{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:29:25Z","timestamp":1791430165339,"version":"4.3.3"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82173912"],"award-info":[{"award-number":["No. 82173912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82173912"],"award-info":[{"award-number":["No. 82173912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82173912"],"award-info":[{"award-number":["No. 82173912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82173912"],"award-info":[{"award-number":["No. 82173912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82173912"],"award-info":[{"award-number":["No. 82173912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82173912"],"award-info":[{"award-number":["No. 82173912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-024-03259-5","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T07:05:02Z","timestamp":1729235102000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism"],"prefix":"10.1186","volume":"21","author":[{"given":"Jiao","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengshuo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"12","key":"3259_CR1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.tips.2012.09.004","volume":"33","author":"W Spooren","year":"2012","unstructured":"Spooren W, et al. Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders. Trends Pharmacol Sci. 2012;33(12):669\u201384.","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"3259_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41392-022-01081-0","volume":"7","author":"CC Jiang","year":"2022","unstructured":"Jiang CC, et al. Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications. Signal Transduct Target Ther. 2022;7(1):229.","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"3259_CR3","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.1007\/s10803-021-05005-9","volume":"51","author":"E Fombonne","year":"2021","unstructured":"Fombonne E, MacFarlane H, Salem AC. Epidemiological surveys of ASD: advances and remaining challenges. J Autism Dev Disord. 2021;51(12):4271\u201390.","journal-title":"J Autism Dev Disord"},{"issue":"8","key":"3259_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nrn3978","volume":"16","author":"ML Estes","year":"2015","unstructured":"Estes ML, McAllister AK. Immune mediators in the brain and peripheral tissues in autism spectrum disorder. Nat Rev Neurosci. 2015;16(8):469\u201386.","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"3259_CR5","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","volume":"19","author":"GW Kreutzberg","year":"1996","unstructured":"Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19(8):312\u20138.","journal-title":"Trends Neurosci"},{"issue":"6","key":"3259_CR6","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1113\/JP272134","volume":"595","author":"TL Tay","year":"2017","unstructured":"Tay TL, et al. Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol. 2017;595(6):1929\u201345.","journal-title":"J Physiol"},{"issue":"45","key":"3259_CR7","doi-asserted-by":"publisher","first-page":"16064","DOI":"10.1523\/JNEUROSCI.4158-11.2011","volume":"31","author":"ME Tremblay","year":"2011","unstructured":"Tremblay ME, et al. The role of microglia in the healthy brain. J Neurosci. 2011;31(45):16064\u20139.","journal-title":"J Neurosci"},{"issue":"4","key":"3259_CR8","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","volume":"68","author":"JT Morgan","year":"2010","unstructured":"Morgan JT, et al. Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol Psychiatry. 2010;68(4):368\u201376.","journal-title":"Biol Psychiatry"},{"issue":"1","key":"3259_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","volume":"57","author":"DL Vargas","year":"2005","unstructured":"Vargas DL, et al. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005;57(1):67\u201381.","journal-title":"Ann Neurol"},{"issue":"12","key":"3259_CR10","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1007\/s10803-012-1513-0","volume":"42","author":"NA Tetreault","year":"2012","unstructured":"Tetreault NA, et al. Microglia in the cerebral cortex in autism. J Autism Dev Disord. 2012;42(12):2569\u201384.","journal-title":"J Autism Dev Disord"},{"issue":"1","key":"3259_CR11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","volume":"70","author":"K Suzuki","year":"2013","unstructured":"Suzuki K, et al. Microglial activation in young adults with autism spectrum disorder. JAMA Psychiat. 2013;70(1):49\u201358.","journal-title":"JAMA Psychiat"},{"issue":"1","key":"3259_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2040-2392-5-3","volume":"5","author":"C Edmonson","year":"2014","unstructured":"Edmonson C, Ziats MN, Rennert OM. Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum. Mol Autism. 2014;5(1):3.","journal-title":"Mol Autism"},{"key":"3259_CR13","doi-asserted-by":"publisher","first-page":"5748","DOI":"10.1038\/ncomms6748","volume":"5","author":"S Gupta","year":"2014","unstructured":"Gupta S, et al. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014;5:5748.","journal-title":"Nat Commun"},{"issue":"3","key":"3259_CR14","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/sj.mp.4001943","volume":"12","author":"BA Corbett","year":"2007","unstructured":"Corbett BA, et al. A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins. Mol Psychiatry. 2007;12(3):292\u2013306.","journal-title":"Mol Psychiatry"},{"key":"3259_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bbi.2017.01.019","volume":"62","author":"AS Lee","year":"2017","unstructured":"Lee AS, Azmitia EC, Whitaker-Azmitia PM. Developmental microglial priming in postmortem autism spectrum disorder temporal cortex. Brain Behav Immun. 2017;62:193\u2013202.","journal-title":"Brain Behav Immun"},{"issue":"10","key":"3259_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110356","volume":"9","author":"JT Morgan","year":"2014","unstructured":"Morgan JT, et al. Stereological study of amygdala glial populations in adolescents and adults with autism spectrum disorder. PLoS ONE. 2014;9(10): e110356.","journal-title":"PLoS ONE"},{"key":"3259_CR17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13229-018-0254-0","volume":"9","author":"MR Bronzuoli","year":"2018","unstructured":"Bronzuoli MR, et al. Neuroglia in the autistic brain: evidence from a preclinical model. Mol Autism. 2018;9:66.","journal-title":"Mol Autism"},{"key":"3259_CR18","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3389\/fncel.2019.00344","volume":"13","author":"T Sanagi","year":"2019","unstructured":"Sanagi T, et al. Segmented Iba1-positive processes of microglia in Autism model marmosets. Front Cell Neurosci. 2019;13:344.","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"3259_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2018-000006","volume":"31","author":"X Li","year":"2018","unstructured":"Li X, et al. Microglia activation in the offspring of prenatal Poly I: C exposed rats: a PET imaging and immunohistochemistry study. Gen Psychiatr. 2018;31(1): e000006.","journal-title":"Gen Psychiatr"},{"issue":"4","key":"3259_CR20","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.bbi.2012.01.011","volume":"26","author":"NV Malkova","year":"2012","unstructured":"Malkova NV, et al. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun. 2012;26(4):607\u201316.","journal-title":"Brain Behav Immun"},{"issue":"4","key":"3259_CR21","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/glia.23284","volume":"66","author":"S Jawaid","year":"2018","unstructured":"Jawaid S, et al. Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome. Glia. 2018;66(4):789\u2013800.","journal-title":"Glia"},{"issue":"7","key":"3259_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020912","volume":"6","author":"Y Heo","year":"2011","unstructured":"Heo Y, et al. Aberrant immune responses in a mouse with behavioral disorders. PLoS ONE. 2011;6(7): e20912.","journal-title":"PLoS ONE"},{"issue":"4","key":"3259_CR23","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00401-017-1751-5","volume":"134","author":"E Coutinho","year":"2017","unstructured":"Coutinho E, et al. Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero. Acta Neuropathol. 2017;134(4):567\u201383.","journal-title":"Acta Neuropathol"},{"key":"3259_CR24","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0196-16.2016","author":"EC Cope","year":"2016","unstructured":"Cope EC, et al. Immature neurons and radial glia, but not astrocytes or microglia, are altered in adult Cntnap2 and Shank3 mice models of Autism. eNeuro. 2016. https:\/\/doi.org\/10.1523\/ENEURO.0196-16.2016.","journal-title":"eNeuro"},{"issue":"2","key":"3259_CR25","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","volume":"179","author":"M Prinz","year":"2019","unstructured":"Prinz M, Jung S, Priller J. Microglia biology: one century of evolving concepts. Cell. 2019;179(2):292\u2013311.","journal-title":"Cell"},{"key":"3259_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/bs.pmbts.2019.06.012","volume":"167","author":"M Andoh","year":"2019","unstructured":"Andoh M, Ikegaya Y, Koyama R. Microglia as possible therapeutic targets for autism spectrum disorders. Prog Mol Biol Transl Sci. 2019;167:223\u201345.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"2","key":"3259_CR27","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","volume":"82","author":"MR Elmore","year":"2014","unstructured":"Elmore MR, et al. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron. 2014;82(2):380\u201397.","journal-title":"Neuron"},{"issue":"4","key":"3259_CR28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00018-022-04225-1","volume":"79","author":"J Han","year":"2022","unstructured":"Han J, et al. Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges. Cell Mol Life Sci. 2022;79(4):219.","journal-title":"Cell Mol Life Sci"},{"key":"3259_CR29","doi-asserted-by":"publisher","first-page":"1022431","DOI":"10.3389\/fncel.2022.1022431","volume":"16","author":"B Basilico","year":"2022","unstructured":"Basilico B, et al. What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior. Front Cell Neurosci. 2022;16:1022431.","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"3259_CR30","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1016\/j.celrep.2019.07.078","volume":"28","author":"M Yamamoto","year":"2019","unstructured":"Yamamoto M, et al. Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation. Cell Rep. 2019;28(11):2923-2938 e8.","journal-title":"Cell Rep"},{"key":"3259_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2020.100079","volume":"5","author":"Z Dwyer","year":"2020","unstructured":"Dwyer Z, et al. Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice. Brain Behav Immun Health. 2020;5: 100079.","journal-title":"Brain Behav Immun Health"},{"issue":"1","key":"3259_CR32","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1038\/s41467-019-11674-z","volume":"10","author":"E Spangenberg","year":"2019","unstructured":"Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer\u2019s disease model. Nat Commun. 2019;10(1):3758.","journal-title":"Nat Commun"},{"issue":"Pt 3","key":"3259_CR33","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1093\/brain\/awv379","volume":"139","author":"A Olmos-Alonso","year":"2016","unstructured":"Olmos-Alonso A, et al. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer\u2019s-like pathology. Brain. 2016;139(Pt 3):891\u2013907.","journal-title":"Brain"},{"issue":"14","key":"3259_CR34","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.1523\/JNEUROSCI.2402-19.2020","volume":"40","author":"RJ Henry","year":"2020","unstructured":"Henry RJ, et al. Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits. J Neurosci. 2020;40(14):2960\u201374.","journal-title":"J Neurosci"},{"issue":"5","key":"3259_CR35","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.cell.2020.02.013","volume":"180","author":"EF Willis","year":"2020","unstructured":"Willis EF, et al. Repopulating microglia promote brain repair in an IL-6-dependent manner. Cell. 2020;180(5):833-846 e16.","journal-title":"Cell"},{"issue":"6","key":"3259_CR36","doi-asserted-by":"publisher","first-page":"10576","DOI":"10.1002\/jcb.28344","volume":"120","author":"F Tahmasebi","year":"2019","unstructured":"Tahmasebi F, et al. Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model. J Cell Biochem. 2019;120(6):10576\u201386.","journal-title":"J Cell Biochem"},{"issue":"1","key":"3259_CR37","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/brain\/awz363","volume":"143","author":"JD Crapser","year":"2020","unstructured":"Crapser JD, et al. Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington\u2019s disease. Brain. 2020;143(1):266\u201388.","journal-title":"Brain"},{"issue":"6","key":"3259_CR38","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1038\/s41380-020-0671-2","volume":"26","author":"S Ikezu","year":"2021","unstructured":"Ikezu S, et al. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2021;26(6):1808\u201331.","journal-title":"Mol Psychiatry"},{"key":"3259_CR39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bbi.2015.09.001","volume":"55","author":"L Torres","year":"2016","unstructured":"Torres L, et al. Dynamic microglial modulation of spatial learning and social behavior. Brain Behav Immun. 2016;55:6\u201316.","journal-title":"Brain Behav Immun"},{"issue":"6","key":"3259_CR40","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/mp.2013.155","volume":"19","author":"T Kreisel","year":"2014","unstructured":"Kreisel T, et al. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry. 2014;19(6):699\u2013709.","journal-title":"Mol Psychiatry"},{"key":"3259_CR41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66738","author":"LA Hohsfield","year":"2021","unstructured":"Hohsfield LA, et al. Subventricular zone\/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave. Elife. 2021. https:\/\/doi.org\/10.7554\/eLife.66738.","journal-title":"Elife"},{"issue":"1","key":"3259_CR42","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cell.2011.08.040","volume":"147","author":"O Penagarikano","year":"2011","unstructured":"Penagarikano O, et al. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell. 2011;147(1):235\u201346.","journal-title":"Cell"},{"issue":"Pt A","key":"3259_CR43","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","volume":"299","author":"C Nicolini","year":"2018","unstructured":"Nicolini C, Fahnestock M. The valproic acid-induced rodent model of autism. Exp Neurol. 2018;299(Pt A):217\u201327.","journal-title":"Exp Neurol"},{"issue":"1","key":"3259_CR44","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1038\/s41598-019-39434-5","volume":"9","author":"X Xing","year":"2019","unstructured":"Xing X, et al. Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice. Sci Rep. 2019;9(1):3041.","journal-title":"Sci Rep"},{"issue":"3","key":"3259_CR45","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/nprot.2006.170","volume":"1","author":"RM Deacon","year":"2006","unstructured":"Deacon RM. Assessing nest building in mice. Nat Protoc. 2006;1(3):1117\u20139.","journal-title":"Nat Protoc"},{"issue":"7","key":"3259_CR46","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1016\/j.cell.2021.02.009","volume":"184","author":"SA Buffington","year":"2021","unstructured":"Buffington SA, et al. Dissecting the contribution of host genetics and the microbiome in complex behaviors. Cell. 2021;184(7):1740-1756 e16.","journal-title":"Cell"},{"key":"3259_CR47","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.brainres.2010.09.026","volume":"1380","author":"JL Silverman","year":"2011","unstructured":"Silverman JL, et al. Sociability and motor functions in Shank1 mutant mice. Brain Res. 2011;1380:120\u201337.","journal-title":"Brain Res"},{"issue":"3","key":"3259_CR48","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0896-6273(01)00319-1","volume":"30","author":"MS Szczypka","year":"2001","unstructured":"Szczypka MS, et al. Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron. 2001;30(3):819\u201328.","journal-title":"Neuron"},{"issue":"2","key":"3259_CR49","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/glia.23529","volume":"67","author":"J Han","year":"2019","unstructured":"Han J, et al. Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders. Glia. 2019;67(2):217\u201331.","journal-title":"Glia"},{"issue":"2","key":"3259_CR50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11920-018-0874-2","volume":"20","author":"SL Ferri","year":"2018","unstructured":"Ferri SL, Abel T, Brodkin ES. Sex differences in Autism spectrum disorder: a review. Curr Psychiatry Rep. 2018;20(2):9.","journal-title":"Curr Psychiatry Rep"},{"issue":"6","key":"3259_CR51","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1111\/j.1471-4159.2011.07630.x","volume":"120","author":"JM Schwarz","year":"2012","unstructured":"Schwarz JM, Sholar PW, Bilbo SD. Sex differences in microglial colonization of the developing rat brain. J Neurochem. 2012;120(6):948\u201363.","journal-title":"J Neurochem"},{"issue":"10","key":"3259_CR52","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1016\/j.celrep.2018.08.001","volume":"24","author":"D Guneykaya","year":"2018","unstructured":"Guneykaya D, et al. Transcriptional and translational differences of microglia from male and female brains. Cell Rep. 2018;24(10):2773-2783 e6.","journal-title":"Cell Rep"},{"issue":"1","key":"3259_CR53","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","volume":"50","author":"TR Hammond","year":"2019","unstructured":"Hammond TR, et al. Single-Cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes. Immunity. 2019;50(1):253-271 e6.","journal-title":"Immunity"},{"issue":"2","key":"3259_CR54","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.neuron.2019.02.006","volume":"102","author":"JW VanRyzin","year":"2019","unstructured":"VanRyzin JW, et al. Microglial phagocytosis of newborn cells is induced by endocannabinoids and sculpts sex differences in juvenile rat social play. Neuron. 2019;102(2):435-449 e6.","journal-title":"Neuron"},{"issue":"8","key":"3259_CR55","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nrn.2017.61","volume":"18","author":"MM McCarthy","year":"2017","unstructured":"McCarthy MM, Nugent BM, Lenz KM. Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain. Nat Rev Neurosci. 2017;18(8):471\u201384.","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"3259_CR56","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1073\/pnas.1619312114","volume":"114","author":"SM Schaafsma","year":"2017","unstructured":"Schaafsma SM, et al. Sex-specific gene-environment interactions underlying ASD-like behaviors. Proc Natl Acad Sci U S A. 2017;114(6):1383\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3259_CR57","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/s42003-023-05215-0","volume":"6","author":"MS Dawson","year":"2023","unstructured":"Dawson MS, et al. Sexual dimorphism in the social behaviour of Cntnap2-null mice correlates with disrupted synaptic connectivity and increased microglial activity in the anterior cingulate cortex. Commun Biol. 2023;6(1):846.","journal-title":"Commun Biol"},{"key":"3259_CR58","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ijdevneu.2014.10.003","volume":"40","author":"TM Mowery","year":"2015","unstructured":"Mowery TM, et al. Embryological exposure to valproic acid disrupts morphology of the deep cerebellar nuclei in a sexually dimorphic way. Int J Dev Neurosci. 2015;40:15\u201323.","journal-title":"Int J Dev Neurosci"},{"issue":"6","key":"3259_CR59","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/jnc.12147","volume":"124","author":"KC Kim","year":"2013","unstructured":"Kim KC, et al. Male-specific alteration in excitatory post-synaptic development and social interaction in pre-natal valproic acid exposure model of autism spectrum disorder. J Neurochem. 2013;124(6):832\u201343.","journal-title":"J Neurochem"},{"key":"3259_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104441","volume":"110","author":"N Kazlauskas","year":"2019","unstructured":"Kazlauskas N, et al. Sex-specific effects of prenatal valproic acid exposure on sociability and neuroinflammation: relevance for susceptibility and resilience in autism. Psychoneuroendocrinology. 2019;110: 104441.","journal-title":"Psychoneuroendocrinology"},{"key":"3259_CR61","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3389\/fimmu.2018.00698","volume":"9","author":"KM Lenz","year":"2018","unstructured":"Lenz KM, Nelson LH. Microglia and beyond: innate immune cells as regulators of brain development and behavioral function. Front Immunol. 2018;9:698.","journal-title":"Front Immunol"},{"issue":"21","key":"3259_CR62","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","volume":"110","author":"RC Paolicelli","year":"2022","unstructured":"Paolicelli RC, et al. Microglia states and nomenclature: a field at its crossroads. Neuron. 2022;110(21):3458\u201383.","journal-title":"Neuron"},{"issue":"7","key":"3259_CR63","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","volume":"141","author":"MA Lemmon","year":"2010","unstructured":"Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2010;141(7):1117\u201334.","journal-title":"Cell"},{"issue":"1","key":"3259_CR64","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrn2495","volume":"10","author":"A Nishiyama","year":"2009","unstructured":"Nishiyama A, et al. Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat Rev Neurosci. 2009;10(1):9\u201322.","journal-title":"Nat Rev Neurosci"},{"key":"3259_CR65","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12974-015-0366-9","volume":"12","author":"NN Dagher","year":"2015","unstructured":"Dagher NN, et al. Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice. J Neuroinflammation. 2015;12:139.","journal-title":"J Neuroinflammation"},{"issue":"9","key":"3259_CR66","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1158\/1078-0432.CCR-13-3033","volume":"20","author":"TS Kim","year":"2014","unstructured":"Kim TS, et al. Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor. Clin Cancer Res. 2014;20(9):2350\u201362.","journal-title":"Clin Cancer Res"},{"key":"3259_CR67","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.expneurol.2019.04.011","volume":"318","author":"Y Liu","year":"2019","unstructured":"Liu Y, et al. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019;318:32\u201341.","journal-title":"Exp Neurol"},{"issue":"38","key":"3259_CR68","doi-asserted-by":"publisher","first-page":"23336","DOI":"10.1073\/pnas.1922788117","volume":"117","author":"F Lei","year":"2020","unstructured":"Lei F, et al. CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages. Proc Natl Acad Sci U S A. 2020;117(38):23336\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3259_CR69","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12974-022-02559-y","volume":"19","author":"Y Ishihara","year":"2022","unstructured":"Ishihara Y, et al. A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure. J Neuroinflammation. 2022;19(1):195.","journal-title":"J Neuroinflammation"},{"key":"3259_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.148963","volume":"1838","author":"M Reza Naghdi","year":"2024","unstructured":"Reza Naghdi M, et al. The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism. Brain Res. 2024;1838: 148963.","journal-title":"Brain Res"},{"issue":"10","key":"3259_CR71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026077","volume":"6","author":"MV Mehta","year":"2011","unstructured":"Mehta MV, Gandal MJ, Siegel SJ. mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. PLoS ONE. 2011;6(10): e26077.","journal-title":"PLoS ONE"},{"key":"3259_CR72","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neuro.2022.05.008","volume":"91","author":"Z Liu","year":"2022","unstructured":"Liu Z, et al. Vitamin A supplementation ameliorates prenatal valproic acid-induced autism-like behaviors in rats. Neurotoxicology. 2022;91:155\u201365.","journal-title":"Neurotoxicology"},{"issue":"1","key":"3259_CR73","doi-asserted-by":"publisher","first-page":"13077","DOI":"10.1038\/s41598-018-31385-7","volume":"8","author":"N Eissa","year":"2018","unstructured":"Eissa N, et al. The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. Sci Rep. 2018;8(1):13077.","journal-title":"Sci Rep"},{"issue":"4","key":"3259_CR74","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2336","volume":"116","author":"S Chen","year":"2024","unstructured":"Chen S, et al. The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK\/CREB\/BDNF signaling pathway. Birth Defects Res. 2024;116(4): e2336.","journal-title":"Birth Defects Res"},{"issue":"22","key":"3259_CR75","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.1021\/acschemneuro.0c00482","volume":"11","author":"K Wang","year":"2020","unstructured":"Wang K, et al. Glyoxalase 1 inhibitor alleviates Autism-like phenotype in a prenatal valproic acid-induced mouse model. ACS Chem Neurosci. 2020;11(22):3786\u201392.","journal-title":"ACS Chem Neurosci"},{"issue":"4","key":"3259_CR76","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/FBP.0000000000000720","volume":"34","author":"F Taheri","year":"2023","unstructured":"Taheri F, et al. Amelioration of cognition impairments in the valproic acid-induced animal model of autism by ciproxifan, a histamine H3-receptor antagonist. Behav Pharmacol. 2023;34(4):179\u201396.","journal-title":"Behav Pharmacol"},{"key":"3259_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2024.114464","volume":"185","author":"Z Soltani","year":"2024","unstructured":"Soltani Z, et al. Investigating the effect of exposure to monosodium glutamate during pregnancy on development of autism in male rat offspring. Food Chem Toxicol. 2024;185: 114464.","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"3259_CR78","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/pcn.12833","volume":"73","author":"F Huang","year":"2019","unstructured":"Huang F, et al. Betaine ameliorates prenatal valproic-acid-induced Autism-like behavioral abnormalities in mice by promoting homocysteine metabolism. Psychiatry Clin Neurosci. 2019;73(6):317\u201322.","journal-title":"Psychiatry Clin Neurosci"},{"issue":"11","key":"3259_CR79","doi-asserted-by":"publisher","first-page":"3996","DOI":"10.3390\/ijms21113996","volume":"21","author":"N Eissa","year":"2020","unstructured":"Eissa N, et al. The dual-active histamine H(3) receptor antagonist and acetylcholine esterase inhibitor E100 alleviates autistic-like behaviors and oxidative stress in valproic acid induced Autism in mice. Int J Mol Sci. 2020;21(11):3996.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3259_CR80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116363","volume":"10","author":"D Baronio","year":"2015","unstructured":"Baronio D, et al. Effects of an H3R antagonist on the animal model of autism induced by prenatal exposure to valproic acid. PLoS ONE. 2015;10(1): e0116363.","journal-title":"PLoS ONE"},{"issue":"5","key":"3259_CR81","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3390\/ph16050769","volume":"16","author":"MM Nakhal","year":"2023","unstructured":"Nakhal MM, et al. Canagliflozin ameliorates oxidative stress and autistic-like features in valproic-acid-induced autism in rats: comparison with aripiprazole action. Pharmaceuticals (Basel). 2023;16(5):769.","journal-title":"Pharmaceuticals (Basel)"},{"key":"3259_CR82","volume-title":"Desk reference to the diagnostic criteria from DSM-5","author":"AP Association","year":"2013","unstructured":"Association AP. Desk reference to the diagnostic criteria from DSM-5. Washington, DC: American Psychiatric Publishing; 2013."},{"key":"3259_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105742","volume":"169","author":"L Balasco","year":"2022","unstructured":"Balasco L, et al. Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2(-\/-) mice. Neurobiol Dis. 2022;169: 105742.","journal-title":"Neurobiol Dis"},{"key":"3259_CR84","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.3389\/fpsyg.2015.01805","volume":"6","author":"LK Bicks","year":"2015","unstructured":"Bicks LK, et al. Prefrontal cortex and social cognition in mouse and man. Front Psychol. 2015;6:1805.","journal-title":"Front Psychol"},{"issue":"3","key":"3259_CR85","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.neubiorev.2010.02.005","volume":"35","author":"M Langen","year":"2011","unstructured":"Langen M, et al. The neurobiology of repetitive behavior: \u2026and men. Neurosci Biobehav Rev. 2011;35(3):356\u201365.","journal-title":"Neurosci Biobehav Rev"},{"key":"3259_CR86","doi-asserted-by":"publisher","first-page":"12540","DOI":"10.1038\/ncomms12540","volume":"7","author":"A Miyamoto","year":"2016","unstructured":"Miyamoto A, et al. Microglia contact induces synapse formation in developing somatosensory cortex. Nat Commun. 2016;7:12540.","journal-title":"Nat Commun"},{"issue":"1","key":"3259_CR87","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/s41467-018-03566-5","volume":"9","author":"L Weinhard","year":"2018","unstructured":"Weinhard L, et al. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction. Nat Commun. 2018;9(1):1228.","journal-title":"Nat Commun"},{"issue":"19","key":"3259_CR88","doi-asserted-by":"publisher","first-page":"6176","DOI":"10.1073\/pnas.1423205112","volume":"112","author":"O Varea","year":"2015","unstructured":"Varea O, et al. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2\/Caspr2 knockout neurons. Proc Natl Acad Sci U S A. 2015;112(19):6176\u201381.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3259_CR89","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ajhg.2007.09.017","volume":"82","author":"B Bakkaloglu","year":"2008","unstructured":"Bakkaloglu B, et al. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am J Hum Genet. 2008;82(1):165\u201373.","journal-title":"Am J Hum Genet"},{"issue":"10","key":"3259_CR90","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.tins.2021.08.005","volume":"44","author":"SM Banker","year":"2021","unstructured":"Banker SM, et al. Hippocampal contributions to social and cognitive deficits in autism spectrum disorder. Trends Neurosci. 2021;44(10):793\u2013807.","journal-title":"Trends Neurosci"},{"issue":"6","key":"3259_CR91","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1002\/glia.23135","volume":"65","author":"RA Rice","year":"2017","unstructured":"Rice RA, et al. Microglial repopulation resolves inflammation and promotes brain recovery after injury. Glia. 2017;65(6):931\u201344.","journal-title":"Glia"},{"issue":"11","key":"3259_CR92","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/nrn.2017.110","volume":"18","author":"U Neniskyte","year":"2017","unstructured":"Neniskyte U, Gross CT. Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders. Nat Rev Neurosci. 2017;18(11):658\u201370.","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"3259_CR93","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020545","volume":"7","author":"DP Schafer","year":"2015","unstructured":"Schafer DP, Stevens B. Microglia function in central nervous system development and plasticity. Cold Spring Harb Perspect Biol. 2015;7(10): a020545.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"7589","key":"3259_CR94","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature16549","volume":"530","author":"A Sekar","year":"2016","unstructured":"Sekar A, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530(7589):177\u201383.","journal-title":"Nature"},{"issue":"7","key":"3259_CR95","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/35081509","volume":"2","author":"MH Johnson","year":"2001","unstructured":"Johnson MH. Functional brain development in humans. Nat Rev Neurosci. 2001;2(7):475\u201383.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"3259_CR96","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1080\/17470210701508715","volume":"61","author":"SJ Blakemore","year":"2008","unstructured":"Blakemore SJ. Development of the social brain during adolescence. Q J Exp Psychol (Hove). 2008;61(1):40\u20139.","journal-title":"Q J Exp Psychol (Hove)"},{"issue":"7","key":"3259_CR97","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1093\/cercor\/bhy046","volume":"28","author":"V Zerbi","year":"2018","unstructured":"Zerbi V, et al. Dysfunctional Autism risk genes cause circuit-specific connectivity deficits with distinct developmental trajectories. Cereb Cortex. 2018;28(7):2495\u2013506.","journal-title":"Cereb Cortex"},{"issue":"5","key":"3259_CR98","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1038\/s41380-024-02413-y","volume":"29","author":"T Komori","year":"2024","unstructured":"Komori T, et al. Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. Mol Psychiatry. 2024;29(5):1338\u201349.","journal-title":"Mol Psychiatry"},{"key":"3259_CR99","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.bbi.2022.11.003","volume":"107","author":"H Yeh","year":"2023","unstructured":"Yeh H, et al. Microglial WNT5A supports dendritic spines maturation and neuronal firing. Brain Behav Immun. 2023;107:403\u201313.","journal-title":"Brain Behav Immun"},{"issue":"2","key":"3259_CR100","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.cell.2020.05.050","volume":"182","author":"PT Nguyen","year":"2020","unstructured":"Nguyen PT, et al. Microglial remodeling of the extracellular matrix promotes synapse plasticity. Cell. 2020;182(2):388-403 e15.","journal-title":"Cell"},{"key":"3259_CR101","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/1742-2094-9-111","volume":"9","author":"C Halleskog","year":"2012","unstructured":"Halleskog C, et al. Heterotrimeric G protein-dependent WNT-5A signaling to ERK1\/2 mediates distinct aspects of microglia proinflammatory transformation. J Neuroinflammation. 2012;9:111.","journal-title":"J Neuroinflammation"},{"issue":"3","key":"3259_CR102","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.jgg.2023.08.012","volume":"51","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, et al. Sex-biased single-cell genetic landscape in mice with autism spectrum disorder. J Genet Genom. 2024;51(3):338\u201351.","journal-title":"J Genet Genom"},{"issue":"6","key":"3259_CR103","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1159\/000481134","volume":"39","author":"MA Konopko","year":"2017","unstructured":"Konopko MA, Densmore AL, Krueger BK. Sexually dimorphic epigenetic regulation of brain-derived neurotrophic factor in fetal brain in the valproic acid model of Autism spectrum disorder. Dev Neurosci. 2017;39(6):507\u201318.","journal-title":"Dev Neurosci"},{"issue":"7789","key":"3259_CR104","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41586-019-1843-6","volume":"577","author":"MD Reed","year":"2020","unstructured":"Reed MD, et al. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature. 2020;577(7789):249\u201353.","journal-title":"Nature"},{"issue":"9","key":"3259_CR105","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","volume":"17","author":"VX Han","year":"2021","unstructured":"Han VX, et al. Maternal immune activation and neuroinflammation in human neurodevelopmental disorders. Nat Rev Neurol. 2021;17(9):564\u201379.","journal-title":"Nat Rev Neurol"},{"key":"3259_CR106","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/531518","volume":"2015","author":"N Xu","year":"2015","unstructured":"Xu N, Li X, Zhong Y. Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders. Mediat Inflamm. 2015;2015: 531518.","journal-title":"Mediat Inflamm"},{"issue":"8","key":"3259_CR107","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1001\/jamaneurol.2013.143","volume":"70","author":"C Krogias","year":"2013","unstructured":"Krogias C, et al. Successful treatment of anti-Caspr2 syndrome by interleukin 6 receptor blockade through tocilizumab. JAMA Neurol. 2013;70(8):1056\u20139.","journal-title":"JAMA Neurol"},{"issue":"45","key":"3259_CR108","doi-asserted-by":"publisher","first-page":"17849","DOI":"10.1073\/pnas.0706128104","volume":"104","author":"BS Abrahams","year":"2007","unstructured":"Abrahams BS, et al. Genome-wide analyses of human perisylvian cerebral cortical patterning. Proc Natl Acad Sci U S A. 2007;104(45):17849\u201354.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3259_CR109","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jaut.2018.09.012","volume":"96","author":"W Liang","year":"2019","unstructured":"Liang W, et al. Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition. J Autoimmun. 2019;96:168\u201377.","journal-title":"J Autoimmun"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-024-03259-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T18:02:05Z","timestamp":1729274525000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-024-03259-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":109,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3259"],"URL":"https:\/\/doi.org\/10.1186\/s12974-024-03259-5","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]},"assertion":[{"value":"6 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals and approved by the institutional Animal Care and Use Committee on the Ethics of Animal Experiments of the Peking University Health Science Center (ethics approval ID, LA2021258).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"262"}}