{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:08:18Z","timestamp":1789495698001,"version":"build-2803163510"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82071267"],"award-info":[{"award-number":["82071267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371179"],"award-info":[{"award-number":["82371179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation of Jinan","award":["No. 2021GXRC103"],"award-info":[{"award-number":["No. 2021GXRC103"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-024-03241-1","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T11:01:50Z","timestamp":1727521310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["SIRT6 modulates lesion microenvironment in LPC induced demyelination by targeting astrocytic CHI3L1"],"prefix":"10.1186","volume":"21","author":[{"given":"Jingyi","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naigang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongshuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"3241_CR1","doi-asserted-by":"crossref","unstructured":"Woo MS, Engler JB, Friese MA. The neuropathobiology of multiple sclerosis. Nat Rev Neurosci. 2024;25(7):493\u2013513.","DOI":"10.1038\/s41583-024-00823-z"},{"issue":"2","key":"3241_CR2","doi-asserted-by":"publisher","first-page":"e00875","DOI":"10.1002\/brb3.875","volume":"8","author":"H H\u00f8jsgaard Chow","year":"2018","unstructured":"H\u00f8jsgaard Chow H, Schreiber K, Magyari M, Ammitzb\u00f8ll C, B\u00f6rnsen L, Romme Christensen J, et al. Progressive multiple sclerosis, cognitive function, and quality of life. Brain Behav. 2018;8(2):e00875.","journal-title":"Brain Behav"},{"issue":"3","key":"3241_CR3","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.brs.2024.04.012","volume":"17","author":"H Bachmann","year":"2024","unstructured":"Bachmann H, Vandemoortele B, Vermeirssen V, Carrette E, Vonck K, Boon P, Raedt R, et al. Vagus nerve stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination. Brain Stimul. 2024;17(3):575\u201387.","journal-title":"Brain Stimul"},{"key":"3241_CR4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/978-1-4939-9072-6_21","volume":"1936","author":"CE McMurran","year":"2019","unstructured":"McMurran CE, Zhao C, Franklin RJM. Toxin-based models to investigate demyelination and remyelination. Methods Mol Biol. 2019;1936:377\u201396.","journal-title":"Methods Mol Biol"},{"issue":"12","key":"3241_CR5","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.tcb.2021.06.009","volume":"31","author":"A Korotkov","year":"2021","unstructured":"Korotkov A, Seluanov A, Gorbunova V. Sirtuin 6: linking longevity with genome and epigenome stability. Trends Cell Biol. 2021;31(12):994\u20131006.","journal-title":"Trends Cell Biol"},{"issue":"6","key":"3241_CR6","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.14336\/AD.2022.0413","volume":"13","author":"Z Guo","year":"2022","unstructured":"Guo Z, Li P, Ge J, Li H. SIRT6 in aging, metabolism, inflammation and Cardiovascular diseases. Aging Dis. 2022;13(6):1787\u2013822.","journal-title":"Aging Dis"},{"issue":"1","key":"3241_CR7","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s12974-020-01906-1","volume":"17","author":"G Ferrara","year":"2020","unstructured":"Ferrara G, Benzi A, Sturla L, Marubbi D, Frumento D, Spinelli S, et al. Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration. J Neuroinflammation. 2020;17(1):228.","journal-title":"J Neuroinflammation"},{"issue":"13","key":"3241_CR8","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1016\/j.celrep.2017.03.008","volume":"18","author":"S Kaluski","year":"2017","unstructured":"Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, et al. Neuroprotective functions for the histone deacetylase SIRT6. Cell Rep. 2017;18(13):3052\u201362.","journal-title":"Cell Rep"},{"issue":"5","key":"3241_CR9","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41419-022-04866-x","volume":"13","author":"MY Song","year":"2022","unstructured":"Song MY, Yi F, Xiao H, Yin J, Huang Q, Xia J, et al. Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP. Cell Death Dis. 2022;13(5):449.","journal-title":"Cell Death Dis"},{"issue":"3","key":"3241_CR10","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.apsb.2020.11.002","volume":"11","author":"T He","year":"2021","unstructured":"He T, Shang J, Gao C, Guan X, Chen Y, Zhu L, et al. A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2\/FOXC1 axis. Acta Pharm Sin B. 2021;11(3):708\u201326.","journal-title":"Acta Pharm Sin B"},{"issue":"4","key":"3241_CR11","doi-asserted-by":"publisher","first-page":"109035","DOI":"10.1016\/j.celrep.2021.109035","volume":"35","author":"M Portillo","year":"2021","unstructured":"Portillo M, Eremenko E, Kaluski S, Garcia-Venzor A, Onn L, Stein D, et al. SIRT6-CBP-dependent nuclear tau accumulation and its role in protein synthesis. Cell Rep. 2021;35(4):109035.","journal-title":"Cell Rep"},{"issue":"7","key":"3241_CR12","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1007\/s11011-023-01250-2","volume":"38","author":"S Jing","year":"2023","unstructured":"Jing S, Wang X, Zhang Z, Cao D, Huang K, Wang Y, et al. Hesperetin attenuates cognitive dysfunction via SIRT6\/NLRP3 pathway in scopolamine-induced mice. Metab Brain Dis. 2023;38(7):2443\u201356.","journal-title":"Metab Brain Dis"},{"key":"3241_CR13","doi-asserted-by":"publisher","first-page":"110702","DOI":"10.1016\/j.pnpbp.2022.110702","volume":"123","author":"K Hu","year":"2023","unstructured":"Hu K, Chen H, Gao Y, Hua R, Shi X, Li L, et al. Astrocytic SIRT6 is a potential anti-depression and anti-anxiety target. Prog Neuropsychopharmacol Biol Psychiatry. 2023;123:110702.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"6","key":"3241_CR14","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1111\/jnc.15824","volume":"165","author":"F Li","year":"2023","unstructured":"Li F, Liu A, Zhao M, Luo L. Astrocytic Chitinase-3-like protein 1 in neurological diseases: potential roles and future perspectives. J Neurochem. 2023;165(6):772\u201390.","journal-title":"J Neurochem"},{"issue":"574","key":"3241_CR15","doi-asserted-by":"publisher","first-page":"eaax3519","DOI":"10.1126\/scitranslmed.aax3519","volume":"12","author":"BV Lananna","year":"2020","unstructured":"Lananna BV, McKee CA, King MW, Del-Aguila JL, Dimitry JM, Farias FHG, et al. Chi3l1\/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer\u2019s disease pathogenesis. Sci Transl Med. 2020;12(574):eaax3519.","journal-title":"Sci Transl Med"},{"issue":"3","key":"3241_CR16","doi-asserted-by":"publisher","first-page":"e972","DOI":"10.1212\/NXI.0000000000000972","volume":"8","author":"L Cubas-N\u00fa\u00f1ez","year":"2021","unstructured":"Cubas-N\u00fa\u00f1ez L, Gil-Perot\u00edn S, Castillo-Villalba J, L\u00f3pez V, Sol\u00eds Tarazona L, Gasqu\u00e9-Rubio R, et al. Potential role of CHI3L1\u2009+\u2009astrocytes in Progression in MS. Neurol Neuroimmunol Neuroinflamm. 2021;8(3):e972.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"4","key":"3241_CR17","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1136\/jnnp-2019-321916","volume":"91","author":"L Vu","year":"2020","unstructured":"Vu L, An J, Kovalik T, Gendron T, Petrucelli L, Bowser R. Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes. J Neurol Neurosurg Psychiatry. 2020;91(4):350\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"3241_CR18","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41467-024-45067-8","volume":"15","author":"L Hai","year":"2024","unstructured":"Hai L, Hoffmann DC, Wagener RJ, Azorin DD, Hausmann D, Xie R, et al. A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1. Nat Commun. 2024;15(1):968.","journal-title":"Nat Commun"},{"key":"3241_CR19","doi-asserted-by":"publisher","first-page":"113082","DOI":"10.1016\/j.expneurol.2019.113082","volume":"323","author":"JH Im","year":"2020","unstructured":"Im JH, Yeo IJ, Park PH, Choi DY, Han SB, Yun J, et al. Deletion of Chitinase-3-like 1 accelerates stroke development through enhancement of Neuroinflammation by STAT6-dependent M2 microglial inactivation in Chitinase-3-like 1 knockout mice. Exp Neurol. 2020;323:113082.","journal-title":"Exp Neurol"},{"key":"3241_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1146\/annurev-pathol-052016-100218","volume":"12","author":"M Olabarria","year":"2017","unstructured":"Olabarria M, Goldman JE. Disorders of astrocytes: Alexander Disease as a model. Annu Rev Pathol. 2017;12:131\u201352.","journal-title":"Annu Rev Pathol"},{"issue":"2","key":"3241_CR21","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.stem.2018.07.009","volume":"23","author":"L Li","year":"2018","unstructured":"Li L, Tian E, Chen X, Chao J, Klein J, Qu Q, et al. GFAP mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in an hiPSC model of Alexander Disease. Cell Stem Cell. 2018;23(2):239\u2013e2516.","journal-title":"Cell Stem Cell"},{"issue":"1","key":"3241_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12974-023-02721-0","volume":"20","author":"Y Wang","year":"2023","unstructured":"Wang Y, Sadike D, Huang B, Li P, Wu Q, Jiang N, et al. Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4\/MyD88\/NF-\u03baB pathway in LPC-induced demyelination. J Neuroinflammation. 2023;20(1):41.","journal-title":"J Neuroinflammation"},{"issue":"9","key":"3241_CR23","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3390\/cells11091477","volume":"11","author":"J Jin","year":"2022","unstructured":"Jin J, Li W, Wang T, Park BH, Park SK, Kang KP. Loss of Proximal Tubular Sirtuin 6 aggravates unilateral Ureteral obstruction-Induced Tubulointerstitial inflammation and fibrosis by regulation of \u03b2-Catenin acetylation. Cells. 2022;11(9):1477.","journal-title":"Cells"},{"issue":"3","key":"3241_CR24","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/hep.31418","volume":"73","author":"J Zhang","year":"2021","unstructured":"Zhang J, Li Y, Liu Q, Huang Y, Li R, Wu T, et al. Sirt6 alleviated liver fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in hepatic stellate cells. Hepatology. 2021;73(3):1140\u201357. https:\/\/doi.org\/10.1002\/hep.31418. Epub 2020 Nov 10. PMID: 32535965; PMCID: PMC8048913.","journal-title":"Hepatology"},{"issue":"1","key":"3241_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12974-019-1662-6","volume":"17","author":"D Xie","year":"2020","unstructured":"Xie D, Ge X, Ma Y, Tang J, Wang Y, Zhu Y, et al. Clemastine improves hypomyelination in rats with hypoxic-ischemic brain injury by reducing microglia-derived IL-1\u03b2 via P38 signaling pathway. J Neuroinflammation. 2020;17(1):57.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"3241_CR26","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-023-02819-5","volume":"20","author":"J Li","year":"2023","unstructured":"Li J, Xu P, Hong Y, Xie Y, Peng M, Sun R, et al. Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia\/reperfusion injury. J Neuroinflammation. 2023;20(1):148.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"3241_CR27","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s12035-021-02607-3","volume":"59","author":"Y Zou","year":"2022","unstructured":"Zou Y, Zhang J, Liu J, Xu J, Fu L, Ma X, et al. SIRT6 negatively regulates Schwann cells dedifferentiation via targeting c-Jun during Wallerian Degeneration after Peripheral nerve Injury. Mol Neurobiol. 2022;59(1):429\u201344. https:\/\/doi.org\/10.1007\/s12035-021-02607-3. Epub 2021 Oct 27. PMID: 34708329.","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3241_CR28","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41401-020-0442-2","volume":"42","author":"JL Shang","year":"2021","unstructured":"Shang JL, Ning SB, Chen YY, Chen TX, Zhang J. MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacol Sin. 2021;42(1):120\u201331. https:\/\/doi.org\/10.1038\/s41401-020-0442-2. Epub 2020 Jun 15. PMID: 32541922; PMCID: PMC7921659.","journal-title":"Acta Pharmacol Sin"},{"key":"3241_CR29","doi-asserted-by":"publisher","unstructured":"Ribeiro M, Yordanova YN, Noblet V, Herbet G, Ricard D. White matter tracts and executive functions: a review of causal and correlation evidence. Brain. 2024;147(2):352\u2013371. https:\/\/doi.org\/10.1093\/brain\/awad308. PMID: 37703295.","DOI":"10.1093\/brain\/awad308"},{"issue":"1","key":"3241_CR30","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12974-022-02557-0","volume":"19","author":"Y Xie","year":"2022","unstructured":"Xie Y, Chen X, Li Y, Chen S, Liu S, Yu Z, et al. Transforming growth factor-\u03b21 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-\u03baB\/ERK1\/2 pathways. J Neuroinflammation. 2022;19(1):194. https:\/\/doi.org\/10.1186\/s12974-022-02557-0. PMID: 35902863; PMCID: PMC9336072.","journal-title":"J Neuroinflammation"},{"issue":"11","key":"3241_CR31","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.1007\/s12035-020-02060-8","volume":"57","author":"L Ding","year":"2020","unstructured":"Ding L, Zhou J, Ye L, Sun Y, Jiang Z, Gan D, et al. PPAR-\u03b3 is critical for HDAC3-Mediated control of oligodendrocyte progenitor cell proliferation and differentiation after focal demyelination. Mol Neurobiol. 2020;57(11):4810\u201324. https:\/\/doi.org\/10.1007\/s12035-020-02060-8. Epub 2020 Aug 15. PMID: 32803489.","journal-title":"Mol Neurobiol"},{"issue":"23","key":"3241_CR32","doi-asserted-by":"publisher","first-page":"9730","DOI":"10.18632\/aging.204425","volume":"14","author":"H Zhou","year":"2022","unstructured":"Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, et al. Downregulation of Sirt6 by CD38 promotes cell senescence and aging. Aging. 2022;14(23):9730\u201357. https:\/\/doi.org\/10.18632\/aging.204425. Epub 2022 Dec 6. PMID: 36490326; PMCID: PMC9792202.","journal-title":"Aging"},{"issue":"21","key":"3241_CR33","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1016\/j.neuron.2022.09.023","volume":"110","author":"RJM Franklin","year":"2022","unstructured":"Franklin RJM, Simons M. CNS remyelination and inflammation: from basic mechanisms to therapeutic opportunities. Neuron. 2022;110(21):3549\u201365.","journal-title":"Neuron"},{"issue":"43","key":"3241_CR34","doi-asserted-by":"publisher","first-page":"31350","DOI":"10.1074\/jbc.C113.511261","volume":"288","author":"JL Feldman","year":"2013","unstructured":"Feldman JL, Baeza J, Denu JM. Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins. J Biol Chem. 2013;288(43):31350\u20136.","journal-title":"J Biol Chem"},{"issue":"22","key":"3241_CR35","doi-asserted-by":"publisher","first-page":"21313","DOI":"10.1074\/jbc.M413296200","volume":"280","author":"G Liszt","year":"2005","unstructured":"Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem. 2005;280(22):21313\u201320.","journal-title":"J Biol Chem"},{"issue":"1","key":"3241_CR36","doi-asserted-by":"publisher","first-page":"3372","DOI":"10.1038\/s41467-023-39046-8","volume":"14","author":"I Molina-Gonzalez","year":"2023","unstructured":"Molina-Gonzalez I, Holloway RK, Jiwaji Z, Dando O, Kent SA, Emelianova K, et al. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration. Nat Commun. 2023;14(1):3372.","journal-title":"Nat Commun"},{"issue":"5","key":"3241_CR37","doi-asserted-by":"publisher","first-page":"e1002605","DOI":"10.1371\/journal.pbio.1002605","volume":"15","author":"N Camargo","year":"2017","unstructured":"Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, et al. Oligodendroglial myelination requires astrocyte-derived lipids. PLoS Biol. 2017;15(5):e1002605.","journal-title":"PLoS Biol"},{"issue":"5","key":"3241_CR38","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00401-019-01980-7","volume":"137","author":"R Brambilla","year":"2019","unstructured":"Brambilla R. The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis. Acta Neuropathol. 2019;137(5):757\u201383.","journal-title":"Acta Neuropathol"},{"issue":"11","key":"3241_CR39","doi-asserted-by":"publisher","first-page":"5904","DOI":"10.3390\/ijms22115904","volume":"22","author":"R Aharoni","year":"2021","unstructured":"Aharoni R, Eilam R, Arnon R. Astrocytes in multiple sclerosis-essential constituents with diverse multifaceted functions. Int J Mol Sci. 2021;22(11):5904.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3241_CR40","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s41582-023-00801-6","volume":"19","author":"L Klotz","year":"2023","unstructured":"Klotz L, Antel J, Kuhlmann T. Inflammation in multiple sclerosis: consequences for remyelination and disease progression. Nat Rev Neurol. 2023;19(5):305\u201320.","journal-title":"Nat Rev Neurol"},{"key":"3241_CR41","doi-asserted-by":"publisher","unstructured":"Theophanous S, Sargiannidou I, Kleopa KA. Glial Cells as Key Regulators in Neuroinflammatory Mechanisms Associated with Multiple Sclerosis. Int J Mol Sci. 2024;25(17):9588. https:\/\/doi.org\/10.3390\/ijms25179588. PMID: 39273535.","DOI":"10.3390\/ijms25179588"},{"key":"3241_CR42","doi-asserted-by":"publisher","unstructured":"Holm RP, Wandall-Holm MF, Magyari M. Multiple sclerosis in Denmark (1950\u20132023): mean age, sex distribution, incidence and prevalence. Brain. 2024 Jul 20:awae245. https:\/\/doi.org\/10.1093\/brain\/awae245. Epub ahead of print. PMID: 39031688.","DOI":"10.1093\/brain\/awae245"},{"issue":"1","key":"3241_CR43","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/eji.202149589","volume":"52","author":"L Ryan","year":"2022","unstructured":"Ryan L, Mills KHG. Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis. Eur J Immunol. 2022;52(1):24\u201333. https:\/\/doi.org\/10.1002\/eji.202149589. Epub 2021 Nov 13. PMID: 34727577.","journal-title":"Eur J Immunol"},{"issue":"1","key":"3241_CR44","doi-asserted-by":"publisher","first-page":"10010","DOI":"10.1038\/s41598-019-46232-6","volume":"9","author":"A Tassoni","year":"2019","unstructured":"Tassoni A, Farkhondeh V, Itoh Y, Itoh N, Sofroniew MV, Voskuhl RR. The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression [J]. Sci Rep. 2019;9(1):10010.","journal-title":"Sci Rep"},{"key":"3241_CR45","doi-asserted-by":"publisher","first-page":"106610","DOI":"10.1016\/j.nbd.2024.106610","volume":"200","author":"AY Zhang","year":"2024","unstructured":"Zhang AY, Elias E, Manners MT. Sex-dependent astrocyte reactivity: unveiling chronic stress-induced morphological changes across multiple brain regions [J]. Neurobiol Dis. 2024;200:106610.","journal-title":"Neurobiol Dis"},{"issue":"6","key":"3241_CR46","doi-asserted-by":"publisher","first-page":"114278","DOI":"10.1016\/j.celrep.2024.114278","volume":"43","author":"SM Meadows","year":"2024","unstructured":"Meadows SM, Palaguachi F, Jang MW, Licht-Murava A, Barnett D, Zimmer TS, et al. Hippocampal astrocytes induce sex-dimorphic effects on memory [J]. Cell Rep. 2024;43(6):114278.","journal-title":"Cell Rep"},{"key":"3241_CR47","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neurobiolaging.2020.07.009","volume":"96","author":"A Vergallo","year":"2020","unstructured":"Vergallo A, Lista S, Lemercier P, Chiesa PA, Zetterberg H, Blennow K, et al. Association of plasma YKL-40 with brain amyloid-\u03b2 levels, memory performance, and sex in subjective memory complainers [J]. Neurobiol Aging. 2020;96:22\u201332.","journal-title":"Neurobiol Aging"},{"key":"3241_CR48","doi-asserted-by":"publisher","first-page":"146305","DOI":"10.1016\/j.brainres.2019.146305","volume":"1720","author":"C Sanfilippo","year":"2019","unstructured":"Sanfilippo C, Castrogiovanni P, Imbesi R, Kazakowa M, Musumeci G, Blennow K, et al. Sex difference in CHI3L1 expression levels in human brain aging and in Alzheimer\u2019s disease [J]. Brain Res. 2019;1720:146305.","journal-title":"Brain Res"},{"key":"3241_CR49","doi-asserted-by":"crossref","unstructured":"Kachanov A, Kostyusheva A, Brezgin S, Karandashov I, Ponomareva N, Tikhonov A et al. The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution. Med Res Rev. 2024;44(5):2112\u201393.","DOI":"10.1002\/med.22036"},{"issue":"8","key":"3241_CR50","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.3390\/ijms22084180","volume":"22","author":"R Akter","year":"2021","unstructured":"Akter R, Afrose A, Rahman MR, Chowdhury R, Nirzhor SSR, Khan RI, et al. A comprehensive analysis into the therapeutic application of Natural products as SIRT6 modulators in Alzheimer\u2019s Disease, Aging, Cancer, inflammation, and diabetes. Int J Mol Sci. 2021;22(8):4180.","journal-title":"Int J Mol Sci"},{"key":"3241_CR51","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cbi.2019.02.017","volume":"303","author":"M Jayachandran","year":"2019","unstructured":"Jayachandran M, Wu Z, Ganesan K, Khalid S, Chung SM, Xu B. Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats. Chem Biol Interact. 2019;303:62\u20139.","journal-title":"Chem Biol Interact"},{"issue":"5","key":"3241_CR52","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1039\/c2fo10274a","volume":"3","author":"A Murakami","year":"2012","unstructured":"Murakami A, Ohnishi K. Target molecules of food phytochemicals: food science bound for the next dimension. Food Funct. 2012;3(5):462\u201376.","journal-title":"Food Funct"},{"issue":"11","key":"3241_CR53","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1002\/glia.24440","volume":"71","author":"LJ Schr\u00f6der","year":"2023","unstructured":"Schr\u00f6der LJ, Mulenge F, Pavlou A, Skripuletz T, Stangel M, Gudi V, et al. Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination. Glia. 2023;71(11):2573\u201390.","journal-title":"Glia"},{"issue":"8","key":"3241_CR54","first-page":"4025","volume":"130","author":"T Chen","year":"2020","unstructured":"Chen T, Lennon VA, Liu YU, Bosco DB, Li Y, Yi MH, et al. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. J Clin Invest. 2020;130(8):4025\u201338.","journal-title":"J Clin Invest"},{"issue":"5","key":"3241_CR55","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/glia.23955","volume":"69","author":"Y Wei","year":"2021","unstructured":"Wei Y, Chen T, Bosco DB, Xie M, Zheng J, Dheer A, et al. The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus. Glia. 2021;69(5):1155\u201369.","journal-title":"Glia"},{"issue":"1","key":"3241_CR56","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s10020-023-00676-9","volume":"29","author":"X Xiao","year":"2023","unstructured":"Xiao X, Hu H, Zhong Y, Chen Y, Tang K, Pan Z, et al. Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity [J]. Mol Med. 2023;29(1):108.","journal-title":"Mol Med"},{"issue":"5","key":"3241_CR57","doi-asserted-by":"publisher","first-page":"114226","DOI":"10.1016\/j.celrep.2024.114226","volume":"43","author":"Y Song","year":"2024","unstructured":"Song Y, Jiang W, Afridi SK, Wang T, Zhu F, Xu H, et al. Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus. Cell Rep. 2024;43(5):114226.","journal-title":"Cell Rep"},{"issue":"13","key":"3241_CR58","doi-asserted-by":"publisher","first-page":"6526","DOI":"10.7150\/thno.53886","volume":"11","author":"Q Han","year":"2021","unstructured":"Han Q, Xie QR, Li F, Cheng Y, Wu T, Zhang Y, et al. Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer. Theranostics. 2021;11(13):6526\u201341. https:\/\/doi.org\/10.7150\/thno.53886. PMID: 33995674; PMCID: PMC8120217.","journal-title":"Theranostics"},{"issue":"1","key":"3241_CR59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0896-6273(00)80515-2","volume":"21","author":"S Wang","year":"1998","unstructured":"Wang S, Sdrulla AD, diSibio G, Bush G, Nofziger D, Hicks C, et al. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron. 1998;21(1):63\u201375.","journal-title":"Neuron"},{"issue":"1","key":"3241_CR60","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41392-020-00303-7","volume":"5","author":"T Zhao","year":"2020","unstructured":"Zhao T, Su Z, Li Y, Zhang X, You Q. Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduct Target Ther. 2020;5(1):201.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"3241_CR61","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13578-021-00725-y","volume":"11","author":"Y Zou","year":"2021","unstructured":"Zou Y, Zhang J, Xu J, Fu L, Xu Y, Wang X, et al. SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages. Cell Biosci. 2021;11(1):210.","journal-title":"Cell Biosci"},{"issue":"1","key":"3241_CR62","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s12035-021-02607-3","volume":"59","author":"Y Zou","year":"2022","unstructured":"Zou Y, Zhang J, Liu J, Xu J, Fu L, Ma X, et al. SIRT6 negatively regulates Schwann cells dedifferentiation via targeting c-Jun during Wallerian Degeneration after Peripheral nerve Injury. Mol Neurobiol. 2022;59(1):429\u201344.","journal-title":"Mol Neurobiol"},{"issue":"11","key":"3241_CR63","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.1007\/s12035-020-02060-8","volume":"57","author":"L Ding","year":"2020","unstructured":"Ding L, Zhou J, Ye L, Sun Y, Jiang Z, Gan D, et al. PPAR-\u03b3 is critical for HDAC3-Mediated control of oligodendrocyte progenitor cell proliferation and differentiation after focal demyelination. Mol Neurobiol. 2020;57(11):4810\u201324.","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3241_CR64","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12974-019-1586-1","volume":"16","author":"T Chu","year":"2019","unstructured":"Chu T, Zhang YP, Tian Z, Ye C, Zhu M, Shields LBE, et al. Dynamic response of microglia\/macrophage polarization following demyelination in mice. J Neuroinflammation. 2019;16(1):188.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"3241_CR65","doi-asserted-by":"publisher","first-page":"22167","DOI":"10.1038\/s41598-021-01746-w","volume":"11","author":"G Favrais","year":"2021","unstructured":"Favrais G, Saliba E, Savary L, Bodard S, Gulhan Z, Gressens P, et al. Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis. Sci Rep. 2021;11(1):22167.","journal-title":"Sci Rep"},{"issue":"3","key":"3241_CR66","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/bpa.12798","volume":"30","author":"P Huang","year":"2020","unstructured":"Huang P, Zhou Q, Lin Q, Lin L, Wang H, Chen X, et al. Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT\/\u03b2-catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide. Brain Pathol. 2020;30(3):495\u2013514.","journal-title":"Brain Pathol"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03241-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-024-03241-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03241-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T11:02:17Z","timestamp":1727521337000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-024-03241-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3241"],"URL":"https:\/\/doi.org\/10.1186\/s12974-024-03241-1","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,28]]},"assertion":[{"value":"17 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal protocols have been approved by the Animal Care and Utilization Committee of Shandong University and were performed according to the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health of the United States.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"243"}}