{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:44:07Z","timestamp":1792788247976,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"National Program on Key Research Project of China","award":["2016YFD0500406"],"award-info":[{"award-number":["2016YFD0500406"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31502062"],"award-info":[{"award-number":["31502062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2662014BQ022"],"award-info":[{"award-number":["2662014BQ022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31421064"],"award-info":[{"award-number":["31421064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472201"],"award-info":[{"award-number":["31472201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2662014BQ022"],"award-info":[{"award-number":["2662014BQ022"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12974-016-0734-0","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T22:11:58Z","timestamp":1476828718000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis"],"prefix":"10.1186","volume":"13","author":[{"given":"Xiao-Pei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Cheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Bei","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"key":"734_CR1","doi-asserted-by":"crossref","first-page":"e0004191","DOI":"10.1371\/journal.pntd.0004191","volume":"9","author":"A Samkar van","year":"2015","unstructured":"van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D. Streptococcus suis meningitis: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2015;9:e0004191.","journal-title":"PLoS Negl Trop Dis"},{"key":"734_CR2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3201\/eid1206.051194","volume":"12","author":"H Yu","year":"2006","unstructured":"Yu H, Jing H, Chen Z, Zheng H, Zhu X, Wang H, Wang S, Liu L, Zu R, Luo L, et al. Human Streptococcus suis outbreak, Sichuan, China. Emerg Infect Dis. 2006;12:914\u201320.","journal-title":"Emerg Infect Dis"},{"key":"734_CR3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3201\/eid1902.120470","volume":"19","author":"NT Hoa","year":"2013","unstructured":"Hoa NT, Chieu TT, Do Dung S, Long NT, Hieu TQ, Luc NT, Nhuong PT, Huong VT, Trinh DT, Wertheim HF, et al. Streptococcus suis and porcine reproductive and respiratory syndrome, Vietnam. Emerg Infect Dis. 2013;19:331\u20133.","journal-title":"Emerg Infect Dis"},{"key":"734_CR4","first-page":"1001","volume":"6","author":"J Wang","year":"2015","unstructured":"Wang J, Kong D, Zhang S, Jiang H, Zheng Y, Zang Y, Hao H, Jiang Y. Interaction of fibrinogen and muramidase-released protein promotes the development of Streptococcus suis meningitis. Front Microbiol. 2015;6:1001.","journal-title":"Front Microbiol"},{"key":"734_CR5","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/infdis\/jit661","volume":"209","author":"D Takeuchi","year":"2014","unstructured":"Takeuchi D, Akeda Y, Nakayama T, Kerdsin A, Sano Y, Kanda T, Hamada S, Dejsirilert S, Oishi K. The contribution of suilysin to the pathogenesis of Streptococcus suis meningitis. J Infect Dis. 2014;209:1509\u201319.","journal-title":"J Infect Dis"},{"key":"734_CR6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.gene.2013.11.044","volume":"535","author":"Z Wu","year":"2014","unstructured":"Wu Z, Wang W, Tang M, Shao J, Dai C, Zhang W, Fan H, Yao H, Zong J, Chen D, et al. Comparative genomic analysis shows that Streptococcus suis meningitis isolate SC070731 contains a unique 105\u00a0K genomic island. Gene. 2014;535:156\u201364.","journal-title":"Gene"},{"key":"734_CR7","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1128\/IAI.00698-10","volume":"78","author":"L Dominguez-Punaro Mde","year":"2010","unstructured":"Dominguez-Punaro Mde L, Segura M, Contreras I, Lachance C, Houde M, Lecours MP, Olivier M, Gottschalk M. In vitro characterization of the microglial inflammatory response to Streptococcus suis, an important emerging zoonotic agent of meningitis. Infect Immun. 2010;78:5074\u201385.","journal-title":"Infect Immun"},{"key":"734_CR8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/527385","volume":"46","author":"NT Mai","year":"2008","unstructured":"Mai NT, Hoa NT, Nga TV, le Linh D, Chau TT, Sinh DX, Phu NH, Chuong LV, Diep TS, Campbell J, et al. Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis. 2008;46:659\u201367.","journal-title":"Clin Infect Dis"},{"key":"734_CR9","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4049\/jimmunol.179.3.1842","volume":"179","author":"MC Dominguez-Punaro","year":"2007","unstructured":"Dominguez-Punaro MC, Segura M, Plante MM, Lacouture S, Rivest S, Gottschalk M. Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. J Immunol. 2007;179:1842\u201354.","journal-title":"J Immunol"},{"key":"734_CR10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1574-695X.2006.00067.x","volume":"47","author":"M Segura","year":"2006","unstructured":"Segura M, Vanier G, Al-Numani D, Lacouture S, Olivier M, Gottschalk M. Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole-blood culture system. FEMS Immunol Med Microbiol. 2006;47:92\u2013106.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"734_CR11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s13238-014-0037-0","volume":"5","author":"Q Lv","year":"2014","unstructured":"Lv Q, Hao H, Bi L, Zheng Y, Zhou X, Jiang Y. Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activating RhoA and Rac1 GTPase. Protein Cell. 2014;5:261\u20134.","journal-title":"Protein Cell"},{"key":"734_CR12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2180-11-47","volume":"11","author":"L Bonifait","year":"2011","unstructured":"Bonifait L, Grenier D. The SspA subtilisin-like protease of Streptococcus suis triggers a pro-inflammatory response in macrophages through a non-proteolytic mechanism. BMC Microbiol. 2011;11:47.","journal-title":"BMC Microbiol"},{"key":"734_CR13","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1053\/j.gastro.2008.12.059","volume":"136","author":"F Yan","year":"2009","unstructured":"Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek Jr RM, Cover TL, Washington MK, Wilson KT, Polk DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009;136:1297\u2013307. e1291-1293.","journal-title":"Gastroenterology"},{"key":"734_CR14","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1167\/iovs.03-1323","volume":"45","author":"J Zhang","year":"2004","unstructured":"Zhang J, Li H, Wang J, Dong Z, Mian S, Yu FS. Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa-infected human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45:2569\u201376.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"734_CR15","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1093\/emboj\/19.13.3159","volume":"19","author":"MA Olayioye","year":"2000","unstructured":"Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 2000;19:3159\u201367.","journal-title":"EMBO J"},{"key":"734_CR16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","volume":"103","author":"J Schlessinger","year":"2000","unstructured":"Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2000;103:211\u201325.","journal-title":"Cell"},{"key":"734_CR17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01818","volume":"424","author":"X Wang","year":"2003","unstructured":"Wang X, Huong SM, Chiu ML, Raab-Traub N, Huang ES. Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus. Nature. 2003;424:456\u201361.","journal-title":"Nature"},{"key":"734_CR18","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1242\/jcs.033399","volume":"121","author":"RH Tao","year":"2008","unstructured":"Tao RH, Maruyama IN. All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells. J Cell Sci. 2008;121:3207\u201317.","journal-title":"J Cell Sci"},{"key":"734_CR19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1083\/jcb.200106148","volume":"155","author":"I Hoffmann","year":"2001","unstructured":"Hoffmann I, Eugene E, Nassif X, Couraud PO, Bourdoulous S. Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis. J Cell Biol. 2001;155:133\u201343.","journal-title":"J Cell Biol"},{"key":"734_CR20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrc3309","volume":"12","author":"Y Yarden","year":"2012","unstructured":"Yarden Y, Pines G. The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer. 2012;12:553\u201363.","journal-title":"Nat Rev Cancer"},{"key":"734_CR21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.yexcr.2008.10.034","volume":"315","author":"ME Feigin","year":"2009","unstructured":"Feigin ME, Muthuswamy SK. ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion. Exp Cell Res. 2009;315:707\u201316.","journal-title":"Exp Cell Res"},{"key":"734_CR22","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1462-5822.2011.01603.x","volume":"13","author":"KV Swanson","year":"2011","unstructured":"Swanson KV, Griffiss JM, Edwards VL, Stein DC, Song W. Neisseria gonorrhoeae-induced transactivation of EGFR enhances gonococcal invasion. Cell Microbiol. 2011;13:1078\u201390.","journal-title":"Cell Microbiol"},{"key":"734_CR23","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/cmi.12110","volume":"15","author":"CG Frank","year":"2013","unstructured":"Frank CG, Reguerio V, Rother M, Moranta D, Maeurer AP, Garmendia J, Meyer TF, Bengoechea JA. Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation. Cell Microbiol. 2013;15:1212\u201333.","journal-title":"Cell Microbiol"},{"key":"734_CR24","doi-asserted-by":"crossref","first-page":"36185","DOI":"10.1074\/jbc.M503941200","volume":"280","author":"F Mikami","year":"2005","unstructured":"Mikami F, Gu H, Jono H, Andalibi A, Kai H, Li JD. Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathway. J Biol Chem. 2005;280:36185\u201394.","journal-title":"J Biol Chem"},{"key":"734_CR25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","volume":"37","author":"NJ Abbott","year":"2010","unstructured":"Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood\u2013brain barrier. Neurobiol Dis. 2010;37:13\u201325.","journal-title":"Neurobiol Dis"},{"key":"734_CR26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.micres.2016.02.002","volume":"185","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Ding D, Liu M, Yang X, Zong B, Wang X, Chen H, Bei W, Tan C. Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2. Microbiol Res. 2016;185:45\u201354.","journal-title":"Microbiol Res"},{"key":"734_CR27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-5728(97)00036-2","volume":"76","author":"MF Stins","year":"1997","unstructured":"Stins MF, Gilles F, Kim KS. Selective expression of adhesion molecules on human brain microvascular endothelial cells. J Neuroimmunol. 1997;76:81\u201390.","journal-title":"J Neuroimmunol"},{"key":"734_CR28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/mpat.2000.0406","volume":"30","author":"MF Stins","year":"2001","unstructured":"Stins MF, Badger J, Sik Kim K. Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells. Microb Pathog. 2001;30:19\u201328.","journal-title":"Microb Pathog"},{"key":"734_CR29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1203\/00006450-200205000-00003","volume":"51","author":"Y Wang","year":"2002","unstructured":"Wang Y, Kim KS. Role of OmpA and IbeB in Escherichia coli K1 invasion of brain microvascular endothelial cells in vitro and in vivo. Pediatr Res. 2002;51:559\u201363.","journal-title":"Pediatr Res"},{"key":"734_CR30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.vetmic.2008.05.005","volume":"132","author":"L Benga","year":"2008","unstructured":"Benga L, Fulde M, Neis C, Goethe R, Valentin-Weigand P. Polysaccharide capsule and suilysin contribute to extracellular survival of Streptococcus suis co-cultivated with primary porcine phagocytes. Vet Microbiol. 2008;132:211\u20139.","journal-title":"Vet Microbiol"},{"key":"734_CR31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.micpath.2006.07.003","volume":"41","author":"S Shin","year":"2006","unstructured":"Shin S, Paul-Satyaseela M, Lee JS, Romer LH, Kim KS. Focal adhesion kinase is involved in type III group B streptococcal invasion of human brain microvascular endothelial cells. Microb Pathog. 2006;41:168\u201373.","journal-title":"Microb Pathog"},{"key":"734_CR32","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1128\/IAI.00624-10","volume":"78","author":"L Zhu","year":"2010","unstructured":"Zhu L, Maruvada R, Sapirstein A, Malik KU, Peters-Golden M, Kim KS. Arachidonic acid metabolism regulates Escherichia coli penetration of the blood\u2013brain barrier. Infect Immun. 2010;78:4302\u201310.","journal-title":"Infect Immun"},{"key":"734_CR33","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1080\/135502801753248105","volume":"7","author":"X Yan","year":"2001","unstructured":"Yan X, Prosniak M, Curtis MT, Weiss ML, Faber M, Dietzschold B, Fu ZF. Silver-haired bat rabies virus variant does not induce apoptosis in the brain of experimentally infected mice. J Neurovirol. 2001;7:518\u201327.","journal-title":"J Neurovirol"},{"key":"734_CR34","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/IAI.68.2.637-643.2000","volume":"68","author":"N Charland","year":"2000","unstructured":"Charland N, Nizet V, Rubens CE, Kim KS, Lacouture S, Gottschalk M. Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun. 2000;68:637\u201343.","journal-title":"Infect Immun"},{"key":"734_CR35","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.276.5313.718","volume":"276","author":"BB Finlay","year":"1997","unstructured":"Finlay BB, Cossart P. Exploitation of mammalian host cell functions by bacterial pathogens. Science. 1997;276:718\u201325.","journal-title":"Science"},{"key":"734_CR36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cytogfr.2014.06.002","volume":"25","author":"S Chattopadhyay","year":"2014","unstructured":"Chattopadhyay S, Sen GC. Tyrosine phosphorylation in Toll-like receptor signaling. Cytokine Growth Factor Rev. 2014;25:533\u201341.","journal-title":"Cytokine Growth Factor Rev"},{"key":"734_CR37","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/emboj\/16.7.1647","volume":"16","author":"D Graus-Porta","year":"1997","unstructured":"Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 1997;16:1647\u201355.","journal-title":"EMBO J"},{"key":"734_CR38","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1349-7006.2007.00676.x","volume":"99","author":"S Higashiyama","year":"2008","unstructured":"Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H, Matsushita N. Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Sci. 2008;99:214\u201320.","journal-title":"Cancer Sci"},{"key":"734_CR39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrm1548","volume":"6","author":"CP Blobel","year":"2005","unstructured":"Blobel CP. ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol. 2005;6:32\u201343.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"734_CR40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1365-2249.2002.01768.x","volume":"127","author":"M Segura","year":"2002","unstructured":"Segura M, Vadeboncoeur N, Gottschalk M. CD14-dependent and -independent cytokine and chemokine production by human THP-1 monocytes stimulated by Streptococcus suis capsular type 2. Clin Exp Immunol. 2002;127:243\u201354.","journal-title":"Clin Exp Immunol"},{"key":"734_CR41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/intimm\/dxm003","volume":"19","author":"R Graveline","year":"2007","unstructured":"Graveline R, Segura M, Radzioch D, Gottschalk M. TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness. Int Immunol. 2007;19:375\u201389.","journal-title":"Int Immunol"},{"key":"734_CR42","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/jcb.21563","volume":"103","author":"HL Hsieh","year":"2008","unstructured":"Hsieh HL, Sun CC, Wu CB, Wu CY, Tung WH, Wang HH, Yang CM. Sphingosine 1-phosphate induces EGFR expression via Akt\/NF-kappa B and ERK\/AP-1 pathways in rat vascular smooth muscle cells. J Cell Biochem. 2008;103:1732\u201346.","journal-title":"J Cell Biochem"},{"key":"734_CR43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1473-3099(07)70001-4","volume":"7","author":"ZR Lun","year":"2007","unstructured":"Lun ZR, Wang QP, Chen XG, Li AX, Zhu XQ. Streptococcus suis: an emerging zoonotic pathogen. Lancet Infect Dis. 2007;7:201\u20139.","journal-title":"Lancet Infect Dis"},{"key":"734_CR44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1186\/s13104-015-1581-2","volume":"8","author":"JP Auger","year":"2015","unstructured":"Auger JP, Christodoulides M, Segura M, Xu J, Gottschalk M. Interactions of Streptococcus suis serotype 2 with human meningeal cells and astrocytes. BMC Res Notes. 2015;8:607.","journal-title":"BMC Res Notes"},{"key":"734_CR45","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s10753-015-0298-7","volume":"39","author":"Y Sun","year":"2016","unstructured":"Sun Y, Li N, Zhang J, Liu H, Liu J, Xia X, Sun C, Feng X, Gu J, Du C, et al. Enolase of Streptococcus suis serotype 2 enhances blood-brain barrier permeability by inducing IL-8 release. Inflammation. 2016;39:718\u201326.","journal-title":"Inflammation"},{"key":"734_CR46","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrmicro1952","volume":"6","author":"KS Kim","year":"2008","unstructured":"Kim KS. Mechanisms of microbial traversal of the blood-brain barrier. Nat Rev Microbiol. 2008;6:625\u201334.","journal-title":"Nat Rev Microbiol"},{"key":"734_CR47","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/fmb.10.2","volume":"5","author":"M Gottschalk","year":"2010","unstructured":"Gottschalk M, Xu J, Calzas C, Segura M. Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol. 2010;5:371\u201391.","journal-title":"Future Microbiol"},{"key":"734_CR48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1574-695X.2003.tb00648.x","volume":"35","author":"N Vadeboncoeur","year":"2003","unstructured":"Vadeboncoeur N, Segura M, Al-Numani D, Vanier G, Gottschalk M. Pro-inflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2. FEMS Immunol Med Microbiol. 2003;35:49\u201358.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"734_CR49","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.00008-11","volume":"24","author":"BB Mook-Kanamori","year":"2011","unstructured":"Mook-Kanamori BB, Geldhoff M, van der Poll T, van de Beek D. Pathogenesis and pathophysiology of Pneumococcal meningitis. Clin Microbiol Rev. 2011;24:557\u201391.","journal-title":"Clin Microbiol Rev"},{"key":"734_CR50","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00401-015-1531-z","volume":"131","author":"KS Doran","year":"2016","unstructured":"Doran KS, Fulde M, Gratz N, Kim BJ, Nau R, Prasadarao N, Schubert-Unkmeir A, Tuomanen EI, Valentin-Weigand P. Host-pathogen interactions in bacterial meningitis. Acta Neuropathol. 2016;131:185\u2013209.","journal-title":"Acta Neuropathol"},{"key":"734_CR51","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1128\/IAI.00350-08","volume":"76","author":"L Dominguez-Punaro Mde","year":"2008","unstructured":"Dominguez-Punaro Mde L, Segura M, Radzioch D, Rivest S, Gottschalk M. Comparison of the susceptibilities of C57BL\/6 and A\/J mouse strains to Streptococcus suis serotype 2 infection. Infect Immun. 2008;76:3901\u201310.","journal-title":"Infect Immun"},{"key":"734_CR52","doi-asserted-by":"crossref","first-page":"31263","DOI":"10.1074\/jbc.M111.238147","volume":"286","author":"T Suzuki","year":"2011","unstructured":"Suzuki T, Yoshinaga N, Tanabe S. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem. 2011;286:31263\u201371.","journal-title":"J Biol Chem"},{"key":"734_CR53","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mvr.2003.07.001","volume":"67","author":"L Song","year":"2004","unstructured":"Song L, Pachter JS. Monocyte chemoattractant protein-1 alters expression of tight junction-associated proteins in brain microvascular endothelial cells. Microvasc Res. 2004;67:78\u201389.","journal-title":"Microvasc Res"},{"key":"734_CR54","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1242\/jcs.00755","volume":"116","author":"SM Stamatovic","year":"2003","unstructured":"Stamatovic SM, Keep RF, Kunkel SL, Andjelkovic AV. Potential role of MCP-1 in endothelial cell tight junction \u2018opening\u2019: signaling via Rho and Rho kinase. J Cell Sci. 2003;116:4615\u201328.","journal-title":"J Cell Sci"},{"key":"734_CR55","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1016\/j.biomaterials.2014.05.008","volume":"35","author":"AJ Sawyer","year":"2014","unstructured":"Sawyer AJ, Tian W, Saucier-Sawyer JK, Rizk PJ, Saltzman WM, Bellamkonda RV, Kyriakides TR. The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation. Biomaterials. 2014;35:6698\u2013706.","journal-title":"Biomaterials"},{"key":"734_CR56","doi-asserted-by":"crossref","first-page":"26794","DOI":"10.1038\/srep26794","volume":"6","author":"JW Shim","year":"2016","unstructured":"Shim JW, Sandlund J, Hameed MQ, Blazer-Yost B, Zhou FC, Klagsbrun M, Madsen JR. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci Rep. 2016;6:26794.","journal-title":"Sci Rep"},{"key":"734_CR57","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbrc.2005.09.050","volume":"337","author":"S Sugiyama","year":"2005","unstructured":"Sugiyama S, Nakabayashi K, Baba I, Sasazuki T, Shirasawa S. Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. Biochem Biophys Res Commun. 2005;337:271\u20134.","journal-title":"Biochem Biophys Res Commun"},{"key":"734_CR58","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s00204-012-0903-6","volume":"86","author":"S Val","year":"2012","unstructured":"Val S, Belade E, George I, Boczkowski J, Baeza-Squiban A. Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin. Arch Toxicol. 2012;86:1851\u20139.","journal-title":"Arch Toxicol"},{"key":"734_CR59","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2014.03.004","volume":"28","author":"SR Taylor","year":"2014","unstructured":"Taylor SR, Markesbery MG, Harding PA. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and proteolytic processing by a disintegrin and metalloproteinases (ADAM): a regulator of several pathways. Semin Cell Dev Biol. 2014;28:22\u201330.","journal-title":"Semin Cell Dev Biol"},{"key":"734_CR60","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/cmi.12099","volume":"15","author":"VL Edwards","year":"2013","unstructured":"Edwards VL, Wang LC, Dawson V, Stein DC, Song W. Neisseria gonorrhoeae breaches the apical junction of polarized epithelial cells for transmigration by activating EGFR. Cell Microbiol. 2013;15:1042\u201357.","journal-title":"Cell Microbiol"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-016-0734-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T03:43:16Z","timestamp":1589686996000},"score":1,"resource":{"primary":{"URL":"http:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-016-0734-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,19]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["734"],"URL":"https:\/\/doi.org\/10.1186\/s12974-016-0734-0","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,19]]},"article-number":"274"}}