{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:22:21Z","timestamp":1773886941072,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12974-017-1020-5","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T12:10:14Z","timestamp":1513080614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6"],"prefix":"10.1186","volume":"14","author":[{"given":"Leonam G.","family":"Coutinho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Helena Sales","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Witwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucymara F.","family":"Agnez-Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"1020_CR1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/B978-0-444-63600-3.00019-2","volume":"140","author":"MC Brouwer","year":"2017","unstructured":"Brouwer MC, van de Beek D. Management of bacterial central nervous system infections. Handb Clin Neurol. 2017;140:349\u201364.","journal-title":"Handb Clin Neurol"},{"key":"1020_CR2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00401-007-0304-8","volume":"114","author":"D Grandgirard","year":"2007","unstructured":"Grandgirard D, Steiner O, T\u00e4uber MG, Leib SL. An infant mouse model of brain damage in pneumococcal meningitis. Acta Neuropathol. 2007;114:609\u201317.","journal-title":"Acta Neuropathol"},{"key":"1020_CR3","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1172\/JCI119084","volume":"98","author":"SL Leib","year":"1996","unstructured":"Leib SL, Kim YS, Chow LL, Sheldon RA, T\u00e4uber MG. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest. 1996;98:2632\u20139.","journal-title":"J Clin Invest"},{"key":"1020_CR4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.dnarep.2004.11.006","volume":"4","author":"MR Vasko","year":"2005","unstructured":"Vasko MR, Guo C, Kelley MR. The multifunctional DNA repair\/redox enzyme Ape1\/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst). 2005;4:367\u201379.","journal-title":"DNA Repair (Amst)"},{"key":"1020_CR5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mito.2013.10.007","volume":"16","author":"AK Mantha","year":"2014","unstructured":"Mantha AK, Sarkar B, Tell G. A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases. Mitochondrion. 2014;16:38\u201349.","journal-title":"Mitochondrion"},{"key":"1020_CR6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1074\/jbc.274.1.67","volume":"274","author":"TR Waters","year":"1999","unstructured":"Waters TR, Gallinari P, Jiricny J, Swann PF. Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1. J Biol Chem. 1999;274:67\u201374.","journal-title":"J Biol Chem"},{"key":"1020_CR7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/nar\/29.2.430","volume":"29","author":"JW Hill","year":"2001","unstructured":"Hill JW, Hazra TK, Izumi T, Mitra S. Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair. Nucleic Acids Res. 2001;29:430\u20138.","journal-title":"Nucleic Acids Res"},{"key":"1020_CR8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mrrev.2014.11.004","volume":"763","author":"FL Fontes","year":"2015","unstructured":"Fontes FL, Pinheiro DM, Oliveira AH, Oliveira RK, Lajus TB, Agnez-Lima LF. Role of DNA repair in host immune response and inflammation. Mutat Res Rev Mutat Res. 2015;763:246\u201357.","journal-title":"Mutat Res Rev Mutat Res"},{"key":"1020_CR9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/01.STR.30.2.441","volume":"30","author":"M Kawase","year":"1999","unstructured":"Kawase M, Fujimura M, Morita-Fujimura Y, Chan PH. Reduction of apurinic\/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis. Stroke. 1999;30:441\u20138. discussion 449","journal-title":"Stroke"},{"key":"1020_CR10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1006\/nbdi.2001.0396","volume":"8","author":"A Lewen","year":"2001","unstructured":"Lewen A, Sugawara T, Gasche Y, Fujimura M, Chan PH. Oxidative cellular damage and the reduction of APE\/Ref-1 expression after experimental traumatic brain injury. Neurobiol Dis. 2001;8:380\u201390.","journal-title":"Neurobiol Dis"},{"key":"1020_CR11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1067\/mva.2003.100","volume":"37","author":"M Sakurai","year":"2003","unstructured":"Sakurai M, Nagata T, Abe K, Horinouchi T, Itoyama Y, Tabayashi K. Oxidative damage and reduction of redox factor-1 expression after transient spinal cord ischemia in rabbits. J Vasc Surg. 2003;37:446\u201352.","journal-title":"J Vasc Surg"},{"key":"1020_CR12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00799-5","volume":"277","author":"YY Chang","year":"1999","unstructured":"Chang YY, Fujimura M, Morita-Fujimura Y, Kim GW, Huang CY, Wu HS, Kawase M, Copin JC, Chan PH. Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic\/apyrimidinic endonuclease DNA repair enzyme. Neurosci Lett. 1999;277:61\u20134.","journal-title":"Neurosci Lett"},{"key":"1020_CR13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.33549\/physiolres.931388","volume":"58","author":"T Dagci","year":"2009","unstructured":"Dagci T, Armagan G, Konyalioglu S, Yalcin A. Alterations in the expression of the apurinic\/apyrimidinic endonuclease-1\/redox factor-1 (APE\/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells. Physiol Res. 2009;58:427\u201334.","journal-title":"Physiol Res"},{"key":"1020_CR14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mrfmmm.2011.05.012","volume":"713","author":"TA da Silva","year":"2011","unstructured":"da Silva TA, Fontes FL, Coutinho LG, de Souza FR, de Melo JT, de Souto JT, Leib SL, Agnez-Lima LF. SNPs in DNA repair genes associated to meningitis and host immune response. Mutat Res. 2011;713:39\u201347.","journal-title":"Mutat Res"},{"key":"1020_CR15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12881-015-0218-6","volume":"16","author":"FL Fontes","year":"2015","unstructured":"Fontes FL, de Ara\u00fajo LF, Coutinho LG, Leib SL, Agnez-Lima LF. Genetic polymorphisms associated with the inflammatory response in bacterial meningitis. BMC Med Genet. 2015;16:70.","journal-title":"BMC Med Genet"},{"key":"1020_CR16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/1471-2334-13-393","volume":"13","author":"DC Zysset-Burri","year":"2013","unstructured":"Zysset-Burri DC, Bellac CL, Leib SL, Wittwer M. Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis. BMC Infect Dis. 2013;13:393.","journal-title":"BMC Infect Dis"},{"key":"1020_CR17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/183751b0","volume":"183","author":"L Sokoloff","year":"1959","unstructured":"Sokoloff L, Lassen NA, Mckhann GM, Tower DB, Albers W. Effects of pyridoxine withdrawal on cerebral circulation and metabolism in a pyridoxine-dependent child. Nature. 1959;183:751\u20133.","journal-title":"Nature"},{"key":"1020_CR18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/molecules15010442","volume":"15","author":"H Hellmann","year":"2010","unstructured":"Hellmann H, Mooney S. Vitamin B6: a molecule for human health? Molecules. 2010;15:442\u201359.","journal-title":"Molecules"},{"issue":"Suppl 1","key":"1020_CR19","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1017\/S0007114507832971","volume":"98","author":"S Maggini","year":"2007","unstructured":"Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007;98(Suppl 1):S29\u201335.","journal-title":"Br J Nutr"},{"key":"1020_CR20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3945\/jn.109.114397","volume":"140","author":"MS Morris","year":"2010","unstructured":"Morris MS, Sakakeeny L, Jacques PF, Picciano MF, Selhub J. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr. 2010;140:103\u201310.","journal-title":"J Nutr"},{"key":"1020_CR21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000096218","volume":"29","author":"D Grandgirard","year":"2007","unstructured":"Grandgirard D, Bifrare YD, Pleasure SJ, Kummer J, Leib SL, Tauber MG. Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats. Dev Neurosci. 2007;29:134\u201342.","journal-title":"Dev Neurosci"},{"key":"1020_CR22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1086\/426399","volume":"191","author":"YD Bifrare","year":"2005","unstructured":"Bifrare YD, Kummer J, Joss P, Tauber MG, Leib SL. Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis. J Infect Dis. 2005;191:40\u20135.","journal-title":"J Infect Dis"},{"key":"1020_CR23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1741-7007-4-15","volume":"4","author":"RS Coimbra","year":"2006","unstructured":"Coimbra RS, Voisin V, de Saizieu AB, Lindberg RL, Wittwer M, Leppert D, Leib SL. Gene expression in cortex and hippocampus during acute pneumococcal meningitis. BMC Biol. 2006;4:15.","journal-title":"BMC Biol"},{"key":"1020_CR24","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1128\/MCB.02141-06","volume":"27","author":"RS Moubarak","year":"2007","unstructured":"Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J, Susin SA. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol. 2007;27:4844\u201362.","journal-title":"Mol Cell Biol"},{"key":"1020_CR25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.csbj.2015.03.004","volume":"13","author":"DG Fujikawa","year":"2015","unstructured":"Fujikawa DG. The role of excitotoxic programmed necrosis in acute brain injury. Comput Struct Biotechnol J. 2015;13:212\u201321.","journal-title":"Comput Struct Biotechnol J"},{"key":"1020_CR26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-7-49","volume":"7","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Bhavnani BR. Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neurosci. 2006;7:49.","journal-title":"BMC Neurosci"},{"key":"1020_CR27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00401-003-0672-7","volume":"105","author":"C Gianinazzi","year":"2003","unstructured":"Gianinazzi C, Grandgirard D, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Tauber MG, Borner C, Leib SL. Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta Neuropathol. 2003;105:499\u2013507.","journal-title":"Acta Neuropathol"},{"key":"1020_CR28","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","volume":"185","author":"M Leist","year":"1997","unstructured":"Leist M, Single B, Castoldi AF, K\u00fchnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med. 1997;185:1481\u20136.","journal-title":"J Exp Med"},{"key":"1020_CR29","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/BF03401713","volume":"3","author":"M Leist","year":"1997","unstructured":"Leist M, Volbracht C, Kuhnle S, Fava E, Ferrando-May E, Nicotera P. Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide. Mol Med. 1997;3:750\u201364.","journal-title":"Mol Med"},{"key":"1020_CR30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/bbrc.1999.0491","volume":"258","author":"M Leist","year":"1999","unstructured":"Leist M, Single B, Naumann H, Fava E, Simon B, Kuhnle S, Nicotera P. Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999;258:215\u201321.","journal-title":"Biochem Biophys Res Commun"},{"key":"1020_CR31","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/onc.2009.5","volume":"28","author":"CS Busso","year":"2009","unstructured":"Busso CS, Iwakuma T, Izumi T. Ubiquitination of mammalian AP endonuclease(APE1) regulated by the p53-MDM2 signaling pathway. Oncogene. 2009;28:1616\u201325.","journal-title":"Oncogene"},{"key":"1020_CR32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF03342699","volume":"84","author":"A Yoshida","year":"2006","unstructured":"Yoshida A, Pommier Y, Ueda T. Endonuclease activation and chromosomal DNA fragmentation during apoptosis in leukemia cells. Int J Hematol. 2006;84:31\u20137.","journal-title":"Int J Hematol"},{"key":"1020_CR33","doi-asserted-by":"crossref","first-page":"37768","DOI":"10.1074\/jbc.M304914200","volume":"278","author":"A Yoshida","year":"2003","unstructured":"Yoshida A, Urasaki Y, Waltham M, Bergman AC, Pourquier P, Rothwell DG, Inuzuka M, Weinstein JN, Ueda T, Appella E, Hickson ID, Pommier Y. Human apurinic\/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis. J Biol Chem. 2003;278:37768\u201376.","journal-title":"J Biol Chem"},{"key":"1020_CR34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ni885","volume":"4","author":"Z Fan","year":"2003","unstructured":"Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol. 2003;4:145\u201353.","journal-title":"Nat Immunol"},{"key":"1020_CR35","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/01.LAB.0000082393.02727.B5","volume":"83","author":"A Yoshida","year":"2003","unstructured":"Yoshida A, Elner SG, Bian ZM, Kindezelskii AL, Petty HR, Elner VM. Activated monocytes induce human retinal pigment epithelial cell apoptosis through caspase-3 activation. Lab Investig. 2003;83:1117\u201329.","journal-title":"Lab Investig"},{"key":"1020_CR36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.expneurol.2007.08.017","volume":"208","author":"IK Hwang","year":"2007","unstructured":"Hwang IK, Ahn HC, Yoo KY, Lee JY, Suh HW, Kwon YG, Cho JH, Won MH. Changes in immunoreactivity of HSP60 and its neuroprotective effects in the gerbil hippocampal CA1 region induced by transient ischemia. Exp Neurol. 2007;208:247\u201356.","journal-title":"Exp Neurol"},{"key":"1020_CR37","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1002\/jnr.22657","volume":"89","author":"CZ Yang","year":"2011","unstructured":"Yang CZ, Li HL, Zhou Y, Chai RC, Zhao R, Dong Y, et al. A new specialization in astrocytes: glutamate- and ammonia-induced nuclear size changes. J Neurosci Res. 2011;89:2041\u201351.","journal-title":"J Neurosci Res"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-017-1020-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T07:54:09Z","timestamp":1660118049000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-017-1020-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1020"],"URL":"https:\/\/doi.org\/10.1186\/s12974-017-1020-5","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"article-number":"243"}}