{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:54:46Z","timestamp":1793109286530,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS131169"],"award-info":[{"award-number":["NS131169"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX003651"],"award-info":[{"award-number":["BX003651"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-024-03264-8","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T15:03:09Z","timestamp":1729782189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["IL-33\/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke"],"prefix":"10.1186","volume":"21","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Dufort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rios","family":"Sigler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehana K.","family":"Leak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"3264_CR1","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1161\/CIRCRESAHA.116.308427","volume":"120","author":"X Hu","year":"2017","unstructured":"Hu X, De Silva TM, Chen J, Faraci FM. Cerebral vascular Disease and Neurovascular Injury in ischemic stroke. Circ Res. 2017;120:449\u201371.","journal-title":"Circ Res"},{"key":"3264_CR2","doi-asserted-by":"publisher","first-page":"716825","DOI":"10.3389\/fncel.2021.716825","volume":"15","author":"S Chen","year":"2021","unstructured":"Chen S, Shao L, Ma L. Cerebral edema formation after stroke: emphasis on blood-brain barrier and the lymphatic drainage system of the brain. Front Cell Neurosci. 2021;15:716825.","journal-title":"Front Cell Neurosci"},{"key":"3264_CR3","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","volume":"163\u2013164","author":"X Jiang","year":"2018","unstructured":"Jiang X, Andjelkovic AV, Zhu L, Yang T, Bennett MVL, Chen J, Keep RF, Shi Y. Blood-brain barrier dysfunction and recovery after ischemic stroke. Prog Neurobiol. 2018;163\u2013164:144\u201371.","journal-title":"Prog Neurobiol"},{"key":"3264_CR4","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1197\/aemj.9.9.933","volume":"9","author":"F Xiao","year":"2002","unstructured":"Xiao F. Bench to bedside: brain edema and cerebral resuscitation: the present and future. Acad Emerg Medicine: Official J Soc Acad Emerg Med. 2002;9:933\u201346.","journal-title":"Acad Emerg Medicine: Official J Soc Acad Emerg Med"},{"key":"3264_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s12028-021-01341-x","volume":"36","author":"ME McKeown","year":"2022","unstructured":"McKeown ME, Prasad A, Kobsa J, Top I, Snider SB, Kidwell C, Campbell BCV, Davis SM, Donnan GA, Lev M, et al. Midline Shift Greater than 3\u00a0mm independently predicts Outcome after ischemic stroke. Neurocrit Care. 2022;36:46\u201351.","journal-title":"Neurocrit Care"},{"key":"3264_CR6","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S1474-4422(07)70055-8","volume":"6","author":"JM Simard","year":"2007","unstructured":"Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol. 2007;6:258\u201368.","journal-title":"Lancet Neurol"},{"key":"3264_CR7","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1172\/JCI135530","volume":"130","author":"C Iadecola","year":"2020","unstructured":"Iadecola C, Buckwalter MS, Anrather J. Immune responses to stroke: mechanisms, modulation, and therapeutic potential. J Clin Invest. 2020;130:2777\u201388.","journal-title":"J Clin Invest"},{"key":"3264_CR8","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ana.23529","volume":"71","author":"M Gliem","year":"2012","unstructured":"Gliem M, Mausberg AK, Lee JI, Simiantonakis I, van Rooijen N, Hartung HP, Jander S. Macrophages prevent hemorrhagic infarct transformation in murine stroke models. Ann Neurol. 2012;71:743\u201352.","journal-title":"Ann Neurol"},{"key":"3264_CR9","doi-asserted-by":"publisher","first-page":"11499","DOI":"10.1038\/ncomms11499","volume":"7","author":"G Szalay","year":"2016","unstructured":"Szalay G, Martinecz B, Lenart N, Kornyei Z, Orsolits B, Judak L, Csaszar E, Fekete R, West BL, Katona G, et al. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun. 2016;7:11499.","journal-title":"Nat Commun"},{"key":"3264_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41593-020-00773-6","volume":"24","author":"P Mastorakos","year":"2021","unstructured":"Mastorakos P, Mihelson N, Luby M, Burks SR, Johnson K, Hsia AW, Witko J, Frank JA, Latour L, McGavern DB. Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury. Nat Neurosci. 2021;24:245\u201358.","journal-title":"Nat Neurosci"},{"key":"3264_CR11","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/sj.jcbfm.9600229","volume":"26","author":"OB Dimitrijevic","year":"2006","unstructured":"Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV. Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury. J Cereb Blood Flow Metab. 2006;26:797\u2013810.","journal-title":"J Cereb Blood Flow Metab"},{"key":"3264_CR12","doi-asserted-by":"publisher","first-page":"10523","DOI":"10.1038\/ncomms10523","volume":"7","author":"Y Shi","year":"2016","unstructured":"Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, et al. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury. Nat Commun. 2016;7:10523.","journal-title":"Nat Commun"},{"key":"3264_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/imr.12552","volume":"278","author":"LY Drake","year":"2017","unstructured":"Drake LY, Kita H. IL-33: biological properties, functions, and roles in airway disease. Immunol Rev. 2017;278:173\u201384.","journal-title":"Immunol Rev"},{"key":"3264_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1146\/annurev-immunol-101320-124243","volume":"40","author":"GK Dwyer","year":"2022","unstructured":"Dwyer GK, D\u2019Cruz LM, Turnquist HR. Emerging functions of IL-33 in Homeostasis and Immunity. Annu Rev Immunol. 2022;40:15\u201343.","journal-title":"Annu Rev Immunol"},{"key":"3264_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nri2692","volume":"10","author":"FY Liew","year":"2010","unstructured":"Liew FY, Pitman NI, McInnes IB. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol. 2010;10:103\u201310.","journal-title":"Nat Rev Immunol"},{"key":"3264_CR16","doi-asserted-by":"publisher","first-page":"4692","DOI":"10.1523\/JNEUROSCI.3233-16.2017","volume":"37","author":"Y Yang","year":"2017","unstructured":"Yang Y, Liu H, Zhang H, Ye Q, Wang J, Yang B, Mao L, Zhu W, Leak RK, Xiao B, et al. ST2\/IL-33-Dependent microglial response limits Acute Ischemic Brain Injury. J Neurosci. 2017;37:4692\u2013704.","journal-title":"J Neurosci"},{"key":"3264_CR17","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.neuron.2015.01.013","volume":"85","author":"SP Gadani","year":"2015","unstructured":"Gadani SP, Walsh JT, Smirnov I, Zheng J, Kipnis J. The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. Neuron. 2015;85:703\u20139.","journal-title":"Neuron"},{"key":"3264_CR18","doi-asserted-by":"publisher","first-page":"860772","DOI":"10.3389\/fimmu.2022.860772","volume":"13","author":"D Xie","year":"2022","unstructured":"Xie D, Miao W, Xu F, Yuan C, Li S, Wang C, Junagade A, Hu X. IL-33\/ST2 Axis protects against Traumatic Brain Injury through Enhancing the Function of Regulatory T Cells. Front Immunol. 2022;13:860772.","journal-title":"Front Immunol"},{"key":"3264_CR19","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1172\/JCI133008","volume":"130","author":"T Li","year":"2020","unstructured":"Li T, Zhang Z, Bartolacci JG, Dwyer GK, Liu Q, Mathews LR, Velayutham M, Roessing AS, Lee YC, Dai H, et al. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. 2020;130:5397\u2013412.","journal-title":"J Clin Invest"},{"key":"3264_CR20","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1161\/STROKEAHA.120.032444","volume":"52","author":"D Xie","year":"2021","unstructured":"Xie D, Liu H, Xu F, Su W, Ye Q, Yu F, Austin TJ, Chen J, Hu X. IL33 (interleukin 33)\/ST2 (interleukin 1 receptor-like 1) Axis drives protective microglial responses and promotes White Matter Integrity after Stroke. Stroke. 2021;52:2150\u201361.","journal-title":"Stroke"},{"key":"3264_CR21","doi-asserted-by":"publisher","first-page":"113233","DOI":"10.1016\/j.expneurol.2020.113233","volume":"328","author":"X Liu","year":"2020","unstructured":"Liu X, Hu R, Pei L, Si P, Wang C, Tian X, Wang X, Liu H, Wang B, Xia Z, et al. Regulatory T cell is critical for interleukin-33-mediated neuroprotection against stroke. Exp Neurol. 2020;328:113233.","journal-title":"Exp Neurol"},{"key":"3264_CR22","doi-asserted-by":"publisher","first-page":"576970","DOI":"10.1016\/j.jneuroim.2019.576970","volume":"333","author":"W Xiao","year":"2019","unstructured":"Xiao W, Guo S, Chen L, Luo Y. The role of Interleukin-33 in the modulation of splenic T-cell immune responses after experimental ischemic stroke. J Neuroimmunol. 2019;333:576970.","journal-title":"J Neuroimmunol"},{"key":"3264_CR23","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.bbi.2015.06.013","volume":"49","author":"P Korhonen","year":"2015","unstructured":"Korhonen P, Kanninen KM, Lehtonen S, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, et al. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. Brain Behav Immun. 2015;49:322\u201336.","journal-title":"Brain Behav Immun"},{"key":"3264_CR24","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1093\/brain\/awx111","volume":"140","author":"L Mao","year":"2017","unstructured":"Mao L, Li P, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, et al. Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke. Brain. 2017;140:1914\u201331.","journal-title":"Brain"},{"key":"3264_CR25","doi-asserted-by":"publisher","first-page":"108041","DOI":"10.1016\/j.celrep.2020.108041","volume":"32","author":"Z Xu","year":"2020","unstructured":"Xu Z, Rao Y, Huang Y, Zhou T, Feng R, Xiong S, Yuan TF, Qin S, Lu Y, Zhou X, et al. Efficient strategies for Microglia replacement in the Central Nervous System. Cell Rep. 2020;32:108041.","journal-title":"Cell Rep"},{"key":"3264_CR26","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.1523\/JNEUROSCI.3006-19.2020","volume":"40","author":"E Mondo","year":"2020","unstructured":"Mondo E, Becker SC, Kautzman AG, Schifferer M, Baer CE, Chen J, Huang EJ, Simons M, Schafer DP. A Developmental Analysis of Juxtavascular Microglia Dynamics and interactions with the vasculature. J Neurosci. 2020;40:6503\u201321.","journal-title":"J Neurosci"},{"key":"3264_CR27","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1161\/HYPERTENSIONAHA.120.15581","volume":"76","author":"MM Santisteban","year":"2020","unstructured":"Santisteban MM, Ahn SJ, Lane D, Faraco G, Garcia-Bonilla L, Racchumi G, Poon C, Schaeffer S, Segarra SG, Korbelin J, et al. Endothelium-macrophage crosstalk mediates blood-brain barrier dysfunction in hypertension. Hypertension. 2020;76:795\u2013807.","journal-title":"Hypertension"},{"key":"3264_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41593-023-01497-z","volume":"27","author":"MM Santisteban","year":"2024","unstructured":"Santisteban MM, Schaeffer S, Anfray A, Faraco G, Brea D, Wang G, Sobanko MJ, Sciortino R, Racchumi G, Waisman A, et al. Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. Nat Neurosci. 2024;27:63\u201377.","journal-title":"Nat Neurosci"},{"key":"3264_CR29","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1182\/blood-2009-02-203372","volume":"114","author":"YS Choi","year":"2009","unstructured":"Choi YS, Choi HJ, Min JK, Pyun BJ, Maeng YS, Park H, Kim J, Kim YM, Kwon YG. Interleukin-33 induces angiogenesis and vascular permeability through ST2\/TRAF6-mediated endothelial nitric oxide production. Blood. 2009;114:3117\u201326.","journal-title":"Blood"},{"key":"3264_CR30","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature09522","volume":"468","author":"A Armulik","year":"2010","unstructured":"Armulik A, Genove G, Mae M, Nisancioglu MH, Wallgard E, Niaudet C, He L, Norlin J, Lindblom P, Strittmatter K, et al. Pericytes regulate the blood-brain barrier. Nature. 2010;468:557\u201361.","journal-title":"Nature"},{"key":"3264_CR31","doi-asserted-by":"crossref","unstructured":"Patabendige A, Singh A, Jenkins S, Sen J, Chen R. Astrocyte activation in neurovascular damage and repair following ischaemic stroke. Int J Mol Sci 2021, 22.","DOI":"10.3390\/ijms22084280"},{"key":"3264_CR32","doi-asserted-by":"publisher","first-page":"e1300","DOI":"10.1002\/cti2.1300","volume":"10","author":"Q Ma","year":"2021","unstructured":"Ma Q, Qian Y, Jiang J, Wu J, Song M, Li X, Chen Z, Wang Z, Zhu R, Sun Z, et al. IL-33\/ST2 axis deficiency exacerbates neutrophil-dominant allergic airway inflammation. Clin Transl Immunol. 2021;10:e1300.","journal-title":"Clin Transl Immunol"},{"key":"3264_CR33","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/jcbfm.2015.45","volume":"35","author":"GC Jickling","year":"2015","unstructured":"Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015;35:888\u2013901.","journal-title":"J Cereb Blood Flow Metab"},{"key":"3264_CR34","doi-asserted-by":"publisher","first-page":"e14634","DOI":"10.1111\/cns.14634","volume":"30","author":"Q He","year":"2024","unstructured":"He Q, Wang Y, Fang C, Feng Z, Yin M, Huang J, Ma Y, Mo Z. Advancing stroke therapy: a deep dive into early phase of ischemic stroke and recanalization. CNS Neurosci Ther. 2024;30:e14634.","journal-title":"CNS Neurosci Ther"},{"key":"3264_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12974-021-02316-7","volume":"18","author":"M Piepke","year":"2021","unstructured":"Piepke M, Clausen BH, Ludewig P, Vienhues JH, Bedke T, Javidi E, Rissiek B, Jank L, Brockmann L, Sandrock I, et al. Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response. J Neuroinflammation. 2021;18:265.","journal-title":"J Neuroinflammation"},{"key":"3264_CR36","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.14336\/AD.2023.0226","volume":"14","author":"Q Suo","year":"2023","unstructured":"Suo Q, Deng L, Chen T, Wu S, Qi L, Liu Z, He T, Tian HL, Li W, Tang Y, et al. Optogenetic activation of astrocytes reduces blood-brain barrier disruption via IL-10 in stroke. Aging Dis. 2023;14:1870\u201386.","journal-title":"Aging Dis"},{"key":"3264_CR37","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1167\/iovs.19-27493","volume":"60","author":"N Xu","year":"2019","unstructured":"Xu N, Bo Q, Shao R, Liang J, Zhai Y, Yang S, Wang F, Sun X. Chitinase-3-Like-1 promotes M2 macrophage differentiation and induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2019;60:4596\u2013605.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3264_CR38","doi-asserted-by":"publisher","first-page":"ltac010","DOI":"10.1093\/immadv\/ltac010","volume":"2","author":"BM Freire","year":"2022","unstructured":"Freire BM, de Melo FM, Basso AS. Adrenergic signaling regulation of macrophage function: do we understand it yet? Immunother Adv. 2022;2:ltac010.","journal-title":"Immunother Adv"},{"key":"3264_CR39","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ccell.2015.07.006","volume":"28","author":"L Strauss","year":"2015","unstructured":"Strauss L, Sangaletti S, Consonni FM, Szebeni G, Morlacchi S, Totaro MG, Porta C, Anselmo A, Tartari S, Doni A, et al. RORC1 regulates tumor-promoting emergency Granulo-Monocytopoiesis. Cancer Cell. 2015;28:253\u201369.","journal-title":"Cancer Cell"},{"key":"3264_CR40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.brainresbull.2018.10.009","volume":"143","author":"F Erdo","year":"2018","unstructured":"Erdo F, Bors LA, Farkas D, Bajza A, Gizurarson S. Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Res Bull. 2018;143:155\u201370.","journal-title":"Brain Res Bull"},{"key":"3264_CR41","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jconrel.2014.06.053","volume":"189","author":"L Kozlovskaya","year":"2014","unstructured":"Kozlovskaya L, Abou-Kaoud M, Stepensky D. Quantitative analysis of drug delivery to the brain via nasal route. J Control Release. 2014;189:133\u201340.","journal-title":"J Control Release"},{"key":"3264_CR42","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1111\/cns.14160","volume":"29","author":"GS Fitzgerald","year":"2023","unstructured":"Fitzgerald GS, Chuchta TG, McNay EC. Insulin-like growth factor-2 is a promising candidate for the treatment and prevention of Alzheimer\u2019s disease. CNS Neurosci Ther. 2023;29:1449\u201369.","journal-title":"CNS Neurosci Ther"},{"key":"3264_CR43","doi-asserted-by":"crossref","unstructured":"Zhang SR, Piepke M, Chu HX, Broughton BR, Shim R, Wong CH, Lee S, Evans MA, Vinh A, Sakkal S et al. IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke. JCI Insight 2018, 3.","DOI":"10.1172\/jci.insight.121560"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03264-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-024-03264-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03264-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T16:03:52Z","timestamp":1729785832000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-024-03264-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3264"],"URL":"https:\/\/doi.org\/10.1186\/s12974-024-03264-8","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"19 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were approved by the University of Pittsburgh Institutional Animal Care and Use Committee and performed following the Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"274"}}