{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:31Z","timestamp":1791919711117,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171458"],"award-info":[{"award-number":["82171458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901186"],"award-info":[{"award-number":["81901186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101374"],"award-info":[{"award-number":["82101374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974188"],"award-info":[{"award-number":["81974188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammation contributes to the poor prognosis of intracerebral hemorrhage (ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in multiple pathogenic processes. In the present study, we aimed to investigated the beneficial effects of IF in attenuating neuroinflammation and neurological deficits in a mouse model of ICH and to investigate the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      ICH was modeled by intrastriatal injection of autologous blood and IF was modeled by every-other-day feeding in male control mice (C57BL\/6), mice with and microglia specific knockout Sirt3\n                      <jats:sup>f\/f<\/jats:sup>\n                      ;Cx3cr1-Cre (Sirt3 cKO), and Sirt3\n                      <jats:sup>f\/f<\/jats:sup>\n                      (wild-type) mice. Brain tissues and arterial blood were harvested at 1, 3, 7 and 28\u00a0days after ICH for immunohistochemistry analysis of Iba-1, DARPP-32 and HO-1, morphological analysis by HE staining and inflammatory factor release tests by ELISA. Neurological functions were approached by corner test and cylinder test. Fluorescent double-labeled staining of Iba-1 with CD16, Arg1 or Sirt3 was used to provide direct image of co-expression of these molecules in microglia. TUNEL, cleaved caspase-3 and Nissl staining was performed to evaluate cellular injuries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IF alleviated neurological deficits in both acute and chronic phases after ICH. Morphologically, IF enhanced hematoma clearance, reduced brain edema in acute phase and attenuated striatum atrophy in chronic phase. In addition, IF decreased the numbers of TUNEL\n                      <jats:sup>+<\/jats:sup>\n                      cells and increased Nissl\n                      <jats:sup>+<\/jats:sup>\n                      neuron number at day 1, 3 and 7 after ICH. IF suppressed CD16\n                      <jats:sup>+<\/jats:sup>\n                      Iba-1\n                      <jats:sup>+<\/jats:sup>\n                      microglia activation at day 3 after ICH and reduced inflammatory releases, such as IL-1\u03b2 and TNF-\u03b1. The above effects of IF were attenuated by microglia Sirt3 deletion partly because of an inhibition of Nrf2\/HO-1 signaling pathway. Interestingly, IF increased Iba-1\n                      <jats:sup>+<\/jats:sup>\n                      microglia number at day 7 which mainly expressed Arg1 while decreased the proinflammatory factor levels. In mice with microglia-specific Sirt3 deletion, the effects of IF on Iba-1\n                      <jats:sup>+<\/jats:sup>\n                      microglia activation and anti-inflammatory factor expressions were attenuated when compared with wild-type Sirt3\n                      <jats:sup>f\/f<\/jats:sup>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IF protects against ICH by suppressing the inflammatory responses via the Sirt3\/Nrf2\/HO-1 pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12974-022-02474-2","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T05:03:53Z","timestamp":1653627833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3\/Nrf2\/HO-1 pathway"],"prefix":"10.1186","volume":"19","author":[{"given":"Shuhui","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-9917","authenticated-orcid":false,"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"2474_CR1","doi-asserted-by":"publisher","first-page":"e20200213","DOI":"10.1084\/jem.20200213","volume":"217","author":"Z Li","year":"2020","unstructured":"Li Z, Li M, Shi SX, Yao N, Cheng X, Guo A, et al. Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage. J Exp Med. 2020;217:e20200213.","journal-title":"J Exp Med"},{"key":"2474_CR2","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1084\/jem.20171905","volume":"215","author":"K Vaibhav","year":"2018","unstructured":"Vaibhav K, Braun M, Khan MB, Fatima S, Saad N, Shankar A, et al. Remote ischemic post-conditioning promotes hematoma resolution via ampk-dependent immune regulation. J Exp Med. 2018;215:2636\u201354.","journal-title":"J Exp Med"},{"key":"2474_CR3","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0140-6736(13)60986-1","volume":"382","author":"AD Mendelow","year":"2013","unstructured":"Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A, Mitchell PM, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (stich ii): a randomised trial. Lancet. 2013;382:397\u2013408.","journal-title":"Lancet"},{"key":"2474_CR4","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1001\/jama.2019.13014","volume":"322","author":"JB Kuramatsu","year":"2019","unstructured":"Kuramatsu JB, Biffi A, Gerner ST, Sembill JA, Sprugel MI, Leasure A, et al. Association of surgical hematoma evacuation vs conservative treatment with functional outcome in patients with cerebellar intracerebral hemorrhage. JAMA. 2019;322:1392\u2013403.","journal-title":"JAMA"},{"key":"2474_CR5","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/s41467-017-00770-7","volume":"8","author":"X Zhao","year":"2017","unstructured":"Zhao X, Ting SM, Liu CH, Sun G, Kruzel M, Roy-O\u2019Reilly M, et al. Neutrophil polarization by il-27 as a therapeutic target for intracerebral hemorrhage. Nat Commun. 2017;8:602.","journal-title":"Nat Commun"},{"key":"2474_CR6","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s12975-019-00745-4","volume":"11","author":"C Tao","year":"2020","unstructured":"Tao C, Keep RF, Xi G, Hua Y. Cd47 blocking antibody accelerates hematoma clearance after intracerebral hemorrhage in aged rats. Transl Stroke Res. 2020;11:541\u201351.","journal-title":"Transl Stroke Res"},{"key":"2474_CR7","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1007\/s12035-016-9785-6","volume":"54","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Zhang Z, Lu H, Yang Q, Wu H, Wang J. Microglial polarization and inflammatory mediators after intracerebral hemorrhage. Mol Neurobiol. 2017;54:1874\u201386.","journal-title":"Mol Neurobiol"},{"key":"2474_CR8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s12974-020-02015-9","volume":"17","author":"M Wang","year":"2020","unstructured":"Wang M, Ye X, Hu J, Zhao Q, Lv B, Ma W, et al. Nod1\/rip2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice. J Neuroinflammation. 2020;17:364.","journal-title":"J Neuroinflammation"},{"key":"2474_CR9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.nbd.2018.06.001","volume":"126","author":"S Dai","year":"2019","unstructured":"Dai S, Hua Y, Keep RF, Novakovic N, Fei Z, Xi G. Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats. Neurobiol Dis. 2019;126:76\u201384.","journal-title":"Neurobiol Dis"},{"key":"2474_CR10","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1126\/science.1172539","volume":"328","author":"L Fontana","year":"2010","unstructured":"Fontana L, Partridge L, Longo VD. Extending healthy life span\u2013from yeast to humans. Science. 2010;328:321\u20136.","journal-title":"Science"},{"key":"2474_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030638","author":"C Kim","year":"2020","unstructured":"Kim C, Pinto AM, Bordoli C, Buckner LP, Kaplan PC, Del Arenal IM, et al. Energy restriction enhances adult hippocampal neurogenesis-associated memory after four weeks in an adult human population with central obesity; a randomized controlled trial. Nutrients. 2020. https:\/\/doi.org\/10.3390\/nu12030638.","journal-title":"Nutrients"},{"key":"2474_CR12","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/s41467-020-14676-4","volume":"11","author":"Z Liu","year":"2020","unstructured":"Liu Z, Dai X, Zhang H, Shi R, Hui Y, Jin X, et al. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nat Commun. 2020;11:855.","journal-title":"Nat Commun"},{"key":"2474_CR13","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1073\/pnas.0808587106","volume":"106","author":"AV Witte","year":"2009","unstructured":"Witte AV, Fobker M, Gellner R, Knecht S, Floel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A. 2009;106:1255\u201360.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"2474_CR14","doi-asserted-by":"publisher","first-page":"6365","DOI":"10.1038\/s41380-021-01102-4","volume":"26","author":"GP Dias","year":"2021","unstructured":"Dias GP, Murphy T, Stangl D, Ahmet S, Morisse B, Nix A, et al. Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene klotho. Mol Psychiatry. 2021;26(11):6365\u201379.","journal-title":"Mol Psychiatry."},{"key":"2474_CR15","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1038\/s41467-018-07033-z","volume":"9","author":"S Matsui","year":"2018","unstructured":"Matsui S, Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, et al. Neuronal sirt1 regulates macronutrient-based diet selection through fgf21 and oxytocin signalling in mice. Nat Commun. 2018;9:4604.","journal-title":"Nat Commun"},{"key":"2474_CR16","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.jaci.2020.07.035","volume":"146","author":"VD Longo","year":"2020","unstructured":"Longo VD, Cortellino S. Fasting, dietary restriction, and immunosenescence. J Allergy Clin Immunol. 2020;146:1002\u20134.","journal-title":"J Allergy Clin Immunol"},{"key":"2474_CR17","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1177\/0271678X211009362","volume":"41","author":"R Vemuganti","year":"2021","unstructured":"Vemuganti R, Arumugam TV. Much ado about eating: Intermittent fasting and post-stroke neuroprotection. J Cereb Blood Flow Metab. 2021;41:1791\u20133.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2474_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101269","author":"DB Stagg","year":"2021","unstructured":"Stagg DB, Gillingham JR, Nelson AB, Lengfeld JE, Andre d\u2019Avignon D, Puchalska P, et al. Diminished ketone interconversion, hepatic tca cycle flux, and glucose production in d-beta-hydroxybutyrate dehydrogenase hepatocyte-deficient mice. Mol Metab. 2021. https:\/\/doi.org\/10.1016\/j.molmet.2021.101269.","journal-title":"Mol Metab"},{"key":"2474_CR19","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.redox.2017.09.016","volume":"14","author":"T Chen","year":"2018","unstructured":"Chen T, Dai SH, Li X, Luo P, Zhu J, Wang YH, et al. Sirt1-sirt3 axis regulates human blood-brain barrier permeability in response to ischemia. Redox Biol. 2018;14:229\u201336.","journal-title":"Redox Biol"},{"key":"2474_CR20","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s12975-020-00790-4","volume":"11","author":"J Wei","year":"2020","unstructured":"Wei J, Wang M, Jing C, Keep RF, Hua Y, Xi G. Multinucleated giant cells in experimental intracerebral hemorrhage. Transl Stroke Res. 2020;11:1095\u2013102.","journal-title":"Transl Stroke Res"},{"key":"2474_CR21","doi-asserted-by":"crossref","unstructured":"Chang CF, Massey J, Osherov A, Angenendt da Costa LH, Sansing LH. Bexarotene enhances macrophage erythrophagocytosis and hematoma clearance in experimental intracerebral hemorrhage. Stroke 2020;51:612\u2013618","DOI":"10.1161\/STROKEAHA.119.027037"},{"key":"2474_CR22","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/s12974-018-1256-8","volume":"15","author":"L Zhao","year":"2018","unstructured":"Zhao L, Chen S, Sherchan P, Ding Y, Zhao W, Guo Z, et al. Recombinant ctrp9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice. J Neuroinflammation. 2018;15:215.","journal-title":"J Neuroinflammation"},{"key":"2474_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.redox.2018.09.022","volume":"20","author":"J Mo","year":"2019","unstructured":"Mo J, Enkhjargal B, Travis ZD, Zhou K, Wu P, Zhang G, et al. Ave 0991 attenuates oxidative stress and neuronal apoptosis via mas\/pka\/creb\/ucp-2 pathway after subarachnoid hemorrhage in rats. Redox Biol. 2019;20:75\u201386.","journal-title":"Redox Biol"},{"key":"2474_CR24","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1172\/JCI95612","volume":"128","author":"CF Chang","year":"2018","unstructured":"Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, et al. Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage. J Clin Invest. 2018;128:607\u201324.","journal-title":"J Clin Invest"},{"key":"2474_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0047-6374(90)90107-Q","volume":"55","author":"CL Goodrick","year":"1990","unstructured":"Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider N. Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age. Mech Ageing Dev. 1990;55:69\u201387.","journal-title":"Mech Ageing Dev"},{"key":"2474_CR26","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1161\/CIRCRESAHA.121.319147","volume":"128","author":"RM Touyz","year":"2021","unstructured":"Touyz RM. Gut dysbiosis-induced hypertension is ameliorated by intermittent fasting. Circ Res. 2021;128:1255\u20137.","journal-title":"Circ Res"},{"key":"2474_CR27","doi-asserted-by":"publisher","first-page":"13533","DOI":"10.1073\/pnas.1820282116","volume":"116","author":"T Miyauchi","year":"2019","unstructured":"Miyauchi T, Uchida Y, Kadono K, Hirao H, Kawasoe J, Watanabe T, et al. Up-regulation of foxo1 and reduced inflammation by beta-hydroxybutyric acid are essential diet restriction benefits against liver injury. Proc Natl Acad Sci U S A. 2019;116:13533\u201342.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2474_CR28","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1038\/s41467-019-09897-1","volume":"10","author":"Y Liu","year":"2019","unstructured":"Liu Y, Cheng A, Li YJ, Yang Y, Kishimoto Y, Zhang S, et al. Sirt3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in app mutant mice. Nat Commun. 2019;10:1886.","journal-title":"Nat Commun"},{"key":"2474_CR29","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev-nutr-052020-041327","volume":"41","author":"KA Varady","year":"2021","unstructured":"Varady KA, Cienfuegos S, Ezpeleta M, Gabel K. Cardiometabolic benefits of intermittent fasting. Annu Rev Nutr. 2021;41:333\u201361.","journal-title":"Annu Rev Nutr"},{"key":"2474_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12974-021-02112-3","volume":"18","author":"S Deng","year":"2021","unstructured":"Deng S, Jin P, Sherchan P, Liu S, Cui Y, Huang L, et al. Recombinant ccl17-dependent ccr4 activation alleviates neuroinflammation and neuronal apoptosis through the pi3k\/akt\/foxo1 signaling pathway after ich in mice. J Neuroinflammation. 2021;18:62.","journal-title":"J Neuroinflammation"},{"key":"2474_CR31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.bbi.2021.02.001","volume":"94","author":"Q Li","year":"2021","unstructured":"Li Q, Lan X, Han X, Durham F, Wan J, Weiland A, et al. Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating cd36. Brain Behav Immun. 2021;94:437\u201357.","journal-title":"Brain Behav Immun"},{"key":"2474_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.725268","volume":"12","author":"Y Liu","year":"2021","unstructured":"Liu Y, Deng S, Song Z, Zhang Q, Guo Y, Yu Y, et al. Mlif modulates microglia polarization in ischemic stroke by targeting eef1a1. Front Pharmacol. 2021;12: 725268.","journal-title":"Front Pharmacol"},{"key":"2474_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.675660","volume":"12","author":"J Liu","year":"2021","unstructured":"Liu J, Liu L, Wang X, Jiang R, Bai Q, Wang G. Microglia: a double-edged sword in intracerebral hemorrhage from basic mechanisms to clinical research. Front Immunol. 2021;12: 675660.","journal-title":"Front Immunol"},{"key":"2474_CR34","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.freeradbiomed.2019.02.018","volume":"135","author":"P Rojas-Morales","year":"2019","unstructured":"Rojas-Morales P, Leon-Contreras JC, Aparicio-Trejo OE, Reyes-Ocampo JG, Medina-Campos ON, Jimenez-Osorio AS, et al. Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med. 2019;135:60\u20137.","journal-title":"Free Radic Biol Med"},{"key":"2474_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101107","volume":"62","author":"ZD Zhou","year":"2020","unstructured":"Zhou ZD, Tan EK. Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of parkinson\u2019s disease. Ageing Res Rev. 2020;62: 101107.","journal-title":"Ageing Res Rev"},{"key":"2474_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110252","volume":"38","author":"V Sahasrabuddhe","year":"2022","unstructured":"Sahasrabuddhe V, Ghosh HS. Cx3cr1-cre induction leads to microglial activation and ifn-1 signaling caused by DNA damage in early postnatal brain. Cell Rep. 2022;38: 110252.","journal-title":"Cell Rep"},{"key":"2474_CR37","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12974-022-02381-6","volume":"19","author":"K Zhou","year":"2022","unstructured":"Zhou K, Han J, Lund H, Boggavarapu NR, Lauschke VM, Goto S, et al. An overlooked subset of cx3cr1(wt\/wt) microglia in the cx3cr1(creer-eyfp\/wt) mouse has a repopulation advantage over cx3cr1(creer-eyfp\/wt) microglia following microglial depletion. J Neuroinflammation. 2022;19:20.","journal-title":"J Neuroinflammation"},{"key":"2474_CR38","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1111\/epi.14526","volume":"59","author":"B Zhang","year":"2018","unstructured":"Zhang B, Zou J, Han L, Beeler B, Friedman JL, Griffin E, et al. The specificity and role of microglia in epileptogenesis in mouse models of tuberous sclerosis complex. Epilepsia. 2018;59:1796\u2013806.","journal-title":"Epilepsia"},{"key":"2474_CR39","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neuroscience.2021.04.022","volume":"465","author":"AR Vasconcelos","year":"2021","unstructured":"Vasconcelos AR, da Paixao AG, Kinoshita PF, Orellana AM, Scavone C, Kawamoto EM. Toll-like receptor 4 signaling is critical for the adaptive cellular stress response effects induced by intermittent fasting in the mouse brain. Neuroscience. 2021;465:142\u201353.","journal-title":"Neuroscience"},{"key":"2474_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060892","author":"I Khan","year":"2021","unstructured":"Khan I, Saeed K, Jo MG, Kim MO. 17-beta estradiol rescued immature rat brain against glutamate-induced oxidative stress and neurodegeneration via regulating nrf2\/ho-1 and map-kinase signaling pathway. Antioxidants (Basel). 2021. https:\/\/doi.org\/10.3390\/antiox10060892.","journal-title":"Antioxidants (Basel)"},{"key":"2474_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107846","volume":"225","author":"YQ Zhou","year":"2021","unstructured":"Zhou YQ, Mei W, Tian XB, Tian YK, Liu DQ, Ye DW. The therapeutic potential of nrf2 inducers in chronic pain: evidence from preclinical studies. Pharmacol Ther. 2021;225: 107846.","journal-title":"Pharmacol Ther"},{"key":"2474_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.06.031","author":"Y Fang","year":"2021","unstructured":"Fang Y, Chen B, Gong AY, Malhotra D, Gupta R, Dworkin LD, et al. The ketone body beta-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults. Kidney Int. 2021. https:\/\/doi.org\/10.1016\/j.kint.2021.06.031.","journal-title":"Kidney Int"},{"key":"2474_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2020.101066","volume":"80","author":"P Abrescia","year":"2020","unstructured":"Abrescia P, Treppiccione L, Rossi M, Bergamo P. Modulatory role of dietary polyunsaturated fatty acids in nrf2-mediated redox homeostasis. Prog Lipid Res. 2020;80: 101066.","journal-title":"Prog Lipid Res"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-022-02474-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-022-02474-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-022-02474-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T05:09:59Z","timestamp":1653628199000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-022-02474-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2474"],"URL":"https:\/\/doi.org\/10.1186\/s12974-022-02474-2","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,27]]},"assertion":[{"value":"28 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have declared that no competing interests exist.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"122"}}