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All animal care and experimental procedures conformed with the French Decret number 2013-118, 1 February 2013 NOR: AGRG1231951D in accordance with the European Community guidelines (directive 2010\/63\/UE). In France, any sampling of biological material in animals for ex vivo experimentation does not require prior agreement of the ethics committee (COMOTHEA Poitou Charentes).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Technology Transfer Accelerating Company \u201cSATT Grand Centre ()\u201d financially enabled the maturation of the mouse blood-brain barrier model (BBB) developed by the co-inventors (Guyl\u00e8ne PAGE, Emilie DUGAST, Hanitriniaina RABEONY, Damien CHASSAING, and Thierry JANET). The results described in this article were obtained using this BBB model which a patent is under pending approval (FR17\/57643). The other authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"182"}}