Waksman G, Lamartine J. Gene structure and promoter analysis of the human GJB6 gene encoding connexin 30. Gene. 2005;350:33\u201340.","journal-title":"Gene"},{"issue":"5","key":"510_CR25","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/jnc.12443","volume":"127","author":"EA Eugenin","year":"2013","unstructured":"Eugenin EA, Berman JW. Cytochrome C dysregulation induced by HIV infection of astrocytes results in bystander apoptosis of uninfected astrocytes by an IP and calcium dependent mechanism. J Neurochem. 2013;127(5):644\u201351.","journal-title":"J Neurochem"},{"key":"510_CR26","doi-asserted-by":"crossref","unstructured":"Orellana JA, Saez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA. HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism. J Neurochem. 2013.","DOI":"10.1111\/jnc.12492"},{"key":"510_CR27","doi-asserted-by":"crossref","first-page":"RC114","DOI":"10.1523\/JNEUROSCI.20-23-j0004.2000","volume":"20","author":"HS Duffy","year":"2000","unstructured":"Duffy HS, John GR, Lee SC, Brosnan CF, Spray DC. Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci. 2000;20:RC114.","journal-title":"J Neurosci"},{"key":"510_CR28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1006\/jmbi.1999.3060","volume":"293","author":"J Karn","year":"1999","unstructured":"Karn J. Tackling Tat. J Mol Biol. 1999;293:235\u201354.","journal-title":"J Mol Biol"},{"key":"510_CR29","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1073\/pnas.96.4.1285","volume":"96","author":"K Fujinaga","year":"1999","unstructured":"Fujinaga K, Taube R, Wimmer J, Cujec TP, Peterlin BM. Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T. Proc Natl Acad Sci U S A. 1999;96:1285\u201390.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"510_CR30","first-page":"121","volume":"389","author":"G Mousseau","year":"2015","unstructured":"Mousseau G, Mediouni S, Valente ST. Targeting HIV transcription: the quest for a functional cure. Curr Top Microbiol Immunol. 2015;389:121\u201345.","journal-title":"Curr Top Microbiol Immunol"},{"key":"510_CR31","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s13365-012-0144-8","volume":"19","author":"M Bachani","year":"2013","unstructured":"Bachani M, Sacktor N, McArthur JC, Nath A, Rumbaugh J. Detection of anti-tat antibodies in CSF of individuals with HIV-associated neurocognitive disorders. J Neurovirol. 2013;19:82\u20138.","journal-title":"J Neurovirol"},{"key":"510_CR32","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11904-014-0255-3","volume":"12","author":"Z Zayyad","year":"2015","unstructured":"Zayyad Z, Spudich S. Neuropathogenesis of HIV: from initial neuroinvasion to HIV-associated neurocognitive disorder (HAND). Curr HIV\/AIDS Rep. 2015;12:16\u201324.","journal-title":"Curr HIV\/AIDS Rep"},{"key":"510_CR33","first-page":"54","volume":"17","author":"D Elbirt","year":"2015","unstructured":"Elbirt D, Mahlab-Guri K, Bezalel-Rosenberg S, Gill H, Attali M, Asher I. HIV-associated neurocognitive disorders (HAND). Isr Med Assoc J. 2015;17:54\u20139.","journal-title":"Isr Med Assoc J"},{"key":"510_CR34","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.micinf.2005.11.014","volume":"8","author":"JE King","year":"2006","unstructured":"King JE, Eugenin EA, Buckner CM, Berman JW. HIV tat and neurotoxicity. Microbes Infect. 2006;8:1347\u201357.","journal-title":"Microbes Infect"},{"key":"510_CR35","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.expneurol.2013.11.004","volume":"251","author":"A Nath","year":"2014","unstructured":"Nath A, Steiner J. Synaptodendritic injury with HIV-Tat protein: what is the therapeutic target? Exp Neurol. 2014;251:112\u20134.","journal-title":"Exp Neurol"},{"key":"510_CR36","doi-asserted-by":"crossref","unstructured":"Al-Harthi L. Interplay between Wnt\/beta-Catenin signaling and HIV: virologic and biologic consequences in the CNS. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2012.","DOI":"10.1007\/s11481-012-9411-y"},{"key":"510_CR37","doi-asserted-by":"publisher","first-page":"5864","DOI":"10.1128\/JVI.02234-06","volume":"81","author":"D Carroll-Anzinger","year":"2007","unstructured":"Carroll-Anzinger D, Kumar A, Adarichev V, Kashanchi F, Al-Harthi L. Human immunodeficiency virus-restricted replication in astrocytes and the ability of gamma interferon to modulate this restriction are regulated by a downstream effector of the Wnt signaling pathway. J Virol. 2007;81:5864\u201371.","journal-title":"J Virol"},{"key":"510_CR38","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.4049\/jimmunol.1100099","volume":"186","author":"W Li","year":"2011","unstructured":"Li W, Henderson LJ, Major EO, Al-Harthi L. IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner. J Immunol. 2011;186:6771\u20138.","journal-title":"J Immunol"},{"key":"510_CR39","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/glia.22763","volume":"63","author":"MH Richards","year":"2015","unstructured":"Richards MH, Narasipura SD, Kim S, Seaton MS, Lutgen V, Al-Harthi L. Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS. Glia. 2015;63:441\u201351.","journal-title":"Glia"},{"key":"510_CR40","doi-asserted-by":"publisher","first-page":"6542","DOI":"10.1523\/JNEUROSCI.6512-10.2011","volume":"31","author":"K Allen","year":"2011","unstructured":"Allen K, Fuchs EC, Jaschonek H, Bannerman DM, Monyer H. Gap junctions between interneurons are required for normal spatial coding in the hippocampus and short-term spatial memory. J Neurosci. 2011;31:6542\u201352.","journal-title":"J Neurosci"},{"key":"510_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1126\/science.1193785","volume":"331","author":"S Bissiere","year":"2011","unstructured":"Bissiere S, Zelikowsky M, Ponnusamy R, Jacobs NS, Blair HT, Fanselow MS. Electrical synapses control hippocampal contributions to fear learning and memory. Science. 2011;331:87\u201391.","journal-title":"Science"},{"key":"510_CR42","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s11064-014-1277-3","volume":"39","author":"S Jiang","year":"2014","unstructured":"Jiang S, Wang YQ, Xu CF, Li YN, Guo R, Li L. Involvement of connexin43 in the infrasonic noise-induced glutamate release by cultured astrocytes. Neurochem Res. 2014;39:833\u201342.","journal-title":"Neurochem Res"},{"key":"510_CR43","doi-asserted-by":"publisher","first-page":"7743","DOI":"10.1523\/JNEUROSCI.0341-09.2009","volume":"29","author":"SE Lutz","year":"2009","unstructured":"Lutz SE, Zhao Y, Gulinello M, Lee SC, Raine CS, Brosnan CF. Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation. J Neurosci. 2009;29:7743\u201352.","journal-title":"J Neurosci"},{"key":"510_CR44","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1096\/fj.11-198416","volume":"26","author":"J Stehberg","year":"2012","unstructured":"Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverria C, Orellana JA, et al. Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J. 2012;26:3649\u201357.","journal-title":"FASEB J"},{"key":"510_CR45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.neulet.2011.07.018","volume":"502","author":"Y Wang","year":"2011","unstructured":"Wang Y, Belousov AB. Deletion of neuronal gap junction protein connexin 36 impairs hippocampal LTP. Neurosci Lett. 2011;502:30\u20132.","journal-title":"Neurosci Lett"},{"key":"510_CR46","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fphys.2014.00096","volume":"5","author":"S Velasquez","year":"2014","unstructured":"Velasquez S, Eugenin EA. Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases. Front Physiol. 2014;5:96.","journal-title":"Front Physiol"},{"key":"510_CR47","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/2210","volume":"1","author":"JH Lin","year":"1998","unstructured":"Lin JH, Weigel H, Cotrina ML, Liu S, Bueno E, Hansen AJ, et al. Gap-junction-mediated propagation and amplification of cell injury. Nat Neurosci. 1998;1:494\u2013500.","journal-title":"Nat Neurosci"},{"key":"510_CR48","doi-asserted-by":"publisher","first-page":"497","DOI":"10.2307\/3579865","volume":"150","author":"EI Azzam","year":"1998","unstructured":"Azzam EI, de Toledo SM, Gooding T, Little JB. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res. 1998;150:497\u2013504.","journal-title":"Radiat Res"},{"key":"510_CR49","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1074\/jbc.270.8.3863","volume":"270","author":"ZQ Chen","year":"1995","unstructured":"Chen ZQ, Lefebvre D, Bai XH, Reaume A, Rossant J, Lye SJ. Identification of two regulatory elements within the promoter region of the mouse connexin 43 gene. J Biol Chem. 1995;270:3863\u20138.","journal-title":"J Biol Chem"},{"key":"510_CR50","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1098\/rspb.1994.0018","volume":"255","author":"W Yu","year":"1994","unstructured":"Yu W, Dahl G, Werner R. The connexin43 gene is responsive to oestrogen. Proc Biol Sci. 1994;255:125\u201332.","journal-title":"Proc Biol Sci"},{"key":"510_CR51","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1089\/104454902760599672","volume":"21","author":"G He","year":"2002","unstructured":"He G, Ylisastigui L, Margolis DM. The regulation of HIV-1 gene expression: the emerging role of chromatin. DNA Cell Biol. 2002;21:697\u2013705.","journal-title":"DNA Cell Biol"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0510-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12974-016-0510-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0510-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0510-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T07:00:22Z","timestamp":1589526022000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-016-0510-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["510"],"URL":"https:\/\/doi.org\/10.1186\/s12974-016-0510-1","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]},"assertion":[{"value":"1 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"54"}}