{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:24:14Z","timestamp":1790742254465,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003000","name":"Stichting MS Research","doi-asserted-by":"publisher","award":["programme grant 14-358e"],"award-info":[{"award-number":["programme grant 14-358e"]}],"id":[{"id":"10.13039\/501100003000","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Amsterdam Neuroscience","award":["Proof of Concept Fund NCA 2013"],"award-info":[{"award-number":["Proof of Concept Fund NCA 2013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12974-018-1352-9","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T09:22:34Z","timestamp":1542100954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-6833","authenticated-orcid":false,"given":"Marloes H. J.","family":"Hagens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep V.","family":"Golla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn T.","family":"Wijburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maqsood","family":"Yaqub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Heijtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn D.","family":"Steenwijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J. P.","family":"Brev\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Schuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan A.","family":"Reekie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kassiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"van Dam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.","family":"Windhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep","family":"Killestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N. M.","family":"van Berckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Lammertsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"1352_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1212\/WNL.0000000000002441","volume":"86","author":"P O'Connor","year":"2016","unstructured":"O'Connor P, Comi G, Freedman MS, Miller AE, Kappos L, Bouchard JP, et al. Long-term safety and efficacy of teriflunomide: nine-year follow-up of the randomized TEMSO study. Neurology. 2016;86:10.","journal-title":"Neurology"},{"key":"1352_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/nrneurol.2015.106","volume":"11","author":"A Rovira","year":"2015","unstructured":"Rovira A, Wattjes MP, Tintore M, Tur C, Yousry TA, Sormani MP, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process. Nat Rev Neurol. 2015;11:8.","journal-title":"Nat Rev Neurol"},{"key":"1352_CR3","first-page":"10","volume":"11","author":"MP Wattjes","year":"2015","unstructured":"Wattjes MP, Rovira A, Miller D, Yousry TA, Sormani MP, de Stefano MP, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis--establishing disease prognosis and monitoring patients. Nat Rev Neurol. 2015;11:10.","journal-title":"Nat Rev Neurol"},{"key":"1352_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00019052-200206000-00003","volume":"15","author":"F Barkhof","year":"2002","unstructured":"Barkhof F. The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol. 2002;15:3.","journal-title":"Curr Opin Neurol"},{"key":"1352_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrneurol.2012.168","volume":"8","author":"H Lassmann","year":"2012","unstructured":"Lassmann H, van Horssen J, Mahad D. Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol. 2012;8:11.","journal-title":"Nat Rev Neurol"},{"key":"1352_CR6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/S1474-4422(14)70305-9","volume":"14","author":"B Hemmer","year":"2015","unstructured":"Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol. 2015;14:4.","journal-title":"Lancet Neurol"},{"key":"1352_CR7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S1474-4422(14)70256-X","volume":"14","author":"DH Mahad","year":"2015","unstructured":"Mahad DH, Trapp BD, Lassmann H. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015;14:2.","journal-title":"Lancet Neurol"},{"key":"1352_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1177\/1352458516674568","volume":"23","author":"L Airas","year":"2017","unstructured":"Airas L, Rissanen E, Rinne J. Imaging of microglial activation in MS using PET: research use and potential future clinical application. Mult Scler. 2017;23:4.","journal-title":"Mult Scler"},{"key":"1352_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/WCO.0000000000000326","volume":"29","author":"M Hagens","year":"2016","unstructured":"Hagens M, van Berckel B, Barkhof F. Novel MRI and PET markers of neuroinflammation in multiple sclerosis. Curr Opin Neurol. 2016;29:3.","journal-title":"Curr Opin Neurol"},{"key":"1352_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1177\/0271678X17748786","volume":"38","author":"P Cumming","year":"2018","unstructured":"Cumming P, Burgher B, Patkar O, Breakspear M, Vasdev N, Thomas P, et al. Sifting through the surfeit of neuroinflammation tracers. J Cereb Blood Flow Metab. 2018;38:2.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1352_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/(SICI)1097-4547(19971015)50:2<345::AID-JNR22>3.0.CO;2-5","volume":"50","author":"E Vowinckel","year":"1997","unstructured":"Vowinckel E, Reutens D, Becher B, Verge G, Evans A, Owens T, et al. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res. 1997;50:2.","journal-title":"J Neurosci Res"},{"issue":"Pt 11","key":"1352_CR12","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1093\/brain\/123.11.2321","volume":"123","author":"RB Banati","year":"2000","unstructured":"Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, Heppner F, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain. 2000;123(Pt 11):2321\u201337.","journal-title":"Brain"},{"key":"1352_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1212\/WNL.0b013e3182635645","volume":"79","author":"M Politis","year":"2012","unstructured":"Politis M, Giannetti P, Su P, Turkheimer F, Keihaninejad S, Wu K, et al. Increased PK11195 PET binding in the cortex of patients with MS correlates with disability. Neurology. 2012;79:6.","journal-title":"Neurology"},{"key":"1352_CR14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.2967\/jnumed.113.131698","volume":"55","author":"E Rissanen","year":"2014","unstructured":"Rissanen E, Tuisku J, Rokka J, Paavilainen T, Parkkola R, Rinne JO, et al. In vivo detection of diffuse inflammation in secondary progressive multiple sclerosis using PET imaging and the radioligand 11C-PK11195. J Nucl Med. 2014;55:6.","journal-title":"J Nucl Med"},{"key":"1352_CR15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.nbd.2014.01.018","volume":"65","author":"Paolo Giannetti","year":"2014","unstructured":"Giannetti P, Politis M, Su P, Turkheimer F, Malik O, Keihaninejad S, et al. Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: an in vivo [11C](R)-PK11195-PET pilot study. Neurobiol Dis. 2014;65:203\u201310.","journal-title":"Neurobiology of Disease"},{"key":"1352_CR16","doi-asserted-by":"publisher","first-page":"Pt 1","DOI":"10.1093\/brain\/awu331","volume":"138","author":"P Giannetti","year":"2015","unstructured":"Giannetti P, Politis M, Su P, Turkheimer FE, Malik O, Keihaninejad S, et al. Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome. Brain. 2015;138:Pt 1.","journal-title":"Brain"},{"key":"1352_CR17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2967\/jnumed.106.036764","volume":"48","author":"H Boutin","year":"2007","unstructured":"Boutin H, Chauveau F, Thominiaux C, Gregoire MC, James ML, Trebossen R, et al. 11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. J Nucl Med. 2007;48:4.","journal-title":"J Nucl Med"},{"key":"1352_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1021\/jm7014556","volume":"51","author":"CJ Fookes","year":"2008","unstructured":"Fookes CJ, Pham TQ, Mattner F, Greguric I, Loc'h C, Liu X, et al. Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography. J Med Chem. 2008;51:13.","journal-title":"J Med Chem"},{"key":"1352_CR19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.neuroimage.2009.11.056","volume":"49","author":"WC Kreisl","year":"2010","unstructured":"Kreisl WC, Fujita M, Fujimura Y, Kimura N, Jenko KJ, Kannan P, et al. Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission tomographic imaging of this inflammation biomarker. NeuroImage. 2010;49:4.","journal-title":"NeuroImage"},{"key":"1352_CR20","first-page":"3","volume":"22","author":"H Wadsworth","year":"2012","unstructured":"Wadsworth H, Jones PA, Chau WF, Durrant C, Fouladi N, Passmore J, et al. [18F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO). Bioorg Med Chem Lett. 2012;22:3.","journal-title":"Bioorg Med Chem Lett"},{"key":"1352_CR21","first-page":"9","volume":"47","author":"MR Zhang","year":"2004","unstructured":"Zhang MR, Maeda J, Ogawa M, Noguchi J, Ito T, Yoshida Y, et al. Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. J Med Chem. 2004;47:9.","journal-title":"J Med Chem"},{"key":"1352_CR22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2967\/jnumed.107.046151","volume":"49","author":"ML James","year":"2008","unstructured":"James ML, Fulton RR, Vercoullie J, Henderson DJ, Garreau L, Chalon S, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008;49:5.","journal-title":"J Nucl Med"},{"key":"1352_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/dmd.112.046342","volume":"41","author":"MA Peyronneau","year":"2013","unstructured":"Peyronneau MA, Saba W, Goutal S, Damont A, Dolle F, Kassiou M, et al. Metabolism and quantification of [18F]DPA-714, a new TSPO positron emission tomography radioligand. Drug Metab Dispos. 2013;41:1.","journal-title":"Drug Metab Dispos"},{"key":"1352_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2967\/jnumed.110.079459","volume":"52","author":"DR Owen","year":"2011","unstructured":"Owen DR, Gunn RN, Rabiner EA, Bennacef I, Fujita M, Kreisl WC, et al. Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med. 2011;52:1.","journal-title":"J Nucl Med"},{"key":"1352_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2967\/jnumed.115.156083","volume":"56","author":"S Lavisse","year":"2015","unstructured":"Lavisse S, Garcia-Lorenzo D, Peyronneau MA, Bodini B, Thiriez C, Kuhnast B, et al. Optimized quantification of translocator protein radioligand 18F-DPA-714 uptake in the brain of genotyped healthy volunteers. J Nucl Med. 2015;56:7.","journal-title":"J Nucl Med"},{"key":"1352_CR26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/jcbfm.2014.261","volume":"35","author":"SS Golla","year":"2015","unstructured":"Golla SS, Boellaard R, Oikonen V, Hoffmann A, van Berckel BN, Windhorst AD, et al. Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer\u2019s disease patients. J Cereb Blood Flow Metab. 2015;35:5.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1352_CR27","doi-asserted-by":"crossref","unstructured":"Ribeiro MJ, Vercouillie J, Debiais S, Cottier JP, Bonnaud I, Camus V, et al. Could 18F-DPA-714 PET imaging be interesting to use in the early post-stroke period? EJNMMI Res. 2014;4:28.","DOI":"10.1186\/s13550-014-0028-4"},{"key":"1352_CR28","doi-asserted-by":"publisher","first-page":"Pt 4","DOI":"10.1093\/brain\/aww017","volume":"139","author":"L Hamelin","year":"2016","unstructured":"Hamelin L, Lagarde J, Dorothee G, Leroy C, Labit M, Comley RA, et al. Early and protective microglial activation in Alzheimer\u2019s disease: a prospective study using 18F-DPA-714 PET imaging. Brain. 2016;139:Pt 4.","journal-title":"Brain"},{"key":"1352_CR29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/jcbfm.2014.202","volume":"35","author":"CA Salinas","year":"2015","unstructured":"Salinas CA, Searle GE, Gunn RN. The simplified reference tissue model: model assumption violations and their impact on binding potential. J Cereb Blood Flow Metab. 2015;35:2.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1352_CR30","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2967\/jnumed.109.067512","volume":"50","author":"H Folkersma","year":"2009","unstructured":"Folkersma H, Boellaard R, Vandertop WP, Kloet RW, Lubberink M, Lammertsma AA, et al. Reference tissue models and blood-brain barrier disruption: lessons from (R)-[11C]PK11195 in traumatic brain injury. J Nucl Med. 2009;50:12.","journal-title":"J Nucl Med"},{"key":"1352_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s002590000405","volume":"28","author":"R Boellaard","year":"2001","unstructured":"Boellaard R, van Lingen A, van Balen SC, Hoving BG, Lammertsma AA. Characteristics of a new fully programmable blood sampling device for monitoring blood radioactivity during PET. Eur J Nucl Med. 2001;28:1.","journal-title":"Eur J Nucl Med"},{"key":"1352_CR32","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.nicl.2013.10.003","volume":"3","author":"Martijn D. Steenwijk","year":"2013","unstructured":"Steenwijk MD, Pouwels PJ, Daams M, van Dalen JW, Caan MW, Richard E, et al. Accurate white matter lesion segmentation by k nearest neighbor classification with tissue type priors (kNN-TTPs). Neuroimage Clin. 2013;3:462\u20139.","journal-title":"NeuroImage: Clinical"},{"key":"1352_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jmri.22214","volume":"32","author":"DT Chard","year":"2010","unstructured":"Chard DT, Jackson JS, Miller DH, Wheeler-Kingshott CA. Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes. J Magn Reson Imaging. 2010;32:1.","journal-title":"J Magn Reson Imaging"},{"key":"1352_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroimage.2004.01.016","volume":"22","author":"J Cizek","year":"2004","unstructured":"Cizek J, Herholz K, Vollmar S, Schrader R, Klein J, Heiss WD. Fast and robust registration of PET and MR images of human brain. NeuroImage. 2004;22:1.","journal-title":"NeuroImage"},{"key":"1352_CR35","volume-title":"VINCI-volume imaging in neurological research, co-registration and ROIs included. Forschung und wissenschaftliches Rechnen 2003 (Kremer K, Macho V, eds)","author":"S Vollmar","year":"2004","unstructured":"Vollmar S, Cizek J, Sue J, Klein A, Jacbos K, Herholz K. VINCI-volume imaging in neurological research, co-registration and ROIs included. Forschung und wissenschaftliches Rechnen 2003 (Kremer K, Macho V, eds); 2004."},{"key":"1352_CR36","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.neuroimage.2004.10.017","volume":"24","author":"C Svarer","year":"2005","unstructured":"Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbol S, Frokjaer VG, et al. MR-based automatic delineation of volumes of interest in human brain PET images using probability maps. NeuroImage. 2005;24:4.","journal-title":"NeuroImage"},{"key":"1352_CR37","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/hbm.10123","volume":"19","author":"A Hammers","year":"2003","unstructured":"Hammers A, Allom R, Koepp MJ, Free SL, Myers R, Lemieux L, et al. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp. 2003;19:4.","journal-title":"Hum Brain Mapp"},{"key":"1352_CR38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S1474-4422(17)30159-X","volume":"16","author":"GB Frisoni","year":"2017","unstructured":"Frisoni GB, Boccardi M, Barkhof F, Blennow K, Cappa S, Chiotis K, et al. Strategic roadmap for an early diagnosis of Alzheimer\u2019s disease based on biomarkers. Lancet Neurol. 2017;16:8.","journal-title":"Lancet Neurol"},{"key":"1352_CR39","first-page":"6","volume":"34","author":"G Rizzo","year":"2014","unstructured":"Rizzo G, Veronese M, Tonietto M, Zanotti-Fregonara P, Turkheimer FE, Bertoldo A. Kinetic modeling without accounting for the vascular component impairs the quantification of [11C]PBR28 brain PET data. J Cereb Blood Flow Metab. 2014;34:6.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1352_CR40","doi-asserted-by":"crossref","unstructured":"Wimberley C, Lavisse S, Brulon V, Peyronneau MA, Leroy C, Bodini B, et al. Impact of endothelial TSPO on the quantification of 18F-DPA-714. J Nucl Med. 2018;59:307\u201314.","DOI":"10.2967\/jnumed.117.195396"},{"key":"1352_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2990.2000.00217.x","volume":"26","author":"P van der Valk","year":"2000","unstructured":"van der Valk P, De Groot CJ. Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS. Neuropathol Appl Neurobiol. 2000;26:1.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"1352_CR42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.2967\/jnumed.108.050583","volume":"49","author":"G Tomasi","year":"2008","unstructured":"Tomasi G, Edison P, Bertoldo A, Roncaroli F, Singh P, Gerhard A, et al. Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer\u2019s disease. J Nucl Med. 2008;49:8.","journal-title":"J Nucl Med"},{"key":"1352_CR43","first-page":"1","volume":"48","author":"FE Turkheimer","year":"2007","unstructured":"Turkheimer FE, Edison P, Pavese N, Roncaroli F, Anderson AN, Hammers A, et al. Reference and target region modeling of [11C]-(R)-PK11195 brain studies. J Nucl Med. 2007;48:1.","journal-title":"J Nucl Med"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1352-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12974-018-1352-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-018-1352-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T19:08:16Z","timestamp":1573585696000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-018-1352-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1352"],"URL":"https:\/\/doi.org\/10.1186\/s12974-018-1352-9","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"15 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Medical Ethics Review Board of the VU University Medical Center and was registered under the number 2014.356. All subjects gave written informed consent prior to participation.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"DH is employed by Philips Healthcare. JK has accepted speaker and consultancy fees from Merck-Serono, Teva, Biogen, Genzyme, Roche and Novartis. FB is supported by the NIHR UCLH Biomedical Research Centre and serves as a consultant for Bayer-Schering Pharma, Sanofi-Aventis, Genzyme, Biogen-Idec, Teva, Novartis, Roche, Synthon BV and Jansen Research. All other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"314"}}