{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:52:57Z","timestamp":1793692377625,"version":"4.5.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2014CB541600"],"award-info":[{"award-number":["2014CB541600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501002"],"award-info":[{"award-number":["81501002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81220108009"],"award-info":[{"award-number":["81220108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Science and Advanced Technology Research Project of Chongqing","award":["cstc2016jcyjA1730"],"award-info":[{"award-number":["cstc2016jcyjA1730"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12974-017-0940-4","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T08:58:54Z","timestamp":1503046734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats"],"prefix":"10.1186","volume":"14","author":[{"given":"Hengli","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-9138","authenticated-orcid":false,"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"940_CR1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pneurobio.2010.08.001","volume":"92","author":"J Wang","year":"2010","unstructured":"Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol. 2010;92:463\u201377.","journal-title":"Prog Neurobiol"},{"key":"940_CR2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12975-014-0384-4","volume":"6","author":"S Chen","year":"2015","unstructured":"Chen S, Yang Q, Chen G, Zhang JH. An update on inflammation in the acute phase of intracerebral hemorrhage. Transl Stroke Res. 2015;6:4\u20138.","journal-title":"Transl Stroke Res"},{"key":"940_CR3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ana.24070","volume":"75","author":"Q Ma","year":"2014","unstructured":"Ma Q, Chen S, Hu Q, Feng H, Zhang JH, Tang J. NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol. 2014;75:209\u201319.","journal-title":"Ann Neurol"},{"key":"940_CR4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cjtee.2015.11.010","volume":"18","author":"X Weng","year":"2015","unstructured":"Weng X, Tan Y, Chu X, Wu XF, Liu R, Tian Y, Li L, Guo F, Ouyang Q, Li L. N-methyl-d-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral hemorrhage. Chin J Traumatol. 2015;18:254\u20138.","journal-title":"Chin J Traumatol"},{"key":"940_CR5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.molimm.2014.12.018","volume":"65","author":"Z Yang","year":"2015","unstructured":"Yang Z, Zhong L, Xian R, Yuan B. MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage. Mol Immunol. 2015;65:267\u201376.","journal-title":"Mol Immunol"},{"key":"940_CR6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2015.08.002","volume":"287","author":"B Yuan","year":"2015","unstructured":"Yuan B, Shen H, Lin L, Su T, Zhong S, Yang Z. Recombinant adenovirus encoding NLRP3 RNAi attenuate inflammation and brain injury after intracerebral hemorrhage. J Neuroimmunol. 2015;287:71\u20135.","journal-title":"J Neuroimmunol"},{"key":"940_CR7","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1007\/s12035-015-9304-1","volume":"53","author":"Y Cui","year":"2016","unstructured":"Cui Y, Duan X, Li H, Dang B, Yin J, Wang Y, Gao A, Yu Z, Chen G. Hydrogen sulfide ameliorates early brain injury following subarachnoid hemorrhage in rats. Mol Neurobiol. 2016;53:3646\u201357.","journal-title":"Mol Neurobiol"},{"key":"940_CR8","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","volume":"16","author":"K Abe","year":"1996","unstructured":"Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16:1066\u201371.","journal-title":"J Neurosci"},{"key":"940_CR9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12975-016-0459-5","volume":"7","author":"H Liu","year":"2016","unstructured":"Liu H, Wang Y, Xiao Y, Hua Z, Cheng J, Jia J. Hydrogen sulfide attenuates tissue plasminogen activator-induced cerebral hemorrhage following experimental stroke. Transl Stroke Res. 2016;7:209\u201319.","journal-title":"Transl Stroke Res"},{"key":"940_CR10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12974-016-0488-8","volume":"13","author":"M Lee","year":"2016","unstructured":"Lee M, McGeer EG, McGeer PL. Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. J Neuroinflammation. 2016;13:32.","journal-title":"J Neuroinflammation"},{"key":"940_CR11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.arr.2015.10.001","volume":"24","author":"M Tewari","year":"2015","unstructured":"Tewari M, Seth P. Emerging role of P2X7 receptors in CNS health and disease. Ageing Res Rev. 2015;24:328\u201342.","journal-title":"Ageing Res Rev"},{"key":"940_CR12","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1096\/fj.14-268714","volume":"29","author":"A Franceschini","year":"2015","unstructured":"Franceschini A, Capece M, Chiozzi P, Falzoni S, Sanz JM, Sarti AC, Bonora M, Pinton P, Di Virgilio F. The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein. FASEB J. 2015;29:2450\u201361.","journal-title":"FASEB J"},{"key":"940_CR13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12974-015-0409-2","volume":"12","author":"L Feng","year":"2015","unstructured":"Feng L, Chen Y, Ding R, Fu Z, Yang S, Deng X, Zeng J. P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite. J Neuroinflammation. 2015;12:190.","journal-title":"J Neuroinflammation"},{"key":"940_CR14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11302-014-9417-4","volume":"10","author":"I Villar-Menendez","year":"2014","unstructured":"Villar-Menendez I, Nunez F, Diaz-Sanchez S, Albasanz JL, Taura J, Fernandez-Duenas V, Ferrer I, Martin M, Ciruela F, Barrachina M. Striatal adenosine A2A receptor expression is controlled by S-adenosyl-l-methionine-mediated methylation. Purinergic Signal. 2014;10:523\u20138.","journal-title":"Purinergic Signal"},{"key":"940_CR15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2826.2000.00441.x","volume":"12","author":"C Russo Dello","year":"2000","unstructured":"Dello Russo C, Tringali G, Ragazzoni E, Maggiano N, Menini E, Vairano M, Preziosi P, Navarra P. Evidence that hydrogen sulphide can modulate hypothalamo-pituitary-adrenal axis function: in vitro and in vivo studies in the rat. J Neuroendocrinol. 2000;12:225\u201333.","journal-title":"J Neuroendocrinol"},{"key":"940_CR16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/STROKEAHA.114.007265","volume":"46","author":"Y Chen","year":"2015","unstructured":"Chen Y, Zhang Y, Tang J, Liu F, Hu Q, Luo C, Tang J, Feng H, Zhang JH. Norrin protected blood-brain barrier via frizzled-4\/beta-catenin pathway after subarachnoid hemorrhage in rats. Stroke. 2015;46:529\u201336.","journal-title":"Stroke"},{"key":"940_CR17","doi-asserted-by":"crossref","first-page":"23286","DOI":"10.1038\/srep23286","volume":"6","author":"H Zhao","year":"2016","unstructured":"Zhao H, Zhang X, Dai Z, Feng Y, Li Q, Zhang JH, Liu X, Chen Y, Feng H. P2X7 receptor suppression preserves blood-brain barrier through inhibiting RhoA activation after experimental intracerebral hemorrhage in rats. Sci Rep. 2016;6:23286.","journal-title":"Sci Rep"},{"key":"940_CR18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbi.2016.05.020","volume":"58","author":"Y Tao","year":"2016","unstructured":"Tao Y, Li L, Jiang B, Feng Z, Yang L, Tang J, Chen Q, Zhang J, Tan Q, Feng H, et al. Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1\/M2 polarization through the cAMP\/PKA pathway in an experimental GMH rat model. Brain Behav Immun. 2016;58:118\u201329.","journal-title":"Brain Behav Immun"},{"key":"940_CR19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s12975-014-0362-x","volume":"6","author":"L Wang","year":"2015","unstructured":"Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang R, Liu Z, Zhang J. Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells. Transl Stroke Res. 2015;6:50\u20139.","journal-title":"Transl Stroke Res"},{"key":"940_CR20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2045-9912-2-9","volume":"2","author":"Y Soejima","year":"2012","unstructured":"Soejima Y, Ostrowski RP, Manaenko A, Fujii M, Tang J, Zhang JH. Hyperbaric oxygen preconditioning attenuates hyperglycemia enhanced hemorrhagic transformation after transient MCAO in rats. Med Gas Res. 2012;2:9.","journal-title":"Med Gas Res"},{"key":"940_CR21","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrneurol.2012.210","volume":"8","author":"JH Zhang","year":"2012","unstructured":"Zhang JH, Badaut J, Tang J, Obenaus A, Hartman R, Pearce WJ. The vascular neural network\u2014a new paradigm in stroke pathophysiology. Nat Rev Neurol. 2012;8:711\u20136.","journal-title":"Nat Rev Neurol"},{"issue":"15","key":"940_CR22","first-page":"2197","volume":"23","author":"Y Yin","year":"2017","unstructured":"Yin Y, Ge H, Zhang JH, Feng H. Targeting vascular neural network in intracerebral hemorrhage. Curr Pharm Des. 2017;23(15):2197\u2013205.","journal-title":"Curr Pharm Des"},{"key":"940_CR23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fncel.2014.00388","volume":"8","author":"E Mracsko","year":"2014","unstructured":"Mracsko E, Veltkamp R. Neuroinflammation after intracerebral hemorrhage. Front Cell Neurosci. 2014;8:388.","journal-title":"Front Cell Neurosci"},{"key":"940_CR24","doi-asserted-by":"crossref","first-page":"746068","DOI":"10.1155\/2013\/746068","volume":"2013","author":"RA Taylor","year":"2013","unstructured":"Taylor RA, Sansing LH. Microglial responses after ischemic stroke and intracerebral hemorrhage. Clin Dev Immunol. 2013;2013:746068.","journal-title":"Clin Dev Immunol"},{"key":"940_CR25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-3-319-18144-8_9","volume":"230","author":"K Kida","year":"2015","unstructured":"Kida K, Ichinose F. Hydrogen sulfide and neuroinflammation. Handb Exp Pharmacol. 2015;230:181\u20139.","journal-title":"Handb Exp Pharmacol"},{"key":"940_CR26","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","volume":"100","author":"LF Hu","year":"2007","unstructured":"Hu LF, Wong PT, Moore PK, Bian JS. Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia. J Neurochem. 2007;100:1121\u20138.","journal-title":"J Neurochem"},{"key":"940_CR27","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/jcbfm.2014.223","volume":"35","author":"Y Geng","year":"2015","unstructured":"Geng Y, Li E, Mu Q, Zhang Y, Wei X, Li H, Cheng L, Zhang B. Hydrogen sulfide inhalation decreases early blood-brain barrier permeability and brain edema induced by cardiac arrest and resuscitation. J Cereb Blood Flow Metab. 2015;35:494\u2013500.","journal-title":"J Cereb Blood Flow Metab"},{"key":"940_CR28","doi-asserted-by":"crossref","first-page":"4723416","DOI":"10.1155\/2016\/4723416","volume":"2016","author":"E Pouokam","year":"2016","unstructured":"Pouokam E, Althaus M. Epithelial electrolyte transport physiology and the gasotransmitter hydrogen sulfide. Oxidative Med Cell Longev. 2016;2016:4723416.","journal-title":"Oxidative Med Cell Longev"},{"key":"940_CR29","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/MIB.0000000000000345","volume":"21","author":"JP Motta","year":"2015","unstructured":"Motta JP, Flannigan KL, Agbor TA, Beatty JK, Blackler RW, Workentine ML, Da Silva GJ, Wang R, Buret AG, Wallace JL. Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production. Inflamm Bowel Dis. 2015;21:1006\u201317.","journal-title":"Inflamm Bowel Dis"},{"key":"940_CR30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1165\/rcmb.2015-0014OC","volume":"55","author":"F Li","year":"2016","unstructured":"Li F, Zhang P, Zhang M, Liang L, Sun X, Li M, Tang Y, Bao A, Gong J, Zhang J, et al. Hydrogen sulfide prevents and partially reverses ozone-induced features of lung inflammation and emphysema in mice. Am J Respir Cell Mol Biol. 2016;55:72\u201381.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"940_CR31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/CIRCGENETICS.113.000381","volume":"7","author":"S Toldo","year":"2014","unstructured":"Toldo S, Das A, Mezzaroma E, Chau VQ, Marchetti C, Durrant D, Samidurai A, Van Tassell BW, Yin C, Ockaili RA, et al. Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice. Circ Cardiovasc Genet. 2014;7:311\u201320.","journal-title":"Circ Cardiovasc Genet"},{"key":"940_CR32","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/jcbfm.2013.242","volume":"34","author":"F Yang","year":"2014","unstructured":"Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F, Xin T, Pang Q, Yi F. NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J Cereb Blood Flow Metab. 2014;34:660\u20137.","journal-title":"J Cereb Blood Flow Metab"},{"key":"940_CR33","doi-asserted-by":"crossref","first-page":"10555","DOI":"10.1038\/ncomms10555","volume":"7","author":"M Karmakar","year":"2016","unstructured":"Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP. Nat Commun. 2016;7:10555.","journal-title":"Nat Commun"},{"key":"940_CR34","doi-asserted-by":"crossref","first-page":"e0130624","DOI":"10.1371\/journal.pone.0130624","volume":"10","author":"A Gustin","year":"2015","unstructured":"Gustin A, Kirchmeyer M, Koncina E, Felten P, Losciuto S, Heurtaux T, Tardivel A, Heuschling P, Dostert C. NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes. PLoS One. 2015;10:e0130624.","journal-title":"PLoS One"},{"key":"940_CR35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-016-0520-z","volume":"13","author":"Y Cai","year":"2016","unstructured":"Cai Y, Kong H, Pan YB, Jiang L, Pan XX, Hu L, Qian YN, Jiang CY, Liu WT. Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia. J Neuroinflammation. 2016;13:53.","journal-title":"J Neuroinflammation"},{"key":"940_CR36","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1523\/JNEUROSCI.5512-08.2009","volume":"29","author":"M Monif","year":"2009","unstructured":"Monif M, Reid CA, Powell KL, Smart ML, Williams DA. The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci. 2009;29:3781\u201391.","journal-title":"J Neurosci"},{"key":"940_CR37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0166-2236(89)90038-6","volume":"12","author":"GL Cantoni","year":"1989","unstructured":"Cantoni GL, Mudd SH, Andreoli V. Affective disorders and S-adenosylmethionine: a new hypothesis. Trends Neurosci. 1989;12:319\u201324.","journal-title":"Trends Neurosci"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-017-0940-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T01:06:50Z","timestamp":1589764010000},"score":1,"resource":{"primary":{"URL":"http:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-017-0940-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["940"],"URL":"https:\/\/doi.org\/10.1186\/s12974-017-0940-4","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,18]]},"article-number":"163"}}