{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:26:35Z","timestamp":1793125595250,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS20989"],"award-info":[{"award-number":["NS20989"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12974-016-0693-5","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T12:20:24Z","timestamp":1472559624000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["A murine model of inflammation-induced cerebral microbleeds"],"prefix":"10.1186","volume":"13","author":[{"given":"Rachita K.","family":"Sumbria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mher Mahoney","family":"Grigoryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Vasilevko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana B.","family":"Krasieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Scadeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra K.","family":"Dvornikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annlia","family":"Paganini-Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Cribbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"issue":"2","key":"693_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S1474-4422(09)70013-4","volume":"8","author":"SM Greenberg","year":"2009","unstructured":"Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 2009;8(2):165\u201374. Epub 2009\/01\/24.","journal-title":"Lancet Neurol"},{"issue":"11","key":"693_CR2","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1161\/STROKEAHA.111.626655","volume":"42","author":"M Fisher","year":"2011","unstructured":"Fisher M, Vasilevko V, Passos GF, Ventura C, Quiring D, Cribbs DH. Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy. Stroke. 2011;42(11):3300\u20133. Epub 2011\/09\/10.","journal-title":"Stroke"},{"key":"693_CR3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1750-1326-6-22","volume":"6","author":"M Meyer-Luehmann","year":"2011","unstructured":"Meyer-Luehmann M, Mora JR, Mielke M, Spires-Jones TL, de Calignon A, von Andrian UH, et al. T cell mediated cerebral hemorrhages and microhemorrhages during passive Abeta immunization in APPPS1 transgenic mice. Mol Neurodegener. 2011;6:22. Epub 2011\/03\/11.","journal-title":"Mol Neurodegener"},{"issue":"3","key":"693_CR4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00401-011-0925-9","volume":"123","author":"Y Okamoto","year":"2012","unstructured":"Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, et al. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2012;123(3):381\u201394. Epub 2011\/12\/16.","journal-title":"Acta Neuropathol"},{"issue":"3","key":"693_CR5","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/acel.12315","volume":"14","author":"P Toth","year":"2015","unstructured":"Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, et al. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell. 2015;14(3):400\u20138. Epub 2015\/02\/14.","journal-title":"Aging Cell"},{"issue":"12","key":"693_CR6","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1161\/STROKEAHA.110.593657","volume":"41","author":"M Fisher","year":"2010","unstructured":"Fisher M, French S, Ji P, Kim RC. Cerebral microbleeds in the elderly: a pathological analysis. Stroke. 2010;41(12):2782\u20135. Epub 2010\/10\/30.","journal-title":"Stroke"},{"issue":"11","key":"693_CR7","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1590\/S0004-282X2012001100017","volume":"70","author":"DG Correa","year":"2012","unstructured":"Correa DG, Cruz Junior LC, Bahia PR, Gasparetto EL. Intracerebral microbleeds in sepsis: susceptibility-weighted MR imaging findings. Arq Neuropsiquiatr. 2012;70(11):903\u20134. Epub 2012\/11\/24.","journal-title":"Arq Neuropsiquiatr"},{"issue":"9","key":"693_CR8","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.parkreldis.2015.06.019","volume":"21","author":"K Yamashiro","year":"2015","unstructured":"Yamashiro K, Tanaka R, Hoshino Y, Hatano T, Nishioka K, Hattori N. The prevalence and risk factors of cerebral microbleeds in patients with Parkinson\u2019s disease. Parkinsonism Relat Disord. 2015;21(9):1076\u201381. Epub 2015\/07\/05.","journal-title":"Parkinsonism Relat Disord"},{"issue":"7","key":"693_CR9","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1164\/rccm.201303-0455OC","volume":"188","author":"L Lahousse","year":"2013","unstructured":"Lahousse L, Vernooij MW, Darweesh SK, Akoudad S, Loth DW, Joos GF, et al. Chronic obstructive pulmonary disease and cerebral microbleeds. The Rotterdam Study. Am J Respir Crit Care Med. 2013;188(7):783\u20138. Epub 2013\/07\/28.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"693_CR10","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1212\/WNL.0000000000001237","volume":"84","author":"YL Huang","year":"2015","unstructured":"Huang YL, Kuo YS, Tseng YC, Chen DY, Chiu WT, Chen CJ. Susceptibility-weighted MRI in mild traumatic brain injury. Neurology. 2015;84(6):580\u20135. Epub 2015\/01\/13.","journal-title":"Neurology"},{"issue":"Suppl 1","key":"693_CR11","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","volume":"69","author":"C Franceschi","year":"2014","unstructured":"Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4\u20139. Epub 2014\/05\/17.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"11","key":"693_CR12","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1161\/STROKEAHA.111.621193","volume":"42","author":"K Miwa","year":"2011","unstructured":"Miwa K, Tanaka M, Okazaki S, Furukado S, Sakaguchi M, Kitagawa K. Relations of blood inflammatory marker levels with cerebral microbleeds. Stroke. 2011;42(11):3202\u20136. Epub 2011\/08\/27.","journal-title":"Stroke"},{"issue":"8","key":"693_CR13","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1212\/WNL.0000000000001279","volume":"84","author":"A Shoamanesh","year":"2015","unstructured":"Shoamanesh A, Preis SR, Beiser AS, Vasan RS, Benjamin EJ, Kase CS, et al. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology. 2015;84(8):825\u201332. Epub 2015\/01\/30.","journal-title":"Neurology"},{"issue":"11","key":"693_CR14","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1161\/STROKEAHA.112.656744","volume":"43","author":"JR Romero","year":"2012","unstructured":"Romero JR, Preis SR, Beiser AS, DeCarli C, Lee DY, Viswanathan A, et al. Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart Study. Stroke. 2012;43(11):3091\u20134. Epub 2012\/09\/11.","journal-title":"Stroke"},{"issue":"11","key":"693_CR15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1369\/0022155414546692","volume":"62","author":"S Liu","year":"2014","unstructured":"Liu S, Grigoryan MM, Vasilevko V, Sumbria RK, Paganini-Hill A, Cribbs DH, et al. Comparative analysis of H&E and Prussian blue staining in a mouse model of cerebral microbleeds. J Histochem Cytochem. 2014;62(11):767\u201373. Epub 2014\/07\/27.","journal-title":"J Histochem Cytochem"},{"issue":"5","key":"693_CR16","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1586\/14737175.2015.1035712","volume":"15","author":"T Dziedzic","year":"2015","unstructured":"Dziedzic T. Systemic inflammation as a therapeutic target in acute ischemic stroke. Expert Rev Neurother. 2015;15(5):523\u201331. Epub 2015\/04\/14.","journal-title":"Expert Rev Neurother"},{"issue":"7","key":"693_CR17","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1161\/01.STR.19.7.863","volume":"19","author":"JM Hallenbeck","year":"1988","unstructured":"Hallenbeck JM, Dutka AJ, Kochanek PM, Siren A, Pezeshkpour GH, Feuerstein G. Stroke risk factors prepare rat brainstem tissues for modified local Shwartzman reaction. Stroke. 1988;19(7):863\u20139. Epub 1988\/07\/01.","journal-title":"Stroke"},{"issue":"8","key":"693_CR18","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1016\/j.neurobiolaging.2011.04.008","volume":"33","author":"RP Rouhl","year":"2012","unstructured":"Rouhl RP, Damoiseaux JG, Lodder J, Theunissen RO, Knottnerus IL, Staals J, et al. Vascular inflammation in cerebral small vessel disease. Neurobiol Aging. 2012;33(8):1800\u20136. Epub 2011\/05\/24.","journal-title":"Neurobiol Aging"},{"issue":"3","key":"693_CR19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.it.2012.09.004","volume":"34","author":"M Bosmann","year":"2013","unstructured":"Bosmann M, Ward PA. The inflammatory response in sepsis. Trends Immunol. 2013;34(3):129\u201336. Epub 2012\/10\/06.","journal-title":"Trends Immunol"},{"issue":"4","key":"693_CR20","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1093\/ndt\/gfl019","volume":"21","author":"P Pauletto","year":"2006","unstructured":"Pauletto P, Rattazzi M. Inflammation and hypertension: the search for a link. Nephrol Dial Transplant. 2006;21(4):850\u20133. Epub 2006\/02\/09.","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"693_CR21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1023\/A:1007074420772","volume":"20","author":"NJ Abbott","year":"2000","unstructured":"Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol. 2000;20(2):131\u201347. Epub 2000\/03\/04.","journal-title":"Cell Mol Neurobiol"},{"issue":"15","key":"693_CR22","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1212\/WNL.0000000000000871","volume":"83","author":"M Fisher","year":"2014","unstructured":"Fisher M. Cerebral microbleeds: where are we now? Neurology. 2014;83(15):1304\u20135. Epub 2014\/09\/05.","journal-title":"Neurology"},{"issue":"1","key":"693_CR23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ajpath.2011.10.001","volume":"180","author":"JE Juskewitch","year":"2012","unstructured":"Juskewitch JE, Knudsen BE, Platt JL, Nath KA, Knutson KL, Brunn GJ, et al. LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels. Am J Pathol. 2012;180(1):32\u201340. Epub 2011\/11\/10.","journal-title":"Am J Pathol"},{"issue":"1","key":"693_CR24","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12974-015-0434-1","volume":"12","author":"WA Banks","year":"2015","unstructured":"Banks WA, Gray AM, Erickson MA, Salameh TS, Damodarasamy M, Sheibani N, et al. Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. J Neuroinflammation. 2015;12(1):223. Epub 2015\/11\/27.","journal-title":"J Neuroinflammation"},{"issue":"11","key":"693_CR25","doi-asserted-by":"publisher","first-page":"5860","DOI":"10.4049\/jimmunol.168.11.5860","volume":"168","author":"N Munshi","year":"2002","unstructured":"Munshi N, Fernandis AZ, Cherla RP, Park IW, Ganju RK. Lipopolysaccharide-induced apoptosis of endothelial cells and its inhibition by vascular endothelial growth factor. J Immunol. 2002;168(11):5860\u20136. Epub 2002\/05\/23.","journal-title":"J Immunol"},{"issue":"11","key":"693_CR26","doi-asserted-by":"publisher","first-page":"7280","DOI":"10.4049\/jimmunol.0801376","volume":"182","author":"H Karahashi","year":"2009","unstructured":"Karahashi H, Michelsen KS, Arditi M. Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK. J Immunol. 2009;182(11):7280\u20136. Epub 2009\/05\/21.","journal-title":"J Immunol"},{"issue":"1","key":"693_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neulet.2003.08.028","volume":"352","author":"S Veszelka","year":"2003","unstructured":"Veszelka S, Urbanyi Z, Pazmany T, Nemeth L, Obal I, Dung NT, et al. Human serum amyloid P component attenuates the bacterial lipopolysaccharide-induced increase in blood-brain barrier permeability in mice. Neurosci Lett. 2003;352(1):57\u201360. Epub 2003\/11\/15.","journal-title":"Neurosci Lett"},{"issue":"5","key":"693_CR28","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1212\/WNL.0b013e3182452928","volume":"78","author":"MM Poels","year":"2012","unstructured":"Poels MM, Ikram MA, van der Lugt A, Hofman A, Niessen WJ, Krestin GP, et al. Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology. 2012;78(5):326\u201333. Epub 2012\/01\/21.","journal-title":"Neurology"},{"issue":"13","key":"693_CR29","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1089\/neu.2013.3080","volume":"31","author":"OY Glushakova","year":"2014","unstructured":"Glushakova OY, Johnson D, Hayes RL. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. J Neurotrauma. 2014;31(13):1180\u201393. Epub 2014\/02\/26.","journal-title":"J Neurotrauma"},{"key":"693_CR30","doi-asserted-by":"crossref","unstructured":"He XF, Lan Y, Zhang Q, Liu DX, Wang Q, Liang FY, et al. Deferoxamine inhibits microglial activation, attenuates blood-brain barrier disruption, rescues dendritic damage and improves spatial memory in a mouse model of microhemorrhages. J Neurochem. 2016. Epub 2016\/05\/12.","DOI":"10.1111\/jnc.13657"},{"issue":"5","key":"693_CR31","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/sj.jcbfm.9600590","volume":"28","author":"B Stefanovic","year":"2008","unstructured":"Stefanovic B, Hutchinson E, Yakovleva V, Schram V, Russell JT, Belluscio L, et al. Functional reactivity of cerebral capillaries. J Cereb Blood Flow Metab. 2008;28(5):961\u201372. Epub 2007\/12\/07.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"7","key":"693_CR32","doi-asserted-by":"publisher","first-page":"H1367","DOI":"10.1152\/ajpheart.00417.2011","volume":"302","author":"TP Santisakultarm","year":"2012","unstructured":"Santisakultarm TP, Cornelius NR, Nishimura N, Schafer AI, Silver RT, Doerschuk PC, et al. In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice. Am J Physiol Heart Circ Physiol. 2012;302(7):H1367\u201377. Epub 2012\/01\/24.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"693_CR33","doi-asserted-by":"publisher","first-page":"e0148441","DOI":"10.1371\/journal.pone.0148441","volume":"11","author":"A Hoffmann","year":"2016","unstructured":"Hoffmann A, Kunze R, Helluy X, Milford D, Heiland S, Bendszus M, et al. High-field MRI reveals a drastic increase of hypoxia-induced microhemorrhages upon tissue reoxygenation in the mouse brain with strong predominance in the olfactory bulb. PLoS One. 2016;11(2):e0148441. Epub 2016\/02\/11.","journal-title":"PLoS One"},{"issue":"1","key":"693_CR34","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2174\/187152709787601858","volume":"8","author":"DM Wilcock","year":"2009","unstructured":"Wilcock DM, Colton CA. Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice. CNS Neurol Disord Drug Targets. 2009;8(1):50\u201364. Epub 2009\/03\/12.","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"10","key":"693_CR35","doi-asserted-by":"publisher","first-page":"e26612","DOI":"10.1371\/journal.pone.0026612","volume":"6","author":"NL Rosidi","year":"2011","unstructured":"Rosidi NL, Zhou J, Pattanaik S, Wang P, Jin W, Brophy M, et al. Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration. PLoS One. 2011;6(10):e26612. Epub 2011\/10\/27.","journal-title":"PLoS One"},{"issue":"5","key":"693_CR36","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/jcbfm.2013.1","volume":"33","author":"TL Sudduth","year":"2013","unstructured":"Sudduth TL, Powell DK, Smith CD, Greenstein A, Wilcock DM. Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J Cereb Blood Flow Metab. 2013;33(5):708\u201315. Epub 2013\/01\/31.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"Pt 8","key":"693_CR37","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1093\/brain\/awv162","volume":"138","author":"A Charidimou","year":"2015","unstructured":"Charidimou A, Linn J, Vernooij MW, Opherk C, Akoudad S, Baron JC, et al. Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. Brain. 2015;138(Pt 8):2126\u201339. Epub 2015\/06\/28.","journal-title":"Brain"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0693-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12974-016-0693-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0693-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0693-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T10:43:59Z","timestamp":1657190639000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-016-0693-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["693"],"URL":"https:\/\/doi.org\/10.1186\/s12974-016-0693-5","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]},"assertion":[{"value":"6 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"218"}}