{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:11:39Z","timestamp":1789809099697,"version":"4.0.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean Government (MISP)","award":["2013R1A4A1069486"],"award-info":[{"award-number":["2013R1A4A1069486"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12974-016-0656-x","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T10:02:02Z","timestamp":1469008922000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4+Foxp3+ T and IL-17+CD4+ Th17 cells"],"prefix":"10.1186","volume":"13","author":[{"given":"Jin Hyoung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit Mahadev","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdenebelig","family":"Uyangaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdaus Mohd Altaf","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Youel","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Kug","family":"Eo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"issue":"2","key":"656_CR1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/rmv.712","volume":"22","author":"GJ Sips","year":"2012","unstructured":"Sips GJ, Wilschut J, Smit JM. Neuroinvasive flavivirus infections. Rev Med Virol. 2012;22(2):69\u201387.","journal-title":"Rev Med Virol"},{"issue":"3","key":"656_CR2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/WCO.0b013e328360dd2b","volume":"26","author":"MR Wilson","year":"2013","unstructured":"Wilson MR. Emerging viral infections. Curr Opin Neurol. 2013;26(3):301\u20136.","journal-title":"Curr Opin Neurol"},{"issue":"1","key":"656_CR3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7774\/cevr.2014.3.1.58","volume":"3","author":"YY Go","year":"2014","unstructured":"Go YY, Balasuriya UB, Lee CK. Zoonotic encephalitides caused by arboviruses: transmission and epidemiology of alphaviruses and flaviviruses. Clin Exp Vaccine Res. 2014;3(1):58\u201377.","journal-title":"Clin Exp Vaccine Res"},{"key":"656_CR4","unstructured":"Japanese encephalitis: status of surveillance and immunization in Asia and the Western Pacific, 2012. Wkly Epidemiol Rec. 2013;88(34):357-364."},{"issue":"12 Suppl","key":"656_CR5","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1038\/nm1144","volume":"10","author":"JS Mackenzie","year":"2004","unstructured":"Mackenzie JS, Gubler DJ, Petersen LR. Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses. Nat Med. 2004;10(12 Suppl):S98\u2013109.","journal-title":"Nat Med"},{"key":"656_CR6","volume-title":"West Nile Virus activity\u2014human disease cases reported. 2005\u20132009","author":"Center for Disease","year":"2009","unstructured":"Center for Disease. West Nile Virus activity\u2014human disease cases reported. 2005\u20132009. 2009. http:\/\/www.cdc.gov\/ncidod\/dvbid\/westnile\/sur&control.htm . (Accessed: 4th September 2014)."},{"issue":"1","key":"656_CR7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/sj.icb.7100012","volume":"85","author":"NJ King","year":"2007","unstructured":"King NJ, Getts DR, Getts MT, Rana S, Shrestha B, Kesson AM. Immunopathology of flavivirus infections. Immunol Cell Biol. 2007;85(1):33\u201342.","journal-title":"Immunol Cell Biol"},{"issue":"5","key":"656_CR8","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1177\/0300985810372507","volume":"47","author":"T Kimura","year":"2010","unstructured":"Kimura T, Sasaki M, Okumura M, Kim E, Sawa H. Flavivirus encephalitis: pathological aspects of mouse and other animal models. Vet Pathol. 2010;47(5):806\u201318.","journal-title":"Vet Pathol"},{"issue":"2","key":"656_CR9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4110\/in.2012.12.2.48","volume":"12","author":"YW Han","year":"2012","unstructured":"Han YW, Singh SK, Eo SK. The roles and perspectives of toll-like receptors and CD4(+) helper T cell subsets in acute viral encephalitis. Immune Netw. 2012;12(2):48\u201357.","journal-title":"Immune Netw"},{"issue":"Pt 4","key":"656_CR10","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1099\/vir.0.013565-0","volume":"91","author":"CJ Chen","year":"2010","unstructured":"Chen CJ, Ou YC, Lin SY, Raung SL, Liao SL, Lai CY, et al. Glial activation involvement in neuronal death by Japanese encephalitis virus infection. J Gen Virol. 2010;91(Pt 4):1028\u201337.","journal-title":"J Gen Virol"},{"issue":"5","key":"656_CR11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/glia.20474","volume":"55","author":"A Ghoshal","year":"2007","unstructured":"Ghoshal A, Das S, Ghosh S, Mishra MK, Sharma V, Koli P, et al. Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia. 2007;55(5):483\u201396.","journal-title":"Glia"},{"issue":"1-3","key":"656_CR12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12026-012-8333-3","volume":"54","author":"SV Bardina","year":"2012","unstructured":"Bardina SV, Lim JK. The role of chemokines in the pathogenesis of neurotropic flaviviruses. Immunol Res. 2012;54(1-3):121\u201332.","journal-title":"Immunol Res"},{"issue":"4","key":"656_CR13","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.4049\/jimmunol.180.4.2641","volume":"180","author":"B Zhang","year":"2008","unstructured":"Zhang B, Chan YK, Lu B, Diamond MS, Klein RS. CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. J Immunol. 2008;180(4):2641\u20139.","journal-title":"J Immunol"},{"issue":"4","key":"656_CR14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1089\/vim.2008.0057","volume":"21","author":"MJ Hofer","year":"2008","unstructured":"Hofer MJ, Carter SL, Muller M, Campbell IL. Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong. Viral Immunol. 2008;21(4):425\u201333.","journal-title":"Viral Immunol"},{"issue":"12","key":"656_CR15","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1073\/pnas.0801544105","volume":"105","author":"GS Campanella","year":"2008","unstructured":"Campanella GS, Tager AM, El Khoury JK, Thomas SY, Abrazinski TA, Manice LA, et al. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acd Sci USA. 2008;105(12):4814\u20139.","journal-title":"Proc Natl Acd Sci USA"},{"issue":"8","key":"656_CR16","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1084\/jem.20042530","volume":"202","author":"WG Glass","year":"2005","unstructured":"Glass WG, Lim JK, Cholera R, Pletnev AG, Gao JL, Murphy PM. Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med. 2005;202(8):1087\u201398.","journal-title":"J Exp Med"},{"issue":"9","key":"656_CR17","doi-asserted-by":"crossref","first-page":"e44834","DOI":"10.1371\/journal.pone.0044834","volume":"7","author":"M Larena","year":"2012","unstructured":"Larena M, Regner M, Lobigs M. The chemokine receptor CCR5, a therapeutic target for HIV\/AIDS antagonists, is critical for recovery in a mouse model of Japanese encephalitis. PLoS One. 2012;7(9):e44834.","journal-title":"PLoS One"},{"issue":"17","key":"656_CR18","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1128\/JVI.03421-13","volume":"88","author":"D Michlmayr","year":"2014","unstructured":"Michlmayr D, McKimmie CS, Pingen M, Haxton B, Mansfield K, Johnson N, et al. Defining the chemokine basis for leukocyte recruitment during viral encephalitis. J Virol. 2014;88(17):9553\u201367.","journal-title":"J Virol"},{"issue":"1","key":"656_CR19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20051970","volume":"203","author":"WG Glass","year":"2006","unstructured":"Glass WG, McDermott DH, Lim JK, Lekhong S, Yu SF, Frank WA, et al. CCR5 deficiency increases risk of symptomatic West Nile virus infection. J Exp Med. 2006;203(1):35\u201340.","journal-title":"J Exp Med"},{"issue":"1","key":"656_CR20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF03401665","volume":"3","author":"PA Zimmerman","year":"1997","unstructured":"Zimmerman PA, Buckler-White A, Alkhatib G, Spalding T, Kubofcik J, Combadiere C, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med. 1997;3(1):23\u201336.","journal-title":"Mol Med"},{"issue":"6","key":"656_CR21","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.4049\/jimmunol.1500801","volume":"195","author":"DJ Campbell","year":"2015","unstructured":"Campbell DJ. Control of regulatory T cell migration, function, and homeostasis. J Immunol. 2015;195(6):2507\u201313.","journal-title":"J Immunol"},{"issue":"4","key":"656_CR22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.it.2012.01.002","volume":"33","author":"Y Ding","year":"2012","unstructured":"Ding Y, Xu J, Bromberg JS. Regulatory T cell migration during an immune response. Trends Immunol. 2012;33(4):174\u201380.","journal-title":"Trends Immunol"},{"issue":"5","key":"656_CR23","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.4049\/jimmunol.180.5.3049","volume":"180","author":"AP Moreira","year":"2008","unstructured":"Moreira AP, Cavassani KA, Massafera Tristao FS, Campanelli AP, Martinez R, Rossi MA, et al. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. J Immunol. 2008;180(5):3049\u201356.","journal-title":"J Immunol"},{"issue":"11","key":"656_CR24","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1084\/jem.20060956","volume":"203","author":"E Yurchenko","year":"2006","unstructured":"Yurchenko E, Tritt M, Hay V, Shevach EM, Belkaid Y, Piccirillo CA. CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med. 2006;203(11):2451\u201360.","journal-title":"J Exp Med"},{"issue":"11","key":"656_CR25","first-page":"3266","volume":"119","author":"MC Lanteri","year":"2009","unstructured":"Lanteri MC, O'Brien KM, Purtha WE, Cameron MJ, Lund JM, Owen RE, et al. Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest. 2009;119(11):3266\u201377.","journal-title":"J Clin Invest"},{"issue":"5","key":"656_CR26","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1084\/jem.20061381","volume":"204","author":"K Luhn","year":"2007","unstructured":"Luhn K, Simmons CP, Moran E, Dung NT, Chau TN, Quyen NT, et al. Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection. J Exp Med. 2007;204(5):979\u201385.","journal-title":"J Exp Med"},{"issue":"9","key":"656_CR27","doi-asserted-by":"crossref","first-page":"e1004319","DOI":"10.1371\/journal.ppat.1004319","volume":"10","author":"YW Han","year":"2014","unstructured":"Han YW, Choi JY, Uyangaa E, Kim SB, Kim JH, Kim BS, et al. Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways. PLoS Pathog. 2014;10(9):e1004319.","journal-title":"PLoS Pathog"},{"issue":"10","key":"656_CR28","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/nm1292","volume":"11","author":"M Frentsch","year":"2005","unstructured":"Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, Rothe M, et al. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med. 2005;11(10):1118\u201324.","journal-title":"Nat Med"},{"issue":"1","key":"656_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2006.1","volume":"1","author":"PK Chattopadhyay","year":"2006","unstructured":"Chattopadhyay PK, Yu J, Roederer M. Live-cell assay to detect antigen-specific CD4+ T-cell responses by CD154 expression. Nat Protoc. 2006;1(1):1\u20136.","journal-title":"Nat Protoc"},{"key":"656_CR30","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/1742-2094-9-270","volume":"9","author":"RL Terry","year":"2012","unstructured":"Terry RL, Getts DR, Deffrasnes C, van Vreden C, Campbell IL, King NJ. Inflammatory monocytes and the pathogenesis of viral encephalitis. J Neuroinflammation. 2012;9:270.","journal-title":"J Neuroinflammation."},{"issue":"10","key":"656_CR31","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1084\/jem.20080421","volume":"205","author":"DR Getts","year":"2008","unstructured":"Getts DR, Terry RL, Getts MT, Muller M, Rana S, Shrestha B, et al. Ly6c+ \u201cinflammatory monocytes\u201d are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. J Exp Med. 2008;205(10):2319\u201337.","journal-title":"J Exp Med"},{"issue":"1","key":"656_CR32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/1389203711314010004","volume":"14","author":"A Suzumura","year":"2013","unstructured":"Suzumura A. Neuron-microglia interaction in neuroinflammation. Curr Protein Pept Sci. 2013;14(1):16\u201320.","journal-title":"Curr Protein Pept Sci"},{"issue":"5","key":"656_CR33","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1084\/jem.184.5.1737","volume":"184","author":"AL Ford","year":"1996","unstructured":"Ford AL, Foulcher E, Lemckert FA, Sedgwick JD. Microglia induce CD4 T lymphocyte final effector function and death. J Exp Med. 1996;184(5):1737\u201345.","journal-title":"J Exp Med"},{"key":"656_CR34","first-page":"37","volume":"341","author":"AA Maghazachi","year":"2010","unstructured":"Maghazachi AA. Role of chemokines in the biology of natural killer cells. Curr Top Microbiol Immunol. 2010;341:37\u201358.","journal-title":"Curr Top Microbiol Immunol."},{"key":"656_CR35","first-page":"126954","volume":"2014","author":"CE Oliveira de","year":"2014","unstructured":"de Oliveira CE, Oda JM, Losi Guembarovski R, de Oliveira KB, Ariza CB, Neto JS, et al. CC chemokine receptor 5: the interface of host immunity and cancer. Dis Markers. 2014;2014:126954.","journal-title":"Dis Markers."},{"issue":"7","key":"656_CR36","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/eji.201243152","volume":"43","author":"M Larena","year":"2013","unstructured":"Larena M, Regner M, Lobigs M. Cytolytic effector pathways and IFN-gamma help protect against Japanese encephalitis. Eur J Immunol. 2013;43(7):1789\u201398.","journal-title":"Eur J Immunol"},{"issue":"11","key":"656_CR37","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1128\/JVI.02611-10","volume":"85","author":"M Larena","year":"2011","unstructured":"Larena M, Regner M, Lee E, Lobigs M. Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis. J Virol. 2011;85(11):5446\u201355.","journal-title":"J Virol"},{"issue":"5","key":"656_CR38","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1086\/381768","volume":"189","author":"P Kumar","year":"2004","unstructured":"Kumar P, Sulochana P, Nirmala G, Chandrashekar R, Haridattatreya M, Satchidanandam V. Impaired T helper 1 function of nonstructural protein 3-specific T cells in Japanese patients with encephalitis with neurological sequelae. J Infect Dis. 2004;189(5):880\u201391.","journal-title":"J Infect Dis"},{"issue":"9","key":"656_CR39","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.4049\/jimmunol.1000032","volume":"184","author":"DN Kroetz","year":"2010","unstructured":"Kroetz DN, Deepe Jr GS. CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection. J Immunol. 2010;184(9):5224\u201331.","journal-title":"J Immunol"},{"issue":"8","key":"656_CR40","doi-asserted-by":"crossref","first-page":"e1004315","DOI":"10.1371\/journal.ppat.1004315","volume":"10","author":"EK Moser","year":"2014","unstructured":"Moser EK, Hufford MM, Braciale TJ. Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. PLoS Pathog. 2014;10(8):e1004315.","journal-title":"PLoS Pathog"},{"issue":"12","key":"656_CR41","doi-asserted-by":"crossref","first-page":"e1001221","DOI":"10.1371\/journal.ppat.1001221","volume":"6","author":"A Haque","year":"2010","unstructured":"Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, de Labastida F, et al. CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathog. 2010;6(12):e1001221.","journal-title":"PLoS Pathog"},{"issue":"1","key":"656_CR42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/IAI.74.1.135-143.2006","volume":"74","author":"JL Hardison","year":"2006","unstructured":"Hardison JL, Wrightsman RA, Carpenter PM, Kuziel WA, Lane TE, Manning JE. The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006;74(1):135\u201343.","journal-title":"Infect Immun"},{"issue":"6","key":"656_CR43","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1371\/journal.ppat.0020049","volume":"2","author":"IA Khan","year":"2006","unstructured":"Khan IA, Thomas SY, Moretto MM, Lee FS, Islam SA, Combe C, et al. CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog. 2006;2(6):e49.","journal-title":"PLoS Pathog"},{"issue":"8","key":"656_CR44","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1128\/JVI.02626-06","volume":"81","author":"M Thapa","year":"2007","unstructured":"Thapa M, Kuziel WA, Carr DJ. Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. J Virol. 2007;81(8):3704\u201313.","journal-title":"J Virol"},{"issue":"12","key":"656_CR45","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1002\/eji.200838628","volume":"38","author":"SA Fadel","year":"2008","unstructured":"Fadel SA, Bromley SK, Medoff BD, Luster AD. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Eur J Immunol. 2008;38(12):3376\u201387.","journal-title":"Eur J Immunol"},{"issue":"5","key":"656_CR46","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.4049\/jimmunol.173.5.3287","volume":"173","author":"HM Algood","year":"2004","unstructured":"Algood HM, Flynn JL. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol. 2004;173(5):3287\u201396.","journal-title":"J Immunol"},{"issue":"15","key":"656_CR47","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1128\/JVI.79.15.9831-9841.2005","volume":"79","author":"N Ank","year":"2005","unstructured":"Ank N, Petersen K, Malmgaard L, Mogensen SC, Paludan SR. Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2. J Virol. 2005;79(15):9831\u201341.","journal-title":"J Virol"},{"issue":"8","key":"656_CR48","doi-asserted-by":"crossref","first-page":"e1004279","DOI":"10.1371\/journal.ppat.1004279","volume":"10","author":"J Zhao","year":"2014","unstructured":"Zhao J, Perlman S. Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages. PLoS Pathog. 2014;10(8):e1004279.","journal-title":"PLoS Pathog"},{"issue":"4","key":"656_CR49","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1182\/blood.V99.4.1237","volume":"99","author":"A Nansen","year":"2002","unstructured":"Nansen A, Christensen JP, Andreasen SO, Bartholdy C, Christensen JE, Thomsen AR. The role of CC chemokine receptor 5 in antiviral immunity. Blood. 2002;99(4):1237\u201345.","journal-title":"Blood"},{"issue":"12","key":"656_CR50","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1128\/JVI.78.12.6449-6458.2004","volume":"78","author":"KE Peterson","year":"2004","unstructured":"Peterson KE, Errett JS, Wei T, Dimcheff DE, Ransohoff R, Kuziel WA, et al. MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis. J Virol. 2004;78(12):6449\u201358.","journal-title":"J Virol"},{"issue":"1","key":"656_CR51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/viro.2001.1050","volume":"288","author":"WG Glass","year":"2001","unstructured":"Glass WG, Liu MT, Kuziel WA, Lane TE. Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology. 2001;288(1):8\u201317.","journal-title":"Virology"},{"key":"656_CR52","doi-asserted-by":"crossref","first-page":"17548","DOI":"10.1038\/srep17548","volume":"5","author":"JH Kim","year":"2015","unstructured":"Kim JH, Choi JY, Kim SB, Uyangaa E, Patil AM, Han YW, et al. CD11chi dendritic cells regulate Ly-6Chi monocyte differentiation to preserve immune-privileged CNS in lethal neuroinflammation. Sci Rep. 2015;5:17548.","journal-title":"Sci Rep"},{"key":"656_CR53","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1742-2094-11-132","volume":"11","author":"J Cazareth","year":"2014","unstructured":"Cazareth J, Guyon A, Heurteaux C, Chabry J, Petit-Paitel A. Molecular and cellular neuroinflammation status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2\/CCL2 signaling. J Neuroinflammation. 2014;11:132.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"656_CR54","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1189\/jlb.0605337","volume":"79","author":"CA Reichel","year":"2006","unstructured":"Reichel CA, Khandoga A, Anders HJ, Schlondorff D, Luckow B, Krombach F. Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophul migration to postischemic tissue. J Leukoc Biol. 2006;79(1):114\u201322.","journal-title":"J Leukoc Biol"},{"key":"656_CR55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2202-14-19","volume":"14","author":"MC Vilela","year":"2013","unstructured":"Vilela MC, Lima GK, Rodrigues DH, Lacerda-Queiroz N, Pedroso VSP, Miranda AS, et al. Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis. BMC Neurosci. 2013;14:19.","journal-title":"BMC Neurosci"},{"issue":"7","key":"656_CR56","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1089\/dna.2015.2962","volume":"35","author":"X Kang","year":"2016","unstructured":"Kang X, Zhang X, Liu Z, Xu H, Wang T, He L, et al. CXCR2-mediated granulocytic myeloid-derived suppressor cells\u2019 functional characterization and their role in maternal fetal interface. DNA Cell Biol. 2016;35(7):358\u201365.","journal-title":"DNA Cell Biol"},{"issue":"1","key":"656_CR57","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.1003003","volume":"186","author":"JK Lim","year":"2011","unstructured":"Lim JK, Obara CJ, Rivollier A, Pletnev AG, Kelsall BL, Murphy PM. Chemokine receptor CCR2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. J Immunol. 2011;186(1):471\u20138.","journal-title":"J Immunol"},{"key":"656_CR58","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1182\/blood-2007-10-118497","volume":"112","author":"AE Cardona","year":"2008","unstructured":"Cardona AE, Sasse ME, Liu L, Cardona SM, Mizutani M, Savarin C, et al. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood. 2008;112:256\u201363.","journal-title":"Blood"},{"key":"656_CR59","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","volume":"32","author":"JW Griffith","year":"2014","unstructured":"Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014;32:659\u2013702.","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"656_CR60","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.autrev.2014.08.019","volume":"13","author":"RP Singh","year":"2014","unstructured":"Singh RP, Hasan S, Sharma S, Nagra S, Yamaguchi DT, Wong DT, et al. Th17 cells in inflammation and autoimmunity. Autoimmun Rev. 2014;13(12):1174\u201381.","journal-title":"Autoimmun Rev"},{"issue":"1-3","key":"656_CR61","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12026-014-8540-1","volume":"59","author":"AF Christiaansen","year":"2014","unstructured":"Christiaansen AF, Knudson CJ, Weiss KA, Varga SM. The CD4 T cell response to respiratory syncytial virus infection. Immunol Res. 2014;59(1-3):109\u201317.","journal-title":"Immunol Res"},{"issue":"6","key":"656_CR62","doi-asserted-by":"crossref","first-page":"e1003410","DOI":"10.1371\/journal.ppat.1003410","volume":"9","author":"Q Wang","year":"2013","unstructured":"Wang Q, Zhou J, Zhang B, Tian Z, Tang J, Zheng Y, et al. Hepatitis B virus induces IL-23 production in antigen presenting cells and causes liver damage via the IL-23\/IL-17 axis. PLoS Pathog. 2013;9(6):e1003410.","journal-title":"PLoS Pathog"},{"key":"656_CR63","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1038\/srep05431","volume":"4","author":"RK Peckham","year":"2014","unstructured":"Peckham RK, Brill R, Foster DS, Bowen AL, Leigh JA, Coffey TJ, et al. Two distinct populations of bovine IL-17+ T-cells can be induced and WC1+IL-17+\u03b3\u03b4 T-cells are effective killers of protozoan parasites. Sci Rep. 2014;4:5431.","journal-title":"Sci Rep"},{"issue":"2","key":"656_CR64","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00705-007-1098-7","volume":"153","author":"V Saxena","year":"2008","unstructured":"Saxena V, Mathur A, Krishnani N, Dhole TN. An insufficient anti-inflammatory cytokine response in mouse brain is associated with increased tissue pathology and viral load during Japanese encephalitis virus infection. Arch Virol. 2008;153(2):283\u201392.","journal-title":"Arch Virol"},{"issue":"45","key":"656_CR65","doi-asserted-by":"crossref","first-page":"16053","DOI":"10.1073\/pnas.1418966111","volume":"111","author":"KA Kulcsar","year":"2014","unstructured":"Kulcsar KA, Baxter VK, Greene IP, Griffin DE. Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis. Proc Natl Acd Sci USA. 2014;111(45):16053\u20138.","journal-title":"Proc Natl Acd Sci USA"},{"issue":"7090","key":"656_CR66","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"E Bettelli","year":"2006","unstructured":"Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235\u20138.","journal-title":"Nature"},{"issue":"6","key":"656_CR67","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.20080034","volume":"205","author":"M Lochner","year":"2008","unstructured":"Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, et al. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med. 2008;205(6):1381\u201393.","journal-title":"J Exp Med"},{"key":"656_CR68","first-page":"277","volume":"6","author":"E Ryst Van Der","year":"2015","unstructured":"Van Der Ryst E. Maraviroc\u2014a CCR5 antagonist for the treatment of HIV-1 infection. Front Immunol. 2015;6:277.","journal-title":"Front Immunol."}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0656-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T13:07:44Z","timestamp":1568207264000},"score":1,"resource":{"primary":{"URL":"http:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-016-0656-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,20]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["656"],"URL":"https:\/\/doi.org\/10.1186\/s12974-016-0656-x","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,20]]},"article-number":"223"}}