{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:20:42Z","timestamp":1793888442770,"version":"4.8.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Inner Wheel Australia"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1110195"],"award-info":[{"award-number":["APP1110195"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12974-018-1089-5","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T04:47:04Z","timestamp":1518842824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-461X","authenticated-orcid":false,"given":"Courtney A.","family":"McDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayla R.","family":"Penny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison C. B.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Nekkanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Yawno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margie","family":"Castillo-Melendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Fahey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Jenkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,17]]},"reference":[{"key":"1089_CR1","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1161\/hs1101.098367","volume":"32","author":"J Chen","year":"2001","unstructured":"Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, Sanchez-Ramos J, Chopp M. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32:2682\u20138.","journal-title":"Stroke"},{"key":"1089_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.expneurol.2016.06.017","volume":"283","author":"J Li","year":"2016","unstructured":"Li J, Yawno T, Sutherland A, Loose J, Nitsos I, Bischof R, Castillo-Melendez M, McDonald CA, Wong FY, Jenkin G, Miller SL. Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells. Exp Neurol. 2016;283:179\u201387.","journal-title":"Exp Neurol"},{"key":"1089_CR3","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1113\/JP271104","volume":"594","author":"JD Aridas","year":"2016","unstructured":"Aridas JD, McDonald CA, Paton MC, Yawno T, Sutherland AE, Nitsos I, Pham Y, Ditchfield M, Fahey MC, Wong F, et al. Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb. J Physiol. 2016;594:1421\u201335.","journal-title":"J Physiol"},{"key":"1089_CR4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1089\/scd.2009.0049","volume":"19","author":"PM Pimentel-Coelho","year":"2010","unstructured":"Pimentel-Coelho PM, Magalhaes ES, Lopes LM, deAzevedo LC, Santiago MF, Mendez-Otero R. Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum. Stem Cells Dev. 2010;19:351\u20138.","journal-title":"Stem Cells Dev"},{"key":"1089_CR5","doi-asserted-by":"publisher","first-page":"e20194","DOI":"10.1371\/journal.pone.0020194","volume":"6","author":"M Geissler","year":"2011","unstructured":"Geissler M, Dinse HR, Neuhoff S, Kreikemeier K, Meier C. Human umbilical cord blood cells restore brain damage induced changes in rat somatosensory cortex. PLoS One. 2011;6:e20194.","journal-title":"PLoS One"},{"key":"1089_CR6","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1203\/01.pdr.0000197309.08852.f5","volume":"59","author":"C Meier","year":"2006","unstructured":"Meier C, Middelanis J, Wasielewski B, Neuhoff S, Roth-Haerer A, Gantert M, Dinse HR, Dermietzel R, Jensen A. Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells. Pediatr Res. 2006;59:244\u20139.","journal-title":"Pediatr Res"},{"key":"1089_CR7","doi-asserted-by":"publisher","unstructured":"McDonald CA, Fahey MC, Jenkin G, Miller SL. Umbilical cord blood cells for treatment of cerebral palsy; timing and treatment options. Pediatr Res. 2017. https:\/\/doi.org\/10.1038\/pr.2017.236","DOI":"10.1038\/pr.2017.236"},{"key":"1089_CR8","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/stem.1304","volume":"31","author":"K Min","year":"2013","unstructured":"Min K, Song J, Kang JY, Ko J, Ryu JS, Kang MS, Jang SJ, Kim SH, Oh D, Kim MK, et al. Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial. Stem Cells. 2013;31:581\u201391.","journal-title":"Stem Cells"},{"key":"1089_CR9","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1089\/scd.2015.0074","volume":"24","author":"M Kang","year":"2015","unstructured":"Kang M, Min K, Jang J, Kim SC, Kang MS, Jang SJ, Lee JY, Kim SH, Kim MK, An SA, Kim M. Involvement of immune responses in the efficacy of cord blood cell therapy for cerebral palsy. Stem Cells Dev. 2015;24:2259\u201368.","journal-title":"Stem Cells Dev"},{"key":"1089_CR10","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.jcyt.2015.02.010","volume":"17","author":"YA Romanov","year":"2015","unstructured":"Romanov YA, Tarakanov OP, Radaev SM, Dugina TN, Ryaskina SS, Darevskaya AN, Morozova YV, Khachatryan WA, Lebedev KE, Zotova NS, et al. Human allogeneic AB0\/Rh-identical umbilical cord blood cells in the treatment of juvenile patients with cerebral palsy. Cytotherapy. 2015;17:969\u201378.","journal-title":"Cytotherapy"},{"key":"1089_CR11","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.5966\/sctm.2015-0372","volume":"5","author":"I Novak","year":"2016","unstructured":"Novak I, Walker K, Hunt RW, Wallace EM, Fahey M, Badawi N. Concise review: stem cell interventions for people with cerebral palsy: systematic review with meta-analysis. Stem Cells Transl Med. 2016;5:1014\u201325.","journal-title":"Stem Cells Transl Med"},{"key":"1089_CR12","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1182\/blood-2013-02-453175","volume":"122","author":"KK Ballen","year":"2013","unstructured":"Ballen KK, Gluckman E, Broxmeyer HE. Umbilical cord blood transplantation: the first 25 years and beyond. Blood. 2013;122:491\u20138.","journal-title":"Blood"},{"key":"1089_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/14653240510027190","volume":"7","author":"HE Broxmeyer","year":"2005","unstructured":"Broxmeyer HE. Biology of cord blood cells and future prospects for enhanced clinical benefit. Cytotherapy. 2005;7:209\u201318.","journal-title":"Cytotherapy"},{"key":"1089_CR14","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s10561-011-9262-4","volume":"13","author":"PV Phuc","year":"2012","unstructured":"Phuc PV, Ngoc VB, Lam DH, Tam NT, Viet PQ, Ngoc PK. Isolation of three important types of stem cells from the same samples of banked umbilical cord blood. Cell Tissue Bank. 2012;13:341\u201351.","journal-title":"Cell Tissue Bank"},{"key":"1089_CR15","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/j.1365-2141.2009.07781.x","volume":"147","author":"J Tolar","year":"2009","unstructured":"Tolar J, Hippen KL, Blazar BR. Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells. Br J Haematol. 2009;147:200\u20136.","journal-title":"Br J Haematol"},{"key":"1089_CR16","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1073\/pnas.86.10.3828","volume":"86","author":"HE Broxmeyer","year":"1989","unstructured":"Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D, Arny M, Thomas L, Boyse EA. Human umbilical cord blood as a potential source of transplantable hematopoietic stem\/progenitor cells. Proc Natl Acad Sci U S A. 1989;86:3828\u201332.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1089_CR17","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.jcyt.2015.03.002","volume":"17","author":"K Geneugelijk","year":"2015","unstructured":"Geneugelijk K, Spierings E. Immunogenetic factors in the selection of cord blood units for transplantation: current search strategies and future perspectives. Cytotherapy. 2015;17:702\u201310.","journal-title":"Cytotherapy"},{"key":"1089_CR18","first-page":"738","volume":"84","author":"G Sirchia","year":"1999","unstructured":"Sirchia G, Rebulla P. Placental\/umbilical cord blood transplantation. Haematologica. 1999;84:738\u201347.","journal-title":"Haematologica"},{"key":"1089_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2202-9-30","volume":"9","author":"S Hau","year":"2008","unstructured":"Hau S, Reich DM, Scholz M, Naumann W, Emmrich F, Kamprad M, Boltze J. Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro. BMC Neurosci. 2008;9:30.","journal-title":"BMC Neurosci"},{"key":"1089_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jsgi.2005.12.003","volume":"13","author":"JR Duncan","year":"2006","unstructured":"Duncan JR, Cock ML, Suzuki K, Scheerlinck JP, Harding R, Rees SM. Chronic endotoxin exposure causes brain injury in the ovine fetus in the absence of hypoxemia. J Soc Gynecol Investig. 2006;13:87\u201396.","journal-title":"J Soc Gynecol Investig"},{"key":"1089_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4939-1118-9_21","volume-title":"Perinatal stem cells","author":"C McDonald","year":"2014","unstructured":"McDonald C, Short M, Jenkin G, Bernard C. The potential of human amnion epithelial cells as an immunomodulatory and neuroregenerative treatment for multiple sclerosis. In: Atala A, Murphy SV, editors. Perinatal stem cells. New York: Springer; 2014. p. 231\u201342."},{"key":"1089_CR22","doi-asserted-by":"publisher","first-page":"16467","DOI":"10.1523\/JNEUROSCI.2582-14.2014","volume":"34","author":"D Yang","year":"2014","unstructured":"Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS, Liu CY, et al. Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci. 2014;34:16467\u201381.","journal-title":"J Neurosci"},{"key":"1089_CR23","doi-asserted-by":"crossref","unstructured":"Hagberg H, Mallard C, Ferriero DM, Vannucci SJ, Levison SW, Vexler ZS, Gressens P. The role of inflammation in perinatal brain injury. Nat Rev Neurol. 2015;11(4):192-208.","DOI":"10.1038\/nrneurol.2015.13"},{"key":"1089_CR24","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ana.410090206","volume":"9","author":"JE Rice 3rd","year":"1981","unstructured":"Rice JE 3rd, Vannucci RC, Brierley JB. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol. 1981;9:131\u201341.","journal-title":"Ann Neurol"},{"key":"1089_CR25","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1203\/PDR.0b013e31816d9117","volume":"63","author":"NM Jones","year":"2008","unstructured":"Jones NM, Kardashyan L, Callaway JK, Lee EM, Beart PM. Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats. Pediatr Res. 2008;63:620\u20134.","journal-title":"Pediatr Res"},{"key":"1089_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bbr.2017.06.036","volume":"333","author":"JD Teo","year":"2017","unstructured":"Teo JD, Morris MJ, Jones NM. Hypoxic postconditioning improves behavioural deficits at 6 weeks following hypoxic-ischemic brain injury in neonatal rats. Behav Brain Res. 2017;333:27\u201334.","journal-title":"Behav Brain Res"},{"key":"1089_CR27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12974-015-0322-8","volume":"12","author":"CA McDonald","year":"2015","unstructured":"McDonald CA, Payne NL, Sun G, Moussa L, Siatskas C, Lim R, Wallace EM, Jenkin G, Bernard CC. Immunosuppressive potential of human amnion epithelial cells in the treatment of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2015;12:112.","journal-title":"J Neuroinflammation"},{"key":"1089_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jneuroim.2014.09.022","volume":"277","author":"CA McDonald","year":"2014","unstructured":"McDonald CA, Payne NL, Sun G, Clayton DJ, Del Borgo MP, Aguilar MI, Perlmutter P, Bernard CC. Single beta(3)-amino acid substitutions to MOG peptides suppress the development of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014;277:67\u201376.","journal-title":"J Neuroimmunol"},{"key":"1089_CR29","doi-asserted-by":"publisher","first-page":"373","DOI":"10.4161\/cam.5.5.17948","volume":"5","author":"MA Short","year":"2011","unstructured":"Short MA, Campanale N, Litwak S, Bernard CC. Quantitative and phenotypic analysis of bone marrow-derived cells in the intact and inflamed central nervous system. Cell Adhes Migr. 2011;5:373\u201381.","journal-title":"Cell Adhes Migr"},{"key":"1089_CR30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/scrt542","volume":"6","author":"JL Tan","year":"2015","unstructured":"Tan JL, Chan ST, Lo CY, Deane JA, McDonald CA, Bernard CC, Wallace EM, Lim R. Amnion cell mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response. Stem Cell Res Ther. 2015;6:8.","journal-title":"Stem Cell Res Ther"},{"key":"1089_CR31","doi-asserted-by":"publisher","unstructured":"Zhang X, Lian W, Lou W, Han S, Lu C, Zuo K, Su H, Xu J, Cao C, Tang T, et al. Transcatheter arterial infusion of autologous CD133(+) cells for diabetic peripheral artery disease. Stem Cells Int. 2016. https:\/\/doi.org\/10.1155\/2016\/6925357","DOI":"10.1155\/2016\/6925357"},{"key":"1089_CR32","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1182\/blood-2006-12-062471","volume":"109","author":"JM Melero-Martin","year":"2007","unstructured":"Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood. 2007;109:4761\u20138.","journal-title":"Blood"},{"key":"1089_CR33","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1002\/stem.1164","volume":"30","author":"Y Liu","year":"2012","unstructured":"Liu Y, Teoh SH, Chong MS, Lee ES, Mattar CN, Randhawa NK, Zhang ZY, Medina RJ, Kamm RD, Fisk NM, et al. Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells. Stem Cells. 2012;30:1911\u201324.","journal-title":"Stem Cells"},{"key":"1089_CR34","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3389\/fphys.2016.00599","volume":"7","author":"NA Malinovskaya","year":"2016","unstructured":"Malinovskaya NA, Komleva YK, Salmin VV, Morgun AV, Shuvaev AN, Panina YA, Boitsova EB, Salmina AB. Endothelial progenitor cells physiology and metabolic plasticity in brain angiogenesis and blood-brain barrier modeling. Front Physiol. 2016;7:599.","journal-title":"Front Physiol"},{"key":"1089_CR35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/shk.0b013e31805cddce","volume":"29","author":"CH Kao","year":"2008","unstructured":"Kao CH, Chen SH, Chio CC, Lin MT. Human umbilical cord blood-derived CD34+ cells may attenuate spinal cord injury by stimulating vascular endothelial and neurotrophic factors. Shock. 2008;29:49\u201355.","journal-title":"Shock"},{"key":"1089_CR36","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00441-012-1401-0","volume":"348","author":"K Rosenkranz","year":"2012","unstructured":"Rosenkranz K, Kumbruch S, Tenbusch M, Marcus K, Marschner K, Dermietzel R, Meier C. Transplantation of human umbilical cord blood cells mediated beneficial effects on apoptosis, angiogenesis and neuronal survival after hypoxic-ischemic brain injury in rats. Cell Tissue Res. 2012;348:429\u201338.","journal-title":"Cell Tissue Res"},{"key":"1089_CR37","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/j.1750-3639.2011.00495.x","volume":"21","author":"V Moline-Velazquez","year":"2011","unstructured":"Moline-Velazquez V, Cuervo H, Vila-Del Sol V, Ortega MC, Clemente D, de Castro F. Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis. Brain Pathol. 2011;21:678\u201391.","journal-title":"Brain Pathol"},{"key":"1089_CR38","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/cei.12143","volume":"174","author":"N Rieber","year":"2013","unstructured":"Rieber N, Gille C, Kostlin N, Schafer I, Spring B, Ost M, Spieles H, Kugel HA, Pfeiffer M, Heininger V, et al. Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses. Clin Exp Immunol. 2013;174:45\u201352.","journal-title":"Clin Exp Immunol"},{"key":"1089_CR39","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.mcn.2014.01.004","volume":"59","author":"TA Womble","year":"2014","unstructured":"Womble TA, Green S, Shahaduzzaman M, Grieco J, Sanberg PR, Pennypacker KR, Willing AE. Monocytes are essential for the neuroprotective effect of human cord blood cells following middle cerebral artery occlusion in rat. Mol Cell Neurosci. 2014;59:76\u201384.","journal-title":"Mol Cell Neurosci"},{"key":"1089_CR40","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/pr.2012.71","volume":"72","author":"ES Kim","year":"2012","unstructured":"Kim ES, Ahn SY, Im GH, Sung DK, Park YR, Choi SH, Choi SJ, Chang YS, Oh W, Lee JH, Park WS. Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats. Pediatr Res. 2012;72:277\u201384.","journal-title":"Pediatr Res"},{"key":"1089_CR41","doi-asserted-by":"publisher","first-page":"e0120893","DOI":"10.1371\/journal.pone.0120893","volume":"10","author":"WS Park","year":"2015","unstructured":"Park WS, Sung SI, Ahn SY, Yoo HS, Sung DK, Im GH, Choi SJ, Chang YS. Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy. PLoS One. 2015;10:e0120893.","journal-title":"PLoS One"},{"key":"1089_CR42","doi-asserted-by":"publisher","first-page":"723","DOI":"10.3727\/096368911X586783","volume":"21","author":"J Boltze","year":"2012","unstructured":"Boltze J, Reich DM, Hau S, Reymann KG, Strassburger M, Lobsien D, Wagner DC, Kamprad M, Stahl T. Assessment of neuroprotective effects of human umbilical cord blood mononuclear cell subpopulations in vitro and in vivo. Cell Transplant. 2012;21:723\u201337.","journal-title":"Cell Transplant"},{"key":"1089_CR43","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neuroscience.2014.01.018","volume":"263","author":"M Tsuji","year":"2014","unstructured":"Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M, et al. Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke. Neuroscience. 2014;263:148\u201358.","journal-title":"Neuroscience"},{"key":"1089_CR44","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.3727\/096368912X657620","volume":"22","author":"NL Payne","year":"2013","unstructured":"Payne NL, Sun G, McDonald C, Layton D, Moussa L, Emerson-Webber A, Veron N, Siatskas C, Herszfeld D, Price J, Bernard CC. Distinct immunomodulatory and migratory mechanisms underpin the therapeutic potential of human mesenchymal stem cells in autoimmune demyelination. Cell Transplant. 2013;22:1409\u201325.","journal-title":"Cell Transplant"},{"key":"1089_CR45","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.exphem.2006.07.011","volume":"34","author":"G Kogler","year":"2006","unstructured":"Kogler G, Sensken S, Wernet P. Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood. Exp Hematol. 2006;34:1589\u201395.","journal-title":"Exp Hematol"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1089-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T13:30:58Z","timestamp":1660483858000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-018-1089-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,17]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1089"],"URL":"https:\/\/doi.org\/10.1186\/s12974-018-1089-5","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,17]]},"assertion":[{"value":"16 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experiments in this project were performed with human ethics approval from Monash Health Human Ethics Committee and animal ethics approval from Monash Medical Centre Animal Ethics Committee A. All experiments were performed in accordance with the Australian National Health and Medical Research Council guidelines.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"47"}}