{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:44:23Z","timestamp":1790815463858,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EC1403E"],"award-info":[{"award-number":["01EC1403E"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EC1403F"],"award-info":[{"award-number":["01EC1403F"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12974-017-0804-y","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T12:44:32Z","timestamp":1486385072000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis"],"prefix":"10.1186","volume":"14","author":[{"given":"Uta","family":"Baddack-Werncke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Busch-Dienstfertig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh Chandar","family":"Maddila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Grobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"804_CR1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1126\/science.1230720","volume":"339","author":"I Tabas","year":"2013","unstructured":"Tabas I, Glass CK. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science. 2013;339:166\u201372.","journal-title":"Science"},{"key":"804_CR2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"GS Firestein","year":"2003","unstructured":"Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423:356\u201361.","journal-title":"Nature"},{"key":"804_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2015.10.003","volume":"65","author":"E Zampeli","year":"2015","unstructured":"Zampeli E, Vlachoyiannopoulos PG, Tzioufas AG. Treatment of rheumatoid arthritis: unraveling the conundrum. J Autoimmun. 2015;65:1\u201318.","journal-title":"J Autoimmun"},{"key":"804_CR4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.intimp.2015.03.019","volume":"27","author":"D Rossi","year":"2015","unstructured":"Rossi D, Modena V, Sciascia S, Roccatello D. Rheumatoid arthritis: biological therapy other than anti-TNF. Int Immunopharmacol. 2015;27:185\u20138.","journal-title":"Int Immunopharmacol"},{"key":"804_CR5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tips.2015.02.001","volume":"36","author":"I Marije","year":"2015","unstructured":"Marije I, Koenders MI, van den Berg WB. Novel therapeutic targets in rheumatoid arthritis. Trends Pharmacol Sci. 2015;36:189\u201395.","journal-title":"Trends Pharmacol Sci"},{"key":"804_CR6","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1111\/pme.12213","volume":"14","author":"S Perrot","year":"2013","unstructured":"Perrot S, Dieude P, Perocheau D, Allanore Y. Comparison of pain, pain burden, coping strategies, and attitudes between patients with systemic sclerosis and patients with rheumatoid arthritis: a cross-sectional study. Pain Med. 2013;14:1776\u201385.","journal-title":"Pain Med"},{"key":"804_CR7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/ard.2008.092163","volume":"68","author":"D Huscher","year":"2009","unstructured":"Huscher D, Thiele K, Gromnica-Ihle E, Hein G, Demary W, Dreher R, et al. Dose-related patterns of glucocorticoid-induced side effects. Ann Rheum Dis. 2009;68:1119\u201324.","journal-title":"Ann Rheum Dis"},{"key":"804_CR8","doi-asserted-by":"crossref","first-page":"c7086","DOI":"10.1136\/bmj.c7086","volume":"342","author":"S Trelle","year":"2011","unstructured":"Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ. 2011;342:c7086.","journal-title":"BMJ"},{"key":"804_CR9","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/ncomms2625","volume":"4","author":"U Baddack","year":"2013","unstructured":"Baddack U, Hartmann S, Bang H, Grobe J, Loddenkemper C, Lipp M, et al. A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB\/c mice. Nat Commun. 2013;4:1644.","journal-title":"Nat Commun"},{"key":"804_CR10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","volume":"50","author":"MM Nielen","year":"2004","unstructured":"Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50:380\u20136.","journal-title":"Arthritis Rheum"},{"key":"804_CR11","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","volume":"48","author":"S Rantapaa-Dahlqvist","year":"2003","unstructured":"Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741\u20139.","journal-title":"Arthritis Rheum"},{"key":"804_CR12","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/art.20316","volume":"50","author":"FA Gaalen van","year":"2004","unstructured":"van Gaalen FA, van Aken J, Huizinga TW, Schreuder GM, Breedveld FC, Zanelli E, et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum. 2004;50:2113\u201321.","journal-title":"Arthritis Rheum"},{"key":"804_CR13","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/1529-0131(200008)43:8<1831::AID-ANR19>3.0.CO;2-6","volume":"43","author":"EJ Kroot","year":"2000","unstructured":"Kroot EJ, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, van\u2019t Hof M, et al. The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 2000;43:1831\u20135.","journal-title":"Arthritis Rheum"},{"key":"804_CR14","first-page":"22","volume":"521","author":"FQ Cunha","year":"2003","unstructured":"Cunha FQ, Ferreira SH. Peripheral hyperalgesic cytokines. Adv Exp Med Biol. 2003;521:22\u201339.","journal-title":"Adv Exp Med Biol"},{"key":"804_CR15","doi-asserted-by":"crossref","first-page":"e27638","DOI":"10.4161\/jkst.27638","volume":"2","author":"M Busch-Dienstfertig","year":"2013","unstructured":"Busch-Dienstfertig M, Gonzalez-Rodriguez S. IL-4, JAK-STAT signaling, and pain. Jak Stat. 2013;2:e27638.","journal-title":"Jak Stat"},{"key":"804_CR16","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1189\/jlb.0405223","volume":"78","author":"HL Rittner","year":"2005","unstructured":"Rittner HL, Machelska H, Stein C. Leukocytes in the regulation of pain and analgesia. J Leukoc Biol. 2005;78:1215\u201322.","journal-title":"J Leukoc Biol"},{"key":"804_CR17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tips.2013.03.006","volume":"34","author":"C Stein","year":"2013","unstructured":"Stein C, K\u00fcchler S. Targeting inflammation and wound healing by opioids. Trends Pharmacol Sci. 2013;34:303\u201312.","journal-title":"Trends Pharmacol Sci"},{"key":"804_CR18","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1124\/pr.110.003145","volume":"63","author":"C Stein","year":"2011","unstructured":"Stein C, Machelska H. Modulation of peripheral sensory neurons by the immune system: implications for pain therapy. Pharmacol Rev. 2011;63:860\u201381.","journal-title":"Pharmacol Rev"},{"key":"804_CR19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2013.09.020","volume":"146","author":"J Bou\u00e9","year":"2014","unstructured":"Bou\u00e9 J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G. Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice. Gastroenterology. 2014;146:166\u2013715.","journal-title":"Gastroenterology"},{"issue":"1","key":"804_CR20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/nmo.12008","volume":"25","author":"E Valdez-Morales","year":"2013","unstructured":"Valdez-Morales E, Guerrero-Alba R, Ochoa-Cortes F, Benson J, Spreadbury I, Hurlbut D, Miranda-Morales M, Lomax AE, Vanner S. Release of endogenous opioids during a chronic IBD model suppresses the excitability of colonic DRG neurons. Neurogastroenterol Motil. 2013;25(1):39\u201346.","journal-title":"Neurogastroenterol Motil"},{"key":"804_CR21","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1053\/j.gastro.2006.01.045","volume":"130","author":"M Verma-Gandhu","year":"2006","unstructured":"Verma-Gandhu M, Bercik P, Motomura Y, Verdu EF, Khan WI, Blennerhassett PA, et al. CD4(+) T-cell modulation of visceral nociception in mice. Gastroenterology. 2006;130:1721\u20138.","journal-title":"Gastroenterology"},{"key":"804_CR22","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.4049\/jimmunol.1003335","volume":"186","author":"J Bou\u00e9","year":"2011","unstructured":"Bou\u00e9 J, Blanpied C, Brousset P, Vergnolle N, Dietrich G. Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice. J Immunol. 2011;186:5078\u201384.","journal-title":"J Immunol"},{"key":"804_CR23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1213\/01.ANE.0000099369.23397.D7","volume":"98","author":"S Hermanussen","year":"2004","unstructured":"Hermanussen S, Do M, Cabot PJ. Reduction of beta-endorphin-containing immune cells in inflamed paw tissue corresponds with a reduction in immune-derived antinociception: reversible by donor activated lymphocytes. Anesth Analg. 2004;98:723\u20139.","journal-title":"Anesth Analg"},{"key":"804_CR24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.bbi.2010.04.001","volume":"24","author":"D Labuz","year":"2010","unstructured":"Labuz D, Schreiter A, Schmidt Y, Brack A, Machelska H. T lymphocytes containing beta-endorphin ameliorate mechanical hypersensitivity following nerve injury. Brain Behav Immun. 2010;24:1045\u201353.","journal-title":"Brain Behav Immun"},{"key":"804_CR25","first-page":"Unit 4.1","volume":"Chapter 4","author":"AM Kruisbeek","year":"2001","unstructured":"Kruisbeek AM. In vivo depletion of CD4- and CD8-specific T cells. Curr Protoc Immunol. 2001;Chapter 4:Unit 4.1.","journal-title":"Curr Protoc Immunol"},{"key":"804_CR26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1172\/JCI36246C1","volume":"119","author":"D Labuz","year":"2009","unstructured":"Labuz D, Schmidt Y, Schreiter A, Rittner HL, Mousa SA, Machelska H. Immune cell-derived opioids protect against neuropathic pain in mice. J Clin Invest. 2009;119:278\u201386.","journal-title":"J Clin Invest"},{"key":"804_CR27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0006-8993(97)01327-9","volume":"784","author":"C Sommer","year":"1998","unstructured":"Sommer C, Schafers M. Painful mononeuropathy in C57BL\/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. Brain Res. 1998;784:154\u201362.","journal-title":"Brain Res"},{"key":"804_CR28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55\u201363.","journal-title":"J Neurosci Methods"},{"key":"804_CR29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1744-8069-8-83","volume":"8","author":"M Busch-Dienstfertig","year":"2012","unstructured":"Busch-Dienstfertig M, Labuz D, Wolfram T, Vogel NN, Stein C. JAK-STAT1\/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats. Mol Pain. 2012;8:83.","journal-title":"Mol Pain"},{"key":"804_CR30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0028-3908(85)90072-3","volume":"24","author":"DR Brown","year":"1985","unstructured":"Brown DR, Goldberg LI. The use of quaternary narcotic antagonists in opiate research. Neuropharmacology. 1985;24:181\u201391.","journal-title":"Neuropharmacology"},{"key":"804_CR31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jaut.2013.06.004","volume":"45","author":"DM Gravano","year":"2013","unstructured":"Gravano DM, Hoyer KK. Promotion and prevention of autoimmune disease by CD8+ T cells. J Autoimmun. 2013;45:68\u201379.","journal-title":"J Autoimmun"},{"key":"804_CR32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.autrev.2012.07.011","volume":"12","author":"H Carvalheiro","year":"2013","unstructured":"Carvalheiro H, da Silva JA, Souto-Carneiro MM. Potential roles for CD8(+) T cells in rheumatoid arthritis. Autoimmun Rev. 2013;12:401\u20139.","journal-title":"Autoimmun Rev"},{"key":"804_CR33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/ard.2011.150318","volume":"71","author":"M Ebbinghaus","year":"2011","unstructured":"Ebbinghaus M, Gajda M, Boettger MK, Schaible HG, Brauer R. The anti-inflammatory effects of sympathectomy in murine antigen-induced arthritis are associated with a reduction of Th1 and Th17 responses. Ann Rheum Dis. 2011;71:253\u201361.","journal-title":"Ann Rheum Dis"},{"key":"804_CR34","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/art.34675","volume":"64","author":"M Ebbinghaus","year":"2012","unstructured":"Ebbinghaus M, Uhlig B, Richter F, von Banchet GS, Gajda M, Brauer R, et al. The role of interleukin-1beta in arthritic pain: main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis. Arthritis Rheum. 2012;64:3897\u2013907.","journal-title":"Arthritis Rheum"},{"key":"804_CR35","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1186\/ar4037","volume":"14","author":"AD Cook","year":"2012","unstructured":"Cook AD, Pobjoy J, Steidl S, Durr M, Braine EL, Turner AL, et al. Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther. 2012;14:R199.","journal-title":"Arthritis Res Ther"},{"key":"804_CR36","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00000542-200108000-00036","volume":"95","author":"HL Rittner","year":"2001","unstructured":"Rittner HL, Brack A, Machelska H, Mousa SA, Bauer M, Sch\u00e4fer M, et al. Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain. Anesthesiology. 2001;95:500\u20138.","journal-title":"Anesthesiology"},{"key":"804_CR37","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1096\/fj.12-208678","volume":"26","author":"A Schreiter","year":"2012","unstructured":"Schreiter A, Gore C, Labuz D, Fournie-Zaluski MC, Roques BP, Stein C, et al. Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. FASEB J. 2012;26:5161\u201371.","journal-title":"FASEB J"},{"key":"804_CR38","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1523\/JNEUROSCI.22-13-05588.2002","volume":"22","author":"H Machelska","year":"2002","unstructured":"Machelska H, Mousa SA, Brack A, Schopohl JK, Rittner HL, Sch\u00e4fer M, et al. Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1. J Neurosci. 2002;22:5588\u201396.","journal-title":"J Neurosci"},{"key":"804_CR39","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.coi.2005.09.014","volume":"17","author":"U Walter","year":"2005","unstructured":"Walter U, Santamaria P. CD8+ T cells in autoimmunity. Curr Opin Immunol. 2005;17:624\u201331.","journal-title":"Curr Opin Immunol"},{"key":"804_CR40","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1002\/art.27729","volume":"62","author":"BR Raposo","year":"2010","unstructured":"Raposo BR, Rodrigues-Santos P, Carvalheiro H, Agua-Doce AM, Carvalho L, Pereira da Silva JA, et al. Monoclonal anti-CD8 therapy induces disease amelioration in the K\/BxN mouse model of spontaneous chronic polyarthritis. Arthritis Rheum. 2010;62:2953\u201362.","journal-title":"Arthritis Rheum"},{"key":"804_CR41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1365-2249.1996.d01-855.x","volume":"106","author":"PD Kiely","year":"1996","unstructured":"Kiely PD, O\u2019Brien D, Oliveira DB. Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity. Clin Exp Immunol. 1996;106:280\u20135.","journal-title":"Clin Exp Immunol"},{"key":"804_CR42","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0008-8749(92)90250-S","volume":"144","author":"S Banerjee","year":"1992","unstructured":"Banerjee S, Webber C, Poole AR. The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells. Cell Immunol. 1992;144:347\u201357.","journal-title":"Cell Immunol"},{"key":"804_CR43","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ni1063","volume":"5","author":"D Hu","year":"2004","unstructured":"Hu D, Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol. 2004;5:516\u201323.","journal-title":"Nat Immunol"},{"key":"804_CR44","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1073\/pnas.95.8.4533","volume":"95","author":"H Jiang","year":"1998","unstructured":"Jiang H, Kashleva H, Xu LX, Forman J, Flaherty L, Pernis B, et al. T cell vaccination induces T cell receptor Vbeta-specific Qa-1-restricted regulatory CD8(+) T cells. Proc Natl Acad Sci U S A. 1998;95:4533\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"804_CR45","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1172\/JCI17935","volume":"112","author":"N Najafian","year":"2003","unstructured":"Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, et al. Regulatory functions of CD8\u2009+\u2009CD28- T cells in an autoimmune disease model. J Clin Invest. 2003;112:1037\u201348.","journal-title":"J Clin Invest"},{"key":"804_CR46","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.humimm.2003.12.001","volume":"65","author":"G Filaci","year":"2004","unstructured":"Filaci G, Fravega M, Negrini S, Procopio F, Fenoglio D, Rizzi M, et al. Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8\u2009+\u2009CD28- T cells and inhibit both T-cell proliferation and CTL function. Hum Immunol. 2004;65:142\u201356.","journal-title":"Hum Immunol"},{"key":"804_CR47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.coi.2006.03.017","volume":"18","author":"LE Harrington","year":"2006","unstructured":"Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol. 2006;18:349\u201356.","journal-title":"Curr Opin Immunol"},{"key":"804_CR48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/ar1478","volume":"7","author":"E Lubberts","year":"2005","unstructured":"Lubberts E, Koenders MI, van den Berg WB. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther. 2005;7:29\u201337.","journal-title":"Arthritis Res Ther"},{"key":"804_CR49","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.4049\/jimmunol.156.11.4520","volume":"156","author":"Y Tada","year":"1996","unstructured":"Tada Y, Ho A, Koh DR, Mak TW. Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis. J Immunol. 1996;156:4520\u20136.","journal-title":"J Immunol"},{"key":"804_CR50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0304-3959(01)00322-0","volume":"93","author":"PJ Cabot","year":"2001","unstructured":"Cabot PJ, Carter L, Sch\u00e4fer M, Stein C. Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain. Pain. 2001;93:207\u201312.","journal-title":"Pain"},{"key":"804_CR51","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-016-0591-x","volume":"13","author":"L Basso","year":"2016","unstructured":"Basso L, Bou\u00e9 J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G. Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice. J Neuroinflammation. 2016;13:132.","journal-title":"J Neuroinflammation"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-017-0804-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:19:07Z","timestamp":1692674347000},"score":1,"resource":{"primary":{"URL":"http:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-017-0804-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["804"],"URL":"https:\/\/doi.org\/10.1186\/s12974-017-0804-y","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]},"article-number":"30"}}