{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:05:48Z","timestamp":1784765148651,"version":"3.55.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"MINECO\u00a0","award":["SAF2013-46292-R"],"award-info":[{"award-number":["SAF2013-46292-R"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12974-018-1096-6","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T02:47:49Z","timestamp":1519786069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The effect of excess weight on circulating inflammatory cytokines in drug-na\u00efve first-episode psychosis individuals"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-6515","authenticated-orcid":false,"given":"Mar\u00eda","family":"Juncal-Ruiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Riesco-D\u00e1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Ortiz-Garc\u00eda","family":"de la Foz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariluz","family":"Ram\u00edrez-Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obdulia","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Irure-Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Leza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"L\u00f3pez-Hoyos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicto","family":"Crespo-Facorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"1096_CR1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.cellimm.2012.01.001","volume":"273","author":"L \u00c1lvarez-Rodr\u00edguez","year":"2012","unstructured":"\u00c1lvarez-Rodr\u00edguez L, L\u00f3pez-Hoyos M, Mu\u00f1oz-Cacho P, Mart\u00ednez-Taboada VM. Aging is associated with circulating cytokine dysregulation. Cell Immunol. 2012;273:124\u201332.","journal-title":"Cell Immunol"},{"issue":"8","key":"1096_CR2","doi-asserted-by":"publisher","first-page":"390","DOI":"10.4239\/wjd.v8.i8.390","volume":"8","author":"A Annamalai","year":"2017","unstructured":"Annamalai A, Kosir U, Tek C. Prevalence of obesity and diabetes in patients with schizophrenia. World J Diabetes. 2017;8(8):390\u20136.","journal-title":"World J Diabetes"},{"key":"1096_CR3","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.psyneuen.2012.04.001","volume":"37","author":"W Beumer","year":"2012","unstructured":"Beumer W, Drexhage RC, De Wit H, Versnel MA, Drexhage HA, Cohen D. Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome. Psychoneruendocrinology. 2012;37:1901\u201311.","journal-title":"Psychoneruendocrinology"},{"key":"1096_CR4","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.3390\/ijms18112238","volume":"18","author":"L Borska","year":"2017","unstructured":"Borska L, Kremlacek J, Andrys C, Krejsek J, Hamakova K, Borsky P, Palicka V, et al. Systemic inflammation, oxidative damage to nucleic acids, and metabolic syndrome in the pathogenesis of psoriasis. Int J Mol Sci. 2017;18:2238.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1096_CR5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.psychres.2006.08.005","volume":"158","author":"B Crespo-Facorro","year":"2008","unstructured":"Crespo-Facorro B, Carrasco-Mar\u00edn E, P\u00e9rez-Iglesias R, Pelayo-Ter\u00e1n JM, Fernandez- Prieto L, Leyva-Cobi\u00e1n F, V\u00e1zquez-Barquero JL. Interleukin-12 plasma levels in drug-na\u00efve patients with a first episode of psychosis: effects of antipsychotic drugs. Psychiatry Res. 2008;158(2):206\u201316.","journal-title":"Psychiatry Res"},{"key":"1096_CR6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bbi.2012.06.010","volume":"31","author":"M Di Nicola","year":"2012","unstructured":"Di Nicola M, Cattaneo A, Hepgul N, Di Forti M, Aitchison KJ, Janiri L, Murray RM, Dazzan P, Pariante CM, Mondelli V. Serum and gene expression profile of cytokines in first-episode psychosis. Brain Behav Immun. 2012;31:90\u20135.","journal-title":"Brain Behav Immun"},{"key":"1096_CR7","doi-asserted-by":"crossref","unstructured":"Ding M, Song X, Zhao J, Gao J, Li X, Yang G, Wang X, Harrington A, Fan X, Lv L. Activation of Th17 cells in drug naive, first episode schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry. 2014;51:78\u201382.","DOI":"10.1016\/j.pnpbp.2014.01.001"},{"key":"1096_CR8","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/mp.2012.110","volume":"18","author":"SG Fillman","year":"2013","unstructured":"Fillman SG, Cloonan N, Catts VS, Miller LC, Wong J, McCrossin T, et al. Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol Psychiatry. 2013;18:206\u201314.","journal-title":"Mol Psychiatry"},{"key":"1096_CR9","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1093\/schbul\/sbv002","volume":"41","author":"G Fond","year":"2015","unstructured":"Fond G, d\u2019Albis MA, Jamain S, Tamouza R, Arango C, Fleischhacker WW, Glenth\u00f8j B, et al. The promise of biological markers for treatment response in first-episode psycho-sis: a systematic review. Schizophr Bull. 2015;41:559\u201373.","journal-title":"Schizophr Bull"},{"key":"1096_CR10","doi-asserted-by":"publisher","unstructured":"Fond G, Resseguier N, Sch\u00fcrhoff F, Godin O, Andrianarisoa M, Brunel L, Bulzacka E, et al. Relationships between low-grade peripheral inflammation and psychotropic drugs in schizophrenia: results from the national FACE-SZ cohort. Eur Arch Psychiatry Clin Neurosci. 2017; https:\/\/doi.org\/10.1007\/s00406-017-0847-1 .","DOI":"10.1007\/s00406-017-0847-1"},{"issue":"2","key":"1096_CR11","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/schbul\/sbt001","volume":"40","author":"B Garc\u00eda-Bueno","year":"2014","unstructured":"Garc\u00eda-Bueno B, Bioque M, Mac-Dowell KS, Barcones MF, Mart\u00ednez-Cengotitabengoa M, Pina-Camacho L, Rodr\u00edguez-Jim\u00e9nez R, S\u00e1iz PA, Castro C, Lafuente A, Santab\u00e1rbara J, Gonz\u00e1lez-Pinto A, Parellada M, Rubio G, Garc\u00eda-Portilla MP, Mic\u00f3 JA, Bernardo M, Leza JC. Pro-\/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. Schizophr Bull. 2014a;40(2):376\u201387.","journal-title":"Schizophr Bull"},{"key":"1096_CR12","doi-asserted-by":"publisher","unstructured":"Garc\u00eda-Bueno B, Bioque M, MacDowell KS, Santab\u00e1rbara J, Mart\u00ednez-Cengotitabengoa M, Moreno C, S\u00e1iz PA, Berrocoso E, Gass\u00f3 P, Fe Barcones M, Gonz\u00e1lez-Pinto A, Parellada M, Bobes J, Mic\u00f3 JA, Bernardo M, Leza JC. Pro-\/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study. Int J Neuropsychopharmacol. 2014b;18(2) https:\/\/doi.org\/10.1093\/ijnp\/pyu037 .","DOI":"10.1093\/ijnp\/pyu037"},{"issue":"3","key":"1096_CR13","doi-asserted-by":"publisher","first-page":"E46","DOI":"10.1503\/jpn.150195","volume":"41","author":"B Garc\u00eda-Bueno","year":"2016","unstructured":"Garc\u00eda-Bueno B, Gass\u00f3 P, MacDowell KS, Callado LF, Mas S, Bernardo M, Lafuente A, Meana JJ, Leza JC. Evidence of activation of the Toll-like receptor-4 pro-inflammatory pathway in patients with schizophrenia. J Psychiatry Neurosci. 2016 May;41(3):E46\u201355. https:\/\/doi.org\/10.1503\/jpn.150195 .","journal-title":"J Psychiatry Neurosci"},{"key":"1096_CR14","doi-asserted-by":"publisher","unstructured":"Hayes LN, Severance EG, Leek JT, Gressitt KL, Rohleder C, Coughlin JM, Leweke M, et al. Inflammatory molecular signature associated with infectious agents in psychosis. Schizophr Bull. 2014; p. 963\u201372. https:\/\/doi.org\/10.1093\/schbul\/sbu052 .","DOI":"10.1093\/schbul\/sbu052"},{"key":"1096_CR15","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","volume":"70","author":"BJ Miller","year":"2011","unstructured":"Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry. 2011;70:663\u201371.","journal-title":"Biol Psychiatry"},{"issue":"7203","key":"1096_CR16","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428\u201335.","journal-title":"Nature"},{"key":"1096_CR17","doi-asserted-by":"publisher","unstructured":"Monteiro R & Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediat Inflamm. 2010; 2010: 289645. https:\/\/doi.org\/10.1155\/2010\/289645 .","DOI":"10.1155\/2010\/289645"},{"issue":"4","key":"1096_CR18","doi-asserted-by":"publisher","first-page":"pyu042","DOI":"10.1093\/ijnp\/pyu042","volume":"18","author":"C Noto","year":"2015","unstructured":"Noto C, Ota VK, Gouvea ES, Rizzo LB, Spindola LM, Honda PH, Cordeiro Q, et al. Effects of risperidone on cytokine profile in drug-na\u00efve first-episode psychosis. Int J Neuropsychopharmacol. 2015 Feb;18(4):pyu042. https:\/\/doi.org\/10.1093\/ijnp\/pyu042 .","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"1096_CR19","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/j.1751-7893.2008.00074.x","volume":"2","author":"JM Pelayo-Ter\u00e1n","year":"2008","unstructured":"Pelayo-Ter\u00e1n JM, P\u00e9rez-Iglesias R, Ram\u00edrez-Bonilla M, Gonz\u00e1lez-Blanch C, Mart\u00ednez-Garc\u00eda O, Pardo-Garc\u00eda G, Rodr\u00edguez-S\u00e1nchez JM, et al. Epidemiological factors associated with treated incidence of first-episode non-affective psychosis in Cantabria: insights from the Clinical Programme on Early Phases of Psychosis. Early Interv Psychiatry. 2008;2(3):178\u201387.","journal-title":"Early Interv Psychiatry"},{"key":"1096_CR20","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jpsychores.2015.06.011","volume":"79","author":"P Petrikis","year":"2015","unstructured":"Petrikis P, Voulgari PV, Tzallas AT, Archimandriti DT, Skapinakis P, Mavreas V. Cytokine profile in drug-naive, first episode patients with psychosis. J Psychosom Res. 2015;79:324\u20137.","journal-title":"J Psychosom Res"},{"key":"1096_CR21","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.schres.2013.02.017","volume":"147","author":"JS Rao","year":"2013","unstructured":"Rao JS, Kim H-W, Harry GJ, Rapoport SI, Reese EA. Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients. Schizophr Res. 2013;147:24\u201331.","journal-title":"Schizophr Res"},{"issue":"3","key":"1096_CR22","doi-asserted-by":"publisher","first-page":"e0121971","DOI":"10.1371\/journal.pone.0121971","volume":"10","author":"FM Schmidt","year":"2015","unstructured":"Schmidt FM, Weschenfelder J, Sander C, Minkwitz J, Thormann J, ChittkaT MR, et al. Inflammatory cytokines in general and central obesity and modulating effects of physical activity. PLoS One. 2015;10(3):e0121971.","journal-title":"PLoS One"},{"issue":"2","key":"1096_CR23","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00213-013-3382-4","volume":"231","author":"X Song","year":"2014","unstructured":"Song X, Fan X, Li X, Zhang W, Gao J, Zhao J, Harrington A, Ziedonis D, Changes LL. In pro-inflammatory cytokines and body weight during 6-month risperidone treatment in drug naive, first-episode schizophrenia. Psychopharmacology. 2014;231(2):319\u201325.","journal-title":"Psychopharmacology"},{"key":"1096_CR24","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bbi.2014.01.018","volume":"40","author":"P Su\u00e1rez-Pinilla","year":"2014","unstructured":"Su\u00e1rez-Pinilla P, L\u00f3pez-Gil J, Crespo-Facorro B. Immune system: a possible nexus between cannabinoids and psychosis. Brain Behav Immun. 2014;40:269\u201382.","journal-title":"Brain Behav Immun"},{"issue":"3","key":"1096_CR25","doi-asserted-by":"publisher","first-page":"203","DOI":"10.17305\/bjbms.2017.1381","volume":"17","author":"D \u0160umanovi\u0107-Glamuzina","year":"2017","unstructured":"\u0160umanovi\u0107-Glamuzina D, \u010culo F, \u010culo MI, Konjevoda P, Jerkovi\u0107-Ragu\u017e M. A comparison of blood and cerebrospinal fluid cytokines (IL-1\u03b2, IL-6, IL-18, TNF-\u03b1) in neonates with perinatal hypoxia. Bosn J Basic Med Sci. 2017;17(3):203\u201310. https:\/\/doi.org\/10.17305\/bjbms.2017.1381 .","journal-title":"Bosn J Basic Med Sci"},{"key":"1096_CR26","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/S0006-3223(97)85394-2","volume":"41","author":"JH Thakore","year":"1997","unstructured":"Thakore JH, Richards PJ, Reznek RH, Martin A, Dinan TG. Increased intra-abdominal fat deposition in patients with major depressive illness as measured by computed tomography. Biol Psychiatry. 1997;41:1140\u20132.","journal-title":"Biol Psychiatry"},{"issue":"3","key":"1096_CR27","doi-asserted-by":"publisher","first-page":"e1075","DOI":"10.1038\/tp.2017.4","volume":"7","author":"CF Van Kesteren","year":"2017","unstructured":"Van Kesteren CF, Gremmels H, de Witte LD, Hol EM, Van Gool AR, Falkai PG, Kahn RS, Sommer IE. Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies. Transl Psychiatry. 2017;7(3):e1075.","journal-title":"Transl Psychiatry"},{"key":"1096_CR28","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ni.2431","volume":"13","author":"H Yamane","year":"2012","unstructured":"Yamane H, Paul WE. Cytokines of the \u03b3(c) family control CD4+ T cells differentiation and function. Nat Immunol. 2012;13:1037\u201344.","journal-title":"Nat Immunol"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1096-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T20:48:25Z","timestamp":1570826905000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-018-1096-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1096"],"URL":"https:\/\/doi.org\/10.1186\/s12974-018-1096-6","relation":{"is-referenced-by":[{"id-type":"doi","id":"10.1186\/s12991-025-00587-5","asserted-by":"object"}]},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]},"assertion":[{"value":"23 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Approval status: approved. Approval number 2016.119. Board name: Comit\u00e9 \u00c9tico de Investigaci\u00f3n Cl\u00ednica de Cantabria. Board affiliation: CEIC de Cantabria. Email: eclinicos4@idival.org","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Prof. Crespo-Facorro has received speaking honoraria (advisory board and educational lectures) and travel expenses from Teva, Otsuka, Lundbeck, and Johnson & Johnson in the last 3\u00a0years. Dr. Juncal-Ruiz has received travel expenses from Lundbeck, Johnson & Johnson, and Rovi in the last 3\u00a0years. Dr. Ramirez-Bonilla has received travel expenses from Lundbeck and Johnson & Johnson in the last 3\u00a0years. Prof. L\u00f3pez Hoyos, Prof. Leza, Dr. Riesco-Davila, Dr. Ocejo-Vi\u00f1al, Dr. Irure-Ventura, Mrs. Martinez-Garcia, and Mr. Ortiz-Garcia declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"63"}}