{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:48:20Z","timestamp":1791920900923,"version":"4.3.4"},"reference-count":233,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medical Research Council","award":["MR\/X503125\/1"],"award-info":[{"award-number":["MR\/X503125\/1"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parkinson\u2019s disease (PD) and Alzheimer\u2019s disease (AD) are neurodegenerative disorders caused by the interaction of genetic, environmental, and familial factors. These diseases have distinct pathologies and symptoms that are linked to specific cell populations in the brain. Notably, the immune system has been implicated in both diseases, with a particular focus on the dysfunction of microglia, the brain\u2019s resident immune cells, contributing to neuronal loss and exacerbating symptoms. Researchers use models of the neuroimmune system to gain a deeper understanding of the physiological and biological aspects of these neurodegenerative diseases and how they progress. Several in vitro and in vivo models, including 2D cultures and animal models, have been utilized. Recently, advancements have been made in optimizing these existing models and developing 3D models and organ-on-a-chip systems, holding tremendous promise in accurately mimicking the intricate intracellular environment. As a result, these models represent a crucial breakthrough in the transformation of current treatments for PD and AD by offering potential for conducting long-term disease-based modeling for therapeutic testing, reducing reliance on animal models, and significantly improving cell viability compared to conventional 2D models. The application of 3D and organ-on-a-chip models in neurodegenerative disease research marks a prosperous step forward, providing a more realistic representation of the complex interactions within the neuroimmune system. Ultimately, these refined models of the neuroimmune system aim to aid in the quest to combat and mitigate the impact of debilitating neuroimmune diseases on patients and their families.<\/jats:p>","DOI":"10.1186\/s12974-024-03024-8","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T12:02:28Z","timestamp":1706011348000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Modeling the neuroimmune system in Alzheimer\u2019s and Parkinson\u2019s diseases"],"prefix":"10.1186","volume":"21","author":[{"given":"Wendy","family":"Balestri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca C.","family":"Bobotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel J.","family":"Curle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Kothakota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnoosh","family":"Kalantarnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Hangad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Hoorfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-\u00c8ve","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan J.","family":"El-Jawhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Willerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Reinwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"3024_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.10.004","volume":"112","author":"S Ghavami","year":"2014","unstructured":"Ghavami S, Shojaei S, Yeganeh B, Ande SR, Jangamreddy JR, Mehrpour M, et al. Autophagy and apoptosis dysfunction in neurodegenerative disorders. Prog Neurobiol. 2014;112:24\u201349.","journal-title":"Prog Neurobiol"},{"issue":"22","key":"3024_CR2","doi-asserted-by":"publisher","first-page":"8411","DOI":"10.1523\/JNEUROSCI.2745-14.2015","volume":"35","author":"E Hennessy","year":"2015","unstructured":"Hennessy E, Griffin EW, Cunningham C. Astrocytes are primed by chronic neurodegeneration to produce exaggerated chemokine and cell infiltration responses to acute stimulation with the cytokines IL-1\u03b2 and TNF-\u03b1. J Neurosci. 2015;35(22):8411\u201322.","journal-title":"J Neurosci"},{"key":"3024_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147308","volume":"1758","author":"V Vedam-Mai","year":"2021","unstructured":"Vedam-Mai V. Harnessing the immune system for the treatment of Parkinson\u2019s disease. Brain Res. 2021;1758: 147308.","journal-title":"Brain Res"},{"issue":"9","key":"3024_CR4","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.3390\/life12091440","volume":"12","author":"T Zieneldien","year":"2022","unstructured":"Zieneldien T, Kim J, Sawmiller D, Cao C. The immune system as a therapeutic target for Alzheimer\u2019s disease. Life. 2022;12(9):1440.","journal-title":"Life"},{"issue":"4","key":"3024_CR5","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033118","volume":"10","author":"MG Erkkinen","year":"2017","unstructured":"Erkkinen MG, Kim MO, Geschwind MD. Clinical neurology and epidemiology of the major neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2017;10(4): a033118.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3024_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112924","volume":"149","author":"S Cetin","year":"2022","unstructured":"Cetin S, Knez D, Gobec S, Kos J, Pi\u0161lar A. Cell models for Alzheimer\u2019s and Parkinson\u2019s disease: at the interface of biology and drug discovery. Biomed Pharmacother. 2022;149: 112924.","journal-title":"Biomed Pharmacother"},{"key":"3024_CR7","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3389\/fcell.2020.00729","volume":"8","author":"TW Kim","year":"2020","unstructured":"Kim TW, Koo SY, Studer L. Pluripotent stem cell therapies for Parkinson disease: present challenges and future opportunities. Front Cell Dev Biol. 2020;8:729.","journal-title":"Front Cell Dev Biol"},{"key":"3024_CR8","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fcell.2020.00328","volume":"8","author":"A Slanzi","year":"2020","unstructured":"Slanzi A, Iannoto G, Rossi B, Zenaro E, Constantin G. In vitro models of neurodegenerative diseases. Front Cell Dev Biol. 2020;8:328.","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"3024_CR9","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/jnnp-2018-319148","volume":"90","author":"XN Shen","year":"2019","unstructured":"Shen XN, Niu LD, Wang YJ, Cao XP, Liu Q, Tan L, et al. Inflammatory markers in Alzheimer\u2019s disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies. J Neurol Neurosurg Psychiatry. 2019;90(5):590\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"3024_CR10","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/gps.5124","volume":"34","author":"E King","year":"2019","unstructured":"King E, O\u2019Brien J, Donaghy P, Williams-Gray CH, Lawson RA, Morris CM, et al. Inflammation in mild cognitive impairment due to Parkinson\u2019s disease, Lewy body disease, and Alzheimer\u2019s disease. Int J Geriatr Psychiatry. 2019;34(8):1244\u201350.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"12","key":"3024_CR11","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1111\/ene.14450","volume":"27","author":"ANW Degersk\u00e4r","year":"2020","unstructured":"Degersk\u00e4r ANW, Englund EM. Cause of death in autopsy-confirmed dementia disorders. Eur J Neurol. 2020;27(12):2415\u201321.","journal-title":"Eur J Neurol"},{"issue":"1","key":"3024_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13024-018-0258-4","volume":"13","author":"EGZ Centeno","year":"2018","unstructured":"Centeno EGZ, Cimarosti H, Bithell A. 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling. Mol Neurodegener. 2018;13(1):27.","journal-title":"Mol Neurodegener"},{"key":"3024_CR13","doi-asserted-by":"crossref","unstructured":"Mockett BG, Richter M, Abraham WC, M\u00fcller UC. Therapeutic potential of secreted amyloid precursor protein APPs\u03b1. Front Mol Neurosci. 2017;10.","DOI":"10.3389\/fnmol.2017.00030"},{"issue":"10","key":"3024_CR14","doi-asserted-by":"publisher","first-page":"869","DOI":"10.2174\/1567205017666201203142103","volume":"17","author":"DV Zaretsky","year":"2020","unstructured":"Zaretsky DV, Zaretskaia M. Degradation products of amyloid protein: are they the culprits? Curr Alzheimer Res. 2020;17(10):869\u201380.","journal-title":"Curr Alzheimer Res"},{"issue":"3","key":"3024_CR15","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/alz.12701","volume":"19","author":"EB Rischel","year":"2022","unstructured":"Rischel EB, Gejl M, Brock B, Rungby J, Gjedde A. In Alzheimer\u2019s disease, amyloid beta accumulation is a protective mechanism that ultimately fails. Alzheimer\u2019s & Dementia. 2022;19(3):771\u201383.","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"3024_CR16","unstructured":"National Institute on Aging. Alzheimer\u2019s Disease Genetics Fact Sheet [Internet]. [cited 2023 Aug 31]. Available from: https:\/\/www.nia.nih.gov\/health\/alzheimers-disease-genetics-fact-sheet."},{"issue":"10","key":"3024_CR17","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ng.439","volume":"41","author":"JC Lambert","year":"2009","unstructured":"Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer\u2019s disease. Nat Genet. 2009;41(10):1094\u20139.","journal-title":"Nat Genet"},{"issue":"11","key":"3024_CR18","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","volume":"14","author":"TK Ulland","year":"2018","unstructured":"Ulland TK, Colonna M. TREM2\u2014a key player in microglial biology and Alzheimer disease. Nat Rev Neurol. 2018;14(11):667\u201375.","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"3024_CR19","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1021\/acs.jproteome.0c00137","volume":"19","author":"J Sinsky","year":"2020","unstructured":"Sinsky J, Majerova P, Kovac A, Kotlyar M, Jurisica I, Hanes J. Physiological tau interactome in brain and its link to tauopathies. J Proteome Res. 2020;19(6):2429\u201342.","journal-title":"J Proteome Res"},{"issue":"3","key":"3024_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0197-4580(94)00176-2","volume":"16","author":"JQ Trojanowski","year":"1995","unstructured":"Trojanowski JQ, Shin RW, Schmidt ML, Lee VMY. Relationship between plaques, tangles, and dystrophic processes in Alzheimer\u2019s disease. Neurobiol Aging. 1995;16(3):335\u201340.","journal-title":"Neurobiol Aging"},{"key":"3024_CR21","doi-asserted-by":"crossref","unstructured":"Ferguson AC, Tank R, Lyall LM, Ward J, Celis-Morales C, Strawbridge R, et al. Alzheimer\u2019s disease susceptibility gene apolipoprotein E (APOE) and blood biomarkers in UK biobank (N = 395,769). Beason-Held L, editor. J Alzheimer\u2019s Dis. 2020;1\u201311.","DOI":"10.3233\/JAD-200338"},{"issue":"4","key":"3024_CR22","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.3390\/ijms22042110","volume":"22","author":"WM Van Oostveen","year":"2021","unstructured":"Van Oostveen WM, De Lange ECM, Orzechowski A. Molecular sciences imaging techniques in Alzheimer\u2019s disease: a review of applications in early diagnosis and longitudinal monitoring. Int J Mol Sci. 2021;22(4):2110.","journal-title":"Int J Mol Sci"},{"key":"3024_CR23","doi-asserted-by":"crossref","unstructured":"Sutherland K, Li T, Cao C. Alzheimer\u2019s disease and the immune system. SOJ Neurol. 2015;2(1).","DOI":"10.15226\/2374-6858\/2\/1\/00112"},{"issue":"4","key":"3024_CR24","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/jgh3.12450","volume":"5","author":"AH Tan","year":"2021","unstructured":"Tan AH, Hor JW, Chong CW, Lim SY. Probiotics for Parkinson\u2019s disease: current evidence and future directions. JGH Open. 2021;5(4):414\u20139.","journal-title":"JGH Open"},{"issue":"11","key":"3024_CR25","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","volume":"17","author":"BM Bettcher","year":"2021","unstructured":"Bettcher BM, Tansey MG, Doroth\u00e9e G, Heneka MT. Peripheral and central immune system crosstalk in Alzheimer disease\u2014a research prospectus. Nat Rev Neurol. 2021;17(11):689\u2013701.","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"3024_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.stem.2021.01.004","volume":"28","author":"J Piao","year":"2021","unstructured":"Piao J, Zabierowski S, Dubose BN, Hill EJ, Navare M, Claros N, et al. Preclinical efficacy and safety of a human embryonic stem cell-derived midbrain dopamine progenitor product, MSK-DA01. Cell Stem Cell. 2021;28(2):217\u201329.","journal-title":"Cell Stem Cell"},{"issue":"44","key":"3024_CR27","doi-asserted-by":"publisher","first-page":"1910250","DOI":"10.1002\/adfm.201910250","volume":"30","author":"B Qiu","year":"2020","unstructured":"Qiu B, Bessler N, Figler K, Buchholz MB, Rios AC, Malda J, et al. Bioprinting neural systems to model central nervous system diseases. Adv Funct Mater. 2020;30(44):1910250.","journal-title":"Adv Funct Mater"},{"key":"3024_CR28","doi-asserted-by":"crossref","unstructured":"Jasmin M, Ahn EH, Voutilainen MH, Fombonne J, Guix C, Viljakainen T, et al. Netrin\u20101 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson\u2019s disease features. EMBO J. 2020;40(3).","DOI":"10.15252\/embj.2020105537"},{"key":"3024_CR29","first-page":"9","volume":"26","author":"KE Fouke","year":"2021","unstructured":"Fouke KE, Wegman ME, Weber SA, Brady EB, Rom\u00e1n-Vendrell C, Morgan JR. Synuclein regulates synaptic vesicle clustering and docking at a vertebrate synapse. Front Cell Dev Biol. 2021;26:9.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"3024_CR30","doi-asserted-by":"publisher","first-page":"167775","DOI":"10.1016\/j.jmb.2022.167775","volume":"435","author":"G Yoo","year":"2023","unstructured":"Yoo G, Shin YK, Lee NK. The role of \u03b1-synuclein in SNARE-mediated synaptic vesicle fusion. J Mol Biol. 2023;435(1):167775.","journal-title":"J Mol Biol"},{"key":"3024_CR31","doi-asserted-by":"crossref","unstructured":"Li Y, Zhu Z, Chen J, Zhang M, Yang Y, Huang P. Dilated perivascular space in the midbrain may reflect dopamine neuronal degeneration in Parkinson\u2019s disease. Front Aging Neurosci. 2020;12.","DOI":"10.3389\/fnagi.2020.00161"},{"issue":"6","key":"3024_CR32","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1136\/jnnp-2020-324606","volume":"92","author":"FPM Oliveira","year":"2021","unstructured":"Oliveira FPM, Walker Z, Walker RWH, Attems J, Castanheira JC, Silva \u00c2, et al. 123I-FP-CIT SPECT in dementia with Lewy bodies, Parkinson\u2019s disease and Alzheimer\u2019s disease: a new quantitative analysis of autopsy confirmed cases. J Neurol Neurosurg Psychiatry. 2021;92(6):662\u20137.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3024_CR33","unstructured":"Johns Hopkins Medicine. The Genetic Link to Parkinson\u2019s Disease [Internet]. [cited 2023 Aug 31]. Available from: https:\/\/www.hopkinsmedicine.org\/health\/conditions-and-diseases\/parkinsons-disease\/the-genetic-link-to-parkinsons-disease."},{"key":"3024_CR34","doi-asserted-by":"crossref","unstructured":"Hatton C, Reeve A, Lax NZ, Blain A, Ng YS, El-Agnaf O, et al. Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies. Acta Neuropathol Commun. 2020;8(1).","DOI":"10.1186\/s40478-020-00985-8"},{"issue":"9996","key":"3024_CR35","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"LV Kalia","year":"2015","unstructured":"Kalia LV, Lang AE. Parkinson\u2019s disease. The Lancet. 2015;386(9996):896\u2013912.","journal-title":"The Lancet"},{"key":"3024_CR36","doi-asserted-by":"crossref","unstructured":"Han JW, Ahn YD, Kim WS, Shin CM, Jeong SJ, Song YS, et al. Psychiatric manifestation in patients with Parkinson\u2019s disease. J Korean Med Sci. 2018;33(47).","DOI":"10.3346\/jkms.2018.33.e300"},{"issue":"8","key":"3024_CR37","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3174\/ajnr.A7171","volume":"42","author":"WC Lin","year":"2021","unstructured":"Lin WC, Lee PL, Lu CH, Lin CP, Chou KH. Linking stage-specific plasma biomarkers to gray matter atrophy in Parkinson disease. Am J Neuroradiol. 2021;42(8):1444\u201351.","journal-title":"Am J Neuroradiol"},{"key":"3024_CR38","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1111\/cns.14149","volume":"29","author":"Z Chen","year":"2023","unstructured":"Chen Z, Wu B, Li G, Zhou L, Zhang L, Liu J. Age and sex differentially shape brain networks in Parkinson\u2019s disease. CNS Neurosci Ther. 2023;29:1907.","journal-title":"CNS Neurosci Ther"},{"key":"3024_CR39","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.bbi.2021.07.022","volume":"97","author":"K Picard","year":"2021","unstructured":"Picard K, Bisht K, Poggini S, Garofalo S, Golia MT, Basilico B, et al. Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. Brain Behav Immun. 2021;97:423\u201339.","journal-title":"Brain Behav Immun"},{"issue":"1","key":"3024_CR40","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/glia.24101","volume":"70","author":"B Basilico","year":"2022","unstructured":"Basilico B, Ferrucci L, Ratano P, Golia MT, Grimaldi A, Rosito M, et al. Microglia control glutamatergic synapses in the adult mouse hippocampus. Glia. 2022;70(1):173\u201395.","journal-title":"Glia"},{"issue":"22","key":"3024_CR41","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1016\/j.cell.2022.09.033","volume":"185","author":"S Wang","year":"2022","unstructured":"Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, et al. TREM2 drives microglia response to amyloid-\u03b2 via SYK-dependent and -independent pathways. Cell. 2022;185(22):4153-4169.e19.","journal-title":"Cell"},{"issue":"8","key":"3024_CR42","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13182","volume":"19","author":"N Yanguas-Cas\u00e1s","year":"2020","unstructured":"Yanguas-Cas\u00e1s N, Crespo-Castrillo A, Arevalo MA, Garcia-Segura LM. Aging and sex: impact on microglia phagocytosis. Aging Cell. 2020;19(8): e13182.","journal-title":"Aging Cell"},{"key":"3024_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113310","volume":"329","author":"NA Devanney","year":"2020","unstructured":"Devanney NA, Stewart AN, Gensel JC. Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma. Exp Neurol. 2020;329: 113310.","journal-title":"Exp Neurol"},{"issue":"19","key":"3024_CR44","doi-asserted-by":"publisher","first-page":"7357","DOI":"10.3390\/ijms21197357","volume":"21","author":"DJ Verdon","year":"2020","unstructured":"Verdon DJ, Mulazzani M, Jenkins MR. Cellular and molecular mechanisms of CD8+ T cell differentiation, dysfunction and exhaustion. Int J Mol Sci. 2020;21(19):7357.","journal-title":"Int J Mol Sci"},{"key":"3024_CR45","doi-asserted-by":"crossref","unstructured":"Rocamora-Reverte L, Melzer FL, W\u00fcrzner R, Weinberger B. The complex role of regulatory T cells in immunity and aging. Front Immunol. 2021;11.","DOI":"10.3389\/fimmu.2020.616949"},{"issue":"1","key":"3024_CR46","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1038\/s41467-021-22479-4","volume":"12","author":"K Kim","year":"2021","unstructured":"Kim K, Wang X, Ragonnaud E, Bodogai M, Illouz T, DeLuca M, et al. Therapeutic B-cell depletion reverses progression of Alzheimer\u2019s disease. Nat Commun. 2021;12(1):2185.","journal-title":"Nat Commun"},{"issue":"1","key":"3024_CR47","first-page":"575","volume":"4","author":"JW Kinney","year":"2018","unstructured":"Kinney JW, Bemiller SM, Murtishaw AS, Leisgang AM, Salazar AM, Lamb BT. Inflammation as a central mechanism in Alzheimer\u2019s disease. Alzheimer\u2019s & Dementia. 2018;4(1):575\u201390.","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"21","key":"3024_CR48","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","volume":"110","author":"RC Paolicelli","year":"2022","unstructured":"Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, et al. Microglia states and nomenclature: a field at its crossroads. Neuron. 2022;110(21):3458\u201383.","journal-title":"Neuron"},{"key":"3024_CR49","doi-asserted-by":"crossref","unstructured":"Gross AL, Walker KA, Moghekar AR, Pettigrew C, Soldan A, Albert MS, et al. Plasma markers of inflammation linked to clinical progression and decline during preclinical AD. Front Aging Neurosci. 2019;11.","DOI":"10.3389\/fnagi.2019.00229"},{"issue":"6","key":"3024_CR50","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.jalz.2019.03.007","volume":"15","author":"AR Morgan","year":"2019","unstructured":"Morgan AR, Touchard S, Leckey C, O\u2019Hagan C, Nevado-Holgado AJ, et al. Inflammatory biomarkers in Alzheimer\u2019s disease plasma. Alzheimer\u2019s & Dementia. 2019;15(6):776\u201387.","journal-title":"Alzheimer\u2019s & Dementia."},{"issue":"11","key":"3024_CR51","doi-asserted-by":"publisher","first-page":"110961","DOI":"10.1016\/j.celrep.2022.110961","volume":"39","author":"SK Shabestari","year":"2022","unstructured":"Shabestari SK, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, et al. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer\u2019s disease mice. Cell Rep. 2022;39(11):110961.","journal-title":"Cell Rep"},{"key":"3024_CR52","doi-asserted-by":"crossref","unstructured":"St-Pierre MK, VanderZwaag J, Loewen S, Tremblay M\u00c8. All roads lead to heterogeneity: the complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer\u2019s disease. Front Cell Neurosci. 2022;16.","DOI":"10.3389\/fncel.2022.932572"},{"issue":"3","key":"3024_CR53","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.cmet.2019.08.017","volume":"30","author":"FC Bennett","year":"2019","unstructured":"Bennett FC, Liddelow SA. Microglia metabolic breakdown drives Alzheimer\u2019s pathology. Cell Metab. 2019;30(3):405\u20136.","journal-title":"Cell Metab"},{"issue":"3","key":"3024_CR54","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41593-023-01257-z","volume":"26","author":"S De Schepper","year":"2023","unstructured":"De Schepper S, Ge JZ, Crowley G, Ferreira LSS, Garceau D, Toomey CE, et al. Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer\u2019s disease. Nat Neurosci. 2023;26(3):406\u201315.","journal-title":"Nat Neurosci"},{"issue":"5","key":"3024_CR55","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/glia.22966","volume":"64","author":"K Bisht","year":"2016","unstructured":"Bisht K, Sharma KP, Lecours C, S\u00e1nchez MG, El Hajj H, Milior G, et al. Dark microglia: a new phenotype predominantly associated with pathological states. Glia. 2016;64(5):826\u201339.","journal-title":"Glia"},{"key":"3024_CR56","doi-asserted-by":"publisher","first-page":"175909142092533","DOI":"10.1177\/1759091420925335","volume":"12","author":"MK St-Pierre","year":"2020","unstructured":"St-Pierre MK, \u0160imon\u010di\u010dov\u00e1 E, B\u00f6gi E, Tremblay M\u00c8. Shedding light on the dark side of the microglia. ASN Neuro. 2020;12:1759091420925335.","journal-title":"ASN Neuro"},{"issue":"11","key":"3024_CR57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI152565","volume":"132","author":"P Yan","year":"2022","unstructured":"Yan P, Kim KW, Xiao Q, Ma X, Czerniewski LR, Liu H, et al. Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer\u2019s disease. J Clin Invest. 2022;132(11): e152565.","journal-title":"J Clin Invest"},{"issue":"1","key":"3024_CR58","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12979-021-00236-x","volume":"18","author":"U Munawara","year":"2021","unstructured":"Munawara U, Catanzaro M, Xu W, Tan C, Hirokawa K, Bosco N, et al. Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer\u2019s disease. Immunity & Ageing. 2021;18(1):29.","journal-title":"Immunity & Ageing"},{"issue":"1","key":"3024_CR59","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13195-021-00940-2","volume":"14","author":"JL Sanchez-Sanchez","year":"2022","unstructured":"Sanchez-Sanchez JL, Giudici KV, Guyonnet S, Delrieu J, Li Y, Bateman RJ, et al. Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. Alzheimer\u2019s Res Ther. 2022;14(1):5.","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"1","key":"3024_CR60","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s12974-021-02308-7","volume":"18","author":"J Machhi","year":"2021","unstructured":"Machhi J, Yeapuri P, Lu Y, Foster E, Chikhale R, Herskovitz J, et al. CD4+ effector T cells accelerate Alzheimer\u2019s disease in mice. J Neuroinflammation. 2021;18(1):272.","journal-title":"J Neuroinflammation"},{"issue":"13","key":"3024_CR61","doi-asserted-by":"publisher","first-page":"110557","DOI":"10.1016\/j.celrep.2022.110557","volume":"38","author":"J Zhou","year":"2022","unstructured":"Zhou J, Geng Y, Su T, Wang Q, Ren Y, Zhao J, et al. NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury. Cell Rep. 2022;38(13):110557.","journal-title":"Cell Rep"},{"issue":"1","key":"3024_CR62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12974-021-02099-x","volume":"18","author":"AF Batista","year":"2021","unstructured":"Batista AF, Rody T, Forny-Germano L, Cerdeiro S, Bellio M, Ferreira ST, et al. Interleukin-1\u03b2 mediates alterations in mitochondrial fusion\/fission proteins and memory impairment induced by amyloid-\u03b2 oligomers. J Neuroinflammation. 2021;18(1):54.","journal-title":"J Neuroinflammation"},{"issue":"7","key":"3024_CR63","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1002\/glia.23318","volume":"66","author":"M Plescher","year":"2018","unstructured":"Plescher M, Seifert G, Hansen JN, Bedner P, Steinh\u00e4user C, Halle A. Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer\u2019s disease mouse model. Glia. 2018;66(7):1464\u201380.","journal-title":"Glia"},{"issue":"1","key":"3024_CR64","doi-asserted-by":"publisher","first-page":"15955","DOI":"10.1038\/s41598-021-95535-0","volume":"11","author":"DK Franco-Bocanegra","year":"2021","unstructured":"Franco-Bocanegra DK, Gourari Y, McAuley C, Chatelet DS, Johnston DA, Nicoll JAR, et al. Microglial morphology in Alzheimer\u2019s disease and after A\u03b2 immunotherapy. Sci Rep. 2021;11(1):15955.","journal-title":"Sci Rep"},{"issue":"1","key":"3024_CR65","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/s41598-018-19807-y","volume":"8","author":"WJ Lee","year":"2018","unstructured":"Lee WJ, Liao YC, Wang YF, Lin IF, Wang SJ, Fuh JL. Plasma MCP-1 and cognitive decline in patients with Alzheimer\u2019s disease and mild cognitive impairment: a two-year follow-up study. Sci Rep. 2018;8(1):1280.","journal-title":"Sci Rep"},{"key":"3024_CR66","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.bbi.2021.08.234","volume":"98","author":"L Dai","year":"2021","unstructured":"Dai L, Wang Q, Lv X, Gao F, Chen Z, Shen Y. Elevated \u03b2-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer\u2019s disease. Brain Behav Immun. 2021;98:337\u201348.","journal-title":"Brain Behav Immun"},{"key":"3024_CR67","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.bbi.2020.05.070","volume":"89","author":"MS Unger","year":"2020","unstructured":"Unger MS, Li E, Scharnagl L, Poupardin R, Altendorfer B, Mrowetz H, et al. CD8+ T-cells infiltrate Alzheimer\u2019s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice. Brain Behav Immun. 2020;89:67\u201386.","journal-title":"Brain Behav Immun"},{"issue":"7","key":"3024_CR68","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1093\/brain\/awm111","volume":"130","author":"CH Williams-Gray","year":"2007","unstructured":"Williams-Gray CH, Foltynie T, Brayne CEG, Robbins TW, Barker RA. Evolution of cognitive dysfunction in an incident Parkinson\u2019s disease cohort. Brain. 2007;130(7):1787\u201398.","journal-title":"Brain"},{"issue":"11","key":"3024_CR69","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1136\/jnnp-2013-305277","volume":"84","author":"CH Williams-Gray","year":"2013","unstructured":"Williams-Gray CH, Mason SL, Evans JR, Foltynie T, Brayne C, Robbins TW, et al. The CamPaIGN study of Parkinson\u2019s disease: 10-year outlook in an incident population-based cohort. J Neurol Neurosurg Psychiatry. 2013;84(11):1258\u201364.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"3024_CR70","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1093\/brain\/awp245","volume":"132","author":"CH Williams-Gray","year":"2009","unstructured":"Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, et al. The distinct cognitive syndromes of Parkinson\u2019s disease: 5 year follow-up of the CamPaIGN cohort. Brain. 2009;132(11):2958\u201369.","journal-title":"Brain"},{"issue":"9","key":"3024_CR71","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/ng.642","volume":"42","author":"TH Hamza","year":"2010","unstructured":"Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson\u2019s disease. Nat Genet. 2010;42(9):781\u20135.","journal-title":"Nat Genet"},{"issue":"11","key":"3024_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027109","volume":"6","author":"EM Hill-Burns","year":"2011","unstructured":"Hill-Burns EM, Factor SA, Zabetian CP, Thomson G, Payami H. Evidence for more than one Parkinson\u2019s disease-associated variant within the HLA region. PLoS ONE. 2011;6(11): e27109.","journal-title":"PLoS ONE"},{"issue":"4","key":"3024_CR73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175882","volume":"12","author":"S Pierce","year":"2017","unstructured":"Pierce S, Coetzee GA. Parkinson\u2019s disease-associated genetic variation is linked to quantitative expression of inflammatory genes. PLoS ONE. 2017;12(4): e0175882.","journal-title":"PLoS ONE"},{"issue":"7","key":"3024_CR74","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1001\/jamaneurol.2017.0469","volume":"74","author":"A Witoelar","year":"2017","unstructured":"Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, et al. Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurol. 2017;74(7):780.","journal-title":"JAMA Neurol"},{"key":"3024_CR75","doi-asserted-by":"publisher","first-page":"1103053","DOI":"10.3389\/fimmu.2023.1103053","volume":"14","author":"M Li","year":"2023","unstructured":"Li M, Wan J, Xu Z, Tang B. The association between Parkinson\u2019s disease and autoimmune diseases: a systematic review and meta-analysis. Front Immunol. 2023;14:1103053.","journal-title":"Front Immunol"},{"issue":"11","key":"3024_CR76","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41577-022-00684-6","volume":"22","author":"MG Tansey","year":"2022","unstructured":"Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol. 2022;22(11):657\u201373.","journal-title":"Nat Rev Immunol"},{"key":"3024_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135164","volume":"735","author":"IO Awogbindin","year":"2020","unstructured":"Awogbindin IO, Ishola IO, St-Pierre MK, Carrier M, Savage JC, Di Paolo T, et al. Remodeling microglia to a protective phenotype in Parkinson\u2019s disease? Neurosci Lett. 2020;735: 135164.","journal-title":"Neurosci Lett"},{"issue":"2","key":"3024_CR78","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.neuron.2017.06.020","volume":"95","author":"LM De Biase","year":"2017","unstructured":"De Biase LM, Schuebel KE, Fusfeld ZH, Jair K, Hawes IA, Cimbro R, et al. Local cues establish and maintain region-specific phenotypes of basal ganglia microglia. Neuron. 2017;95(2):341\u201356.","journal-title":"Neuron"},{"issue":"3","key":"3024_CR79","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2013.159","volume":"21","author":"Y Tang","year":"2014","unstructured":"Tang Y, Li T, Li J, Yang J, Liu H, Zhang XJ, et al. Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson\u2019s disease. Cell Death Differ. 2014;21(3):369\u201380.","journal-title":"Cell Death Differ"},{"issue":"3","key":"3024_CR80","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1093\/brain\/awab446","volume":"145","author":"S Smaji\u0107","year":"2022","unstructured":"Smaji\u0107 S, Prada-Medina CA, Landoulsi Z, Ghelfi J, Delcambre S, Dietrich C, et al. Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain. 2022;145(3):964\u201378.","journal-title":"Brain"},{"key":"3024_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-020-01083-5","volume":"8","author":"A Kouli","year":"2020","unstructured":"Kouli A, Camacho M, Allinson K, Williams-Gray CH. Neuroinflammation and protein pathology in Parkinson\u2019s disease dementia. Acta Neuropathol Commun. 2020;8:1\u201319.","journal-title":"Acta Neuropathol Commun"},{"issue":"5","key":"3024_CR82","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S1474-4422(09)70068-7","volume":"8","author":"KR Chaudhuri","year":"2009","unstructured":"Chaudhuri KR, Schapira AHV. Non-motor symptoms of Parkinson\u2019s disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 2009;8(5):464\u201374.","journal-title":"Lancet Neurol"},{"issue":"1","key":"3024_CR83","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41531-021-00263-x","volume":"8","author":"C Pellegrini","year":"2022","unstructured":"Pellegrini C, D\u2019Antongiovanni V, Miraglia F, Rota L, Benvenuti L, Di Salvo C, et al. Enteric \u03b1-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson\u2019s disease before brain pathology. NPJ Parkinsons Dis. 2022;8(1):9.","journal-title":"NPJ Parkinsons Dis"},{"issue":"7660","key":"3024_CR84","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nature22815","volume":"546","author":"D Sulzer","year":"2017","unstructured":"Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, et al. T cells from patients with Parkinson\u2019s disease recognize \u03b1-synuclein peptides. Nature. 2017;546(7660):656\u201361.","journal-title":"Nature"},{"key":"3024_CR85","doi-asserted-by":"crossref","unstructured":"Grozdanov V, Bliederhaeuser C, Ruf WP, Roth V, Fundel-Clemens K, Zondler L, et al. Inflammatory dysregulation of blood monocytes in Parkinson\u2019s disease patients. Acta Neuropathol. 2014;128:651\u201363.","DOI":"10.1007\/s00401-014-1345-4"},{"issue":"7","key":"3024_CR86","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1002\/mds.26563","volume":"31","author":"CH Williams-Gray","year":"2016","unstructured":"Williams-Gray CH, Wijeyekoon R, Yarnall AJ, Lawson RA, Breen DP, Evans JR, et al. Serum immune markers and disease progression in an incident Parkinson\u2019s disease cohort (ICICLE-PD). Mov Disord. 2016;31(7):995\u20131003.","journal-title":"Mov Disord"},{"key":"3024_CR87","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.3389\/fimmu.2018.02122","volume":"9","author":"X Chen","year":"2018","unstructured":"Chen X, Hu Y, Cao Z, Liu Q, Cheng Y. Cerebrospinal fluid inflammatory cytokine aberrations in Alzheimer\u2019s disease, Parkinson\u2019s disease and amyotrophic lateral sclerosis: a systematic review and meta-analysis. Front Immunol. 2018;9:2122.","journal-title":"Front Immunol"},{"key":"3024_CR88","doi-asserted-by":"crossref","unstructured":"Yan Z, Yang W, Wei H, Dean MN, Standaert DG, Cutter GR, et al. Dysregulation of the adaptive immune system in patients with early-stage Parkinson disease. Neurol Neuroimmunol Neuroinflamm. 2021;8(5).","DOI":"10.1212\/NXI.0000000000001036"},{"issue":"s1","key":"3024_CR89","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.3233\/JPD-223152","volume":"12","author":"E Contaldi","year":"2022","unstructured":"Contaldi E, Magistrelli L, Comi C. T lymphocytes in Parkinson\u2019s disease. J Parkinson\u2019s Dis. 2022;12(s1):S65\u201374.","journal-title":"J Parkinson\u2019s Dis"},{"key":"3024_CR90","doi-asserted-by":"publisher","first-page":"720","DOI":"10.3389\/fneur.2017.00720","volume":"8","author":"A Shalash","year":"2017","unstructured":"Shalash A, Salama M, Makar M, Roushdy T, Elrassas HH, Mohamed W, et al. Elevated serum \u03b1-synuclein autoantibodies in patients with Parkinson\u2019s disease relative to Alzheimer\u2019s disease and controls. Front Neurol. 2017;8:720.","journal-title":"Front Neurol"},{"key":"3024_CR91","doi-asserted-by":"crossref","unstructured":"Li R, Tropea TF, Baratta LR, Zuroff L, Diaz-Ortiz ME, Zhang B, et al. Abnormal B-cell and Tfh-cell profiles in patients with Parkinson disease: a cross-sectional study. Neurol Neuroimmunol Neuroinflamm. 2022;9(2).","DOI":"10.1212\/NXI.0000000000001125"},{"key":"3024_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.814239","volume":"13","author":"P Wang","year":"2022","unstructured":"Wang P, Luo M, Zhou W, Jin X, Xu Z, Yan S, et al. Global characterization of peripheral B cells in Parkinson\u2019s disease by single-cell RNA and BCR sequencing. Front Immunol. 2022;13: 814239.","journal-title":"Front Immunol"},{"issue":"5","key":"3024_CR93","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/jcbfm.2015.32","volume":"35","author":"MT Gray","year":"2015","unstructured":"Gray MT, Woulfe JM. Striatal blood\u2013brain barrier permeability in Parkinson\u2019s disease. J Cereb Blood Flow Metab. 2015;35(5):747\u201350.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"10284","key":"3024_CR94","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, Holstege H, Ch\u00e9telat G, Teunissen CE, et al. Alzheimer\u2019s disease. The Lancet. 2021;397(10284):1577\u201390.","journal-title":"The Lancet"},{"issue":"2","key":"3024_CR95","first-page":"190","volume":"9","author":"ZS Khachaturian","year":"2022","unstructured":"Khachaturian ZS. The \u2018aducanumab story\u2019: will the last chapter spell the end of the \u2018amyloid hypothesis\u2019 or mark a new beginning? J Prevent Alzheimer\u2019s Dis. 2022;9(2):190\u20132.","journal-title":"J Prevent Alzheimer\u2019s Dis"},{"issue":"S9","key":"3024_CR96","doi-asserted-by":"publisher","DOI":"10.1002\/alz.042978","volume":"16","author":"K Baruch","year":"2020","unstructured":"Baruch K, Kertser A, Matalon O, Forsht O, Braiman S, Shochat E, et al. IBC-Ab002, an anti-PD-L1 monoclonal antibody tailored for treating Alzheimer\u2019s disease. Alzheimer\u2019s & Dementia. 2020;16(S9): e042978.","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"1","key":"3024_CR97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-021-00948-8","volume":"14","author":"BW Kang","year":"2022","unstructured":"Kang BW, Kim F, Cho JY, Kim SY, Rhee J, Choung JJ. Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. Alzheimer\u2019s Res Ther. 2022;14(1):1\u201317.","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"1","key":"3024_CR98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-020-00736-w","volume":"13","author":"SH Koh","year":"2021","unstructured":"Koh SH, Kwon HS, Choi SH, Jeong JH, Na HR, Lee CN, et al. Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer\u2019s disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial. Alzheimer\u2019s Res Ther. 2021;13(1):1\u201311.","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"3024_CR99","doi-asserted-by":"crossref","unstructured":"Kaeberlein M, Galvan V. Rapamycin and Alzheimer\u2019s disease: time for a clinical trial? Sci Transl Med. 2019;11(476).","DOI":"10.1126\/scitranslmed.aar4289"},{"issue":"3","key":"3024_CR100","first-page":"1","volume":"2019","author":"R McShane","year":"2019","unstructured":"McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, et al. Memantine for dementia. Cochrane Database Syst Rev. 2019;2019(3):1\u2013446.","journal-title":"Cochrane Database Syst Rev"},{"key":"3024_CR101","doi-asserted-by":"crossref","unstructured":"N\u00f8rgaard CH, Friedrich S, Hansen CT, Gerds T, Ballard C, M\u00f8ller DV, et al. Treatment with glucagon\u2010like peptide\u20101 receptor agonists and incidence of dementia: data from pooled double\u2010blind randomized controlled trials and nationwide disease and prescription registers. Alzheimer\u2019s & Dementia. 2022;8(1).","DOI":"10.1002\/trc2.12268"},{"issue":"3","key":"3024_CR102","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.3233\/JAD-215511","volume":"86","author":"X Hua","year":"2022","unstructured":"Hua X, Church K, Walker W, L\u2019Hostis P, Viardot G, Danjou P, et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of the positive modulator of HGF\/MET, fosgonimeton, in healthy volunteers and subjects with Alzheimer\u2019s disease: randomized, placebo-controlled, double-blind, phase I clinical trial. J Alzheimer\u2019s Dis. 2022;86(3):1399.","journal-title":"J Alzheimer\u2019s Dis"},{"key":"3024_CR103","unstructured":"Alzheimer Disease\u2014ClinicalTrials.gov [Internet]. [cited 2023 Apr 5]. Available from: https:\/\/clinicaltrials.gov\/ct2\/results?term=drugs&cond=Alzheimer+Disease&Search=Apply&recrs=b&recrs=a&recrs=f&recrs=d&age_v=&gndr=&type=&rslt=."},{"issue":"1","key":"3024_CR104","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/2047-9158-2-22","volume":"2","author":"R Mehanna","year":"2013","unstructured":"Mehanna R, Lai EC. Deep brain stimulation in Parkinson\u2019s disease. Transl Neurodegener. 2013;2(1):22.","journal-title":"Transl Neurodegener"},{"key":"3024_CR105","doi-asserted-by":"crossref","unstructured":"Mehanna R, Bajwa JA, Fernandez H, Wagle Shukla AA, others. Cognitive impact of deep brain stimulation on Parkinson\u2019s disease patients. Parkinson\u2019s Dis. 2017;2017.","DOI":"10.1155\/2017\/3085140"},{"key":"3024_CR106","doi-asserted-by":"publisher","first-page":"862","DOI":"10.12688\/f1000research.25634.1","volume":"9","author":"TB Stoker","year":"2020","unstructured":"Stoker TB, Barker RA. Recent developments in the treatment of Parkinson\u2019s disease. F1000Res. 2020;9:862.","journal-title":"F1000Res"},{"issue":"190","key":"3024_CR107","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108352","volume":"1","author":"G Marucci","year":"2021","unstructured":"Marucci G, Buccioni M, Ben DD, Lambertucci C, Volpini R, Amenta F. Efficacy of acetylcholinesterase inhibitors in Alzheimer\u2019s disease. Neuropharmacology. 2021;1(190): 108352.","journal-title":"Neuropharmacology"},{"issue":"1","key":"3024_CR108","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","volume":"388","author":"CH van Dyck","year":"2023","unstructured":"van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in early Alzheimer\u2019s disease. N Engl J Med. 2023;388(1):9\u201321.","journal-title":"N Engl J Med"},{"key":"3024_CR109","unstructured":"FDA Grants Accelerated Approval for Alzheimer\u2019s Disease Treatment | FDA [Internet]. [cited 2023 Mar 23]. Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-disease-treatment."},{"issue":"5","key":"3024_CR110","first-page":"363","volume":"329","author":"HD Larkin","year":"2023","unstructured":"Larkin HD. Lecanemab gains FDA approval for early Alzheimer disease. JAMA. 2023;329(5):363\u2013363.","journal-title":"JAMA"},{"key":"3024_CR111","doi-asserted-by":"crossref","unstructured":"Tolar M, Abushakra S, Hey JA, Porsteinsson A, Sabbagh M. Aducanumab, gantenerumab, BAN2401, and ALZ-801\u2014the first wave of amyloid-targeting drugs for Alzheimer\u2019s disease with potential for near term approval. Alzheimers Res Ther. 2020;12(1).","DOI":"10.1186\/s13195-020-00663-w"},{"key":"3024_CR112","unstructured":"ANAVEX\u00ae2-73 (BLARCAMESINE) PHASE 2B\/3 STUDY MET PRIMARY AND KEY SECONDARY ENDPOINTS, [Internet]. [cited 2023 Mar 22]. Available from: https:\/\/www.anavex.com\/post\/anavex-2-73-blarcamesine-phase-2b-3-study-met-primary-and-key-secondary-endpoints."},{"key":"3024_CR113","first-page":"12","volume":"29","author":"KG Yiannopoulou","year":"2020","unstructured":"Yiannopoulou KG, Papageorgiou SG. Current and future treatments in Alzheimer disease: an update. J Cent Nerv Syst Dis. 2020;29:12.","journal-title":"J Cent Nerv Syst Dis"},{"key":"3024_CR114","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s00702-018-1900-6","volume":"125","author":"TN Tran","year":"2018","unstructured":"Tran TN, Vo TNN, Frei K, Truong DD. Levodopa-induced dyskinesia: clinical features, incidence, and risk factors. J Neural Transm. 2018;125:1109\u201317.","journal-title":"J Neural Transm"},{"issue":"24","key":"3024_CR115","doi-asserted-by":"publisher","first-page":"e2238","DOI":"10.1212\/WNL.0000000000006643","volume":"91","author":"P Turcano","year":"2018","unstructured":"Turcano P, Mielke MM, Bower JH, Parisi JE, Cutsforth-Gregory JK, Ahlskog JE, et al. Levodopa-induced dyskinesia in Parkinson disease: a population-based cohort study. Neurology. 2018;91(24):e2238\u201343.","journal-title":"Neurology"},{"issue":"9","key":"3024_CR116","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s40263-019-00661-z","volume":"33","author":"F Carbone","year":"2019","unstructured":"Carbone F, Djamshidian A, Seppi K, Poewe W. Apomorphine for Parkinson\u2019s disease: efficacy and safety of current and new formulations. CNS Drugs. 2019;33(9):905\u201318.","journal-title":"CNS Drugs"},{"issue":"8","key":"3024_CR117","doi-asserted-by":"publisher","first-page":"1900195","DOI":"10.1002\/bies.201900195","volume":"42","author":"M Khalifeh","year":"2020","unstructured":"Khalifeh M, Read MI, Barreto GE, Sahebkar A. Trehalose against Alzheimer\u2019s disease: insights into a potential therapy. BioEssays. 2020;42(8):1900195.","journal-title":"BioEssays"},{"issue":"4","key":"3024_CR118","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/acn3.754","volume":"6","author":"LW Jin","year":"2019","unstructured":"Jin LW, Di LJ, Nguyen HM, Singh V, Singh L, Chavez M, et al. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer\u2019s disease. Ann Clin Transl Neurol. 2019;6(4):723\u201338.","journal-title":"Ann Clin Transl Neurol"},{"key":"3024_CR119","doi-asserted-by":"crossref","unstructured":"Cummings J, Lee G, Nahed P, Kambar MEZN, Zhong K, Fonseca J, et al. Alzheimer\u2019s disease drug development pipeline: 2022. Alzheimer\u2019s and Dementia. 2022;8(1).","DOI":"10.1002\/trc2.12295"},{"issue":"7","key":"3024_CR120","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1093\/brain\/awab129","volume":"144","author":"AG Patel","year":"2021","unstructured":"Patel AG, Nehete PN, Krivoshik SR, Pei X, Cho EL, Nehete BP, et al. Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer\u2019s disease pathology in aged squirrel monkeys. Brain. 2021;144(7):2146.","journal-title":"Brain"},{"key":"3024_CR121","first-page":"12","volume":"18","author":"YL Wang","year":"2022","unstructured":"Wang YL, Zhang Y, Xu J. Sodium oligomannate combined with rivastigmine may improve cerebral blood flow and cognitive impairment following CAR-T cell therapy: a case report. Front Oncol. 2022;18:12.","journal-title":"Front Oncol"},{"issue":"1","key":"3024_CR122","volume":"7","author":"H Potter","year":"2021","unstructured":"Potter H, Woodcock JH, Boyd TD, Coughlan CM, O\u2019Shaughnessy JR, Borges MT, et al. Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer\u2019s disease. Alzheimer\u2019s & Dementia. 2021;7(1): e12158.","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"S9","key":"3024_CR123","doi-asserted-by":"publisher","DOI":"10.1002\/alz.054669","volume":"17","author":"M Ward","year":"2021","unstructured":"Ward M, Long H, Schwabe T, Rhinn H, Tassi I, Salazar SV, et al. A phase 1 study of AL002 in healthy volunteers. Alzheimer\u2019s & Dementia. 2021;17(S9): e054669.","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"2","key":"3024_CR124","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3233\/JAD-200711","volume":"78","author":"N Torres-Acosta","year":"2020","unstructured":"Torres-Acosta N, O\u2019Keefe JH, O\u2019Keefe EL, Isaacson R, Small G. Therapeutic potential of TNF-\u03b1 inhibition for Alzheimer\u2019s disease prevention. J Alzheimer\u2019s Dis. 2020;78(2):619.","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"102","key":"3024_CR125","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.nbd.2017.02.010","volume":"1","author":"KP MacPherson","year":"2017","unstructured":"MacPherson KP, Sompol P, Kannarkat GT, Chang J, Sniffen L, Wildner ME, et al. Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice. Neurobiol Dis. 2017;1(102):81.","journal-title":"Neurobiol Dis"},{"issue":"4","key":"3024_CR126","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF02220605","volume":"43","author":"L Lennard","year":"1992","unstructured":"Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol. 1992;43(4):329\u201339.","journal-title":"Eur J Clin Pharmacol"},{"issue":"6","key":"3024_CR127","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41551-018-0235-9","volume":"2","author":"L Labanieh","year":"2018","unstructured":"Labanieh L, Majzner RG, Mackall CL. Programming CAR-T cells to kill cancer. Nat Biomed Eng. 2018;2(6):377\u201391.","journal-title":"Nat Biomed Eng"},{"issue":"2","key":"3024_CR128","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/00042307-200103000-00002","volume":"11","author":"P Nickerson","year":"2001","unstructured":"Nickerson P, Jeffery J, Rush D. Long-term allograft surveillance: the role of protocol biopsies. Curr Opin Urol. 2001;11(2):133\u20137.","journal-title":"Curr Opin Urol"},{"issue":"1","key":"3024_CR129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-43613-9","volume":"9","author":"O Candini","year":"2019","unstructured":"Candini O, Grisendi G, Foppiani EM, Brogli M, Aramini B, Masciale V, et al. A novel 3D in vitro platform for pre-clinical investigations in drug testing, gene therapy, and immuno-oncology. Sci Rep. 2019;9(1):1\u201312.","journal-title":"Sci Rep"},{"issue":"3","key":"3024_CR130","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/abd56b","volume":"13","author":"Z Jin","year":"2021","unstructured":"Jin Z, Li X, Zhang X, Desousa P, Xu T, Wu A. Engineering the fate and function of human T-Cells via 3D bioprinting. Biofabrication. 2021;13(3): 035016.","journal-title":"Biofabrication"},{"issue":"4","key":"3024_CR131","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/imm.12929","volume":"154","author":"JI Gray","year":"2018","unstructured":"Gray JI, Westerhof LM, MacLeod MKL. The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination. Immunology. 2018;154(4):574\u201381.","journal-title":"Immunology"},{"issue":"1","key":"3024_CR132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-6150-3-34","volume":"3","author":"AL Snow","year":"2008","unstructured":"Snow AL, Oliveira JB, Zheng L, Dale JK, Fleisher TA, Lenardo MJ. Critical role for BIM in T cell receptor restimulation-induced death. Biol Direct. 2008;3(1):1\u201317.","journal-title":"Biol Direct"},{"issue":"88","key":"3024_CR133","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.actbio.2019.02.016","volume":"1","author":"DG Leach","year":"2019","unstructured":"Leach DG, Young S, Hartgerink JD. Advances in immunotherapy delivery from implantable and injectable biomaterials. Acta Biomater. 2019;1(88):15\u201331.","journal-title":"Acta Biomater"},{"issue":"12","key":"3024_CR134","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1007\/s00262-021-02941-4","volume":"70","author":"W Lu","year":"2021","unstructured":"Lu W, Wei Y, Cao Y, Xiao X, Li Q, Lyu H, et al. CD19 CAR-T cell treatment conferred sustained remission in B-ALL patients with minimal residual disease. Cancer Immunol Immunother. 2021;70(12):3501\u201311.","journal-title":"Cancer Immunol Immunother"},{"issue":"16_Supplement","key":"3024_CR135","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1158\/1538-7445.AM2020-2216","volume":"80","author":"JP Goodridge","year":"2020","unstructured":"Goodridge JP, Reiser JW, Bjordahl R, Mandal M, Chang C, Clarck R, et al. Combinational strategy targeting B cell malignancy using iPSC engineered CAR-NK (FT596) and CAR-T cell (FT819) platforms with therapeutic antibody to achieve an effective deep and durable response. Cancer Res. 2020;80(16_Supplement):2216\u20132216.","journal-title":"Cancer Res"},{"issue":"2","key":"3024_CR136","doi-asserted-by":"publisher","first-page":"40","DOI":"10.51934\/jomit.1042774","volume":"3","author":"MY Egrilmez","year":"2021","unstructured":"Egrilmez MY, Karabay U, Aydemir S, Baykara B, Husemoglu RB. The cellular responses of human macrophages seeded on 3D printed thermoplastic polyurethane scaffold. J Med Innovat Technol. 2021;3(2):40\u20135.","journal-title":"J Med Innovat Technol."},{"issue":"3","key":"3024_CR137","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s40964-017-0023-1","volume":"2","author":"J Xiao","year":"2017","unstructured":"Xiao J, Gao Y. The manufacture of 3D printing of medical grade TPU. Prog Addit Manuf. 2017;2(3):117\u201323.","journal-title":"Prog Addit Manuf"},{"issue":"4","key":"3024_CR138","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.bbrc.2020.02.042","volume":"524","author":"X Huang","year":"2020","unstructured":"Huang X, He C, Lin G, Lu L, Xing K, Hua X, et al. Induced CD10 expression during monocyte-to-macrophage differentiation identifies a unique subset of macrophages in pancreatic ductal adenocarcinoma. Biochem Biophys Res Commun. 2020;524(4):1064\u201371.","journal-title":"Biochem Biophys Res Commun"},{"issue":"13","key":"3024_CR139","doi-asserted-by":"publisher","first-page":"12298","DOI":"10.1021\/acsami.9b00264","volume":"11","author":"A Aldrich","year":"2019","unstructured":"Aldrich A, Kuss MA, Duan B, Kielian T. 3D bioprinted scaffolds containing viable macrophages and antibiotics promote clearance of Staphylococcus aureus craniotomy-associated biofilm infection. ACS Appl Mater Interfaces. 2019;11(13):12298\u2013307.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"6","key":"3024_CR140","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.ijantimicag.2010.07.008","volume":"36","author":"M Lefebvre","year":"2010","unstructured":"Lefebvre M, Jacqueline C, Amador G, Le Mabecque V, Miegeville A, Potel G, et al. Efficacy of daptomycin combined with rifampicin for the treatment of experimental methicillin-resistant Staphylococcus aureus (MRSA) acute osteomyelitis. Int J Antimicrob Agents. 2010;36(6):542\u20134.","journal-title":"Int J Antimicrob Agents"},{"issue":"20","key":"3024_CR141","doi-asserted-by":"publisher","first-page":"5972","DOI":"10.3390\/ma14205972","volume":"14","author":"F Woitschach","year":"2021","unstructured":"Woitschach F, Kloss M, Schlodder K, Borck A, Grabow N, Reisinger EC, et al. In vitro study of the interaction of innate immune cells with liquid silicone rubber coated with Zwitterionic methyl methacrylate and thermoplastic polyurethanes. Materials. 2021;14(20):5972.","journal-title":"Materials"},{"issue":"11","key":"3024_CR142","doi-asserted-by":"publisher","first-page":"7355","DOI":"10.1007\/s12035-019-1605-3","volume":"56","author":"LM de Medeiros","year":"2019","unstructured":"de Medeiros LM, De Bastiani MA, Rico EP, Schonhofen P, Pfaffenseller B, Wollenhaupt-Aguiar B, et al. Cholinergic differentiation of human neuroblastoma SH-SY5Y cell line and its potential use as an in vitro model for Alzheimer\u2019s disease studies. Mol Neurobiol. 2019;56(11):7355\u201367.","journal-title":"Mol Neurobiol"},{"issue":"10","key":"3024_CR143","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/s41593-018-0237-7","volume":"21","author":"L Gan","year":"2018","unstructured":"Gan L, Cookson MR, Petrucelli L, La Spada AR. Converging pathways in neurodegeneration, from genetics to mechanisms. Nat Neurosci. 2018;21(10):1300\u20139.","journal-title":"Nat Neurosci"},{"key":"3024_CR144","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/978-1-62703-640-5_2","volume":"1078","author":"J Kovalevich","year":"2013","unstructured":"Kovalevich J, Langford D. Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology. Methods Mol Biol. 2013;1078:9\u201321.","journal-title":"Methods Mol Biol"},{"key":"3024_CR145","first-page":"13","volume":"4","author":"J Zhao","year":"2020","unstructured":"Zhao J, Liu X, Xia W, Zhang Y, Wang C. Targeting amyloidogenic processing of APP in Alzheimer\u2019s disease. Front Mol Neurosci. 2020;4:13.","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"3024_CR146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-017-0149-0","volume":"12","author":"H Xicoy","year":"2017","unstructured":"Xicoy H, Wieringa B, Martens GJM. The SH-SY5Y cell line in Parkinson\u2019s disease research: a systematic review. Mol Neurodegener. 2017;12(1):1\u201311.","journal-title":"Mol Neurodegener"},{"issue":"5","key":"3024_CR147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063862","volume":"8","author":"JA Korecka","year":"2013","unstructured":"Korecka JA, van Kesteren RE, Blaas E, Spitzer SO, Kamstra JH, Smit AB, et al. Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS ONE. 2013;8(5): e63862.","journal-title":"PLoS ONE"},{"issue":"5","key":"3024_CR148","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1021\/acs.jmedchem.9b00797","volume":"63","author":"DG Brown","year":"2019","unstructured":"Brown DG, Wobst HJ. Opportunities and challenges in phenotypic screening for neurodegenerative disease research. J Med Chem. 2019;63(5):1823\u201340.","journal-title":"J Med Chem"},{"issue":"3","key":"3024_CR149","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.mcn.2010.06.017","volume":"45","author":"O Cooper","year":"2010","unstructured":"Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, et al. Differentiation of human ES and Parkinson\u2019s disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci. 2010;45(3):258\u201366.","journal-title":"Mol Cell Neurosci"},{"issue":"36","key":"3024_CR150","doi-asserted-by":"publisher","first-page":"15921","DOI":"10.1073\/pnas.1010209107","volume":"107","author":"G Hargus","year":"2010","unstructured":"Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, et al. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci. 2010;107(36):15921\u20136.","journal-title":"Proc Natl Acad Sci"},{"key":"3024_CR151","doi-asserted-by":"crossref","unstructured":"Ochalek A, Szczesna K, Petazzi P, Kobolak J, Dinnyes A. Generation of cholinergic and dopaminergic interneurons from human pluripotent stem cells as a relevant tool for in vitro modeling of neurological disorders and therapy. Stem Cells Int. 2016;2016.","DOI":"10.1155\/2016\/5838934"},{"issue":"4","key":"3024_CR152","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.3233\/JAD-2010-091363","volume":"20","author":"L Agholme","year":"2010","unstructured":"Agholme L, Lindstr\u00f6m T, K\u00e5gedal K, Marcusson J, Hallbeck M. An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons. J Alzheimer\u2019s Dis. 2010;20(4):1069\u201382.","journal-title":"J Alzheimer\u2019s Dis"},{"key":"3024_CR153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-16-1","volume":"16","author":"AM Hossini","year":"2015","unstructured":"Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, et al. Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer\u2019s disease donor as a model for investigating AD-associated gene regulatory networks. BMC Genomics. 2015;16:1\u201322.","journal-title":"BMC Genomics"},{"issue":"5","key":"3024_CR154","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.biomaterials.2013.11.028","volume":"35","author":"D Zhang","year":"2014","unstructured":"Zhang D, Pekkanen-Mattila M, Shahsavani M, Falk A, Teixeira AI, Herland A. A 3D Alzheimer\u2019s disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons. Biomaterials. 2014;35(5):1420\u20138.","journal-title":"Biomaterials"},{"key":"3024_CR155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-016-0139-7","volume":"11","author":"SH Choi","year":"2016","unstructured":"Choi SH, Kim YH, Quinti L, Tanzi RE, Kim DY. 3D culture models of Alzheimer\u2019s disease: a road map to a \u201ccure-in-a-dish.\u201d Mol Neurodegener. 2016;11:1\u201311.","journal-title":"Mol Neurodegener"},{"issue":"12","key":"3024_CR156","doi-asserted-by":"publisher","first-page":"2100097","DOI":"10.1002\/anbr.202100097","volume":"1","author":"NS Sharma","year":"2021","unstructured":"Sharma NS, Karan A, Lee D, Yan Z, Xie J. Advances in modeling Alzheimer\u2019s disease in vitro. Adv Nanobiomed Res. 2021;1(12):2100097.","journal-title":"Adv Nanobiomed Res"},{"issue":"9","key":"3024_CR157","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163072","volume":"11","author":"HK Lee","year":"2016","unstructured":"Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, et al. Three dimensional human neuro-spheroid model of Alzheimer\u2019s disease based on differentiated induced pluripotent stem cells. PLoS ONE. 2016;11(9): e0163072.","journal-title":"PLoS ONE"},{"key":"3024_CR158","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3389\/fncel.2020.00151","volume":"14","author":"MA Hern\u00e1ndez-Sapi\u00e9ns","year":"2020","unstructured":"Hern\u00e1ndez-Sapi\u00e9ns MA, Reza-Zald\u00edvar EE, Cevallos RR, M\u00e1rquez-Aguirre AL, Gazarian K, Canales-Aguirre AA. A three-dimensional Alzheimer\u2019s disease cell culture model using iPSC-derived neurons carrying A246E mutation in PSEN1. Front Cell Neurosci. 2020;14:151.","journal-title":"Front Cell Neurosci"},{"key":"3024_CR159","doi-asserted-by":"crossref","unstructured":"Lomoio S, Pandey RS, Rouleau N, Menicacci B, Kim W, Cantley WL, et al. 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer\u2019s disease. Mol Psychiatry. 2023;1\u201312.","DOI":"10.1038\/s41380-023-02147-3"},{"issue":"1","key":"3024_CR160","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/s41467-020-15120-3","volume":"11","author":"SS Kwak","year":"2020","unstructured":"Kwak SS, Washicosky KJ, Brand E, Von Maydell D, Aronson J, Kim S, et al. Amyloid-\u03b242\/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer\u2019s disease. Nat Commun. 2020;11(1):1377.","journal-title":"Nat Commun"},{"issue":"4","key":"3024_CR161","doi-asserted-by":"publisher","first-page":"dmm038042","DOI":"10.1242\/dmm.038042","volume":"12","author":"TR Taylor-Whiteley","year":"2019","unstructured":"Taylor-Whiteley TR, Le Maitre CL, Duce JA, Dalton CF, Smith DP. Recapitulating Parkinson\u2019s disease pathology in a three-dimensional human neural cell culture model. Dis Model Mech. 2019;12(4):dmm038042.","journal-title":"Dis Model Mech"},{"issue":"11","key":"3024_CR162","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1039\/C5LC00180C","volume":"15","author":"EL Moreno","year":"2015","unstructured":"Moreno EL, Hachi S, Hemmer K, Trietsch SJ, Baumuratov AS, Hankemeier T, et al. Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture. Lab Chip. 2015;15(11):2419\u201328.","journal-title":"Lab Chip"},{"issue":"2","key":"3024_CR163","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00018-021-04047-7","volume":"79","author":"NJ Fiore","year":"2022","unstructured":"Fiore NJ, Ganat YM, Devkota K, Batorsky R, Lei M, Lee K, et al. Bioengineered models of Parkinson\u2019s disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment. Cell Mol Life Sci. 2022;79(2):1\u201320.","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"3024_CR164","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ac7eec","volume":"14","author":"S Abdelrahman","year":"2022","unstructured":"Abdelrahman S, Alsanie WF, Khan ZN, Albalawi HI, Felimban RI, Moretti M, et al. A Parkinson\u2019s disease model composed of 3D bioprinted dopaminergic neurons within a biomimetic peptide scaffold. Biofabrication. 2022;14(4): 044103.","journal-title":"Biofabrication"},{"issue":"22","key":"3024_CR165","doi-asserted-by":"publisher","first-page":"10727","DOI":"10.3390\/app112210727","volume":"11","author":"E Saylam","year":"2021","unstructured":"Saylam E, Akkaya Y, Ilhan E, Cesur S, Guler E, Sahin A, et al. Levodopa-loaded 3D-printed poly (Lactic) acid\/chitosan neural tissue scaffold as a promising drug delivery system for the treatment of Parkinson\u2019s disease. Appl Sci. 2021;11(22):10727.","journal-title":"Appl Sci"},{"key":"3024_CR166","doi-asserted-by":"crossref","unstructured":"Cun\u00ed-L\u00f3pez C, Quek H, Oikari LE, Stewart R, Nguyen TH, Sun Y, et al. 3D models of Alzheimer\u2019s disease patient microglia recapitulate disease phenotype and show differential drug responses compared to 2D. bioRxiv. 2021;2021\u20133.","DOI":"10.1101\/2021.03.17.435758"},{"issue":"7","key":"3024_CR167","first-page":"1267","volume":"70","author":"S Sabate-Soler","year":"2022","unstructured":"Sabate-Soler S, Louise Nickels S, Saraiva C, Berger E, Dubonyte U, Barmpa K, et al. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Wiley Online Library. 2022;70(7):1267\u201388.","journal-title":"Wiley Online Library"},{"issue":"3","key":"3024_CR168","first-page":"409","volume":"37","author":"B Markus","year":"2020","unstructured":"Markus B, Anna-Sophie S, Simon G, Dominik L, Alice K, Marvin R, et al. Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies. Altex. 2020;37(3):409\u201328.","journal-title":"Altex"},{"issue":"8","key":"3024_CR169","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/j.stemcr.2021.06.011","volume":"16","author":"R Xu","year":"2021","unstructured":"Xu R, Boreland AJ, Li X, Erickson C, Jin M, Atkins C, et al. Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology. Stem Cell Reports. 2021;16(8):1923\u201337.","journal-title":"Stem Cell Reports"},{"key":"3024_CR170","doi-asserted-by":"crossref","unstructured":"Song L, Yuan X, Jones Z, Vied C, Miao Y, Marzano M, et al. Functionalization of brain region-specific spheroids with isogenic microglia-like cells. Sci Rep. 2019;9(1).","DOI":"10.1038\/s41598-019-47444-6"},{"issue":"19","key":"3024_CR171","doi-asserted-by":"publisher","first-page":"6243","DOI":"10.1039\/D0AN01373K","volume":"145","author":"H Cai","year":"2020","unstructured":"Cai H, Ao Z, Hu L, Moon Y, Wu Z, Lu HC, et al. Acoustofluidic assembly of 3D neurospheroids to model Alzheimer\u2019s disease. Analyst. 2020;145(19):6243\u201353.","journal-title":"Analyst"},{"key":"3024_CR172","first-page":"1","volume":"11","author":"R Ilaria","year":"2020","unstructured":"Ilaria R, Marta T, Gianluigi F, Diego A, Carmen G. 3D brain tissue physiological model with co-cultured primary neurons and glial cells in hydrogels. J Tissue Eng. 2020;11:1\u201313.","journal-title":"J Tissue Eng"},{"issue":"1","key":"3024_CR173","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-59310-x","volume":"10","author":"JM Chemmarappally","year":"2020","unstructured":"Chemmarappally JM, Pegram HCN, Abeywickrama N, Fornari E, Hargreaves AJ, De Girolamo LA, et al. A co-culture nanofibre scaffold model of neural cell degeneration in relevance to Parkinson\u2019s disease. Sci Rep. 2020;10(1):1\u201314.","journal-title":"Sci Rep"},{"key":"3024_CR174","doi-asserted-by":"publisher","first-page":"45001","DOI":"10.1088\/1758-5090\/ace21b","volume":"15","author":"L Rueda-Gensini","year":"2023","unstructured":"Rueda-Gensini L, Serna JA, Rubio D, Camilo Orozco J, Bola\u00f1os NI, Cruz JC, et al. Three-dimensional neuroimmune co-culture system for modeling Parkinson\u2019s disease microenvironments in vitro. Biofabrication. 2023;15:45001.","journal-title":"Biofabrication"},{"issue":"2","key":"3024_CR175","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00401-016-1662-x","volume":"133","author":"E Drummond","year":"2017","unstructured":"Drummond E, Wisniewski T. Alzheimer\u2019s disease: experimental models and reality. Acta Neuropathol. 2017;133(2):155\u201375.","journal-title":"Acta Neuropathol"},{"key":"3024_CR176","first-page":"15","volume":"4","author":"TH Sundaramoorthy","year":"2022","unstructured":"Sundaramoorthy TH, Castanho I. The Neuroepigenetic landscape of vertebrate and invertebrate models of neurodegenerative diseases. Epigenet Insights. 2022;4:15.","journal-title":"Epigenet Insights"},{"issue":"274","key":"3024_CR177","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.expneurol.2015.05.013","volume":"1","author":"P Fernandez-Funez","year":"2015","unstructured":"Fernandez-Funez P, de Mena L, Rincon-Limas DE. Modeling the complex pathology of Alzheimer\u2019s disease in Drosophila. Exp Neurol. 2015;1(274):58\u201371.","journal-title":"Exp Neurol"},{"key":"3024_CR178","doi-asserted-by":"publisher","first-page":"95895","DOI":"10.3389\/fgene.2014.00279","volume":"5","author":"AG Alexander","year":"2014","unstructured":"Alexander AG, Marfil V, Li C. Use of C. elegans as a model to study Alzheimer\u2019s disease and other neurodegenerative diseases. Front Genet. 2014;5:95895.","journal-title":"Front Genet"},{"issue":"6","key":"3024_CR179","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","volume":"86","author":"B Lemaitre","year":"1996","unstructured":"Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle\/Toll\/Cactus controls the potent antifungal response in Drosophila adults. Cell. 1996;86(6):973\u201383.","journal-title":"Cell"},{"issue":"2","key":"3024_CR180","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cell.2017.03.033","volume":"169","author":"M Tassetto","year":"2017","unstructured":"Tassetto M, Kunitomi M, Andino R. Circulating immune cells mediate a systemic RNAi-based adaptive antiviral response in drosophila. Cell. 2017;169(2):314-325.e13.","journal-title":"Cell"},{"issue":"346","key":"3024_CR181","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577302","volume":"15","author":"J Dhankhar","year":"2020","unstructured":"Dhankhar J, Agrawal N, Shrivastava A. An interplay between immune response and neurodegenerative disease progression: an assessment using Drosophila as a model. J Neuroimmunol. 2020;15(346): 577302.","journal-title":"J Neuroimmunol"},{"issue":"4","key":"3024_CR182","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.neuron.2020.12.008","volume":"109","author":"J Nagai","year":"2021","unstructured":"Nagai J, Yu X, Papouin T, Cheong E. Behaviorally consequential astrocytic regulation of neural circuits. Neuron. 2021;109(4):576\u201396.","journal-title":"Neuron"},{"key":"3024_CR183","doi-asserted-by":"crossref","unstructured":"Sarparast M, Hinman J, Pourmand E, Vonarx D, Ramirez L, Ma W, et al. Cytochrome P450 and epoxide hydrolase metabolites in A\u03b2 and tau-induced neurodegeneration: insights from Caenorhabditis elegans. bioRxiv. 2023;2023.10.02.560527.","DOI":"10.1101\/2023.10.02.560527"},{"issue":"2","key":"3024_CR184","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ni.1836","volume":"11","author":"CR Stewart","year":"2010","unstructured":"Stewart CR, Stuart LM, Wilkinson K, Van Gils JM, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11(2):155.","journal-title":"Nat Immunol"},{"issue":"12","key":"3024_CR185","doi-asserted-by":"publisher","first-page":"e3966","DOI":"10.1371\/journal.pone.0003966","volume":"3","author":"L Tan","year":"2008","unstructured":"Tan L, Schedl P, Song HJ, Garza D, Konsolaki M. The Toll\u2013>NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer\u2019s Abeta42 polypeptide in Drosophila. PLoS ONE. 2008;3(12):e3966.","journal-title":"PLoS ONE"},{"issue":"4","key":"3024_CR186","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s11011-021-00679-7","volume":"36","author":"E Zarini-Gakiye","year":"2021","unstructured":"Zarini-Gakiye E, Sanadgol N, Parivar K, Vaezi G. Alpha-lipoic acid ameliorates tauopathy-induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1\/DrICE ratio and redox homeostasis: age is a determinant factor. Metab Brain Dis. 2021;36(4):669\u201383.","journal-title":"Metab Brain Dis"},{"issue":"3","key":"3024_CR187","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/jnc.15253","volume":"157","author":"CM Cowan","year":"2021","unstructured":"Cowan CM, Sealey MA, Mudher A. Suppression of tau-induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity. J Neurochem. 2021;157(3):684\u201394.","journal-title":"J Neurochem"},{"issue":"52","key":"3024_CR188","doi-asserted-by":"publisher","first-page":"33608","DOI":"10.1073\/pnas.1922392117","volume":"117","author":"KM Lohr","year":"2020","unstructured":"Lohr KM, Frost B, Scherzer C, Feany MB. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Proc Natl Acad Sci U S A. 2020;117(52):33608\u201318.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3024_CR189","doi-asserted-by":"publisher","first-page":"110120","DOI":"10.1016\/j.cbi.2022.110120","volume":"366","author":"YH Siddique","year":"2022","unstructured":"Siddique YH, Rahul A, Ara G, Afzal M, Varshney H, Gaur K, et al. Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer\u2019s disease. Chem Biol Interact. 2022;366:110120.","journal-title":"Chem Biol Interact"},{"issue":"808","key":"3024_CR190","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.145972","volume":"15","author":"A Barati","year":"2022","unstructured":"Barati A, Masoudi R, Yousefi R, Monsefi M, Mirshafiey A. Tau and amyloid beta differentially affect the innate immune genes expression in Drosophila models of Alzheimer\u2019s disease and \u03b2- D Mannuronic acid (M2000) modulates the dysregulation. Gene. 2022;15(808): 145972.","journal-title":"Gene"},{"issue":"28","key":"3024_CR191","doi-asserted-by":"publisher","first-page":"10793","DOI":"10.1073\/pnas.0602493103","volume":"103","author":"Y Yang","year":"2006","unstructured":"Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW, et al. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A. 2006;103(28):10793\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3024_CR192","doi-asserted-by":"publisher","first-page":"66","DOI":"10.31083\/j.jin2102066","volume":"21","author":"N Nayak","year":"2022","unstructured":"Nayak N, Mishra M. Drosophila melanogaster as a model to understand the mechanisms of infection mediated neuroinflammation in neurodegenerative diseases. J Integr Neurosci. 2022;21(2):66.","journal-title":"J Integr Neurosci"},{"issue":"159","key":"3024_CR193","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105482","volume":"1","author":"AL Olsen","year":"2021","unstructured":"Olsen AL, Feany MB. Parkinson\u2019s disease risk genes act in glia to control neuronal \u03b1-synuclein toxicity. Neurobiol Dis. 2021;1(159): 105482.","journal-title":"Neurobiol Dis"},{"issue":"9","key":"3024_CR194","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1002\/term.2728","volume":"12","author":"VD Ranjan","year":"2018","unstructured":"Ranjan VD, Qiu L, Tan EK, Zeng L, Zhang Y. Modelling Alzheimer\u2019s disease: insights from in vivo to in vitro three-dimensional culture platforms. J Tissue Eng Regen Med. 2018;12(9):1944\u201358.","journal-title":"J Tissue Eng Regen Med"},{"issue":"4","key":"3024_CR195","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1093\/nar\/gkab012","volume":"49","author":"NT Doncheva","year":"2021","unstructured":"Doncheva NT, Palasca O, Yarani R, Litman T, Anthon C, Groenen MAM, et al. Human pathways in animal models: possibilities and limitations. Nucleic Acids Res. 2021;49(4):1859\u201371.","journal-title":"Nucleic Acids Res"},{"issue":"Pt 4","key":"3024_CR196","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1093\/brain\/aww016","volume":"139","author":"EE Spangenberg","year":"2016","unstructured":"Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MRP, Blurton-Jones M, et al. Eliminating microglia in Alzheimer\u2019s mice prevents neuronal loss without modulating amyloid-\u03b2 pathology. Brain. 2016;139(Pt 4):1265\u201381.","journal-title":"Brain"},{"issue":"4","key":"3024_CR197","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3390\/molecules23040718","volume":"23","author":"K Dietrich","year":"2018","unstructured":"Dietrich K, Bouter Y, M\u00fcller M, Bayer TA. Synaptic alterations in mouse models for Alzheimer disease\u2014a special focus on N-truncated abeta 4\u201342. Molecules. 2018;23(4):718.","journal-title":"Molecules"},{"issue":"10","key":"3024_CR198","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3390\/pharmaceutics12100944","volume":"12","author":"AR Roda","year":"2020","unstructured":"Roda AR, Esquerda-Canals G, Mart\u00ed-Cl\u00faa J, Villegas S. Cognitive impairment in the 3xTg-AD mouse model of Alzheimer\u2019s disease is affected by A\u03b2-immunotherapy and cognitive stimulation. Pharmaceutics. 2020;12(10):944.","journal-title":"Pharmaceutics"},{"issue":"1","key":"3024_CR199","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s40478-018-0626-x","volume":"6","author":"S Li","year":"2018","unstructured":"Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble A\u03b2 to inspire novel therapeutic avenues for Alzheimer\u2019s disease. Acta Neuropathol Commun. 2018;6(1):121.","journal-title":"Acta Neuropathol Commun"},{"key":"3024_CR200","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bbr.2014.03.009","volume":"266","author":"MK Weintraub","year":"2014","unstructured":"Weintraub MK, Kranjac D, Eimerbrink MJ, Pearson SJ, Vinson BT, Patel J, et al. Peripheral administration of poly I: C leads to increased hippocampal amyloid-beta and cognitive deficits in a non-transgenic mouse. Behav Brain Res. 2014;266:183\u20137.","journal-title":"Behav Brain Res"},{"issue":"4","key":"3024_CR201","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000530185","volume":"45","author":"SM Loewen","year":"2023","unstructured":"Loewen SM, Chavesa AM, Murray CJ, Traetta ME, Burns SE, Pekarik KH, et al. The outcomes of maternal immune activation induced with the viral mimetic poly I:C on microglia in exposed rodent offspring. Dev Neurosci. 2023;45(4):191\u2013209.","journal-title":"Dev Neurosci"},{"issue":"1","key":"3024_CR202","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13024-018-0262-8","volume":"13","author":"PJ Cheng-Hathaway","year":"2018","unstructured":"Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, et al. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer\u2019s disease. Mol Neurodegener. 2018;13(1):29.","journal-title":"Mol Neurodegener"},{"issue":"1","key":"3024_CR203","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","volume":"89","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD, et al. Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. Neuron. 2016;89(1):37\u201353.","journal-title":"Neuron"},{"issue":"4","key":"3024_CR204","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1159\/000085655","volume":"12","author":"S Meeuwsen","year":"2005","unstructured":"Meeuwsen S, Bsibsi M, Persoon-Deen C, Ravid R, van Noort JM. Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus. NeuroImmunoModulation. 2005;12(4):235\u201345.","journal-title":"NeuroImmunoModulation"},{"issue":"11","key":"3024_CR205","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1177\/1535370215576313","volume":"240","author":"I Stojkovska","year":"2015","unstructured":"Stojkovska I, Wagner BM, Morrison BE. Parkinson\u2019s disease and enhanced inflammatory response. Exp Biol Med. 2015;240(11):1387\u201395.","journal-title":"Exp Biol Med"},{"key":"3024_CR206","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2020.100060","volume":"4","author":"I Deng","year":"2020","unstructured":"Deng I, Corrigan F, Zhai G, Zhou XF, Bobrovskaya L. Lipopolysaccharide animal models of Parkinson\u2019s disease: recent progress and relevance to clinical disease. Brain Behavior Immunity-Health. 2020;4: 100060.","journal-title":"Brain Behavior Immunity-Health"},{"issue":"4","key":"3024_CR207","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nrm2873","volume":"11","author":"P Brundin","year":"2010","unstructured":"Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol. 2010;11(4):301\u20137.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"3024_CR208","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3390\/mi12040441","volume":"12","author":"T Cameron","year":"2021","unstructured":"Cameron T, Bennet T, Rowe EM, Anwer M, Wellington CL, Cheung KC. Review of design considerations for brain-on-a-chip models. Micromachines (Basel). 2021;12(4):441.","journal-title":"Micromachines (Basel)"},{"issue":"10","key":"3024_CR209","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.3390\/mi13101573","volume":"13","author":"TC Cameron","year":"2022","unstructured":"Cameron TC, Randhawa A, Grist SM, Bennet T, Hua J, Alde LG, et al. PDMS organ-on-chip design and fabrication: strategies for improving fluidic integration and chip robustness of rapidly prototyped microfluidic in vitro models. Micromachines (Basel). 2022;13(10):1573.","journal-title":"Micromachines (Basel)"},{"issue":"7","key":"3024_CR210","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1021\/acsbiomaterials.0c00640","volume":"7","author":"SB Campbell","year":"2020","unstructured":"Campbell SB, Wu Q, Yazbeck J, Liu C, Okhovatian S, Radisic M. Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems. ACS Biomater Sci Eng. 2020;7(7):2880\u201399.","journal-title":"ACS Biomater Sci Eng"},{"key":"3024_CR211","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12938-020-0752-0","volume":"19","author":"Q Wu","year":"2020","unstructured":"Wu Q, Liu J, Wang X, Feng L, Wu J, Zhu X, et al. Organ-on-a-chip: recent breakthroughs and future prospects. Biomed Eng Online. 2020;19:1\u201319.","journal-title":"Biomed Eng Online"},{"issue":"1","key":"3024_CR212","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s43586-022-00118-6","volume":"2","author":"CM Leung","year":"2022","unstructured":"Leung CM, De Haan P, Ronaldson-Bouchard K, Kim GA, Ko J, Rho HS, et al. A guide to the organ-on-a-chip. Nat Rev Methods Primers. 2022;2(1):33.","journal-title":"Nat Rev Methods Primers"},{"issue":"15","key":"3024_CR213","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1039\/D1LC00241D","volume":"21","author":"M Piergiovanni","year":"2021","unstructured":"Piergiovanni M, Leite SB, Corvi R, Whelan M. Standardisation needs for organ on chip devices. Lab Chip. 2021;21(15):2857\u201368.","journal-title":"Lab Chip"},{"issue":"3","key":"3024_CR214","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1515\/nanoph-2017-0097","volume":"7","author":"F Sima","year":"2018","unstructured":"Sima F, Sugioka K, V\u00e1zquez RM, Osellame R, Kelemen L, Ormos P. Three-dimensional femtosecond laser processing for lab-on-a-chip applications. Nanophotonics. 2018;7(3):613\u201334.","journal-title":"Nanophotonics"},{"issue":"4","key":"3024_CR215","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.3390\/s21041382","volume":"21","author":"R Paoli","year":"2021","unstructured":"Paoli R, Di Giuseppe D, Badiola-Mateos M, Martinelli E, Lopez-Martinez MJ, Samitier J. Rapid manufacturing of multilayered microfluidic devices for organ on a chip applications. Sensors. 2021;21(4):1382.","journal-title":"Sensors"},{"issue":"8","key":"3024_CR216","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3390\/mi13081200","volume":"13","author":"J Ko","year":"2022","unstructured":"Ko J, Park D, Lee S, Gumuscu B, Jeon NL. Engineering organ-on-a-chip to accelerate translational research. Micromachines (Basel). 2022;13(8):1200.","journal-title":"Micromachines (Basel)"},{"issue":"8","key":"3024_CR217","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/mi11080730","volume":"11","author":"JR Puryear III","year":"2020","unstructured":"Puryear JR III, Yoon JK, Kim Y. Advanced fabrication techniques of microengineered physiological systems. Micromachines (Basel). 2020;11(8):730.","journal-title":"Micromachines (Basel)"},{"key":"3024_CR218","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1039\/D3LC00124E","volume":"23","author":"J Kim","year":"2023","unstructured":"Kim J, Yoon T, Kim P, Bekhbat M, Kang SM, Rho HS, et al. Manufactured tissue-to-tissue barrier chip for modeling the human blood\u2013brain barrier and regulation of cellular trafficking. Lab Chip. 2023;23:2990\u20133001.","journal-title":"Lab Chip"},{"issue":"11","key":"3024_CR219","doi-asserted-by":"publisher","first-page":"2100464","DOI":"10.1002\/mame.202100464","volume":"306","author":"N Convery","year":"2021","unstructured":"Convery N, Samardzhieva I, Stormonth-Darling JM, Harrison S, Sullivan GJ, Gadegaard N. 3D printed tooling for injection molded microfluidics. Macromol Mater Eng. 2021;306(11):2100464.","journal-title":"Macromol Mater Eng"},{"key":"3024_CR220","doi-asserted-by":"publisher","DOI":"10.1016\/j.ooc.2020.100005","volume":"2","author":"KIW Kane","year":"2020","unstructured":"Kane KIW, Jarazo J, Moreno EL, Fleming RMT, Schwamborn JC. Passive controlled flow for Parkinson\u2019s disease neuronal cell culture in 3D microfluidic devices. Organs-on-a-Chip. 2020;2: 100005.","journal-title":"Organs-on-a-Chip"},{"key":"3024_CR221","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.1039\/D3LC00131H","volume":"23","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Qiao H, Xu F, Zhao W, Wang J, Gu L, et al. Bioengineering of a human physiologically relevant microfluidic blood\u2013cerebrospinal fluid barrier model. Lab Chip. 2023;23:3002\u201315.","journal-title":"Lab Chip"},{"issue":"1","key":"3024_CR222","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0760-y","volume":"13","author":"JA Brown","year":"2016","unstructured":"Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, et al. Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit. J Neuroinflammation. 2016;13(1):1\u201317.","journal-title":"J Neuroinflammation"},{"issue":"8","key":"3024_CR223","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1039\/D1LC00535A","volume":"22","author":"I Salmon","year":"2022","unstructured":"Salmon I, Grebenyuk S, Fattah ARA, Rustandi G, Pilkington T, Verfaillie C, et al. Engineering neurovascular organoids with 3D printed microfluidic chips. Lab Chip. 2022;22(8):1615\u201329.","journal-title":"Lab Chip"},{"issue":"9","key":"3024_CR224","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1038\/s41596-023-00861-4","volume":"18","author":"YJ Kang","year":"2023","unstructured":"Kang YJ, Diep YN, Tran M, Tran VTA, Ambrin G, Ngo H, et al. Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration. Nat Protocols. 2023;18(9):2838\u201367.","journal-title":"Nat Protocols"},{"issue":"7","key":"3024_CR225","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41593-018-0175-4","volume":"21","author":"J Park","year":"2018","unstructured":"Park J, Wetzel I, Marriott I, Dr\u00e9au D, D\u2019Avanzo C, Kim DY, et al. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer\u2019s disease. Nat Neurosci. 2018;21(7):941\u201351.","journal-title":"Nat Neurosci"},{"key":"3024_CR226","doi-asserted-by":"publisher","first-page":"480449","DOI":"10.3389\/fimmu.2019.02231","volume":"10","author":"J Park","year":"2019","unstructured":"Park J, Baik SH, Mook-Jung I, Irimia D, Cho H. Mimicry of central-peripheral immunity in Alzheimer\u2019s disease and discovery of neurodegenerative roles in neutrophil. Front Immunol. 2019;10:480449.","journal-title":"Front Immunol"},{"issue":"3","key":"3024_CR227","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/abf741","volume":"13","author":"S Seo","year":"2021","unstructured":"Seo S, Choi CH, Yi KS, Kim SU, Lee K, Choi N, et al. An engineered neurovascular unit for modeling neuroinflammation. Biofabrication. 2021;13(3): 035039.","journal-title":"Biofabrication"},{"issue":"12","key":"3024_CR228","doi-asserted-by":"publisher","first-page":"2210123","DOI":"10.1002\/adfm.202210123","volume":"33","author":"S Seo","year":"2023","unstructured":"Seo S, Jang M, Kim H, Sung JH, Choi N, Lee K, et al. Neuro-glia-vascular-on-a-chip system to assess aggravated neurodegeneration via brain endothelial cells upon exposure to diesel exhaust particles. Adv Funct Mater. 2023;33(12):2210123.","journal-title":"Adv Funct Mater"},{"key":"3024_CR229","doi-asserted-by":"crossref","unstructured":"Jorfi M, D\u2019Avanzo C, Kim DY, Irimia D. Three-dimensional models of the human brain development and diseases. Adv Healthc Mater. 2018;7(1).","DOI":"10.1002\/adhm.201700723"},{"issue":"1","key":"3024_CR230","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1038\/s41598-018-20436-8","volume":"8","author":"M Jorfi","year":"2018","unstructured":"Jorfi M, D\u2019avanzo C, Tanzi RE, Kim DY, Irimia D. Human neurospheroid arrays for in vitro studies of Alzheimer\u2019s disease. Sci Rep. 2018;8(1):2450.","journal-title":"Sci Rep"},{"key":"3024_CR231","doi-asserted-by":"publisher","first-page":"227609","DOI":"10.3389\/fnins.2016.00511","volume":"10","author":"JTS Fernandes","year":"2016","unstructured":"Fernandes JTS, Chutna O, Chu V, Conde JP, Outeiro TF. A novel microfluidic cell co-culture platform for the study of the molecular mechanisms of Parkinson\u2019s disease and other synucleinopathies. Front Neurosci. 2016;10:227609.","journal-title":"Front Neurosci"},{"issue":"1","key":"3024_CR232","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1038\/s41467-023-39038-8","volume":"14","author":"JA de Rus","year":"2023","unstructured":"de Rus JA, Alpaugh M, Denis HL, Tancredi JL, Boutin M, Decaestecker J, et al. The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson\u2019s disease. Nat Commun. 2023;14(1):3651.","journal-title":"Nat Commun"},{"key":"3024_CR233","doi-asserted-by":"crossref","unstructured":"Pediaditakis I, Kodella KR, Manatakis DV, Hinojosa CD, Manolakos ES, Rubin LL, et al. Modeling Alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption in Parkinson\u2019s disease. BioRxiv. 2021;2020\u20137.","DOI":"10.1101\/2020.07.22.207340"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03024-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-024-03024-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03024-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T18:13:46Z","timestamp":1731089626000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-024-03024-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,23]]},"references-count":233,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3024"],"URL":"https:\/\/doi.org\/10.1186\/s12974-024-03024-8","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,23]]},"assertion":[{"value":"26 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors have no competing financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}