{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:57:57Z","timestamp":1793246277269,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["3UH2TR000491-02S1"],"award-info":[{"award-number":["3UH2TR000491-02S1"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R25 HL096223-06 student support"],"award-info":[{"award-number":["R25 HL096223-06 student support"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12974-017-0824-7","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:21:16Z","timestamp":1488500476000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease"],"prefix":"10.1186","volume":"14","author":[{"given":"Tracoyia","family":"Roach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Alcendor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"824_CR1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","volume":"5","author":"GW Dick","year":"1952","unstructured":"Dick GW, Kitchen SF, Haddow AJ. Zika virus, isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;5:509\u201320.","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"824_CR2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0035-9203(52)90043-6","volume":"5","author":"GW Dick","year":"1952","unstructured":"Dick GW. Zika virus (II): pathogenicity and physical properties. Trans R Soc Trop Med Hyg. 1952;5:521\u201334.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"824_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0035-9203(54)90006-1","volume":"2","author":"FN MacNamara","year":"1954","unstructured":"MacNamara FN. Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg. 1954;2:139\u20135.","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"824_CR4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3855\/jidc.8217","volume":"2","author":"J Heukelbach","year":"2016","unstructured":"Heukelbach J, Alencar CH, Kelvin AA, de Oliveira WK. Pamplona de G\u00f3es Cavalcanti L.J. Zika virus outbreak in Brazil. Infect Dev Ctries. 2016;2:116\u201320.","journal-title":"Infect Dev Ctries"},{"key":"824_CR5","unstructured":"World Health Organization. Epidemiological alert: neurological syndrome, congenital malformations, and Zika virus infection: implications for public health in the Americas. http: \/\/\n                    www.paho.org\/hq\/index.php?option=com_docman&task=doc_view&Itemid=270&gid\n                    \n                   =32405&lang\u2009=\u2009en. Accessed January 27, 2015."},{"key":"824_CR6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.15585\/mmwr.mm6509e2","volume":"65","author":"W Kleber de Oliveira","year":"2016","unstructured":"Kleber de Oliveira W, Cortez-Escalante J, De Oliveira WT, do Carmo GM, Henriques CM, Coelho GE, et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy-Brazil, 2015. Morb Mortal Wkly Rep. 2016;65:242\u201347.","journal-title":"Morb Mortal Wkly Rep"},{"key":"824_CR7","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","volume":"374","author":"SA Rasmussen","year":"2016","unstructured":"Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika virus and birth defects-reviewing the evidence for causality. N Engl J Med. 2016;374:1981\u201387.","journal-title":"N Engl J Med."},{"key":"824_CR8","unstructured":"Brasil Minist\u00e9rio da Sa\u00fade. Informe Epidemiol\u00f3gico N\u00b0 25-Semana Epidemiol\u00f3gica (SE) 18\/2016 (01\/05 a 07\/05\/2016)-Monitoramento dos casos de microcefalia no Brasil, 2016. \n                    http:\/\/portalsaude.saude.gov.br\/images\/pdf\/2016\/\n                    \n                   maio\/11\/COES-Microcefalias-Informe Epidemiol-gico-25-SE-18-2016-09mai2016-12\u00a0h13.pdf. Accessed June 11, 2016."},{"key":"824_CR9","unstructured":"European Centre for Disease Prevention and Control. Microcephaly in Brazil potentially linked to the Zika virus epidemic. \n                    http:\/\/ecdc.europa.eu\/en\n                    \n                   \/publications\/Publications\/zika-microcephaly -Brazil-rapid-risk-assessment-Nov-2015.pdf. Accessed January 6, 2016."},{"key":"824_CR10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1001\/jamaophthalmol.2016.0267","volume":"5","author":"B de Paula Freitas","year":"2016","unstructured":"de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol. 2016;5:529\u201335.","journal-title":"JAMA Ophthalmol"},{"key":"824_CR11","first-page":"1","volume":"1","author":"CV Ventura","year":"2016","unstructured":"Ventura CV, Maia M, Ventura BV, Linden VV, Ara\u00fajo EB, Ramos RC. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol. 2016;1:1\u20133.","journal-title":"Arq Bras Oftalmol."},{"key":"824_CR12","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","volume":"10015","author":"CV Ventura","year":"2016","unstructured":"Ventura CV, Maia M, Bravo-Filho V, G\u00f3is AL, Belfort Jr R. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet. 2016;10015:228.","journal-title":"Lancet."},{"key":"824_CR13","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1001\/jamaophthalmol.2016.0284","volume":"5","author":"LM Jampol","year":"2016","unstructured":"Jampol LM, Goldstein DA. Zika virus infection and the eye. JAMA Ophthalmol. 2016;5:535\u201336.","journal-title":"JAMA Ophthalmol"},{"key":"824_CR14","doi-asserted-by":"publisher","unstructured":"Belfort R Jr, de Paula Freitas B, de Oliveira Dias JR. Zika virus, microcephaly, and ocular findings\u2014reply. AMA Ophthalmol. doi:\n                    10.1001\/jamaophthalmol.2016.1305\n                    \n                  .","DOI":"10.1001\/jamaophthalmol.2016.1305"},{"key":"824_CR15","doi-asserted-by":"publisher","first-page":"i855","DOI":"10.1136\/bmj.i855","volume":"352","author":"M McCarthy","year":"2016","unstructured":"McCarthy M. Severe eye damage in infants with microcephaly is presumed to be due to Zika virus. BMJ. 2016;352:i855. doi:\n                    10.1136\/bmj.i855\n                    \n                  .","journal-title":"BMJ"},{"key":"824_CR16","doi-asserted-by":"publisher","unstructured":"Ventura CV, Maia M, Travassos SB, Martins TT, Patriota F, Nunes ME, et al. Risk factors associated with the ophthalmoscopic findings identified in infants with presumed Zika virus congenital infection. AMA Ophthalmol. doi:\n                    10.1001\/jamaophthalmol.2016.1784\n                    \n                  .","DOI":"10.1001\/jamaophthalmol.2016.1784"},{"key":"824_CR17","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1001\/jamadermatol.2016.1433","volume":"6","author":"SM Derrington","year":"2016","unstructured":"Derrington SM, Cellura AP, McDermott LE, Gubitosi T, Sonstegard AM, Chen S, et al. Mucocutaneous findings and course in an adult with Zika virus infection. JAMA Dermatol. 2016;6:691\u20133.","journal-title":"JAMA Dermatol."},{"key":"824_CR18","doi-asserted-by":"publisher","unstructured":"Jimenez Corona ME, De la Garza Barroso AL, Rodriguez Mart\u00ednez JC, Luna Guzm\u00e1n NI, Ruiz Matus C, D\u00edaz Qui\u00f1onez JA, et al. Clinical and epidemiological characterization of laboratory-confirmed autochthonous cases of Zika virus disease in Mexico. PLoS Curr. 2016; doi:\n                    10.1371\/currents.outbreaks.a2fe1b3d6d71e24ad2b5afe982824053\n                    \n                  .","DOI":"10.1371\/currents.outbreaks.a2fe1b3d6d71e24ad2b5afe982824053"},{"key":"824_CR19","doi-asserted-by":"publisher","unstructured":"Furtado JM, Esp\u00f3sito DL, Klein TM, Teixeira-Pinto T, da Fonseca BA. Uveitis associated with Zika virus infection. N Engl J Med. 2016; doi: \n                    10.1056\/NEJMc1603618\n                    \n                  .","DOI":"10.1056\/NEJMc1603618"},{"key":"824_CR20","first-page":"864","volume":"43","author":"GA Limb","year":"2002","unstructured":"Limb GA, Salt TE, Munro PM, Moss SE, Khaw PT. In vitro characterization of a spontaneously immortalized human M\u00fcller cell line (MIO-M1). Invest Ophthalmol Vis Sci. 2002;43:864\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"824_CR21","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3201\/eid2205.160065","volume":"5","author":"RS Lanciotti","year":"2016","unstructured":"Lanciotti RS, Lambert AJ, Holodniy M, Saavedra S, del Carmen Castillo Signor L. Phylogeny of Zika virus in Western Hemisphere, 2015. Emerg Infect Dis. 2016;5:933\u20135.","journal-title":"Emerg Infect Dis"},{"key":"824_CR22","doi-asserted-by":"publisher","first-page":"154","DOI":"10.15585\/mmwr.mm6506e2","volume":"6","author":"DL Thomas","year":"2016","unstructured":"Thomas DL, Sharp TM, Torres J, Armstrong PA, Munoz-Jordan J, Ryff KR, et al. Local transmission of Zika Virus\u2014Puerto Rico, November 23, 2015 January 28, 2016. MMWR Morb Mortal Wkly Rep. 2016;6:154\u20138.","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"824_CR23","doi-asserted-by":"publisher","first-page":"451","DOI":"10.15585\/mmwr.mm6517e2","volume":"17","author":"E Dirlikov","year":"2016","unstructured":"Dirlikov E, Ryff KR, Torres-Aponte J, Thomas DL, Perez-Padilla J, Munoz-Jordan J, et al. Update: ongoing Zika virus transmission\u2014Puerto Rico, November 1, 2015-April 14, 2016. MMWR Morb Mortal Wkly Rep. 2016;17:451\u20135.","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"824_CR24","doi-asserted-by":"publisher","first-page":"F75","DOI":"10.1136\/fn.87.2.F75","volume":"87","author":"P Bryant","year":"2002","unstructured":"Bryant P, Morley C, Garland S, Curtis N. Cytomegalovirus transmission from breast milk in premature babies: does it matter? Arch Dis Child Fetal Neonatal Ed. 2002;87:F75\u20137.","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"824_CR25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0166-0934(00)00274-3","volume":"1","author":"M Nawa","year":"2001","unstructured":"Nawa M, Takasaki T, Yamada KI, Akatsuka T, Kurane I. Development of dengue IgM-capture enzyme-linked immunosorbent assay with higher sensitivity using monoclonal detection antibody. J Virol Methods. 2001;1:65\u201370.","journal-title":"J Virol Methods."},{"key":"824_CR26","doi-asserted-by":"publisher","first-page":"13975","DOI":"10.1128\/JVI.78.24.13975-13986.2004","volume":"24","author":"WD Crill","year":"2004","unstructured":"Crill WD, Chang GJ. Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes. J Virol. 2004;24:13975\u201386.","journal-title":"J Virol"},{"key":"824_CR27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/1742-2094-9-95","volume":"9","author":"DJ Alcendor","year":"2012","unstructured":"Alcendor DJ, Charest AM, Zhu WQ, Vigil HE, Knobel SM. Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus. J Neuroinflammation. 2012;9:95.","journal-title":"J Neuroinflammation."},{"key":"824_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jcv.2008.05.005","volume":"1","author":"O Faye","year":"2008","unstructured":"Faye O, Faye O, Dupressoir A, Weidmann M, Ndiaye M, Alpha SA. One-step RT-PCR for detection of Zika virus. J Clin Virol. 2008;1:96\u2013101.","journal-title":"J Clin Virol"},{"key":"824_CR29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12974-014-0219-y","volume":"12","author":"I Wilkerson","year":"2015","unstructured":"Wilkerson I, Laban J, Mitchell JM, Sheibani N, Alcendor DJ. Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease. J Neuroinflammation. 2015;12:2.","journal-title":"J Neuroinflammation"},{"key":"824_CR30","doi-asserted-by":"publisher","first-page":"e2535","DOI":"10.1371\/journal.pone.0002535","volume":"7","author":"JF Djoba Siawaya","year":"2008","unstructured":"Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, et al. An evaluation of commercial fluorescent bead-based luminex cytokine assays. PLoS One. 2008;7:e2535.","journal-title":"PLoS One"},{"key":"824_CR31","first-page":"193","volume":"1","author":"K Noriyuki","year":"2011","unstructured":"Noriyuki K, Shinobu F. Recent advances in ocular drug delivery systems. Polymers. 2011;1:193\u2013221.","journal-title":"Polymers"},{"key":"824_CR32","doi-asserted-by":"publisher","unstructured":"Maharajan MK, Ranjan A, Chu JF, Foo WL, Chai ZX, Lau EY. et al. Zika virus infection: current concerns and perspectives. Clin Rev Allergy Immunol. 2016; doi: \n                    10.1007\/s12016-016-8554-7\n                    \n                  .","DOI":"10.1007\/s12016-016-8554-7"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-017-0824-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12974-017-0824-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-017-0824-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T07:16:37Z","timestamp":1589526997000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-017-0824-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["824"],"URL":"https:\/\/doi.org\/10.1186\/s12974-017-0824-7","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,3]]},"assertion":[{"value":"26 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"43"}}