{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:15:51Z","timestamp":1792800951381,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["M369"],"award-info":[{"award-number":["M369"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stevenage Biosciences Catalyst Open Innovation Challenge in Neurodegenerative disease","id":[{"id":"https:\/\/ror.org\/003dca267","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002927","name":"Addenbrooke's Charitable Trust, Cambridge University Hospitals","doi-asserted-by":"publisher","award":["PF15\/CWG"],"award-info":[{"award-number":["PF15\/CWG"]}],"id":[{"id":"10.13039\/501100002927","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Cambridge Biomedical Research Centre","id":[{"id":"https:\/\/ror.org\/05m8dr349","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R007446\/1"],"award-info":[{"award-number":["MR\/R007446\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome-MRC Cambridge Stem Cell Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12974-018-1206-5","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T08:43:15Z","timestamp":1527496995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Abnormalities of age-related T cell senescence in Parkinson\u2019s disease"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-9743","authenticated-orcid":false,"given":"C. H.","family":"Williams-Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Wijeyekoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"1206_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/S1474-4422(09)70062-6","volume":"8","author":"EC Hirsch","year":"2009","unstructured":"Hirsch EC, Hunot S. Neuroinflammation in Parkinson\u2019s disease: a target for neuroprotection? Lancet Neurol. 2009;8:382\u201397.","journal-title":"Lancet Neurol"},{"key":"1206_CR2","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1016\/j.neuropharm.2012.01.028","volume":"62","author":"LM Collins","year":"2012","unstructured":"Collins LM, Toulouse A, Connor TJ, Nolan YM. Contributions of central and systemic inflammation to the pathophysiology of Parkinson\u2019s disease. Neuropharmacology. 2012;62:2154\u201368.","journal-title":"Neuropharmacology"},{"key":"1206_CR3","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.nbd.2005.08.002","volume":"21","author":"A Gerhard","year":"2006","unstructured":"Gerhard A, Pavese N, Hotton G, Turkheimer F, Es M, Hammers A, Eggert K, Oertel W, Banati RB, Brooks DJ. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson\u2019s disease. Neurobiol Dis. 2006;21:404\u201312.","journal-title":"Neurobiol Dis"},{"key":"1206_CR4","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/npp.2012.255","volume":"38","author":"P Edison","year":"2013","unstructured":"Edison P, Ahmed I, Fan Z, Hinz R, Gelosa G, Ray Chaudhuri K, Walker Z, Turkheimer FE, Brooks DJ. Microglia, amyloid, and glucose metabolism in Parkinson\u2019s disease with and without dementia. Neuropsychopharmacology. 2013;38:938\u201349.","journal-title":"Neuropsychopharmacology"},{"key":"1206_CR5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/ana.20338","volume":"57","author":"Y Ouchi","year":"2005","unstructured":"Ouchi Y, Yoshikawa E, Sekine Y, Futatsubashi M, Kanno T, Ogusu T, Torizuka T. Microglial activation and dopamine terminal loss in early Parkinson\u2019s disease. Ann Neurol. 2005;57:168\u201375.","journal-title":"Ann Neurol"},{"key":"1206_CR6","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1309\/W01Y0B808EMEH12L","volume":"129","author":"J Zhang","year":"2008","unstructured":"Zhang J, Sokal I, Peskind ER, Quinn JF, Jankovic J, Kenney C, Chung KA, Millard SP, Nutt JG, Montine TJ. CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases. Am J Clin Pathol. 2008;129:526\u20139.","journal-title":"Am J Clin Pathol"},{"key":"1206_CR7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1471-2377-14-113","volume":"14","author":"SY Yu","year":"2014","unstructured":"Yu SY, Zuo LJ, Wang F, Chen ZJ, Hu Y, Wang YJ, Wang XM, Zhang W. Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study. BMC Neurol. 2014;14:113.","journal-title":"BMC Neurol"},{"key":"1206_CR8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00401-014-1345-4","volume":"128","author":"V Grozdanov","year":"2014","unstructured":"Grozdanov V, Bliederhaeuser C, Ruf WP, Roth V, Fundel-Clemens K, Zondler L, Brenner D, Martin-Villalba A, Hengerer B, Kassubek J, et al. Inflammatory dysregulation of blood monocytes in Parkinson\u2019s disease patients. Acta Neuropathol. 2014;128:651\u201363.","journal-title":"Acta Neuropathol"},{"key":"1206_CR9","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s11481-012-9402-z","volume":"7","author":"JA Saunders","year":"2012","unstructured":"Saunders JA, Estes KA, Kosloski LM, Allen HE, Dempsey KM, Torres-Russotto DR, Meza JL, Santamaria PM, Bertoni JM, Murman DL, et al. CD4+ regulatory and effector\/memory T cell subsets profile motor dysfunction in Parkinson\u2019s disease. J NeuroImmune Pharmacol. 2012;7:927\u201338.","journal-title":"J NeuroImmune Pharmacol"},{"key":"1206_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jneuroim.2012.07.015","volume":"252","author":"CH Stevens","year":"2012","unstructured":"Stevens CH, Rowe D, Morel-Kopp MC, Orr C, Russell T, Ranola M, Ward C, Halliday GM. Reduced T helper and B lymphocytes in Parkinson\u2019s disease. J Neuroimmunol. 2012;252:95\u20139.","journal-title":"J Neuroimmunol"},{"key":"1206_CR11","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nature22815","volume":"546","author":"D Sulzer","year":"2017","unstructured":"Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, et al. T cells from patients with Parkinson\u2019s disease recognize alpha-synuclein peptides. Nature. 2017;546:656\u201361.","journal-title":"Nature"},{"key":"1206_CR12","first-page":"182","volume":"119","author":"V Brochard","year":"2009","unstructured":"Brochard V, Combadiere B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, et al. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest. 2009;119:182\u201392.","journal-title":"J Clin Invest"},{"key":"1206_CR13","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1289\/ehp.1003013","volume":"119","author":"HM Gao","year":"2011","unstructured":"Gao HM, Zhang F, Zhou H, Kam W, Wilson B, Hong JS. Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson\u2019s disease. Environ Health Perspect. 2011;119:807\u201314.","journal-title":"Environ Health Perspect"},{"key":"1206_CR14","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1136\/jnnp.2008.162883","volume":"81","author":"M Saiki","year":"2010","unstructured":"Saiki M, Baker A, Williams-Gray CH, Foltynie T, Goodman RS, Taylor CJ, Compston DA, Barker RA, Sawcer SJ, Goris A. Association of the human leucocyte antigen region with susceptibility to Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry. 2010;81:890\u20131.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1206_CR15","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/ng.3043","volume":"46","author":"MA Nalls","year":"2014","unstructured":"Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease. Nat Genet. 2014;46:989\u201393.","journal-title":"Nat Genet"},{"key":"1206_CR16","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1002\/mds.26563","volume":"31","author":"CH Williams-Gray","year":"2016","unstructured":"Williams-Gray CH, Wijeyekoon R, Yarnall AJ, Lawson RA, Breen DP, Evans JR, Cummins GA, Duncan GW, Khoo TK, Burn DJ, et al. Serum immune markers and disease progression in an incident Parkinson\u2019s disease cohort (ICICLE-PD). Mov Disord. 2016;31:995\u20131003.","journal-title":"Mov Disord"},{"key":"1206_CR17","first-page":"1680","volume":"19","author":"JP Chou","year":"2013","unstructured":"Chou JP, Effros RB. T cell replicative senescence in human aging. Curr Pharm Des. 2013;19:1680\u201398.","journal-title":"Curr Pharm Des"},{"issue":"Suppl 1","key":"1206_CR18","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1016\/j.jcpa.2009.09.005","volume":"142","author":"G Pawelec","year":"2010","unstructured":"Pawelec G, Larbi A, Derhovanessian E. Senescence of the human immune system. J Comp Pathol. 2010;142(Suppl 1):S39\u201344.","journal-title":"J Comp Pathol"},{"key":"1206_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/cyto.a.22351","volume":"85","author":"A Larbi","year":"2014","unstructured":"Larbi A, Fulop T. From \u201ctruly na\u00efve\u201d to \u201cexhausted senescent\u201d T cells: when markers predict functionality. Cytometry Part A. 2014;85:25\u201335.","journal-title":"Cytometry Part A"},{"key":"1206_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1365-2567.2011.03470.x","volume":"134","author":"M Strioga","year":"2011","unstructured":"Strioga M, Pasukoniene V, Characiejus D. CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease. Immunology. 2011;134:17\u201332.","journal-title":"Immunology"},{"key":"1206_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0047-6374(00)00199-8","volume":"121","author":"R Tarazona","year":"2000","unstructured":"Tarazona R, DelaRosa O, Alonso C, Ostos B, Espejo J, Pena J, Solana R. Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector\/senescent T cells. Mech Ageing Dev. 2000;121:77\u201388.","journal-title":"Mech Ageing Dev"},{"key":"1206_CR22","doi-asserted-by":"publisher","first-page":"5145","DOI":"10.4049\/jimmunol.177.8.5145","volume":"177","author":"Y Le Priol","year":"2006","unstructured":"Le Priol Y, Puthier D, Lecureuil C, Combadiere C, Debre P, Nguyen C, Combadiere B. High cytotoxic and specific migratory potencies of senescent CD8+ CD57+ cells in HIV-infected and uninfected individuals. J Immunol. 2006;177:5145\u201354.","journal-title":"J Immunol"},{"key":"1206_CR23","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1128\/JVI.00045-07","volume":"81","author":"JW Northfield","year":"2007","unstructured":"Northfield JW, Loo CP, Barbour JD, Spotts G, Hecht FM, Klenerman P, Nixon DF, Michaelsson J. Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point. J Virol. 2007;81:5759\u201365.","journal-title":"J Virol"},{"key":"1206_CR24","doi-asserted-by":"publisher","first-page":"B378","DOI":"10.1093\/gerona\/50A.6.B378","volume":"50","author":"FG Ferguson","year":"1995","unstructured":"Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci. 1995;50:B378\u201382.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1206_CR25","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.4049\/jimmunol.169.4.1984","volume":"169","author":"N Khan","year":"2002","unstructured":"Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PA. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol. 2002;169:1984\u201392.","journal-title":"J Immunol"},{"key":"1206_CR26","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.4049\/jimmunol.176.4.2645","volume":"176","author":"SR Hadrup","year":"2006","unstructured":"Hadrup SR, Strindhall J, Kollgaard T, Seremet T, Johansson B, Pawelec G, thor Straten P, Wikby A. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol. 2006;176:2645\u201353.","journal-title":"J Immunol"},{"key":"1206_CR27","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.it.2009.03.013","volume":"30","author":"NP Weng","year":"2009","unstructured":"Weng NP, Akbar AN, Goronzy J. CD28(\u2212) T cells: their role in the age-associated decline of immune function. Trends Immunol. 2009;30:306\u201312.","journal-title":"Trends Immunol"},{"key":"1206_CR28","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00401-010-0722-x","volume":"120","author":"VH Perry","year":"2010","unstructured":"Perry VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol. 2010;120:277\u201386.","journal-title":"Acta Neuropathol"},{"key":"1206_CR29","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","volume":"51","author":"WR Gibb","year":"1988","unstructured":"Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry. 1988;51:745\u201352.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1206_CR30","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1002\/mds.23429","volume":"25","author":"CL Tomlinson","year":"2010","unstructured":"Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE. Systematic review of levodopa dose equivalency reporting in Parkinson\u2019s disease. Mov Disord. 2010;25:2649\u201353.","journal-title":"Mov Disord"},{"key":"1206_CR31","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1093\/brain\/awp245","volume":"132","author":"CH Williams-Gray","year":"2009","unstructured":"Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, Brayne C, Kolachana BS, Weinberger DR, Sawcer SJ, Barker RA. The distinct cognitive syndromes of Parkinson\u2019s disease: 5 year follow-up of the CamPaIGN cohort. Brain. 2009;132:2958\u201369.","journal-title":"Brain"},{"key":"1206_CR32","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0165-5728(00)00422-7","volume":"113","author":"J Bas","year":"2001","unstructured":"Bas J, Calopa M, Mestre M, Mollevi DG, Cutillas B, Ambrosio S, Buendia E. Lymphocyte populations in Parkinson\u2019s disease and in rat models of parkinsonism. J Neuroimmunol. 2001;113:146\u201352.","journal-title":"J Neuroimmunol"},{"key":"1206_CR33","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.parkreldis.2005.07.005","volume":"11","author":"Y Baba","year":"2005","unstructured":"Baba Y, Kuroiwa A, Uitti RJ, Wszolek ZK, Yamada T. Alterations of T-lymphocyte populations in Parkinson disease. Parkinsonism Relat Disord. 2005;11:493\u20138.","journal-title":"Parkinsonism Relat Disord"},{"key":"1206_CR34","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0140-6736(10)62345-8","volume":"377","author":"MA Nalls","year":"2011","unstructured":"International Parkinson Disease Genomics Consortium, Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simon-Sanchez J, Schulte C, Lesage S, et al. Imputation of sequence variants for identification of genetic risks for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies. Lancet. 2011;377:641\u20139.","journal-title":"Lancet"},{"key":"1206_CR35","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1093\/hmg\/dds492","volume":"22","author":"P Holmans","year":"2013","unstructured":"Holmans P, Moskvina V, Jones L, Sharma M, The International Parkinson\u2019s Disease Genomics C, Vedernikov A, Buchel F, Sadd M, Bras JM, Bettella F, et al. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson\u2019s disease. Hum Mol Genet. 2013;22:1039\u201349.","journal-title":"Hum Mol Genet"},{"key":"1206_CR36","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/acn3.369","volume":"3","author":"SA Gagliano","year":"2016","unstructured":"Gagliano SA, Pouget JG, Hardy J, Knight J, Barnes MR, Ryten M, Weale ME. Genomics implicates adaptive and innate immunity in Alzheimer\u2019s and Parkinson\u2019s diseases. Ann Clin Transl Neurol. 2016;3:924\u201333.","journal-title":"Ann Clin Transl Neurol"},{"key":"1206_CR37","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jneuroim.2017.06.004","volume":"310","author":"E Caggiu","year":"2017","unstructured":"Caggiu E, Paulus K, Galleri G, Arru G, Manetti R, Sechi GP, Sechi LA. Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson\u2019s disease. J Neuroimmunol. 2017;310:26\u201331.","journal-title":"J Neuroimmunol"},{"key":"1206_CR38","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","volume":"523","author":"A Louveau","year":"2015","unstructured":"Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337\u201341.","journal-title":"Nature"},{"key":"1206_CR39","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1084\/jem.20161982","volume":"214","author":"SP Gadani","year":"2017","unstructured":"Gadani SP, Smirnov I, Smith AT, Overall CC, Kipnis J. Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury. J Exp Med. 2017;214:285\u201396.","journal-title":"J Exp Med"},{"key":"1206_CR40","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","volume":"10","author":"VH Perry","year":"2014","unstructured":"Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol. 2014;10:217\u201324.","journal-title":"Nat Rev Neurol"},{"key":"1206_CR41","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nature18626","volume":"535","author":"AJ Filiano","year":"2016","unstructured":"Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, Overall CC, Gadani SP, Turner SD, Weng Z, et al. Unexpected role of interferon-\u03b3 in regulating neuronal connectivity and social behaviour. Nature. 2016;535:425.","journal-title":"Nature"},{"key":"1206_CR42","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/apha.12476","volume":"216","author":"M Levite","year":"2016","unstructured":"Levite M. Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases. Acta Physiol (Oxf). 2016;216:42\u201389.","journal-title":"Acta Physiol (Oxf)"},{"key":"1206_CR43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41531-017-0013-5","volume":"3","author":"HE Gendelman","year":"2017","unstructured":"Gendelman HE, Zhang Y, Santamaria P, Olson KE, Schutt CR, Bhatti D, Shetty BLD, Lu Y, Estes KA, Standaert DG, et al. Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson\u2019s disease trial. NPJ Parkinsons Dis. 2017;3:10.","journal-title":"NPJ Parkinsons Dis"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1206-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12974-018-1206-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1206-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T19:05:57Z","timestamp":1558983957000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-018-1206-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,28]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1206"],"URL":"https:\/\/doi.org\/10.1186\/s12974-018-1206-5","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,28]]},"assertion":[{"value":"14 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the East of England\u2014Cambridge Central Research Ethics Committee (ref 03\/303). All participants provided written informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"166"}}