{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:03:32Z","timestamp":1780967012943,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K11211"],"award-info":[{"award-number":["16K11211"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12974-018-1168-7","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T14:29:33Z","timestamp":1524752973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Anti-high mobility group box 1 antibody suppresses local inflammatory reaction and facilitates olfactory nerve recovery following injury"],"prefix":"10.1186","volume":"15","author":[{"given":"Masayoshi","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Tamari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Omar","family":"Al Salihi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"1168_CR1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1001\/archotol.127.5.497","volume":"127","author":"T Miwa","year":"2001","unstructured":"Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER. Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg. 2001;127:497\u2013503.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1168_CR2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1001\/archotol.130.3.317","volume":"130","author":"DV Santos","year":"2004","unstructured":"Santos DV, Reiter ER, DiNardo LJ, Costanzo RM. Hazardous events associated with impaired olfactory function. Arch Otolaryngol Head Neck Surg. 2004;130:317\u20139.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1168_CR3","first-page":"794","volume-title":"Brain injury medicine: principles and practice","author":"RM Costanzo","year":"2012","unstructured":"Costanzo RM, Reiter ER, Yelverton JC. Smell and taste. In: Zasler ND, Katz DI, Zafonte RD, editors. Brain injury medicine: principles and practice. 2nd ed. New York: Demos Medical Publishing; 2012. p. 794\u2013808.","edition":"2"},{"key":"1168_CR4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/brain\/87.1.107","volume":"87","author":"D Sumner","year":"1964","unstructured":"Sumner D. Post-traumatic anosmia. Brain. 1964;87:107\u201320.","journal-title":"Brain"},{"key":"1168_CR5","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1001\/archotol.1982.00790500026006","volume":"108","author":"H Zusho","year":"1982","unstructured":"Zusho H. Posttraumatic anosmia. Arch Otolaryngol. 1982;108:90\u20132.","journal-title":"Arch Otolaryngol"},{"key":"1168_CR6","first-page":"565","volume-title":"Clinical measurements of taste and smell","author":"RM Costanzo","year":"1986","unstructured":"Costanzo RM, Becker DP. Smell and taste disorders in head injury and neurosurgery patients. In: Meiselman HL, Rivlin RS, editors. Clinical measurements of taste and smell. New York: Macmillan Publishing Company; 1986. p. 565\u201378."},{"key":"1168_CR7","first-page":"8","volume":"3","author":"DF Jimenez","year":"1997","unstructured":"Jimenez DF, Sundrani S, Barone CM. Posttraumatic anosmia in craniofacial trauma. J Craniomaxillofac Trauma. 1997;3:8\u201315.","journal-title":"J Craniomaxillofac Trauma"},{"key":"1168_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/ana.21293","volume":"63","author":"B London","year":"2008","unstructured":"London B, Nabet B, Fisher AR, White B, Sammel MD, Doty RL. Predictors of prognosis in patients with olfactory disturbance. Ann Neurol. 2008;63:159\u201366.","journal-title":"Ann Neurol"},{"key":"1168_CR9","first-page":"15","volume":"36","author":"KW Delank","year":"1998","unstructured":"Delank KW, Stoll W. Olfactory function after functional endoscopic sinus surgery for chronic sinusitis. Rhinology. 1998;36:15\u20139.","journal-title":"Rhinology"},{"key":"1168_CR10","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3950\/jibiinkoka.108.986","volume":"108","author":"M Kobayashi","year":"2005","unstructured":"Kobayashi M, Imanishi Y, Ishikawa M, Nishida K, Adachi M, Oishi M, Nakamura S, Sakaida H, Majima Y. Safety and usefulness of the long-term intranasal topical treatment with steroids for olfactory dysfunction. Nippon Jibiinkoka Gakkai Kaiho. 2005;108:986\u201395.","journal-title":"Nippon Jibiinkoka Gakkai Kaiho"},{"issue":"Suppl 1","key":"1168_CR11","doi-asserted-by":"publisher","first-page":"i214","DOI":"10.1093\/chemse\/bjh190","volume":"30","author":"T Miwa","year":"2005","unstructured":"Miwa T, Uramoto N, Tsukatani T, Furukawa M. Middle turbinate fenestration method: a new technique for the treatment of olfactory disturbance due to chronic sinusitis. Chem Senses. 2005;30(Suppl 1):i214\u20135.","journal-title":"Chem Senses"},{"key":"1168_CR12","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/chemse\/bjp038","volume":"34","author":"M Kobayashi","year":"2009","unstructured":"Kobayashi M, Costanzo RM. Olfactory nerve recovery following mild and severe injury and the efficacy of dexamethasone treatment. Chem Senses. 2009;34:573\u201380.","journal-title":"Chem Senses"},{"key":"1168_CR13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.neures.2013.03.015","volume":"76","author":"M Kobayashi","year":"2013","unstructured":"Kobayashi M, Tamari K, Miyamura T, Takeuchi K. Blockade of interleukin-6 receptor suppresses inflammatory reaction and facilitates functional recovery following olfactory system injury. Neurosci Res. 2013;76:125\u201332.","journal-title":"Neurosci Res"},{"key":"1168_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.anl.2016.05.009","volume":"44","author":"MO Al Salihi","year":"2017","unstructured":"Al Salihi MO, Kobayashi M, Tamari K, Miyamura T, Takeuchi K. Tumor necrosis factor-\u03b1 antagonist suppresses local inflammatory reaction and facilitates olfactory nerve recovery following injury. Auris Nasus Larynx. 2017;44:70\u20138.","journal-title":"Auris Nasus Larynx"},{"key":"1168_CR15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3171\/jns.1979.51.3.0307","volume":"51","author":"PR Cooper","year":"1979","unstructured":"Cooper PR, Moody S, Clark WK, Kirkpatrick J, Maravilla K, Gould AL, Drane W. Dexamethasone and severe head injury. A prospective double-blind study. J Neurosurg. 1979;51:307\u201316.","journal-title":"J Neurosurg"},{"key":"1168_CR16","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3171\/jns.1983.58.3.0326","volume":"58","author":"R Braakman","year":"1983","unstructured":"Braakman R, Schouten HJ, Blaauw-van DM, Minderhoud JM. Megadose steroids in severe head injury. Results of a prospective doubleblind clinical trial. J Neurosurg. 1983;58:326\u201330.","journal-title":"J Neurosurg"},{"key":"1168_CR17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3171\/jns.1986.64.1.0081","volume":"64","author":"NM Dearden","year":"1986","unstructured":"Dearden NM, Gibson JS, McDowall DG, Gibson RM, Cameron MM. Effect of high-dose dexamethasone on outcome from severe head injury. J Neurosurg. 1986;64:81\u20138.","journal-title":"J Neurosurg"},{"key":"1168_CR18","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1002\/art.23940","volume":"58","author":"MC Genovese","year":"2008","unstructured":"Genovese MC, McKay JD, Nasonov EL, Mysler EF, da Silva NA, Alecock E, Woodworth T, Gomez-Reino JJ. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008;58:2968\u201380.","journal-title":"Arthritis Rheum"},{"issue":"Suppl 7","key":"1168_CR19","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.4103\/0378-6323.115526","volume":"79","author":"S Dogra","year":"2013","unstructured":"Dogra S, Khullar G. Tumor necrosis factor-\u03b1 antagonists: side effects and their management. Indian J Dermatol Venereol Leprol. 2013;79(Suppl 7):S35\u201346.","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"1168_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nri1594","volume":"5","author":"MT Lotze","year":"2005","unstructured":"Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol. 2005;5:331\u201342.","journal-title":"Nat Rev Immunol"},{"key":"1168_CR21","doi-asserted-by":"publisher","first-page":"12023","DOI":"10.1523\/JNEUROSCI.2435-08.2008","volume":"28","author":"S Muhammad","year":"2008","unstructured":"Muhammad S, Barakat W, Stoyanov S, Murikinati S, Yang H, Tracey KJ, Bendszus M, Rossetti G, Nawroth PP, Bierhaus A, Schwaninger M. The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci. 2008;28:12023\u201331.","journal-title":"J Neurosci"},{"key":"1168_CR22","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nm.2127","volume":"16","author":"M Maroso","year":"2010","unstructured":"Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, Rossetti C, Molteni M, Casalgrandi M, Manfredi AA, Bianchi ME, Vezzani A. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med. 2010;16:413\u20139.","journal-title":"Nat Med"},{"key":"1168_CR23","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1097\/BRS.0b013e3181bd14b6","volume":"35","author":"H Kawabata","year":"2010","unstructured":"Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, Maruyama I, Komiya S. High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Spine. 2010;35:1109\u201315.","journal-title":"Spine"},{"key":"1168_CR24","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3892\/etm.2011.310","volume":"2","author":"K Kikuchi","year":"2011","unstructured":"Kikuchi K, Uchikado H, Miura N, Morimoto Y, Ito T, Tancharoen S, Miyata K, Sakamoto R, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Miyagi N, Kawahara KI. HMGB1 as a therapeutic target in spinal cord injury: a hypothesis for novel therapy development. Exp Ther Med. 2011;2:767\u201370.","journal-title":"Exp Ther Med"},{"key":"1168_CR25","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/ana.23602","volume":"72","author":"Y Okuma","year":"2012","unstructured":"Okuma Y, Liu K, Wake H, Zhang J, Maruo T, Date I, Yoshino T, Ohtsuka A, Otani N, Tomura S, Shima K, Yamamoto Y, Yamamoto H, Takahashi HK, Mori S, Nishibori M. Anti-high mobility group box-1 antibody therapy for traumatic brain injury. Ann Neurol. 2012;72:373\u201384.","journal-title":"Ann Neurol"},{"key":"1168_CR26","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0092-8674(00)81387-2","volume":"87","author":"P Mombaerts","year":"1996","unstructured":"Mombaerts P, Wang F, Dulac C, et al. Visualizing an olfactory sensory map. Cell. 1996;87:675\u201386.","journal-title":"Cell"},{"key":"1168_CR27","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0012-1606(80)90062-7","volume":"74","author":"AI Farbman","year":"1980","unstructured":"Farbman AI, Margolis FL. Olfactory marker protein during ontogeny: immunohistochemical localization. Dev Biol. 1980;74:205\u201315.","journal-title":"Dev Biol"},{"key":"1168_CR28","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/nrn1326","volume":"5","author":"J Silver","year":"2004","unstructured":"Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci. 2004;5:146\u201356.","journal-title":"Nat Rev Neurosci"},{"key":"1168_CR29","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s12035-012-8264-y","volume":"45","author":"P Fang","year":"2012","unstructured":"Fang P, Schachner M, Shen YQ. HMGB1 in development and diseases of the central nervous system. Mol Neurobiol. 2012;45:499\u2013506.","journal-title":"Mol Neurobiol"},{"key":"1168_CR30","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1177\/1073858405278321","volume":"11","author":"MV Sofroniew","year":"2005","unstructured":"Sofroniew MV. Reactive astrocytes in neural repair and protection. Neuroscientist. 2005;11:400\u20137.","journal-title":"Neuroscientist"},{"key":"1168_CR31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.brainresbull.2012.03.002","volume":"88","author":"PC Ren","year":"2012","unstructured":"Ren PC, Zhang Y, Zhang XD, An LJ, Lv HG, He J, Gao CJ, Sun XD. High-mobility group box 1 contributes to mechanical allodynia and spinal astrocytic activation in a mouse model of type 2 diabetes. Brain Res Bull. 2012;88:332\u20137.","journal-title":"Brain Res Bull"},{"key":"1168_CR32","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.2174\/092986709788803024","volume":"16","author":"E Esposito","year":"2009","unstructured":"Esposito E, Cuzzocrea S. TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma. Curr Med Chem. 2009;16:3152\u201367.","journal-title":"Curr Med Chem"},{"key":"1168_CR33","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1164\/ajrccm.164.10.2106117","volume":"164","author":"H Wang","year":"2001","unstructured":"Wang H, Yang H, Czura CJ, Sama AE, Tracey KJ. HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med. 2001;164:1768\u201373.","journal-title":"Am J Respir Crit Care Med"},{"key":"1168_CR34","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1007\/s10753-016-0395-2","volume":"39","author":"M Xu","year":"2016","unstructured":"Xu M, Zhou GM, Wang LH, Zhu L, Liu JM, Wang XD, Li HT, Chen L. Inhibiting high-mobility group box 1 (HMGB1) attenuates inflammatory cytokine expression and neurological deficit in ischemic brain injury following cardiac arrest in rats. Inflammation. 2016;39:1594\u2013602.","journal-title":"Inflammation"},{"key":"1168_CR35","doi-asserted-by":"publisher","first-page":"37755","DOI":"10.1038\/srep37755","volume":"6","author":"J Haruma","year":"2016","unstructured":"Haruma J, Teshigawara K, Hishikawa T, Wang D, Liu K, Wake H, Mori S, Takahashi HK, Sugiu K, Date I, Nishibori M. Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats. Sci Rep. 2016;6:37755.","journal-title":"Sci Rep"},{"key":"1168_CR36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/9780470059593.ch6","volume":"280","author":"H Wang","year":"2007","unstructured":"Wang H, Li W, Goldstein R, Tracey KJ, Sama AE. HMGB1 as a potential therapeutic target. Novartis Found Symp. 2007;280:73\u201385.","journal-title":"Novartis Found Symp"},{"key":"1168_CR37","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","volume":"255","author":"H Wang","year":"2004","unstructured":"Wang H, Yang H, Tracey KJ. Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med. 2004;255:320\u201331.","journal-title":"J Intern Med"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1168-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12974-018-1168-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1168-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T09:02:25Z","timestamp":1693645345000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-018-1168-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,26]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1168"],"URL":"https:\/\/doi.org\/10.1186\/s12974-018-1168-7","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,26]]},"assertion":[{"value":"17 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All protocols and surgical procedures for this study were reviewed and approved by the Institutional Animal Care and Use Committee of Mie University (No. 20-41).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"124"}}