{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:29:35Z","timestamp":1794324575943,"version":"4.9.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471222"],"award-info":[{"award-number":["81471222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taishan Scholars Construction Engineering of Shandong Province","award":["ts20130914"],"award-info":[{"award-number":["ts20130914"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12974-018-1095-7","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T11:06:34Z","timestamp":1519211194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis"],"prefix":"10.1186","volume":"15","author":[{"given":"Ru-Tao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ru","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Tao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Sheng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"issue":"10","key":"1095_CR1","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(08)70215-1","volume":"7","author":"PA van Doorn","year":"2008","unstructured":"van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barre syndrome. Lancet Neurol. 2008;7(10):939\u201350.","journal-title":"Lancet Neurol"},{"key":"1095_CR2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jneuroim.2017.02.003","volume":"305","author":"M Zhang","year":"2017","unstructured":"Zhang M, Liu RT, Zhang P, Zhang N, Yang CL, Yue LT, Li XL, Liu Y, Li H, Du J, et al. Parthenolide inhibits the initiation of experimental autoimmune neuritis. J Neuroimmunol. 2017;305:154\u201361.","journal-title":"J Neuroimmunol"},{"issue":"3","key":"1095_CR3","doi-asserted-by":"publisher","first-page":"999","DOI":"10.4049\/jimmunol.1601318","volume":"198","author":"IA Bettencourt","year":"2017","unstructured":"Bettencourt IA, Powell JD. Targeting metabolism as a novel therapeutic approach to autoimmunity, inflammation, and transplantation. J Immunol. 2017;198(3):999\u20131005.","journal-title":"J Immunol"},{"issue":"23","key":"1095_CR4","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1182\/blood-2009-10-249540","volume":"115","author":"CM Krawczyk","year":"2010","unstructured":"Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood. 2010;115(23):4742\u20139.","journal-title":"Blood"},{"issue":"1","key":"1095_CR5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","volume":"21","author":"EM Palsson-McDermott","year":"2015","unstructured":"Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, et al. Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21(1):65\u201380.","journal-title":"Cell Metab"},{"issue":"3191","key":"1095_CR6","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309\u201314.","journal-title":"Science"},{"issue":"7","key":"1095_CR7","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/cr.2015.68","volume":"25","author":"B Kelly","year":"2015","unstructured":"Kelly B, O'Neill LA. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 2015;25(7):771\u201384.","journal-title":"Cell Res"},{"issue":"6","key":"1095_CR8","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","volume":"186","author":"RD Michalek","year":"2011","unstructured":"Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, Sullivan SA, Nichols AG, Rathmell JC. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol. 2011;186(6):3299\u2013303.","journal-title":"J Immunol"},{"issue":"5930","key":"1095_CR9","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1126\/science.1164097","volume":"324","author":"KE Wellen","year":"2009","unstructured":"Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science. 2009;324(5930):1076\u201380.","journal-title":"Science"},{"issue":"7444","key":"1095_CR10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","volume":"496","author":"GM Tannahill","year":"2013","unstructured":"Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, et al. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238\u201342.","journal-title":"Nature"},{"issue":"1","key":"1095_CR11","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4049\/jimmunol.1501537","volume":"196","author":"Y Yin","year":"2016","unstructured":"Yin Y, Choi SC, Xu Z, Zeumer L, Kanda N, Croker BP, Morel L. Glucose oxidation is critical for CD4+ T cell activation in a mouse model of systemic lupus erythematosus. J Immunol. 2016;196(1):80\u201390.","journal-title":"J Immunol"},{"key":"1095_CR12","doi-asserted-by":"publisher","first-page":"42412","DOI":"10.1038\/srep42412","volume":"7","author":"T Okano","year":"2017","unstructured":"Okano T, Saegusa J, Nishimura K, Takahashi S, Sendo S, Ueda Y, Morinobu A. 3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17\/Treg cell differentiation and suppressing dendritic cell activation. Sci Rep. 2017;7:42412.","journal-title":"Sci Rep"},{"key":"1095_CR13","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.coi.2017.04.010","volume":"46","author":"CM Weyand","year":"2017","unstructured":"Weyand CM, Zeisbrich M, Goronzy JJ. Metabolic signatures of T-cells and macrophages in rheumatoid arthritis. Curr Opin Immunol. 2017;46:112\u201320.","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"1095_CR14","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1177\/0148607192016005464","volume":"16","author":"RA Roubenoff","year":"1992","unstructured":"Roubenoff RA, Borel CO, Hanley DF. Hypermetabolism and hypercatabolism in Guillain-Barre syndrome. JPEN J Parenter Enteral Nutr. 1992;16(5):464\u201372.","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"12","key":"1095_CR15","doi-asserted-by":"publisher","first-page":"e0145075","DOI":"10.1371\/journal.pone.0145075","volume":"10","author":"Y Wang","year":"2015","unstructured":"Wang Y, Li G, Yang S, Gu X, Li X, Liu M, Wu X, Guan Y, Press R, Zhu J, et al. Fasting glucose levels correlate with disease severity of Guillain-Barre syndrome. PLoS One. 2015;10(12):e0145075.","journal-title":"PLoS One"},{"issue":"4","key":"1095_CR16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ni.2833","volume":"15","author":"B Everts","year":"2014","unstructured":"Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, et al. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol. 2014;15(4):323\u201332.","journal-title":"Nat Immunol"},{"issue":"7","key":"1095_CR17","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1084\/jem.20110278","volume":"208","author":"LZ Shi","year":"2011","unstructured":"Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med. 2011;208(7):1367\u201376.","journal-title":"J Exp Med"},{"issue":"2","key":"1095_CR18","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0021-9258(18)64988-9","volume":"224","author":"AN Wick","year":"1957","unstructured":"Wick AN, Drury DR, Nakada HI, Wolfe JB. Localization of the primary metabolic block produced by 2-deoxyglucose. J Biol Chem. 1957;224(2):963\u20139.","journal-title":"J Biol Chem"},{"issue":"3","key":"1095_CR19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1084\/jem.20150900","volume":"213","author":"T Shirai","year":"2016","unstructured":"Shirai T, Nazarewicz RR, Wallis BB, Yanes RE, Watanabe R, Hilhorst M, Tian L, Harrison DG, Giacomini JC, Assimes TL, et al. The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease. J Exp Med. 2016;213(3):337\u201354.","journal-title":"J Exp Med"},{"issue":"5","key":"1095_CR20","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S0028-3908(02)00015-1","volume":"42","author":"LP Zou","year":"2002","unstructured":"Zou LP, Abbas N, Volkmann I, Nennesmo I, Levi M, Wahren B, Winblad B, Hedlund G, Zhu J. Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1\/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue. Neuropharmacology. 2002;42(5):731\u20139.","journal-title":"Neuropharmacology"},{"key":"1095_CR21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.mcn.2015.08.010","volume":"68","author":"H Li","year":"2015","unstructured":"Li H, Wang CC, Zhang M, Li XL, Zhang P, Yue LT, Miao S, Wang S, Liu Y, Li YB, et al. Statin-modified dendritic cells regulate humoral immunity in experimental autoimmune myasthenia gravis. Mol Cell Neurosci. 2015;68:284\u201392.","journal-title":"Mol Cell Neurosci"},{"key":"1095_CR22","doi-asserted-by":"publisher","first-page":"20049","DOI":"10.1038\/srep20049","volume":"6","author":"Y Li","year":"2016","unstructured":"Li Y, Qi W, Song X, Lv S, Zhang H, Yang Q. Huaier extract suppresses breast cancer via regulating tumor-associated macrophages. Sci Rep. 2016;6:20049.","journal-title":"Sci Rep"},{"key":"1095_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.redox.2016.09.005","volume":"10","author":"WA Baseler","year":"2016","unstructured":"Baseler WA, Davies LC, Quigley L, Ridnour LA, Weiss JM, Hussain SP, Wink DA, DW MV. Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production. Redox Biol. 2016;10:12\u201323.","journal-title":"Redox Biol"},{"issue":"Suppl","key":"1095_CR24","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1002\/ana.410270716","volume":"27","author":"HP Hartung","year":"1990","unstructured":"Hartung HP, Toyka KV. T-cell and macrophage activation in experimental autoimmune neuritis and Guillain-Barre syndrome. Ann Neurol. 1990;27(Suppl):S57\u201363.","journal-title":"Ann Neurol"},{"issue":"4","key":"1095_CR25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","volume":"41","author":"S Crotty","year":"2014","unstructured":"Crotty S. T follicular helper cell differentiation, function, and roles in disease. Immunity. 2014;41(4):529\u201342.","journal-title":"Immunity"},{"issue":"2","key":"1095_CR26","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","volume":"71","author":"LE Raez","year":"2013","unstructured":"Raez LE, Papadopoulos K, Ricart AD, Chiorean EG, Dipaola RS, Stein MN, Rocha Lima CM, Schlesselman JJ, Tolba K, Langmuir VK, et al. A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013;71(2):523\u201330.","journal-title":"Cancer Chemother Pharmacol"},{"issue":"Pt 5","key":"1095_CR27","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1093\/brain\/111.5.1039","volume":"111","author":"HP Hartung","year":"1988","unstructured":"Hartung HP, Schafer B, Heininger K, Stoll G, Toyka KV. The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Serial clinical, electrophysiological, biochemical and morphological observations. Brain. 1988;111(Pt 5):1039\u201359.","journal-title":"Brain"},{"issue":"4","key":"1095_CR28","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00415-010-5836-5","volume":"258","author":"MO Lu","year":"2011","unstructured":"Lu MO, Zhu J. The role of cytokines in Guillain-Barre syndrome. J Neurol. 2011;258(4):533\u201348.","journal-title":"J Neurol"},{"issue":"1","key":"1095_CR29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12974-017-0864-z","volume":"14","author":"B Ambrosius","year":"2017","unstructured":"Ambrosius B, Pitarokoili K, Schrewe L, Pedreiturria X, Motte J, Gold R. Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection. J Neuroinflammation. 2017;14(1):92.","journal-title":"J Neuroinflammation"},{"issue":"3","key":"1095_CR30","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.immuni.2016.08.017","volume":"45","author":"H Zeng","year":"2016","unstructured":"Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, et al. mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation. Immunity. 2016;45(3):540\u201354.","journal-title":"Immunity"},{"issue":"3","key":"1095_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/ni.3664","volume":"18","author":"J Jellusova","year":"2017","unstructured":"Jellusova J, Cato MH, Apgar JR, Ramezani-Rad P, Leung CR, Chen C, Richardson AD, Conner EM, Benschop RJ, Woodgett JR, et al. Gsk3 is a metabolic checkpoint regulator in B cells. Nat Immunol. 2017;18(3):303\u201312.","journal-title":"Nat Immunol"},{"issue":"1","key":"1095_CR32","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.expneurol.2011.11.039","volume":"233","author":"K Susuki","year":"2012","unstructured":"Susuki K, Yuki N, Schafer DP, Hirata K, Zhang G, Funakoshi K, Rasband MN. Dysfunction of nodes of Ranvier: a mechanism for anti-ganglioside antibody-mediated neuropathies. Exp Neurol. 2012;233(1):534\u201342.","journal-title":"Exp Neurol"},{"issue":"2","key":"1095_CR33","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/1531-8249(199902)45:2<168::AID-ANA6>3.0.CO;2-6","volume":"45","author":"TW Ho","year":"1999","unstructured":"Ho TW, Willison HJ, Nachamkin I, Li CY, Veitch J, Ung H, Wang GR, Liu RC, Cornblath DR, Asbury AK, et al. Anti-GD1a antibody is associated with axonal but not demyelinating forms of Guillain-Barre syndrome. Ann Neurol. 1999;45(2):168\u201373.","journal-title":"Ann Neurol"},{"issue":"1","key":"1095_CR34","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1159\/000243086","volume":"17","author":"CL De La Hoz","year":"2010","unstructured":"De La Hoz CL, Castro FR, Santos LM, Langone F. Distribution of inducible nitric oxide synthase and tumor necrosis factor-alpha in the peripheral nervous system of Lewis rats during ascending paresis and spontaneous recovery from experimental autoimmune neuritis. Neuroimmunomodulation. 2010;17(1):56\u201366.","journal-title":"Neuroimmunomodulation"},{"issue":"1","key":"1095_CR35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0165-5728(94)00192-Q","volume":"58","author":"J Zielasek","year":"1995","unstructured":"Zielasek J, Jung S, Gold R, Liew FY, Toyka KV, Hartung HP. Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. J Neuroimmunol. 1995;58(1):81\u20138.","journal-title":"J Neuroimmunol"},{"issue":"12","key":"1095_CR36","doi-asserted-by":"publisher","first-page":"5312","DOI":"10.1073\/pnas.92.12.5312","volume":"92","author":"DC Hooper","year":"1995","unstructured":"Hooper DC, Ohnishi ST, Kean R, Numagami Y, Dietzschold B, Koprowski H. Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc Natl Acad Sci U S A. 1995;92(12):5312\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 12","key":"1095_CR37","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1093\/brain\/120.12.2149","volume":"120","author":"EJ Redford","year":"1997","unstructured":"Redford EJ, Kapoor R, Smith KJ. Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible. Brain. 1997;120(Pt 12):2149\u201357.","journal-title":"Brain"},{"issue":"1\u20132","key":"1095_CR38","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S0165-5728(02)00058-9","volume":"126","author":"Y Lee","year":"2002","unstructured":"Lee Y, Shin T. Expression of constitutive endothelial and inducible nitric oxide synthase in the sciatic nerve of Lewis rats with experimental autoimmune neuritis. J Neuroimmunol. 2002;126(1\u20132):78\u201385.","journal-title":"J Neuroimmunol"},{"issue":"4","key":"1095_CR39","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1046\/j.1471-4159.2000.0751455.x","volume":"75","author":"A Bal-Price","year":"2000","unstructured":"Bal-Price A, Brown GC. Nitric-oxide-induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J Neurochem. 2000;75(4):1455\u201364.","journal-title":"J Neurochem"},{"issue":"6","key":"1095_CR40","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1046\/j.1471-4159.1997.68062227.x","volume":"68","author":"JP Bolanos","year":"1997","unstructured":"Bolanos JP, Almeida A, Stewart V, Peuchen S, Land JM, Clark JB, Heales SJ. Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J Neurochem. 1997;68(6):2227\u201340.","journal-title":"J Neurochem"},{"issue":"5","key":"1095_CR41","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1053\/berh.2001.0196","volume":"15","author":"SB Abramson","year":"2001","unstructured":"Abramson SB, Amin AR, Clancy RM, Attur M. The role of nitric oxide in tissue destruction. Best Pract Res Clin Rheumatol. 2001;15(5):831\u201345.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"20","key":"1095_CR42","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.1523\/JNEUROSCI.23-20-07470.2003","volume":"23","author":"JS Won","year":"2003","unstructured":"Won JS, Im YB, Key L, Singh I, Singh AK. The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT\/enhancing binding protein. J Neurosci. 2003;23(20):7470\u20138.","journal-title":"J Neurosci"},{"issue":"2","key":"1095_CR43","first-page":"127","volume":"20","author":"PW Lampert","year":"1969","unstructured":"Lampert PW. Mechanism of demyelination in experimental allergic neuritis. Electron microscopic studies. Lab Investig. 1969;20(2):127\u201338.","journal-title":"Lab Investig"},{"issue":"2","key":"1095_CR44","first-page":"225","volume":"8","author":"RH Ballin","year":"1969","unstructured":"Ballin RH, Thomas PK. Electron microscope observations on demyelination and remyelination in experimental allergic neuritis. 2. Remyelination. J Neurol Sci. 1969;8(2):225\u201337.","journal-title":"J Neurol Sci"},{"key":"1095_CR45","doi-asserted-by":"publisher","first-page":"11635","DOI":"10.1038\/ncomms11635","volume":"7","author":"H Semba","year":"2016","unstructured":"Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, et al. HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:11635.","journal-title":"Nat Commun"},{"issue":"1","key":"1095_CR46","doi-asserted-by":"publisher","first-page":"4900","DOI":"10.1038\/s41598-017-05054-0","volume":"7","author":"LS Forero-Quintero","year":"2017","unstructured":"Forero-Quintero LS, Deitmer JW, Becker HM. Reduction of epileptiform activity in ketogenic mice: the role of monocarboxylate transporters. Sci Rep. 2017;7(1):4900.","journal-title":"Sci Rep"},{"issue":"5","key":"1095_CR47","doi-asserted-by":"publisher","first-page":"e35476","DOI":"10.1371\/journal.pone.0035476","volume":"7","author":"DY Kim","year":"2012","unstructured":"Kim DY, Hao J, Liu R, Turner G, Shi FD, Rho JM. Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS One. 2012;7(5):e35476.","journal-title":"PLoS One"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1095-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T17:01:24Z","timestamp":1660496484000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-018-1095-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1095"],"URL":"https:\/\/doi.org\/10.1186\/s12974-018-1095-7","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]},"assertion":[{"value":"28 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All of the experimental protocols with rats have been approved by the institutional ethics committee of Shandong University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"51"}}