{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:09:36Z","timestamp":1790971776057,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471142"],"award-info":[{"award-number":["81471142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571069"],"award-info":[{"award-number":["81571069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Postdoctoral Science Foundation Commission","award":["2015M580473)"],"award-info":[{"award-number":["2015M580473)"]}]},{"name":"Foundation of Nanjing Medical University","award":["2014NJMUZD015"],"award-info":[{"award-number":["2014NJMUZD015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12974-017-0849-y","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T21:13:50Z","timestamp":1491340430000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression"],"prefix":"10.1186","volume":"14","author":[{"given":"Hai-Jiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Xiu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"849_CR1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/ar2952","volume":"12","author":"N Busso","year":"2010","unstructured":"Busso N, So A. Mechanisms of inflammation in gout. Arthritis Res Ther. 2010;12:206\u201314.","journal-title":"Arthritis Res Ther"},{"key":"849_CR2","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","volume":"388","author":"N Dalbeth","year":"2016","unstructured":"Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016;388:2039\u201352.","journal-title":"Lancet"},{"key":"849_CR3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.berh.2015.04.025","volume":"29","author":"R Ramonda","year":"2015","unstructured":"Ramonda R, Oliviero F, Galozzi P, Frallonardo P, Ortolan A, et al. Molecular mechanisms of pain in crystal-induced arthritis. Best Pract Res Clin Rheumatol. 2015;29:98\u2013110.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"849_CR4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrrheum.2014.32","volume":"10","author":"F Rees","year":"2014","unstructured":"Rees F, Hui M, Doherty M. Optimizing current treatment of gout. Nat Rev Rheumatol. 2014;10:271\u201383.","journal-title":"Nat Rev Rheumatol"},{"key":"849_CR5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon F, P\u00e9trilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237\u201341.","journal-title":"Nature"},{"key":"849_CR6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.24185","volume":"60","author":"WJ Martin","year":"2009","unstructured":"Martin WJ, Walton M, Harper J. Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum. 2009;60:281\u20139.","journal-title":"Arthritis Rheum"},{"key":"849_CR7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2014.04.021","volume":"72","author":"G Trevisan","year":"2014","unstructured":"Trevisan G, Hoffmeister C, Rossato MF, Oliveira SM, Silva MA, Silva CR, et al. TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout. Free Radic Biol Med. 2014;72:200\u20139.","journal-title":"Free Radic Biol Med"},{"key":"849_CR8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresrev.2008.12.020","volume":"60","author":"K Ren","year":"2009","unstructured":"Ren K, Torres R. Role of interleukin-1\u03b2 during pain and inflammation. Brain Res Rev. 2009;60:57\u201364.","journal-title":"Brain Res Rev"},{"key":"849_CR9","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1002\/art.22938","volume":"56","author":"RM Pope","year":"2007","unstructured":"Pope RM, Tschopp J. The role of interleukin-1 and the inflammasome in gout: implications for therapy. Arthritis Rheum. 2007;56:3183\u20138.","journal-title":"Arthritis Rheum"},{"key":"849_CR10","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1136\/ard.2009.109355","volume":"68","author":"R Torres","year":"2009","unstructured":"Torres R, Macdonald L, Croll SD, Reinhardt J, Dore A, Silva CR, et al. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Ann Rheum Dis. 2009;68:1602\u20138.","journal-title":"Ann Rheum Dis"},{"key":"849_CR11","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1002\/art.38747","volume":"66","author":"LL Reber","year":"2014","unstructured":"Reber LL, Marichal T, Sokolove J, Starkl P, Gaudenzio N, Iwakura Y, et al. Contribution of mast cell-derived interleukin-1\u03b2 to uric acid crystal-induced acute arthritis in mice. Arthritis Rheumatol. 2014;66:2881\u201391.","journal-title":"Arthritis Rheumatol"},{"key":"849_CR12","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","volume":"116","author":"CJ Chen","year":"2006","unstructured":"Chen CJ, Shi Y, Hearn A, Fitzgerald K, Golenbock D, Reed G, et al. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest. 2006;116:2262\u201371.","journal-title":"J Clin Invest"},{"key":"849_CR13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nrn3638","volume":"15","author":"JG Walsh","year":"2014","unstructured":"Walsh JG, Muruve DA, C P. Inflammasomes in the CNS. Nat Rev Neurosci. 2014;15:84\u201397.","journal-title":"Nat Rev Neurosci"},{"key":"849_CR14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","volume":"13","author":"E Latz","year":"2013","unstructured":"Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013;13:397\u2013411.","journal-title":"Nat Rev Immunol"},{"key":"849_CR15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/art.33355","volume":"64","author":"FA Amaral","year":"2012","unstructured":"Amaral FA, Costa VV, Tavares LD, Sachs D, Coelho FM, Fagundes CT, et al. NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout. Arthritis Rheum. 2012;64:474\u201384.","journal-title":"Arthritis Rheum"},{"key":"849_CR16","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1002\/art.34677","volume":"64","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi HK. Cherry consumption and decreased risk of recurrent gout attacks. Arthritis Rheum. 2012;64:4004\u201311.","journal-title":"Arthritis Rheum"},{"key":"849_CR17","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1021\/jf903755b","volume":"58","author":"V Usenik","year":"2010","unstructured":"Usenik V, Fajt N, Mikulic-Petkovsek M, Slatnar A, Stampar F, Veberic R. Sweet cherry pomological and biochemical characteristics influenced by rootstock. J Agric Food Chem. 2010;58:4928\u201333.","journal-title":"J Agric Food Chem"},{"key":"849_CR18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/mnfr.201400370","volume":"59","author":"N Martinez-Micaelo","year":"2015","unstructured":"Martinez-Micaelo N, Gonz\u00e1lez-Abu\u00edn N, Pinent M, Ard\u00e9vol A, Blay M. Procyanidin B2 inhibits inflammasome-mediated IL-1\u03b2 production in lipopolysaccharide-stimulated macrophages. Mol Nutr Food Res. 2015;59:262\u20139.","journal-title":"Mol Nutr Food Res"},{"key":"849_CR19","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","volume":"36","author":"R Williams","year":"2004","unstructured":"Williams R, Spencer JPE, Riceevans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med. 2004;36:838\u201349.","journal-title":"Free Radic Biol Med"},{"key":"849_CR20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-016-0520-z","volume":"13","author":"Y Cai","year":"2016","unstructured":"Cai Y, Kong H, Pan YB, Jiang L, Pan XX, Hu L, et al. Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia. J Neuroinflammation. 2016;13:53\u201367.","journal-title":"J Neuroinflammation"},{"key":"849_CR21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55\u201363.","journal-title":"J Neurosci Methods"},{"key":"849_CR22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/rheumatology\/ket352","volume":"53","author":"C Hoffmeister","year":"2014","unstructured":"Hoffmeister C, Silva MA, Rossato MF, Trevisan G, Oliveira SM, Guerra GP, et al. Participation of the TRPV1 receptor in the development of acute gout attacks. Rheumatology. 2014;53:240\u20139.","journal-title":"Rheumatology"},{"key":"849_CR23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/0973-029X.99070","volume":"16","author":"K Sanjai","year":"2012","unstructured":"Sanjai K, Kumarswamy J, Patil A, Papaiah L, Jayaram S, Krishnan L. Evaluation and comparison of decalcification agents on the human teeth. J Oral Maxillofac Pathol. 2012;16:222\u20137.","journal-title":"J Oral Maxillofac Pathol"},{"key":"849_CR24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","volume":"40","author":"F Martinon","year":"2010","unstructured":"Martinon F. Signaling by ROS drives inflammasome activation. Eur J Immunol. 2010;40:616\u20139.","journal-title":"Eur J Immunol"},{"key":"849_CR25","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s10875-010-9440-3","volume":"30","author":"C Jin","year":"2010","unstructured":"Jin C, Flavell RA. Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol. 2010;30:628\u201331.","journal-title":"J Clin Immunol"},{"key":"849_CR26","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1002\/art.27663","volume":"62","author":"CA Dinarello","year":"2010","unstructured":"Dinarello CA. How interleukin-1\u03b2 induces gouty arthritis. Arthritis Rheum. 2010;62:3140\u20134.","journal-title":"Arthritis Rheum"},{"key":"849_CR27","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003","volume":"23","author":"B Viviani","year":"2003","unstructured":"Viviani B, Bartesaghi S, Gardoni F, Vezzani A, Behrens MM, Bartfai T, et al. Interleukin-1\u03b2 enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci. 2003;23:8692\u2013700.","journal-title":"J Neurosci"},{"key":"849_CR28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semarthrit.2014.02.003","volume":"44","author":"PP Khanna","year":"2014","unstructured":"Khanna PP, Gladue HS, Singh MK, FitzGerald JD, Bae S, Prakash S, et al. Treatment of acute gout: a systematic review. Semin Arthritis Rheum. 2014;44:31\u20138.","journal-title":"Semin Arthritis Rheum"},{"key":"849_CR29","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.pain.2011.03.025","volume":"152","author":"C Hoffmeister","year":"2011","unstructured":"Hoffmeister C, Trevisan G, Rossato MF, de Oliveira SM, Gomez MV, Ferreira J. Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats. Pain. 2011;152:1777\u201388.","journal-title":"Pain"},{"key":"849_CR30","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1021\/jf100236v","volume":"58","author":"M Sanz","year":"2010","unstructured":"Sanz M, Cadah\u00eda E, Esteruelas E, Mu\u00f1oz AM, Fern\u00e1ndez De Sim\u00f3n B, Hern\u00e1ndez T, et al. Phenolic compounds in cherry (Prunus avium) heartwood with a view to their use in cooperage. J Agric Food Chem. 2010;58:4907\u201314.","journal-title":"J Agric Food Chem"},{"key":"849_CR31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tifs.2004.04.006","volume":"15","author":"Y Yilmaz","year":"2004","unstructured":"Yilmaz Y, Toledo RT. Health aspects of functional grape seed constituents. Trends Food Sci Technol. 2004;15:422\u201333.","journal-title":"Trends Food Sci Technol"},{"key":"849_CR32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/eji.201545798","volume":"46","author":"FA Amaral","year":"2016","unstructured":"Amaral FA, Bastos LF, Oliveira TH, Dias AC, Oliveira VL, Tavares LD, et al. Transmembrane TNF-\u03b1 is sufficient for articular inflammation and hypernociception in a mouse model of gout. Eur J Immunol. 2016;46:204\u201311.","journal-title":"Eur J Immunol"},{"key":"849_CR33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.intimp.2015.11.010","volume":"30","author":"F Zhu","year":"2016","unstructured":"Zhu F, Yin L, Ji L, Yang F, Zhang G, Shi L, et al. Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: an in vivo and in vitro study. Int Immunopharmacol. 2016;30:36\u201342.","journal-title":"Int Immunopharmacol"},{"key":"849_CR34","first-page":"39","volume":"4","author":"SR Kingsbury","year":"2011","unstructured":"Kingsbury SR, Conaghan, McDermott MF. The role of the NLRP3 inflammasome in gout. J Inflamm Re. 2011;4:39\u201349.","journal-title":"J Inflamm Re"},{"key":"849_CR35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.coi.2012.12.004","volume":"25","author":"M Haneklaus","year":"2013","unstructured":"Haneklaus M, Oneill LA, Coll RC. Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr Opin Immunol. 2013;25:40\u20135.","journal-title":"Curr Opin Immunol"},{"key":"849_CR36","first-page":"148","volume":"13","author":"EK Jo","year":"2015","unstructured":"Jo EK, Kim JK, Shin DM, Sasakawa C. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 2015;13:148\u201359.","journal-title":"Cell Mol Immunol"},{"key":"849_CR37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12950-015-0070-7","volume":"12","author":"SC Zheng","year":"2015","unstructured":"Zheng SC, Zhu XX, Xue Y, Zhang LH, Zou HJ, Qiu JH, et al. Role of the NLRP3 inflammasome in the transient release of IL-1\u03b2 induced by monosodium urate crystals in human fibroblast-like synoviocytes. J Inflamm. 2015;12:30\u20138.","journal-title":"J Inflamm"},{"key":"849_CR38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","volume":"11","author":"R Zhou","year":"2010","unstructured":"Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010;11:136\u201340.","journal-title":"Nat Immunol"},{"key":"849_CR39","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.4049\/jimmunol.1301490","volume":"191","author":"ME Heid","year":"2013","unstructured":"Heid ME, Keyel PA, Kamga C, Shiva S, Watkins SC, Salter RD. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013;191:5230\u20138.","journal-title":"J Immunol"},{"key":"849_CR40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2010","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2010;469:221\u20135.","journal-title":"Nature"},{"key":"849_CR41","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","volume":"10","author":"A Latremoliere","year":"2009","unstructured":"Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10:895\u2013926.","journal-title":"J Pain"},{"key":"849_CR42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cne.902850203","volume":"285","author":"D Men\u00e9trey","year":"1989","unstructured":"Men\u00e9trey D, Gannon A, Levine JD, Basbaum AI. Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol. 1989;285:177\u201395.","journal-title":"J Comp Neurol"},{"key":"849_CR43","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.pain.2004.07.007","volume":"111","author":"SM Sweitzer","year":"2004","unstructured":"Sweitzer SM, Peters MC, Ma JY, Kerr I, Mangadu R, Chakravarty S, et al. Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia. Pain. 2004;111:278\u201385.","journal-title":"Pain"},{"key":"849_CR44","doi-asserted-by":"crossref","unstructured":"Baldassare JJ, Bi Y, Bellone CJ. The role of p38 mitogen-activated protein kinase in IL-1\u03b2 transcription. J Immunol. 1999;162:5367\u201373.","DOI":"10.4049\/jimmunol.162.9.5367"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-017-0849-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:28:28Z","timestamp":1692736108000},"score":1,"resource":{"primary":{"URL":"http:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-017-0849-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["849"],"URL":"https:\/\/doi.org\/10.1186\/s12974-017-0849-y","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]},"article-number":"74"}}