{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:55:09Z","timestamp":1793318109060,"version":"4.5.0"},"reference-count":344,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"European Union\u00b4s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie Grant Agreement","award":["No. 813294"],"award-info":[{"award-number":["No. 813294"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Microvascular brain endothelial cells tightly limit the entry of blood components and peripheral cells into the brain by forming the blood\u2013brain barrier (BBB). The BBB is regulated by a cascade of mechanical and chemical signals including shear stress and elasticity of the adjacent endothelial basement membrane (BM). During physiological aging, but especially in neurological diseases including multiple sclerosis (MS), stroke, small vessel disease, and Alzheimer\u2019s disease (AD), the BBB is exposed to inflammation, rigidity changes of the BM, and disturbed cerebral blood flow (CBF). These altered forces lead to increased vascular permeability, reduced endothelial reactivity to vasoactive mediators, and promote leukocyte transmigration. Whereas the molecular players involved in leukocyte infiltration have been described in detail, the importance of mechanical signalling throughout this process has only recently been recognized. Here, we review relevant features of mechanical forces acting on the BBB under healthy and pathological conditions, as well as the endothelial mechanosensory elements detecting and responding to altered forces. We demonstrate the underlying complexity by focussing on the family of transient receptor potential (TRP) ion channels. A better understanding of these processes will provide insights into the pathogenesis of several neurological disorders and new potential leads for treatment.<\/jats:p>","DOI":"10.1186\/s12974-024-03321-2","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T14:55:40Z","timestamp":1734533740000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tension at the gate: sensing mechanical forces at the blood\u2013brain barrier in health and disease"],"prefix":"10.1186","volume":"21","author":[{"given":"Cathrin E.","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hollaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alwin","family":"Kamermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga E.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"3321_CR1","first-page":"39","volume-title":"Handbook of clinical neurology","author":"B Obermeier","year":"2016","unstructured":"Obermeier B, Verma A, Ransohoff RM. The blood\u2013brain barrier. In: Pittock SJ, Vincent A, editors. Handbook of clinical neurology. Amsterdam: Elsevier; 2016. p. 39\u201359."},{"key":"3321_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","volume":"60","author":"A Varatharaj","year":"2017","unstructured":"Varatharaj A, Galea I. The blood-brain barrier in systemic inflammation. Brain Behav Immun. 2017;60:1\u201312.","journal-title":"Brain Behav Immun"},{"issue":"2","key":"3321_CR3","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","volume":"57","author":"BV Zlokovic","year":"2008","unstructured":"Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008;57(2):178\u2013201.","journal-title":"Neuron"},{"issue":"9","key":"3321_CR4","doi-asserted-by":"publisher","first-page":"183316","DOI":"10.1016\/j.bbamem.2020.183316","volume":"1862","author":"A Angulo-Urarte","year":"2020","unstructured":"Angulo-Urarte A, Van Der Wal T, Huveneers S. Cell-cell junctions as sensors and transducers of mechanical forces. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2020;1862(9):183316.","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"key":"3321_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2202-12-40","volume":"12","author":"L Cucullo","year":"2011","unstructured":"Cucullo L, Hossain M, Puvenna V, Marchi N, Janigro D. The role of shear stress in blood-brain barrier endothelial physiology. BMC Neurosci. 2011;12:40.","journal-title":"BMC Neurosci"},{"issue":"11","key":"3321_CR6","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.cub.2013.04.049","volume":"23","author":"DE Conway","year":"2013","unstructured":"Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol. 2013;23(11):1024\u201330.","journal-title":"Curr Biol"},{"key":"3321_CR7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190062","author":"CP Profaci","year":"2020","unstructured":"Profaci CP, Munji RN, Pulido RS, Daneman R. The blood-brain barrier in health and disease: Important unanswered questions. J Exp Med. 2020. https:\/\/doi.org\/10.1084\/jem.20190062.","journal-title":"J Exp Med"},{"issue":"1","key":"3321_CR8","doi-asserted-by":"publisher","first-page":"H1","DOI":"10.1530\/VB-19-0033","volume":"2","author":"L Marchetti","year":"2020","unstructured":"Marchetti L, Engelhardt B. Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation. Vasc Biol. 2020;2(1):H1-h18.","journal-title":"Vasc Biol"},{"key":"3321_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36731-3","author":"M Castro Dias","year":"2019","unstructured":"Castro Dias M, Coisne C, Lazarevic I, Baden P, Hata M, Iwamoto N, et al. Claudin-3-deficient C57BL\/6J mice display intact brain barriers. 2019. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-018-36731-3."},{"issue":"1","key":"3321_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1247\/csf.13015","volume":"39","author":"N Iwamoto","year":"2014","unstructured":"Iwamoto N, Higashi T, Furuse M. Localization of angulin-1\/LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo. Cell Struct Funct. 2014;39(1):1\u20138.","journal-title":"Cell Struct Funct"},{"key":"3321_CR11","doi-asserted-by":"publisher","first-page":"667213","DOI":"10.3389\/fimmu.2021.667213","volume":"12","author":"JJG Arts","year":"2021","unstructured":"Arts JJG, Mahlandt EK, Schimmel L, Gr\u00f6nloh MLB, van der Niet S, Klein B, et al. Endothelial focal adhesions are functional obstacles for leukocytes during basolateral crawling. Front Immunol. 2021;12:667213.","journal-title":"Front Immunol"},{"issue":"6","key":"3321_CR12","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1191\/1352458503ms965oa","volume":"9","author":"A Minagar","year":"2003","unstructured":"Minagar A, Alexander JS. Blood-brain barrier disruption in multiple sclerosis. Mult Scler. 2003;9(6):540\u20139.","journal-title":"Mult Scler"},{"issue":"1","key":"3321_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pathophys.2010.04.002","volume":"18","author":"JS Alexander","year":"2011","unstructured":"Alexander JS, Zivadinov R, Maghzi A-H, Ganta VC, Harris MK, Minagar A. Multiple sclerosis and cerebral endothelial dysfunction: mechanisms. Pathophysiology. 2011;18(1):3\u201312.","journal-title":"Pathophysiology"},{"key":"3321_CR14","doi-asserted-by":"publisher","DOI":"10.1433\/AD.2024.0286","author":"JA Pradeepkiran","year":"2024","unstructured":"Pradeepkiran JA, Baig J, Islam MA, Kshirsagar S, Reddy PH. Amyloid-\u03b2 and phosphorylated tau are the key biomarkers and predictors of Alzheimer\u2019s disease. Aging Dis. 2024. https:\/\/doi.org\/10.1433\/AD.2024.0286.","journal-title":"Aging Dis"},{"key":"3321_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020408","author":"RI Mehta","year":"2023","unstructured":"Mehta RI, Mehta RI. The vascular-immune hypothesis of Alzheimer\u2019s disease. Biomedicines. 2023. https:\/\/doi.org\/10.3390\/biomedicines11020408.","journal-title":"Biomedicines"},{"issue":"1","key":"3321_CR16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","volume":"16","author":"SM Greenberg","year":"2020","unstructured":"Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ. Cerebral amyloid angiopathy and Alzheimer disease\u2014one peptide, two pathways. Nat Rev Neurol. 2020;16(1):30\u201342.","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"3321_CR17","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1111\/jgs.17684","volume":"70","author":"VS Ho","year":"2022","unstructured":"Ho VS, Cenzer IS, Nguyen BT, Lee SJ. Time to benefit for stroke reduction after blood pressure treatment in older adults: a meta-analysis. J Am Geriatr Soc. 2022;70(5):1558\u201368.","journal-title":"J Am Geriatr Soc"},{"key":"3321_CR18","doi-asserted-by":"publisher","DOI":"10.1433\/AD.2023.1225","author":"X Cheng","year":"2024","unstructured":"Cheng X, Potenza DM, Brenna A, Ajalbert G, Yang Z, Ming XF. Aging increases hypoxia-induced endothelial permeability and blood-brain barrier dysfunction by upregulating arginase-II. Aging Dis. 2024. https:\/\/doi.org\/10.1433\/AD.2023.1225.","journal-title":"Aging Dis"},{"issue":"2","key":"3321_CR19","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/s00330-015-3834-9","volume":"26","author":"MA Binnewijzend","year":"2016","unstructured":"Binnewijzend MA, Benedictus MR, Kuijer JP, van der Flier WM, Teunissen CE, Prins ND, et al. Cerebral perfusion in the predementia stages of Alzheimer\u2019s disease. Eur Radiol. 2016;26(2):506\u201314.","journal-title":"Eur Radiol"},{"issue":"2","key":"3321_CR20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s10571-015-0261-z","volume":"36","author":"CC Hays","year":"2016","unstructured":"Hays CC, Zlatar ZZ, Wierenga CE. The utility of cerebral blood flow as a biomarker of preclinical Alzheimer\u2019s disease. Cell Mol Neurobiol. 2016;36(2):167\u201379.","journal-title":"Cell Mol Neurobiol"},{"issue":"2","key":"3321_CR21","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.jocn.2008.04.009","volume":"16","author":"H Shimizu","year":"2009","unstructured":"Shimizu H, Ghazizadeh M, Sato S, Oguro T, Kawanami O. Interaction between beta-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer\u2019s disease. J Clin Neurosci. 2009;16(2):277\u201382.","journal-title":"J Clin Neurosci"},{"key":"3321_CR22","doi-asserted-by":"publisher","first-page":"601320","DOI":"10.3389\/fphys.2020.601320","volume":"11","author":"MD Howe","year":"2020","unstructured":"Howe MD, McCullough LD, Urayama A. The role of basement membranes in cerebral amyloid angiopathy. Front Physiol. 2020;11:601320.","journal-title":"Front Physiol"},{"issue":"7","key":"3321_CR23","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1474-4422(09)70127-9","volume":"8","author":"H Chabriat","year":"2009","unstructured":"Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG. Cadasil. Lancet Neurol. 2009;8(7):643\u201353.","journal-title":"Lancet Neurol"},{"issue":"2","key":"3321_CR24","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1172\/JCI39733","volume":"120","author":"A Joutel","year":"2010","unstructured":"Joutel A, Monet-Lepr\u00eatre M, Gosele C, Baron-Menguy C, Hammes A, Schmidt S, et al. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J Clin Invest. 2010;120(2):433\u201345.","journal-title":"J Clin Invest"},{"issue":"1","key":"3321_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/jcbfm.2015.62","volume":"36","author":"A Joutel","year":"2016","unstructured":"Joutel A, Haddad I, Ratelade J, Nelson MT. Perturbations of the cerebrovascular matrisome: a convergent mechanism in small vessel disease of the brain? J Cereb Blood Flow Metab. 2016;36(1):143\u201357.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3\u20134","key":"3321_CR26","first-page":"182","volume":"3","author":"N Saji","year":"2016","unstructured":"Saji N, Toba K, Sakurai T. Cerebral small vessel disease and arterial stiffness: tsunami effect in the brain? Pulse. 2016;3(3\u20134):182\u20139.","journal-title":"Pulse"},{"issue":"2","key":"3321_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","volume":"18","author":"RO Weller","year":"2008","unstructured":"Weller RO, Subash M, Preston SD, Mazanti I, Carare RO. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease. Brain Pathol. 2008;18(2):253\u201366.","journal-title":"Brain Pathol"},{"key":"3321_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050651","author":"K Govindpani","year":"2019","unstructured":"Govindpani K, McNamara LG, Smith NR, Vinnakota C, Waldvogel HJ, Faull RL, Kwakowsky A. Vascular dysfunction in Alzheimer\u2019s disease: a prelude to the pathological process or a consequence of it? J Clin Med. 2019. https:\/\/doi.org\/10.3390\/jcm8050651.","journal-title":"J Clin Med"},{"issue":"5","key":"3321_CR29","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.pcad.2006.11.001","volume":"49","author":"D Katritsis","year":"2007","unstructured":"Katritsis D, Kaiktsis L, Chaniotis A, Pantos J, Efstathopoulos EP, Marmarelis V. Wall shear stress: theoretical considerations and methods of measurement. Prog Cardiovasc Dis. 2007;49(5):307\u201329.","journal-title":"Prog Cardiovasc Dis"},{"key":"3321_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612689","author":"Y Zabrodskaya","year":"2023","unstructured":"Zabrodskaya Y, Paramonova N, Litovchenko A, Bazhanova E, Gerasimov A, Sitovskaya D, et al. Neuroinflammatory dysfunction of the blood-brain barrier and basement membrane dysplasia play a role in the development of drug-resistant epilepsy. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms241612689.","journal-title":"Int J Mol Sci"},{"key":"3321_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082041","author":"T Greiner","year":"2021","unstructured":"Greiner T, Kipp M. What guides peripheral immune cells into the central nervous system? Cells. 2021. https:\/\/doi.org\/10.3390\/cells10082041.","journal-title":"Cells"},{"issue":"1","key":"3321_CR32","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13024-024-00706-y","volume":"19","author":"D Hu","year":"2024","unstructured":"Hu D, Weiner HL. Unraveling the dual nature of brain CD8+ T cells in Alzheimer\u2019s disease. Mol Neurodegener. 2024;19(1):16.","journal-title":"Mol Neurodegener"},{"issue":"1","key":"3321_CR33","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1038\/s41467-018-07053-9","volume":"9","author":"J Smolders","year":"2018","unstructured":"Smolders J, Heutinck KM, Fransen NL, Remmerswaal EBM, Hombrink P, Ten Berge IJM, et al. Tissue-resident memory T cells populate the human brain. Nat Commun. 2018;9(1):4593.","journal-title":"Nat Commun"},{"issue":"8","key":"3321_CR34","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.arcmed.2014.11.013","volume":"45","author":"GG Ortiz","year":"2014","unstructured":"Ortiz GG, Pacheco-Mois\u00e9s FP, Mac\u00edas-Islas M, Flores-Alvarado LJ, Mireles-Ram\u00edrez MA, Gonz\u00e1lez-Renovato ED, et al. Role of the blood-brain barrier in multiple sclerosis. Arch Med Res. 2014;45(8):687\u201397.","journal-title":"Arch Med Res"},{"key":"3321_CR35","doi-asserted-by":"publisher","first-page":"110647","DOI":"10.1016\/j.biopha.2020.110647","volume":"131","author":"Q Huang","year":"2020","unstructured":"Huang Q, Wang X, Lin X, Zhang J, You X, Shao A. The role of transient receptor potential channels in blood-brain barrier dysfunction after ischemic stroke. Biomed Pharmacother. 2020;131:110647.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"3321_CR36","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1152\/physrev.00026.2014","volume":"95","author":"S Earley","year":"2015","unstructured":"Earley S, Brayden JE. Transient receptor potential channels in the vasculature. Physiol Rev. 2015;95(2):645\u201390.","journal-title":"Physiol Rev"},{"issue":"7693","key":"3321_CR37","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature25739","volume":"554","author":"M Vanlandewijck","year":"2018","unstructured":"Vanlandewijck M, He L, M\u00e4e MA, Andrae J, Ando K, Del Gaudio F, et al. A molecular atlas of cell types and zonation in the brain vasculature. Nature. 2018;554(7693):475\u201380.","journal-title":"Nature"},{"key":"3321_CR38","doi-asserted-by":"publisher","first-page":"103930","DOI":"10.1016\/j.mvr.2019.103930","volume":"128","author":"X Wang","year":"2020","unstructured":"Wang X, Xu B, Xiang M, Yang X, Liu Y, Liu X, Shen Y. Advances on fluid shear stress regulating blood-brain barrier. Microvasc Res. 2020;128:103930.","journal-title":"Microvasc Res"},{"key":"3321_CR39","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.semcdb.2017.06.002","volume":"71","author":"KM Gray","year":"2017","unstructured":"Gray KM, Stroka KM. Vascular endothelial cell mechanosensing: new insights gained from biomimetic microfluidic models. Semin Cell Dev Biol. 2017;71:106\u201317.","journal-title":"Semin Cell Dev Biol"},{"issue":"4","key":"3321_CR40","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00424-020-02369-2","volume":"472","author":"B Fels","year":"2020","unstructured":"Fels B, Kusche-Vihrog K. It takes more than two to tango: mechanosignaling of the endothelial surface. Pfl\u00fcgers Arch Eur J Physiol. 2020;472(4):419\u201333.","journal-title":"Pfl\u00fcgers Arch Eur J Physiol"},{"key":"3321_CR41","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.copbio.2020.09.004","volume":"66","author":"X Zhang","year":"2020","unstructured":"Zhang X, Kim T-H, Thauland TJ, Li H, Majedi FS, Ly C, et al. Unraveling the mechanobiology of immune cells. Curr Opin Biotechnol. 2020;66:236\u201345.","journal-title":"Curr Opin Biotechnol"},{"issue":"7","key":"3321_CR42","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1161\/CIRCULATIONAHA.111.021824","volume":"124","author":"H Samady","year":"2011","unstructured":"Samady H, Eshtehardi P, McDaniel MC, Suo J, Dhawan SS, Maynard C, et al. Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease. Circulation. 2011;124(7):779\u201388.","journal-title":"Circulation"},{"issue":"10","key":"3321_CR43","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1161\/01.STR.28.10.2067","volume":"28","author":"GJ Hademenos","year":"1997","unstructured":"Hademenos GJ, Massoud TF. Biophysical mechanisms of stroke. Stroke. 1997;28(10):2067\u201377.","journal-title":"Stroke"},{"issue":"9","key":"3321_CR44","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.5551\/jat.63756","volume":"30","author":"T Kamimura","year":"2023","unstructured":"Kamimura T, Aoki S, Nezu T, Eto F, Shiga Y, Nakamori M, et al. Association between carotid wall shear stress-based vascular vector flow mapping and cerebral small vessel disease. J Atheroscler Thromb. 2023;30(9):1165\u201375.","journal-title":"J Atheroscler Thromb"},{"issue":"1","key":"3321_CR45","doi-asserted-by":"publisher","first-page":"100","DOI":"10.14366\/usg.22053","volume":"42","author":"K Rastegari","year":"2023","unstructured":"Rastegari K, Mokhtari-Dizaji M, Harirchian MH, Hashemi H, Ayoobi Yazdi N, Saberi H. Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis. Ultrasonography. 2023;42(1):100\u201310.","journal-title":"Ultrasonography"},{"issue":"1","key":"3321_CR46","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0092-8240(84)80038-5","volume":"46","author":"A Kamiya","year":"1984","unstructured":"Kamiya A, Bukhari R, Togawa T. Adaptive regulation of wall shear stress optimizing vascular tree function. Bull Math Biol. 1984;46(1):127\u201337.","journal-title":"Bull Math Biol"},{"key":"3321_CR47","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fneng.2013.00007","volume":"6","author":"AD Wong","year":"2013","unstructured":"Wong AD, Ye M, Levy AF, Rothstein JD, Bergles DE, Searson PC. The blood-brain barrier: an engineering perspective. Front Neuroeng. 2013;6:7.","journal-title":"Front Neuroeng"},{"issue":"5\u20136","key":"3321_CR48","first-page":"375","volume":"44","author":"AG Koutsiaris","year":"2007","unstructured":"Koutsiaris AG, Tachmitzi SV, Batis N, Kotoula MG, Karabatsas CH, Tsironi E, Chatzoulis DZ. Volume flow and wall shear stress quantification in the human conjunctival capillaries and post-capillary venules in vivo. Biorheology. 2007;44(5\u20136):375\u201386.","journal-title":"Biorheology"},{"key":"3321_CR49","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1046\/j.1523-1755.1998.06720.x","volume":"54","author":"BJ Ballermann","year":"1998","unstructured":"Ballermann BJ, Dardik A, Eng E, Liu A. Shear stress and the endothelium. Kidney Int. 1998;54:S100\u20138.","journal-title":"Kidney Int"},{"issue":"1","key":"3321_CR50","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1038\/srep04951","volume":"4","author":"HE Abaci","year":"2014","unstructured":"Abaci HE, Shen Y-I, Tan S, Gerecht S. Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease. Sci Rep. 2014;4(1):4951.","journal-title":"Sci Rep"},{"issue":"21","key":"3321_CR51","doi-asserted-by":"publisher","first-page":"5618","DOI":"10.1364\/OL.472136","volume":"47","author":"H Cheng","year":"2022","unstructured":"Cheng H, Chen X, Zhong J, Li J, Qiu P, Wang K. Label-free measurement of wall shear stress in the brain venule and arteriole using dual-wavelength third-harmonic-generation line-scanning imaging. Opt Lett. 2022;47(21):5618\u201321.","journal-title":"Opt Lett"},{"issue":"1","key":"3321_CR52","doi-asserted-by":"publisher","first-page":"13957","DOI":"10.1038\/s41598-019-50193-1","volume":"9","author":"GN Grifno","year":"2019","unstructured":"Grifno GN, Farrell AM, Linville RM, Arevalo D, Kim JH, Gu L, Searson PC. Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells. Sci Rep. 2019;9(1):13957.","journal-title":"Sci Rep"},{"issue":"5","key":"3321_CR53","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.matbio.2010.03.004","volume":"29","author":"J Candiello","year":"2010","unstructured":"Candiello J, Cole GJ, Halfter W. Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane. Matrix Biol. 2010;29(5):402\u201310.","journal-title":"Matrix Biol"},{"key":"3321_CR54","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3389\/fphys.2020.00684","volume":"11","author":"E Gordon","year":"2020","unstructured":"Gordon E, Schimmel L, Frye M. The importance of mechanical forces for in vitro endothelial cell biology. Front Physiol. 2020;11:684.","journal-title":"Front Physiol"},{"key":"3321_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00112\/full","author":"JC Kohn","year":"2015","unstructured":"Kohn JC, Lampi MC, Reinhart-King CA. Age-related vascular stiffening: causes and consequences. Front Genet. 2015. https:\/\/doi.org\/10.3389\/fgene.2015.00112\/full.","journal-title":"Front Genet"},{"issue":"10","key":"3321_CR56","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1016\/j.bbamcr.2017.07.006","volume":"1864","author":"C Xue","year":"2017","unstructured":"Xue C, Zhang T, Xie X, Zhang Q, Zhang S, Zhu B, et al. Substrate stiffness regulates arterial-venous differentiation of endothelial progenitor cells via the Ras\/Mek pathway. Biochim Biophys Acta Mol Cell Res. 2017;1864(10):1799\u2013808.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"6936","key":"3321_CR57","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nature01605","volume":"423","author":"BT Marshall","year":"2003","unstructured":"Marshall BT, Long M, Piper JW, Yago T, McEver RP, Zhu C. Direct observation of catch bonds involving cell-adhesion molecules. Nature. 2003;423(6936):190\u20133.","journal-title":"Nature"},{"issue":"11","key":"3321_CR58","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri.2017.74","volume":"17","author":"M Huse","year":"2017","unstructured":"Huse M. Mechanical forces in the immune system. Nat Rev Immunol. 2017;17(11):679\u201390.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"3321_CR59","first-page":"91","volume":"2","author":"C Zhu","year":"2005","unstructured":"Zhu C, McEver RP. Catch bonds: physical models and biological functions. Mol Cell Biomech. 2005;2(3):91.","journal-title":"Mol Cell Biomech"},{"issue":"19","key":"3321_CR60","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1182\/blood-2017-05-783027","volume":"130","author":"VA Morikis","year":"2017","unstructured":"Morikis VA, Chase S, Wun T, Chaikof EL, Magnani JL, Simon SI. Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow. Blood. 2017;130(19):2101\u201310.","journal-title":"Blood"},{"issue":"7","key":"3321_CR61","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1083\/jcb.200810002","volume":"185","author":"F Kong","year":"2009","unstructured":"Kong F, Garc\u00eda AJ, Mould AP, Humphries MJ, Zhu C. Demonstration of catch bonds between an integrin and its ligand. J Cell Biol. 2009;185(7):1275\u201384.","journal-title":"J Cell Biol"},{"issue":"46","key":"3321_CR62","doi-asserted-by":"publisher","first-page":"35967","DOI":"10.1074\/jbc.M110.155770","volume":"285","author":"W Chen","year":"2010","unstructured":"Chen W, Lou J, Zhu C. Forcing switch from short- to intermediate- and long-lived states of the \u03b1a domain generates LFA-1\/ICAM-1 catch bonds. J Biol Chem. 2010;285(46):35967\u201378.","journal-title":"J Biol Chem"},{"issue":"2","key":"3321_CR63","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.bpj.2012.12.007","volume":"104","author":"MP Valignat","year":"2013","unstructured":"Valignat MP, Theodoly O, Gucciardi A, Hogg N, Lellouch AC. T lymphocytes orient against the direction of fluid flow during LFA-1-mediated migration. Biophys J. 2013;104(2):322\u201331.","journal-title":"Biophys J"},{"issue":"8","key":"3321_CR64","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.1073\/pnas.070052697","volume":"97","author":"W Baumgartner","year":"2000","unstructured":"Baumgartner W, Hinterdorfer P, Ness W, Raab A, Vestweber D, Schindler H, Drenckhahn D. Cadherin interaction probed by atomic force microscopy. Proc Natl Acad Sci USA. 2000;97(8):4005\u201310.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"19","key":"3321_CR65","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1016\/j.bpj.2021.03.025","volume":"120","author":"FN Arslan","year":"2021","unstructured":"Arslan FN, Eckert J, Schmidt T, Heisenberg CP. Holding it together: when cadherin meets cadherin. Biophys J. 2021;120(19):4182\u201392.","journal-title":"Biophys J"},{"key":"3321_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00861","author":"E Roux","year":"2020","unstructured":"Roux E, Bougaran P, Dufourcq P, Couffinhal T. Fluid shear stress sensing by the endothelial layer. Front Physiol. 2020. https:\/\/doi.org\/10.3389\/fphys.2020.00861.","journal-title":"Front Physiol"},{"issue":"3","key":"3321_CR67","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1115\/1.3138276","volume":"103","author":"CF Dewey Jr","year":"1981","unstructured":"Dewey CF Jr, Bussolari SR, Gimbrone MA Jr, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng. 1981;103(3):177\u201385.","journal-title":"J Biomech Eng"},{"key":"3321_CR68","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-1-4939-8946-1_5","volume-title":"Blood-brain barrier","author":"KD Rochfort","year":"2019","unstructured":"Rochfort KD, Cummins PM. In vitro cell models of the human blood-brain barrier: demonstrating the beneficial influence of shear stress on brain microvascular endothelial cell phenotype. In: Barichello T, editor. Blood-brain barrier. New York: Springer; 2019. p. 71\u201398."},{"issue":"8","key":"3321_CR69","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1179\/016164104X3789","volume":"26","author":"L Krizanac-Bengez","year":"2004","unstructured":"Krizanac-Bengez L, Mayberg MR, Janigro D. The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology. Neurol Res. 2004;26(8):846\u201353.","journal-title":"Neurol Res"},{"issue":"4","key":"3321_CR70","doi-asserted-by":"publisher","first-page":"100082","DOI":"10.1016\/j.mbm.2024.100082","volume":"2","author":"Z Liu","year":"2024","unstructured":"Liu Z, Ling SD, Liang K, Chen Y, Niu Y, Sun L, et al. Viscoelasticity of ECM and cells\u2014origin, measurement and correlation. Mechanobiol Med. 2024;2(4):100082.","journal-title":"Mechanobiol Med"},{"issue":"1","key":"3321_CR71","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s42003-021-02285-w","volume":"4","author":"CA Dessalles","year":"2021","unstructured":"Dessalles CA, Leclech C, Castagnino A, Barakat AI. Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology. Commun Biol. 2021;4(1):764.","journal-title":"Commun Biol"},{"issue":"1","key":"3321_CR72","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s40824-022-00332-z","volume":"26","author":"M Tran","year":"2022","unstructured":"Tran M, Heo C, Lee LP, Cho H. Human mini-blood\u2013brain barrier models for biomedical neuroscience research: a review. Biomater Res. 2022;26(1):82.","journal-title":"Biomater Res"},{"issue":"1","key":"3321_CR73","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3390\/pharmaceutics16010048","volume":"16","author":"J Kim","year":"2024","unstructured":"Kim J, Shin S-A, Lee CS, Chung HJ. An improved in vitro blood-brain barrier model for the evaluation of drug permeability using transwell with shear stress. Pharmaceutics. 2024;16(1):48.","journal-title":"Pharmaceutics"},{"key":"3321_CR74","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/978-1-0716-2289-6_10","volume-title":"The blood-brain barrier: methods and protocols","author":"G Molins Guti\u00e9rrez","year":"2022","unstructured":"Molins Guti\u00e9rrez G, Martorell J, Salazar-Martin AG, Balcells M. A dynamic, in vitro BBB model to study the effects of varying levels of shear stress. In: Stone N, editor. The blood-brain barrier: methods and protocols. New York: Springer; 2022. p. 175\u201390."},{"issue":"6","key":"3321_CR75","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00401-020-02215-w","volume":"140","author":"N Korte","year":"2020","unstructured":"Korte N, Nortley R, Attwell D. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer\u2019s disease. Acta Neuropathol. 2020;140(6):793\u2013810.","journal-title":"Acta Neuropathol"},{"key":"3321_CR76","doi-asserted-by":"publisher","first-page":"e04645","DOI":"10.7554\/eLife.04645","volume":"4","author":"N Baeyens","year":"2015","unstructured":"Baeyens N, Nicoli S, Schwartz MA. Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. Elife. 2015;4:e04645.","journal-title":"Elife"},{"issue":"7","key":"3321_CR77","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1177\/0271678X16672482","volume":"37","author":"F Garcia-Polite","year":"2017","unstructured":"Garcia-Polite F, Martorell J, Del Rey-Puech P, Melgar-Lesmes P, O\u2019Brien CC, Roquer J, et al. Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium. J Cereb Blood Flow Metab. 2017;37(7):2614\u201325.","journal-title":"J Cereb Blood Flow Metab"},{"key":"3321_CR78","doi-asserted-by":"publisher","first-page":"100171","DOI":"10.1074\/jbc.RA120.015059","volume":"296","author":"SM Swain","year":"2021","unstructured":"Swain SM, Liddle RA. Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress. J Biol Chem. 2021;296:100171.","journal-title":"J Biol Chem"},{"issue":"1","key":"3321_CR79","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1161\/STROKEAHA.119.024148","volume":"51","author":"M Pasi","year":"2020","unstructured":"Pasi M, Cordonnier C. Clinical relevance of cerebral small vessel diseases. Stroke. 2020;51(1):47\u201353.","journal-title":"Stroke"},{"issue":"2","key":"3321_CR80","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1212\/WNL.0000000000004797","volume":"90","author":"M Pasi","year":"2018","unstructured":"Pasi M, Charidimou A, Boulouis G, Auriel E, Ayres A, Schwab KM, et al. Mixed-location cerebral hemorrhage\/microbleeds: Underlying microangiopathy and recurrence risk. Neurology. 2018;90(2):e119\u201326.","journal-title":"Neurology"},{"issue":"1","key":"3321_CR81","doi-asserted-by":"publisher","first-page":"e207977","DOI":"10.1212\/WNL.0000000000207977","volume":"102","author":"MB Goeldlin","year":"2024","unstructured":"Goeldlin MB, Mueller M, Siepen BM, Zhang W, Ozkan H, Locatelli M, et al. CADMUS. Neurology. 2024;102(1):e207977.","journal-title":"Neurology"},{"issue":"4","key":"3321_CR82","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1161\/STROKEAHA.113.002878","volume":"45","author":"A Joutel","year":"2014","unstructured":"Joutel A, Faraci FM. Cerebral small vessel disease. Stroke. 2014;45(4):1215\u201321.","journal-title":"Stroke"},{"issue":"7","key":"3321_CR83","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1093\/eurheartj\/ehaa756","volume":"42","author":"KA Wartolowska","year":"2021","unstructured":"Wartolowska KA, Webb AJS. Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK biobank cohort study. Eur Heart J. 2021;42(7):750\u20137.","journal-title":"Eur Heart J"},{"issue":"4","key":"3321_CR84","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3174\/ajnr.A8212","volume":"45","author":"JW Bartstra","year":"2024","unstructured":"Bartstra JW, van den Beukel T, Kranenburg G, Geurts LJ, den Harder AM, Witkamp T, et al. Increased intracranial arterial pulsatility and microvascular brain damage in pseudoxanthoma elasticum. Am J Neuroradiol. 2024;45(4):386\u201392.","journal-title":"Am J Neuroradiol"},{"key":"3321_CR85","doi-asserted-by":"publisher","first-page":"103165","DOI":"10.1016\/j.nicl.2022.103165","volume":"36","author":"W Lu","year":"2022","unstructured":"Lu W, Yu C, Wang L, Wang F, Qiu J. Perfusion heterogeneity of cerebral small vessel disease revealed via arterial spin labeling MRI and machine learning. Neuroimage Clin. 2022;36:103165.","journal-title":"Neuroimage Clin"},{"key":"3321_CR86","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","volume":"163\u2013164","author":"X Jiang","year":"2018","unstructured":"Jiang X, Andjelkovic AV, Zhu L, Yang T, Bennett MVL, Chen J, et al. Blood-brain barrier dysfunction and recovery after ischemic stroke. Prog Neurobiol. 2018;163\u2013164:144\u201371.","journal-title":"Prog Neurobiol"},{"issue":"1","key":"3321_CR87","doi-asserted-by":"publisher","first-page":"C363","DOI":"10.1152\/ajpcell.00045.2007","volume":"294","author":"E Chang","year":"2008","unstructured":"Chang E, O\u2019Donnell ME, Barakat AI. Shear stress and 17beta-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na\/H exchanger protein levels. Am J Physiol Cell Physiol. 2008;294(1):C363\u201371.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"3321_CR88","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","volume":"9","author":"M Zhang","year":"2024","unstructured":"Zhang M, Liu Q, Meng H, Duan H, Liu X, Wu J, et al. Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 2024;9(1):12.","journal-title":"Signal Transduct Target Ther"},{"issue":"11","key":"3321_CR89","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1016\/j.ajpath.2021.02.023","volume":"191","author":"JW Ashby","year":"2021","unstructured":"Ashby JW, Mack JJ. Endothelial control of cerebral blood flow. Am J Pathol. 2021;191(11):1906\u201316.","journal-title":"Am J Pathol"},{"issue":"5","key":"3321_CR90","doi-asserted-by":"publisher","first-page":"7178","DOI":"10.1096\/fj.202000201R","volume":"34","author":"D Chen","year":"2020","unstructured":"Chen D, Li L, Wang Y, Xu R, Peng S, Zhou L, Deng Z. Ischemia-reperfusion injury of brain induces endothelial-mesenchymal transition and vascular fibrosis via activating let-7i\/TGF-\u03b2R1 double-negative feedback loop. FASEB J. 2020;34(5):7178\u201391.","journal-title":"FASEB J"},{"key":"3321_CR91","doi-asserted-by":"publisher","DOI":"10.1063\/5.0174825","author":"D Sun","year":"2024","unstructured":"Sun D, Ma J, Du L, Liu Q, Yue H, Peng C, et al. Fluid shear stress induced-endothelial phenotypic transition contributes to cerebral ischemia\u2013reperfusion injury and repair. APL Bioeng. 2024. https:\/\/doi.org\/10.1063\/5.0174825.","journal-title":"APL Bioeng"},{"issue":"1","key":"3321_CR92","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12987-024-00537-5","volume":"21","author":"J Protzmann","year":"2024","unstructured":"Protzmann J, Jung F, Jakobsson L, Fredriksson L. Analysis of ischemic stroke-mediated effects on blood\u2013brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging. Fluids Barriers CNS. 2024;21(1):35.","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"3321_CR93","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/ana.20199","volume":"56","author":"LL Latour","year":"2004","unstructured":"Latour LL, Kang DW, Ezzeddine MA, Chalela JA, Warach S. Early blood-brain barrier disruption in human focal brain ischemia. Ann Neurol. 2004;56(4):468\u201377.","journal-title":"Ann Neurol"},{"issue":"6","key":"3321_CR94","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.jalz.2009.04.1233","volume":"5","author":"N Schuff","year":"2009","unstructured":"Schuff N, Matsumoto S, Kmiecik J, Studholme C, Du A, Ezekiel F, et al. Cerebral blood flow in ischemic vascular dementia and Alzheimer\u2019s disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimers Dement. 2009;5(6):454\u201362.","journal-title":"Alzheimers Dement"},{"key":"3321_CR95","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003404","author":"T Tomoto","year":"2023","unstructured":"Tomoto T, Tarumi T, Zhang R. Central arterial stiffness, brain white matter hyperintensity and total brain volume across the adult lifespan. J Hypertens. 2023. https:\/\/doi.org\/10.1097\/HJH.0000000000003404.","journal-title":"J Hypertens"},{"issue":"5","key":"3321_CR96","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/jnc.14234","volume":"144","author":"T Tarumi","year":"2018","unstructured":"Tarumi T, Zhang R. Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness. J Neurochem. 2018;144(5):595\u2013608.","journal-title":"J Neurochem"},{"issue":"3","key":"3321_CR97","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1148\/radiol.2313030996","volume":"231","author":"M Law","year":"2004","unstructured":"Law M, Saindane AM, Ge Y, Babb JS, Johnson G, Mannon LJ, et al. Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion mr imaging findings in normal-appearing white matter. Radiology. 2004;231(3):645\u201352.","journal-title":"Radiology"},{"issue":"4","key":"3321_CR98","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.neuroimage.2006.08.008","volume":"33","author":"S Adhya","year":"2006","unstructured":"Adhya S, Johnson G, Herbert J, Jaggi H, Babb JS, Grossman RI, Inglese M. Pattern of hemodynamic impairment in multiple sclerosis: dynamic susceptibility contrast perfusion MR imaging at 3.0 T. Neuroimage. 2006;33(4):1029\u201335.","journal-title":"Neuroimage"},{"key":"3321_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103135","author":"K Senzaki","year":"2021","unstructured":"Senzaki K, Okada Y, Ochi H, Ochi M, Takei SI, Miura S, et al. Vascular endothelial dysfunction associated with severity in multiple sclerosis. Multiple Scler Related Disorders. 2021. https:\/\/doi.org\/10.1016\/j.msard.2021.103135.","journal-title":"Multiple Scler Related Disorders"},{"issue":"4","key":"3321_CR100","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1177\/19714009211002778","volume":"34","author":"N Mokhber","year":"2021","unstructured":"Mokhber N, Shariatzadeh A, Avan A, Saber H, Babaei GS, Chaimowitz G, Azarpazhooh MR. Cerebral blood flow changes during aging process and in cognitive disorders: a review. Neuroradiol J. 2021;34(4):300\u20137.","journal-title":"Neuroradiol J"},{"key":"3321_CR101","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.nbd.2018.12.018","volume":"124","author":"SB Sankar","year":"2019","unstructured":"Sankar SB, Pybus AF, Liew A, Sanders B, Shah KJ, Wood LB, Buckley EM. Low cerebral blood flow is a non-invasive biomarker of neuroinflammation after repetitive mild traumatic brain injury. Neurobiol Dis. 2019;124:544\u201354.","journal-title":"Neurobiol Dis"},{"issue":"2","key":"3321_CR102","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1136\/svn-2016-000045","volume":"2","author":"Y Chen","year":"2017","unstructured":"Chen Y, Shen F, Liu J, Yang GY. Arterial stiffness and stroke: de-stiffening strategy, a therapeutic target for stroke. Stroke Vasc Neurol. 2017;2(2):65\u201372.","journal-title":"Stroke Vasc Neurol"},{"issue":"5","key":"3321_CR103","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.celrep.2016.12.092","volume":"18","author":"J Song","year":"2017","unstructured":"Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, et al. Endothelial basement membrane laminin 511 contributes to endothelial junctional tightness and thereby inhibits leukocyte transmigration. Cell Rep. 2017;18(5):1256\u201369.","journal-title":"Cell Rep"},{"issue":"10","key":"3321_CR104","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1177\/0271678X17722436","volume":"37","author":"MS Thomsen","year":"2017","unstructured":"Thomsen MS, Routhe LJ, Moos T. The vascular basement membrane in the healthy and pathological brain. J Cereb Blood Flow Metab. 2017;37(10):3300\u201317.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"3321_CR105","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0271678X18801467","volume":"39","author":"Y Yao","year":"2019","unstructured":"Yao Y. Basement membrane and stroke. J Cereb Blood Flow Metab. 2019;39(1):3\u201319.","journal-title":"J Cereb Blood Flow Metab"},{"key":"3321_CR106","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194987","author":"M Kretschmer","year":"2021","unstructured":"Kretschmer M, R\u00fcdiger D, Zahler S. Mechanical aspects of angiogenesis. Cancers. 2021. https:\/\/doi.org\/10.3390\/cancers13194987.","journal-title":"Cancers"},{"issue":"11","key":"3321_CR107","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/dneu.20954","volume":"71","author":"KM Baeten","year":"2011","unstructured":"Baeten KM, Akassoglou K. Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke. Dev Neurobiol. 2011;71(11):1018\u201339.","journal-title":"Dev Neurobiol"},{"issue":"3","key":"3321_CR108","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/CIRCRESAHA.122.322332","volume":"132","author":"J Aman","year":"2023","unstructured":"Aman J, Margadant C. Integrin-dependent cell-matrix adhesion in endothelial health and disease. Circ Res. 2023;132(3):355\u201378.","journal-title":"Circ Res"},{"issue":"1","key":"3321_CR109","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13024-021-00502-y","volume":"16","author":"B Nguyen","year":"2021","unstructured":"Nguyen B, Bix G, Yao Y. Basal lamina changes in neurodegenerative disorders. Mol Neurodegener. 2021;16(1):81.","journal-title":"Mol Neurodegener"},{"issue":"10","key":"3321_CR110","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1038\/jcbfm.2011.99","volume":"31","author":"T Osada","year":"2011","unstructured":"Osada T, Gu YH, Kanazawa M, Tsubota Y, Hawkins BT, Spatz M, et al. Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by \u03b2(1)-integrins. J Cereb Blood Flow Metab. 2011;31(10):1972\u201385.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"3321_CR111","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.bpj.2014.12.023","volume":"108","author":"JC Kohn","year":"2015","unstructured":"Kohn JC, Zhou DW, Bordeleau F, Zhou A, Mason B, Mitchell M, et al. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior. Biophys J. 2015;108(3):471\u20138.","journal-title":"Biophys J"},{"issue":"10","key":"3321_CR112","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1016\/j.bbamcr.2017.07.006","volume":"1864","author":"C Xue","year":"2017","unstructured":"Xue C, Zhang T, Xie X, Zhang Q, Zhang S, Zhu B, et al. Substrate stiffness regulates arterial-venous differentiation of endothelial progenitor cells via the Ras\/Mek pathway. Biochim et Biophys Acta (BBA) - Mol Cell Res. 2017;1864(10):1799\u2013808.","journal-title":"Biochim et Biophys Acta (BBA) - Mol Cell Res"},{"issue":"4","key":"3321_CR113","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1165\/ajrcmb.26.4.4725","volume":"26","author":"KG Birukov","year":"2002","unstructured":"Birukov KG, Birukova AA, Dudek SM, Verin AD, Crow MT, Zhan X, et al. Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 2002;26(4):453\u201364.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3321_CR114","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1471-2202-5-37","volume":"5","author":"O Uspenskaia","year":"2004","unstructured":"Uspenskaia O, Liebetrau M, Herms J, Danek A, Hamann GF. Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels. BMC Neurosci. 2004;5:37.","journal-title":"BMC Neurosci"},{"issue":"2","key":"3321_CR115","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/acel.12045","volume":"12","author":"CA Hawkes","year":"2013","unstructured":"Hawkes CA, Gatherer M, Sharp MM, Dorr A, Yuen HM, Kalaria R, et al. Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-\u03b2 from the mouse brain. Aging Cell. 2013;12(2):224\u201336.","journal-title":"Aging Cell"},{"issue":"4","key":"3321_CR116","doi-asserted-by":"publisher","first-page":"1651157","DOI":"10.1080\/21688370.2019.1651157","volume":"7","author":"MJ Reed","year":"2019","unstructured":"Reed MJ, Damodarasamy M, Banks WA. The extracellular matrix of the blood-brain barrier: structural and functional roles in health, aging, and Alzheimer\u2019s disease. Tissue Barriers. 2019;7(4):1651157.","journal-title":"Tissue Barriers"},{"issue":"4","key":"3321_CR117","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s004010000195","volume":"100","author":"E Farkas","year":"2000","unstructured":"Farkas E, De Jong GI, de Vos RAI, Jansen Steur ENH, Luiten PGM. Pathological features of cerebral cortical capillaries are doubled in Alzheimer\u2019s disease and Parkinson\u2019s disease. Acta Neuropathol. 2000;100(4):395\u2013402.","journal-title":"Acta Neuropathol"},{"issue":"1","key":"3321_CR118","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF00692225","volume":"49","author":"GL Mancardi","year":"1980","unstructured":"Mancardi GL, Perdelli F, Rivano C, Leonardi A, Bugiani O. Thickening of the basement membrane of cortical capillaries in Alzheimer\u2019s disease. Acta Neuropathol. 1980;49(1):79\u201383.","journal-title":"Acta Neuropathol"},{"key":"3321_CR119","doi-asserted-by":"publisher","first-page":"101255","DOI":"10.1016\/j.arr.2021.101255","volume":"66","author":"A Heinz","year":"2021","unstructured":"Heinz A. Elastic fibers during aging and disease. Ageing Res Rev. 2021;66:101255.","journal-title":"Ageing Res Rev"},{"issue":"7","key":"3321_CR120","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1161\/STROKEAHA.108.528091","volume":"40","author":"E Fonck","year":"2009","unstructured":"Fonck E, Feigl GG, Fasel J, Sage D, Unser M, R\u00fcfenacht DA, Stergiopulos N. Effect of aging on elastin functionality in human cerebral arteries. Stroke. 2009;40(7):2552\u20136.","journal-title":"Stroke"},{"issue":"1","key":"3321_CR121","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1152\/japplphysiol.00966.2005","volume":"100","author":"H Girouard","year":"2006","unstructured":"Girouard H, Iadecola C. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol. 2006;100(1):328\u201335.","journal-title":"J Appl Physiol"},{"key":"3321_CR122","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9518.","author":"M Mandal\u00e0","year":"2021","unstructured":"Mandal\u00e0 M, Cipolla MJ. Aging-related structural and functional changes in cerebral arteries: caloric restriction (CR) intervention. J Vasc Med Surg. 2021. https:\/\/doi.org\/10.1126\/science.aav9518.","journal-title":"J Vasc Med Surg"},{"key":"3321_CR123","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9518","author":"R Nortley","year":"2019","unstructured":"Nortley R, Korte N, Izquierdo P, Hirunpattarasilp C, Mishra A, Jaunmuktane Z, et al. Amyloid \u03b2 oligomers constrict human capillaries in Alzheimer\u2019s disease via signaling to pericytes. Science. 2019. https:\/\/doi.org\/10.1126\/science.aav9518.","journal-title":"Science"},{"issue":"Suppl 1","key":"3321_CR124","first-page":"S29","volume":"59","author":"G G\u00fcrler","year":"2022","unstructured":"G\u00fcrler G, Soylu KO, Yemisci M. Importance of pericytes in the pathophysiology of cerebral ischemia. Noro Psikiyatr Ars. 2022;59(Suppl 1):S29-s35.","journal-title":"Noro Psikiyatr Ars"},{"issue":"50","key":"3321_CR125","doi-asserted-by":"publisher","first-page":"39027","DOI":"10.1074\/jbc.M006700200","volume":"275","author":"N Verzijl","year":"2000","unstructured":"Verzijl N, DeGroot J, Thorpe SR, Bank RA, Shaw JN, Lyons TJ, et al. Effect of collagen turnover on the accumulation of advanced glycation end products*. J Biol Chem. 2000;275(50):39027\u201331.","journal-title":"J Biol Chem"},{"issue":"3","key":"3321_CR126","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0021-9150(77)90179-4","volume":"28","author":"J Singh","year":"1977","unstructured":"Singh J, Di Ferrante N, Gyorkey F, Wilson N. Plasma glycosaminoglycans in normal individuals of various age. Atherosclerosis. 1977;28(3):319\u201324.","journal-title":"Atherosclerosis"},{"key":"3321_CR127","first-page":"100097","volume":"15","author":"JR Libby","year":"2024","unstructured":"Libby JR, Royce H, Walker SR, Li L. The role of extracellular matrix in angiogenesis: beyond adhesion and structure. Biomater Biosyst. 2024;15:100097.","journal-title":"Biomater Biosyst"},{"issue":"2","key":"3321_CR128","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/nan.12295","volume":"43","author":"FX Lepelletier","year":"2017","unstructured":"Lepelletier FX, Mann D, Robinson A, Pinteaux E, Boutin H. Early changes in extracellular matrix in Alzheimer\u2019s disease. Neuropathol Appl Neurobiol. 2017;43(2):167\u201382.","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"3","key":"3321_CR129","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1365-2990.2006.00732.x","volume":"32","author":"J Tian","year":"2006","unstructured":"Tian J, Shi J, Smallman R, Iwatsubo T, Mann DMA. Relationships in Alzheimer\u2019s disease between the extent of A\u03b2 deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen. Neuropathol Appl Neurobiol. 2006;32(3):332\u201340.","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"5","key":"3321_CR130","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1177\/1352458517690821","volume":"23","author":"RH Benedict","year":"2017","unstructured":"Benedict RH, DeLuca J, Phillips G, LaRocca N, Hudson LD, Rudick R. Validity of the symbol digit modalities test as a cognition performance outcome measure for multiple sclerosis. Mult Scler. 2017;23(5):721\u201333.","journal-title":"Mult Scler"},{"key":"3321_CR131","doi-asserted-by":"publisher","first-page":"104578","DOI":"10.1016\/j.msard.2023.104578","volume":"71","author":"P Zheng","year":"2023","unstructured":"Zheng P, Pilutti LA, DuBose NG, Motl RW. Vascular function and cognition in persons with multiple sclerosis: preliminary examination. Multiple Scler Related Disorders. 2023;71:104578.","journal-title":"Multiple Scler Related Disorders"},{"issue":"1","key":"3321_CR132","doi-asserted-by":"publisher","first-page":"e01935","DOI":"10.1002\/brb3.1935","volume":"11","author":"JH Bae","year":"2021","unstructured":"Bae JH, Kim JM, Park KY, Han SH. Association between arterial stiffness and the presence of cerebral small vessel disease markers. Brain Behav. 2021;11(1):e01935.","journal-title":"Brain Behav"},{"issue":"11","key":"3321_CR133","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1161\/STROKEAHA.123.042512","volume":"54","author":"T Miyagi","year":"2023","unstructured":"Miyagi T, Ishida A, Shinzato T, Ohya Y. Arterial stiffness is associated with small vessel disease irrespective of blood pressure in stroke-free individuals. Stroke. 2023;54(11):2814\u201321.","journal-title":"Stroke"},{"issue":"1","key":"3321_CR134","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s43044-022-00244-2","volume":"74","author":"H Boshra","year":"2022","unstructured":"Boshra H, Awad M, Hussein M, Elyamani E. Vascular dysfunction and dyslipidemia in multiple sclerosis: are they correlated with disease duration and disability status? Egypt Heart J. 2022;74(1):9.","journal-title":"Egypt Heart J"},{"issue":"5","key":"3321_CR135","doi-asserted-by":"publisher","first-page":"e014621","DOI":"10.1161\/JAHA.119.014621","volume":"9","author":"C Alvarez-Bueno","year":"2020","unstructured":"Alvarez-Bueno C, Cunha PG, Martinez-Vizcaino V, Pozuelo-Carrascosa DP, Visier-Alfonso ME, Jimenez-Lopez E, Cavero-Redondo I. Arterial stiffness and cognition among adults: a systematic review and meta-analysis of observational and longitudinal studies. J Am Heart Assoc. 2020;9(5):e014621.","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"3321_CR136","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3109\/10739689609148289","volume":"3","author":"KL Ohashi","year":"1996","unstructured":"Ohashi KL, Tung DK, Wilson J, Zweifach BW, Schmid-Sch\u00f6nbein GW. Transvascular and interstitial migration of neutrophils in rat mesentery. Microcirculation. 1996;3(2):199\u2013210.","journal-title":"Microcirculation"},{"issue":"4","key":"3321_CR137","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1160\/TH03-04-0220","volume":"90","author":"R Yadav","year":"2003","unstructured":"Yadav R, Larbi KY, Young RE, Nourshargh S. Migration of leukocytes through the vessel wall and beyond. Thromb Haemost. 2003;90(4):598\u2013606.","journal-title":"Thromb Haemost"},{"issue":"7269","key":"3321_CR138","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature08478","volume":"462","author":"I Bartholom\u00e4us","year":"2009","unstructured":"Bartholom\u00e4us I, Kawakami N, Odoardi F, Schl\u00e4ger C, Miljkovic D, Ellwart JW, et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature. 2009;462(7269):94\u20138.","journal-title":"Nature"},{"key":"3321_CR139","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191339","author":"X Zhang","year":"2020","unstructured":"Zhang X, Wang Y, Song J, Gerwien H, Chuquisana O, Chashchina A, et al. The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain. J Exp Med. 2020. https:\/\/doi.org\/10.1084\/jem.20191339.","journal-title":"J Exp Med"},{"issue":"1","key":"3321_CR140","doi-asserted-by":"publisher","first-page":"6855","DOI":"10.1038\/s41598-022-10849-x","volume":"12","author":"RB Riddle","year":"2022","unstructured":"Riddle RB, Jennbacken K, Hansson KM, Harper MT. Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model. Sci Rep. 2022;12(1):6855.","journal-title":"Sci Rep"},{"key":"3321_CR141","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092029","author":"AC Mutgan","year":"2020","unstructured":"Mutgan AC, Jandl K, Kwapiszewska G. Endothelial basement membrane components and their products, matrikines: active drivers of pulmonary hypertension? Cells. 2020. https:\/\/doi.org\/10.3390\/cells9092029.","journal-title":"Cells"},{"key":"3321_CR142","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.239889","author":"C Leclech","year":"2020","unstructured":"Leclech C, Natale CF, Barakat AI. The basement membrane as a structured surface\u2014role in vascular health and disease. J Cell Sci. 2020. https:\/\/doi.org\/10.1242\/jcs.239889.","journal-title":"J Cell Sci"},{"key":"3321_CR143","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/400_020","volume":"43","author":"B Engelhardt","year":"2006","unstructured":"Engelhardt B. Regulation of immune cell entry into the central nervous system. Results Probl Cell Differ. 2006;43:259\u201380.","journal-title":"Results Probl Cell Differ"},{"issue":"8","key":"3321_CR144","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1038\/s41380-022-01637-0","volume":"27","author":"V Haage","year":"2022","unstructured":"Haage V, De Jager PL. Neuroimmune contributions to Alzheimer\u2019s disease: a focus on human data. Mol Psychiatry. 2022;27(8):3164\u201381.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"3321_CR145","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000486200","volume":"18","author":"M Merlini","year":"2018","unstructured":"Merlini M, Kirabali T, Kulic L, Nitsch RM, Ferretti MT. Extravascular CD3+ T cells in brains of Alzheimer disease patients correlate with tau but not with amyloid pathology: an immunohistochemical study. Neurodegener Dis. 2018;18(1):49\u201356.","journal-title":"Neurodegener Dis"},{"key":"3321_CR146","doi-asserted-by":"publisher","first-page":"106461","DOI":"10.1016\/j.nbd.2024.106461","volume":"193","author":"J Zeng","year":"2024","unstructured":"Zeng J, Liao Z, Yang H, Wang Q, Wu Z, Hua F, Zhou Z. T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer\u2019s disease. Neurobiol Dis. 2024;193:106461.","journal-title":"Neurobiol Dis"},{"key":"3321_CR147","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02638","author":"J Rossy","year":"2018","unstructured":"Rossy J, Laufer JM, Legler DF. Role of mechanotransduction and tension in T cell function. Front Immunol. 2018. https:\/\/doi.org\/10.3389\/fimmu.2018.02638.","journal-title":"Front Immunol"},{"issue":"13","key":"3321_CR148","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1242\/jcs.163055","volume":"128","author":"A Schaefer","year":"2015","unstructured":"Schaefer A, Hordijk PL. Cell-stiffness-induced mechanosignaling\u2014a key driver of leukocyte transendothelial migration. J Cell Sci. 2015;128(13):2221\u201330.","journal-title":"J Cell Sci"},{"issue":"1","key":"3321_CR149","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0006-3495(03)74467-1","volume":"85","author":"C Sun","year":"2003","unstructured":"Sun C, Migliorini C, Munn LL. Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice boltzmann analysis. Biophys J. 2003;85(1):208\u201322.","journal-title":"Biophys J"},{"issue":"1","key":"3321_CR150","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/0300985812469883","volume":"50","author":"WA Muller","year":"2013","unstructured":"Muller WA. Getting leukocytes to the site of inflammation. Vet Pathol. 2013;50(1):7\u201322.","journal-title":"Vet Pathol"},{"issue":"1","key":"3321_CR151","doi-asserted-by":"publisher","first-page":"H359","DOI":"10.1152\/ajpheart.00491.2003","volume":"286","author":"X Zhang","year":"2004","unstructured":"Zhang X, Chen A, De Leon D, Li H, Noiri E, Moy VT, Goligorsky MS. Atomic force microscopy measurement of leukocyte-endothelial interaction. Am J Physiol Heart Circ Physiol. 2004;286(1):H359\u201367.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"3321_CR152","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.it.2012.07.004","volume":"33","author":"B Engelhardt","year":"2012","unstructured":"Engelhardt B, Ransohoff RM. Capture, crawl, cross: the T cell code to breach the blood\u2013brain barriers. Trends Immunol. 2012;33(12):579\u201389.","journal-title":"Trends Immunol"},{"issue":"5","key":"3321_CR153","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1172\/JCI8692","volume":"105","author":"MH Siegelman","year":"2000","unstructured":"Siegelman MH, Stanescu D, Estess P. The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion. J Clin Invest. 2000;105(5):683\u201391.","journal-title":"J Clin Invest"},{"issue":"3","key":"3321_CR154","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.neulet.2005.09.028","volume":"392","author":"C Coisne","year":"2006","unstructured":"Coisne C, Faveeuw C, Delplace Y, Dehouck L, Miller F, Cecchelli R, Dehouck B. Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct inflammatory stimuli. Neurosci Lett. 2006;392(3):216\u201320.","journal-title":"Neurosci Lett"},{"issue":"2","key":"3321_CR155","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s004150050313","volume":"246","author":"GV McDonnell","year":"1999","unstructured":"McDonnell GV, McMillan SA, Douglas JP, Droogan AG, Hawkins SA. Serum soluble adhesion molecules in multiple sclerosis: raised sVCAM-1, sICAM-1 and sE-selectin in primary progressive disease. J Neurol. 1999;246(2):87\u201392.","journal-title":"J Neurol"},{"issue":"6","key":"3321_CR156","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/s41591-019-0440-4","volume":"25","author":"H Yousef","year":"2019","unstructured":"Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat Med. 2019;25(6):988\u20131000.","journal-title":"Nat Med"},{"issue":"8","key":"3321_CR157","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1002\/eji.201344214","volume":"44","author":"K Sathiyanadan","year":"2014","unstructured":"Sathiyanadan K, Coisne C, Enzmann G, Deutsch U, Engelhardt B. PSGL-1 and E\/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE. Eur J Immunol. 2014;44(8):2287\u201394.","journal-title":"Eur J Immunol"},{"issue":"1","key":"3321_CR158","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12987-019-0165-2","volume":"17","author":"H Nishihara","year":"2020","unstructured":"Nishihara H, Soldati S, Mossu A, Rosito M, Rudolph H, Muller WA, et al. Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro. Fluids and Barriers of the CNS. 2020;17(1):3.","journal-title":"Fluids and Barriers of the CNS"},{"key":"3321_CR159","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.805657\/full","author":"JA Mapunda","year":"2022","unstructured":"Mapunda JA, Tibar H, Regragui W, Engelhardt B. How does the immune system enter the brain? Front Immunol. 2022. https:\/\/doi.org\/10.3389\/fimmu.2022.805657\/full.","journal-title":"Front Immunol"},{"issue":"6","key":"3321_CR160","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1159\/000341232","volume":"49","author":"R Lyck","year":"2012","unstructured":"Lyck R, Engelhardt B. Going against the tide\u2014how encephalitogenic T cells breach the blood-brain barrier. J Vasc Res. 2012;49(6):497\u2013509.","journal-title":"J Vasc Res"},{"issue":"8","key":"3321_CR161","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.4049\/jimmunol.0903732","volume":"185","author":"O Steiner","year":"2010","unstructured":"Steiner O, Coisne C, Cecchelli R, Boscacci R, Deutsch U, Engelhardt B, Lyck R. Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol. 2010;185(8):4846\u201355.","journal-title":"J Immunol"},{"issue":"10","key":"3321_CR162","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/s41590-019-0491-1","volume":"20","author":"C Zhu","year":"2019","unstructured":"Zhu C, Chen W, Lou J, Rittase W, Li K. Mechanosensing through immunoreceptors. Nat Immunol. 2019;20(10):1269\u201378.","journal-title":"Nat Immunol"},{"issue":"16","key":"3321_CR163","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1091\/mbc.E18-02-0120","volume":"29","author":"SV Pageon","year":"2018","unstructured":"Pageon SV, Govendir MA, Kempe D, Biro M. Mechanoimmunology: molecular-scale forces govern immune cell functions. Mol Biol Cell. 2018;29(16):1919\u201326.","journal-title":"Mol Biol Cell"},{"issue":"2","key":"3321_CR164","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.cell.2014.02.053","volume":"157","author":"B Liu","year":"2014","unstructured":"Liu B, Chen W, Zhu C. Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling. Cell. 2014;157(2):357\u201368.","journal-title":"Cell"},{"key":"3321_CR165","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2019.00045\/full","author":"DL Harrison","year":"2019","unstructured":"Harrison DL, Fang Y, Huang J. T-cell mechanobiology: force sensation, potentiation, and translation. Front Phys. 2019. https:\/\/doi.org\/10.3389\/fphy.2019.00045\/full.","journal-title":"Front Phys"},{"issue":"1","key":"3321_CR166","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.immuni.2007.01.002","volume":"26","author":"R Alon","year":"2007","unstructured":"Alon R, Dustin ML. Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity. 2007;26(1):17\u201327.","journal-title":"Immunity"},{"issue":"1","key":"3321_CR167","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41556-018-0234-9","volume":"21","author":"Z Sun","year":"2019","unstructured":"Sun Z, Costell M, F\u00e4ssler R. Integrin activation by talin, kindlin and mechanical forces. Nat Cell Biol. 2019;21(1):25\u201331.","journal-title":"Nat Cell Biol"},{"issue":"6","key":"3321_CR168","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.molcel.2008.11.018","volume":"32","author":"J Zhu","year":"2008","unstructured":"Zhu J, Luo B-H, Xiao T, Zhang C, Nishida N, Springer TA. Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol Cell. 2008;32(6):849\u201361.","journal-title":"Mol Cell"},{"issue":"5","key":"3321_CR169","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.ceb.2012.08.011","volume":"24","author":"B Shen","year":"2012","unstructured":"Shen B, Delaney MK, Du X. Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction. Curr Opin Cell Biol. 2012;24(5):600\u20136.","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"3321_CR170","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4049\/jimmunol.1900680","volume":"204","author":"B Shao","year":"2020","unstructured":"Shao B, Yago T, Panicker SR, Zhang N, Liu Z, McEver RP. Th1 cells rolling on selectins trigger DAP12-dependent signals that activate integrin \u03b1L\u03b22. J Immunol. 2020;204(1):37\u201348.","journal-title":"J Immunol"},{"issue":"10","key":"3321_CR171","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/ni1499","volume":"8","author":"E Woolf","year":"2007","unstructured":"Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, et al. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol. 2007;8(10):1076\u201385.","journal-title":"Nat Immunol"},{"issue":"3","key":"3321_CR172","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1039\/C4IB00201F","volume":"7","author":"GA Dominguez","year":"2015","unstructured":"Dominguez GA, Anderson NR, Hammer DA. The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged. Integr Biol. 2015;7(3):345\u201355.","journal-title":"Integr Biol"},{"key":"3321_CR173","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00048\/full","author":"J Lee","year":"2018","unstructured":"Lee J, Song KH, Kim T, Doh J. Endothelial cell focal adhesion regulates transendothelial migration and subendothelial crawling of T cells. Front Immunol. 2018. https:\/\/doi.org\/10.3389\/fimmu.2018.00048\/full.","journal-title":"Front Immunol"},{"issue":"1","key":"3321_CR174","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2045-8118-10-7","volume":"10","author":"C Coisne","year":"2013","unstructured":"Coisne C, Lyck R, Engelhardt B. Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo. Fluids Barriers CNS. 2013;10(1):7.","journal-title":"Fluids Barriers CNS"},{"issue":"5","key":"3321_CR175","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/ncb3336","volume":"18","author":"A Elosegui-Artola","year":"2016","unstructured":"Elosegui-Artola A, Oria R, Chen Y, Kosmalska A, P\u00e9rez-Gonz\u00e1lez C, Castro N, et al. Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol. 2016;18(5):540\u20138.","journal-title":"Nat Cell Biol"},{"issue":"10","key":"3321_CR176","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/embor.2010.147","volume":"11","author":"J Renkawitz","year":"2010","unstructured":"Renkawitz J, Sixt M. Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Rep. 2010;11(10):744\u201350.","journal-title":"EMBO Rep"},{"key":"3321_CR177","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23190","author":"M Saitakis","year":"2017","unstructured":"Saitakis M, Dogniaux S, Goudot C, Bufi N, Asnacios S, Maurin M, et al. Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity. Elife. 2017. https:\/\/doi.org\/10.7554\/eLife.23190.","journal-title":"Elife"},{"issue":"20","key":"3321_CR178","first-page":"4470","volume":"127","author":"A Schaefer","year":"2014","unstructured":"Schaefer A, Te Riet J, Ritz K, Hoogenboezem M, Anthony EC, Mul FPJ, et al. Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration. J Cell Sci. 2014;127(20):4470\u201382.","journal-title":"J Cell Sci"},{"issue":"11","key":"3321_CR179","doi-asserted-by":"publisher","first-page":"7057","DOI":"10.4049\/jimmunol.1001638","volume":"185","author":"R Sumagin","year":"2010","unstructured":"Sumagin R, Prizant H, Lomakina E, Waugh RE, Sarelius IH. LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. J Immunol. 2010;185(11):7057\u201366.","journal-title":"J Immunol"},{"issue":"10","key":"3321_CR180","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/intbio\/zyz034","volume":"11","author":"SHJ Kim","year":"2019","unstructured":"Kim SHJ, Hammer DA. Integrin crosstalk allows CD4+ T lymphocytes to continue migrating in the upstream direction after flow. Integr Biol. 2019;11(10):384\u201393.","journal-title":"Integr Biol"},{"issue":"1","key":"3321_CR181","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21541248.2016.1197872","volume":"8","author":"L Schimmel","year":"2017","unstructured":"Schimmel L, Heemskerk N, van Buul JD. Leukocyte transendothelial migration: a local affair. Small GTPases. 2017;8(1):1\u201315.","journal-title":"Small GTPases"},{"key":"3321_CR182","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.148619","author":"R Martinelli","year":"2014","unstructured":"Martinelli R, Zeiger A, Whitfield M, Sciuto T, Dvorak A, Van Vliet K, et al. Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance. J Cell Sci. 2014. https:\/\/doi.org\/10.1242\/jcs.148619.","journal-title":"J Cell Sci"},{"issue":"4","key":"3321_CR183","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1002\/eji.201445125","volume":"45","author":"M Abadier","year":"2015","unstructured":"Abadier M, Haghayegh Jahromi N, Cardoso Alves L, Boscacci R, Vestweber D, Barnum S, et al. Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. Eur J Immunol. 2015;45(4):1043\u201358.","journal-title":"Eur J Immunol"},{"issue":"1","key":"3321_CR184","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/eji.202149238","volume":"52","author":"L Marchetti","year":"2022","unstructured":"Marchetti L, Francisco D, Soldati S, Haghayegh Jahromi N, Barcos S, Gruber I, et al. ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro. Eur J Immunol. 2022;52(1):161\u201377.","journal-title":"Eur J Immunol"},{"issue":"8","key":"3321_CR185","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1016\/j.celrep.2017.10.094","volume":"21","author":"SE Lutz","year":"2017","unstructured":"Lutz SE, Smith JR, Kim DH, Olson CVL, Ellefsen K, Bates JM, et al. Caveolin1 is required for Th1 cell infiltration, but not tight junction remodeling, at the blood-brain barrier in autoimmune neuroinflammation. Cell Rep. 2017;21(8):2104\u201317.","journal-title":"Cell Rep"},{"key":"3321_CR186","doi-asserted-by":"publisher","DOI":"10.1101\/2022.11.15.516689v1.abstract","author":"TN Trevino","year":"2022","unstructured":"Trevino TN, Almousawi AA, Ochoa-Raya A, Zemanski K, Oliveira SD, Marottoli FM, et al. Endothelial caveolin-1 and CXCL10 promote transcellular migration of autoreactive T cells across the blood-brain barrier. bioRxiv. 2022. https:\/\/doi.org\/10.1101\/2022.11.15.516689v1.abstract.","journal-title":"bioRxiv"},{"issue":"1","key":"3321_CR187","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jneuroim.2010.08.011","volume":"229","author":"J Bennett","year":"2010","unstructured":"Bennett J, Basivireddy J, Kollar A, Biron KE, Reickmann P, Jefferies WA, McQuaid S. Blood\u2013brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE. J Neuroimmunol. 2010;229(1):180\u201391.","journal-title":"J Neuroimmunol"},{"issue":"17","key":"3321_CR188","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1242\/jcs.047522","volume":"122","author":"CV Carman","year":"2009","unstructured":"Carman CV. Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions\u2019. J Cell Sci. 2009;122(17):3025\u201335.","journal-title":"J Cell Sci"},{"issue":"8","key":"3321_CR189","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.it.2017.05.002","volume":"38","author":"R Alon","year":"2017","unstructured":"Alon R, Van Buul JD. leukocyte breaching of endothelial barriers: the actin link. Trends Immunol. 2017;38(8):606\u201315.","journal-title":"Trends Immunol"},{"issue":"6","key":"3321_CR190","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.immuni.2007.04.015","volume":"26","author":"CV Carman","year":"2007","unstructured":"Carman CV, Sage PT, Sciuto TE, De La Fuente MA, Geha RS, et al. Transcellular diapedesis is initiated by invasive podosomes. Immunity. 2007;26(6):784\u201397.","journal-title":"Immunity"},{"issue":"1","key":"3321_CR191","doi-asserted-by":"publisher","first-page":"10493","DOI":"10.1038\/ncomms10493","volume":"7","author":"N Heemskerk","year":"2016","unstructured":"Heemskerk N, Schimmel L, Oort C, Van Rijssel J, Yin T, Ma B, et al. F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. Nat Commun. 2016;7(1):10493.","journal-title":"Nat Commun"},{"issue":"6","key":"3321_CR192","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1111\/j.1600-6143.2007.01816.x","volume":"7","author":"LA Smyth","year":"2007","unstructured":"Smyth LA, Afzali B, Tsang J, Lombardi G, Lechler RI. Intercellular transfer of MHC and immunological molecules: molecular mechanisms and biological significance. Am J Transplant. 2007;7(6):1442\u20139.","journal-title":"Am J Transplant"},{"issue":"3","key":"3321_CR193","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.4049\/jimmunol.162.3.1677","volume":"162","author":"RI Brezinschek","year":"1999","unstructured":"Brezinschek RI, Oppenheimer-Marks N, Lipsky PE. Activated T cells acquire endothelial cell surface determinants during transendothelial migration. J Immunol. 1999;162(3):1677\u201384.","journal-title":"J Immunol"},{"issue":"1","key":"3321_CR194","doi-asserted-by":"publisher","first-page":"e55483","DOI":"10.15252\/embr.202255483","volume":"24","author":"MLB Gr\u00f6nloh","year":"2023","unstructured":"Gr\u00f6nloh MLB, Arts JJG, Palacios Mart\u00ednez S, van der Veen AA, Kempers L, van Steen ACI, et al. Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1. EMBO Rep. 2023;24(1):e55483.","journal-title":"EMBO Rep"},{"issue":"2","key":"3321_CR195","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00018-016-2325-8","volume":"74","author":"YL Dorland","year":"2017","unstructured":"Dorland YL, Huveneers S. Cell\u2013cell junctional mechanotransduction in endothelial remodeling. Cell Mol Life Sci. 2017;74(2):279\u201392.","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"3321_CR196","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1242\/bio.20122428","volume":"1","author":"F Twiss","year":"2012","unstructured":"Twiss F, Le Duc Q, Van Der Horst S, Tabdili H, Van Der Krogt G, Wang N, et al. Vinculin-dependent cadherin mechanosensing regulates efficient epithelial barrier formation. Biol Open. 2012;1(11):1128\u201340.","journal-title":"Biol Open"},{"key":"3321_CR197","doi-asserted-by":"crossref","unstructured":"Malinova TS, Angulo-Urarte A, N\u00fcchel J, Tauber M, Van Der Stoel MM, Janssen V, et al. A junctional PACSIN2\/EHD4\/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. Nature Communications. 2021;12(1).","DOI":"10.1038\/s41467-021-22873-y"},{"key":"3321_CR198","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28779-7","author":"C Arbore","year":"2021","unstructured":"Arbore C, Sergides M, Gardini L, Bianchi G, Kashchuk AV, Pertici I, et al. \u03b1-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity. bioRxiv. 2021. https:\/\/doi.org\/10.1038\/s41467-022-28779-7.","journal-title":"bioRxiv"},{"issue":"6352","key":"3321_CR199","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1126\/science.aan2556","volume":"357","author":"DL Huang","year":"2017","unstructured":"Huang DL, Bax NA, Buckley CD, Weis WI, Dunn AR. Vinculin forms a directionally asymmetric catch bond with F-actin. Science. 2017;357(6352):703\u20136.","journal-title":"Science"},{"issue":"10","key":"3321_CR200","doi-asserted-by":"publisher","first-page":"e2109329119","DOI":"10.1073\/pnas.2109329119","volume":"119","author":"LM Owen","year":"2022","unstructured":"Owen LM, Bax NA, Weis WI, Dunn AR. The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin. Proc Natl Acad Sci USA. 2022;119(10):e2109329119.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3321_CR201","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/s41467-022-28779-7","volume":"13","author":"C Arbore","year":"2022","unstructured":"Arbore C, Sergides M, Gardini L, Bianchi G, Kashchuk AV, Pertici I, et al. \u03b1-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity. Nat Commun. 2022;13(1):1146.","journal-title":"Nat Commun"},{"issue":"2","key":"3321_CR202","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/cphy.c180020","volume":"9","author":"Y Fang","year":"2019","unstructured":"Fang Y, Wu D, Birukov KG. Mechanosensing and mechanoregulation of endothelial cell functions. Compr Physiol. 2019;9(2):873\u2013904.","journal-title":"Compr Physiol"},{"issue":"1274","key":"3321_CR203","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1098\/rspb.1988.0038","volume":"234","author":"M Dembo","year":"1988","unstructured":"Dembo M, Torney DC, Saxman K, Hammer D, Murray JD. The reaction-limited kinetics of membrane-to-surface adhesion and detachment. Proc R Soc Lond B. 1988;234(1274):55\u201383.","journal-title":"Proc R Soc Lond B"},{"issue":"22","key":"3321_CR204","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.cub.2012.08.051","volume":"22","author":"C Collins","year":"2012","unstructured":"Collins C, Guilluy C, Welch C, O\u2019Brien ET, Hahn K, Superfine R, et al. Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol. 2012;22(22):2087\u201394.","journal-title":"Curr Biol"},{"issue":"8","key":"3321_CR205","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/ncb0808-883","volume":"10","author":"J Gavard","year":"2008","unstructured":"Gavard J, Gutkind JS. VE-cadherin and claudin-5: it takes two to tango. Nat Cell Biol. 2008;10(8):883\u20135.","journal-title":"Nat Cell Biol"},{"key":"3321_CR206","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00711","author":"I Wimmer","year":"2019","unstructured":"Wimmer I, Tietz S, Nishihara H, Deutsch U, Sallusto F, Gosselet F, et al. PECAM-1 stabilizes blood-brain barrier integrity and favors paracellular T-cell diapedesis across the blood-brain barrier during neuroinflammation. Front Immunol. 2019. https:\/\/doi.org\/10.3389\/fimmu.2019.00711.","journal-title":"Front Immunol"},{"issue":"7057","key":"3321_CR207","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature03952","volume":"437","author":"E Tzima","year":"2005","unstructured":"Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, et al. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature. 2005;437(7057):426\u201331.","journal-title":"Nature"},{"issue":"22","key":"3321_CR208","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.cub.2012.08.051","volume":"22","author":"C Collins","year":"2012","unstructured":"Collins C, Guilluy C, Welch CE, Hahn K, Superfine R, et al. Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol. 2012;22(22):2087\u201394.","journal-title":"Curr Biol"},{"issue":"11","key":"3321_CR209","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1084\/jem.20150353","volume":"212","author":"EW Weber","year":"2015","unstructured":"Weber EW, Han F, Tauseef M, Birnbaumer L, Mehta D, Muller WA. TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response. J Exp Med. 2015;212(11):1883\u201399.","journal-title":"J Exp Med"},{"key":"3321_CR210","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.bbi.2020.12.026","volume":"93","author":"J Winneberger","year":"2021","unstructured":"Winneberger J, Sch\u00f6ls S, Lessmann K, R\u00e1ndez-Garbayo J, Bauer AT, Mohamud Yusuf A, et al. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke. Brain Behav Immun. 2021;93:277\u201387.","journal-title":"Brain Behav Immun"},{"issue":"11","key":"3321_CR211","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1161\/ATVBAHA.108.164707","volume":"28","author":"BL Harry","year":"2008","unstructured":"Harry BL, Sanders JM, Feaver RE, Lansey M, Deem TL, Zarbock A, et al. Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2008;28(11):2003\u20138.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"3321_CR212","doi-asserted-by":"publisher","first-page":"107924","DOI":"10.1016\/j.celrep.2020.107924","volume":"32","author":"AJ Haas","year":"2020","unstructured":"Haas AJ, Zihni C, Ruppel A, Hartmann C, Ebnet K, Tada M, et al. Interplay between extracellular matrix stiffness and JAM-A regulates mechanical load on ZO-1 and tight junction assembly. Cell Rep. 2020;32(3):107924.","journal-title":"Cell Rep"},{"issue":"2","key":"3321_CR213","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/apha.12725","volume":"219","author":"DA Chistiakov","year":"2017","unstructured":"Chistiakov DA, Orekhov AN, Bobryshev YV. Effects of shear stress on endothelial cells: go with the flow. Acta Physiol. 2017;219(2):382\u2013408.","journal-title":"Acta Physiol"},{"issue":"6","key":"3321_CR214","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1083\/jcb.201404140","volume":"208","author":"O Tornavaca","year":"2015","unstructured":"Tornavaca O, Chia M, Dufton N, Almagro LO, Conway DE, Randi AM, et al. ZO-1 controls endothelial adherens junctions, cell\u2013cell tension, angiogenesis, and barrier formation. J Cell Biol. 2015;208(6):821\u201338.","journal-title":"J Cell Biol"},{"issue":"22","key":"3321_CR215","doi-asserted-by":"publisher","first-page":"9944","DOI":"10.1073\/pnas.0914547107","volume":"107","author":"Z Liu","year":"2010","unstructured":"Liu Z, Tan JL, Cohen DM, Yang MT, Sniadecki NJ, Ruiz SA, et al. Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci. 2010;107(22):9944\u20139.","journal-title":"Proc Natl Acad Sci"},{"key":"3321_CR216","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028761","author":"AS Yap","year":"2018","unstructured":"Yap AS, Duszyc K, Viasnoff V. Mechanosensing and mechanotransduction at cell-cell junctions. Cold Spring Harb Perspect Biol. 2018. https:\/\/doi.org\/10.1101\/cshperspect.a028761.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3321_CR217","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00628","author":"W Shihata","year":"2016","unstructured":"Shihata W, Michell D, Andrews K, Chin-Dusting J. Caveolae: a role in endothelial inflammation and mechanotransduction? Front Physiol. 2016. https:\/\/doi.org\/10.3389\/fphys.2016.00628.","journal-title":"Front Physiol"},{"key":"3321_CR218","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1146\/annurev-neuro-070918-050509","volume":"43","author":"P Jin","year":"2020","unstructured":"Jin P, Jan LY, Jan Y-N. Mechanosensitive ion channels: structural features relevant to mechanotransduction mechanisms. Ann Rev Neurosci. 2020;43:207\u201329.","journal-title":"Ann Rev Neurosci"},{"key":"3321_CR219","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1146\/annurev.biophys.37.032807.125836","volume":"39","author":"J Arnad\u00f3ttir","year":"2010","unstructured":"Arnad\u00f3ttir J, Chalfie M. Eukaryotic mechanosensitive channels. Annu Rev Biophys. 2010;39:111\u201337.","journal-title":"Annu Rev Biophys"},{"key":"3321_CR220","doi-asserted-by":"publisher","first-page":"102229","DOI":"10.1016\/j.ceb.2023.102229","volume":"84","author":"AEM Beedle","year":"2023","unstructured":"Beedle AEM, Roca-Cusachs P. The reversibility of cellular mechano-activation. Curr Opin Cell Biol. 2023;84:102229.","journal-title":"Curr Opin Cell Biol"},{"key":"3321_CR221","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.261338","author":"S Sala","year":"2024","unstructured":"Sala S, Caillier A, Oakes PW. Principles and regulation of mechanosensing. J Cell Sci. 2024. https:\/\/doi.org\/10.1242\/jcs.261338.","journal-title":"J Cell Sci"},{"issue":"4","key":"3321_CR222","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/01.RES.0000089257.94002.96","volume":"93","author":"Z-G Jin","year":"2003","unstructured":"Jin Z-G, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC. Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase. Circ Res. 2003;93(4):354\u201363.","journal-title":"Circ Res"},{"issue":"2","key":"3321_CR223","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0006-291X(03)00592-8","volume":"304","author":"H Jong Lee","year":"2003","unstructured":"Jong Lee H, Young KG. Shear stress activates Tie2 receptor tyrosine kinase in human endothelial cells. Biochem Biophys Res Commun. 2003;304(2):399\u2013404.","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"3321_CR224","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/ncb1486","volume":"8","author":"J Gavard","year":"2006","unstructured":"Gavard J, Gutkind JS. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol. 2006;8(11):1223\u201334.","journal-title":"Nat Cell Biol"},{"key":"3321_CR225","doi-asserted-by":"publisher","first-page":"804934","DOI":"10.3389\/fcvm.2021.804934","volume":"8","author":"B Miller","year":"2021","unstructured":"Miller B, Sewell-Loftin MK. Mechanoregulation of vascular endothelial growth factor receptor 2 in angiogenesis. Front Cardiovasc Med. 2021;8:804934.","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"3321_CR226","doi-asserted-by":"publisher","first-page":"112835","DOI":"10.1016\/j.yexcr.2021.112835","volume":"408","author":"E Matsuo","year":"2021","unstructured":"Matsuo E, Okamoto T, Ito A, Kawamoto E, Asanuma K, Wada K, et al. Substrate stiffness modulates endothelial cell function via the YAP-Dll4-Notch1 pathway. Exp Cell Res. 2021;408(1):112835.","journal-title":"Exp Cell Res"},{"issue":"41","key":"3321_CR227","doi-asserted-by":"publisher","first-page":"11525","DOI":"10.1073\/pnas.1613121113","volume":"113","author":"KC Wang","year":"2016","unstructured":"Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, et al. Flow-dependent YAP\/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci USA. 2016;113(41):11525\u201330.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3321_CR228","first-page":"389","volume":"16","author":"HC Huang","year":"2023","unstructured":"Huang HC, Wang TY, Rousseau J, Mungaray M, Michaud C, Plaisier C, et al. Lesion-specific suppression of YAP\/TAZ by biomimetic nanodrug ameliorates atherosclerosis development. bioRxiv. 2023;16:389.","journal-title":"bioRxiv"},{"issue":"7","key":"3321_CR229","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.bbadis.2018.08.008","volume":"1865","author":"G Jia","year":"2019","unstructured":"Jia G, Aroor AR, Jia C, Sowers JR. Endothelial cell senescence in aging-related vascular dysfunction. Biochim Biophys Acta Mol Basis Dis. 2019;1865(7):1802\u20139.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"42","key":"3321_CR230","doi-asserted-by":"publisher","first-page":"15463","DOI":"10.1073\/pnas.0607224103","volume":"103","author":"M Chachisvilis","year":"2006","unstructured":"Chachisvilis M, Zhang YL, Frangos JA. G protein-coupled receptors sense fluid shear stress in endothelial cells. Proc Natl Acad Sci. 2006;103(42):15463\u20138.","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"3321_CR231","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.cell.2018.03.076","volume":"173","author":"J Xu","year":"2018","unstructured":"Xu J, Mathur J, Vessi\u00e8res E, Hammack S, Nonomura K, Favre J, et al. GPR68 senses flow and is essential for vascular physiology. Cell. 2018;173(3):762-75.e16.","journal-title":"Cell"},{"issue":"3","key":"3321_CR232","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.cell.2018.04.001","volume":"173","author":"AJ Iliff","year":"2018","unstructured":"Iliff AJ, Xu XZS. A mechanosensitive GPCR that detects the bloody force. Cell. 2018;173(3):542\u20134.","journal-title":"Cell"},{"issue":"6953","key":"3321_CR233","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nature01905","volume":"425","author":"M-G Ludwig","year":"2003","unstructured":"Ludwig M-G, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, et al. Proton-sensing G-protein-coupled receptors. Nature. 2003;425(6953):93\u20138.","journal-title":"Nature"},{"issue":"3","key":"3321_CR234","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1073\/pnas.1907467117","volume":"117","author":"J Wenzel","year":"2020","unstructured":"Wenzel J, Hansen CE, Bettoni C, Vogt MA, Lembrich B, Natsagdorj R, et al. Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice. Proc Natl Acad Sci. 2020;117(3):1753\u201361.","journal-title":"Proc Natl Acad Sci"},{"issue":"12","key":"3321_CR235","doi-asserted-by":"publisher","first-page":"3690","DOI":"10.1161\/STROKEAHA.120.031479","volume":"51","author":"T Wang","year":"2020","unstructured":"Wang T, Zhou G, He M, Xu Y, Rusyniak WG, Xu Y, et al. GPR68 is a neuroprotective proton receptor in brain ischemia. Stroke. 2020;51(12):3690\u2013700.","journal-title":"Stroke"},{"issue":"10306","key":"3321_CR236","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/S0140-6736(21)00244-0","volume":"398","author":"MP McGinley","year":"2021","unstructured":"McGinley MP, Cohen JA. Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions. Lancet. 2021;398(10306):1184\u201394.","journal-title":"Lancet"},{"issue":"3","key":"3321_CR237","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.devcel.2012.07.015","volume":"23","author":"B Jung","year":"2012","unstructured":"Jung B, Obinata H, Galvani S, Mendelson K, Ding B-S, Skoura A, et al. Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell. 2012;23(3):600\u201310.","journal-title":"Dev Cell"},{"issue":"9","key":"3321_CR238","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/jamaneurol.2014.1065","volume":"71","author":"Y Fu","year":"2014","unstructured":"Fu Y, Hao J, Zhang N, Ren L, Sun N, Li YJ, et al. Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study. JAMA Neurol. 2014;71(9):1092\u2013101.","journal-title":"JAMA Neurol"},{"issue":"12","key":"3321_CR239","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.016371","volume":"132","author":"Z Zhu","year":"2015","unstructured":"Zhu Z, Fu Y, Tian D, Sun N, Han W, Chang G, et al. Combination of the immune modulator fingolimod with alteplase in acute ischemic stroke: a pilot trial. Circulation. 2015;132(12):1104\u201312.","journal-title":"Circulation"},{"issue":"3","key":"3321_CR240","doi-asserted-by":"publisher","first-page":"e0121488","DOI":"10.1371\/journal.pone.0121488","volume":"10","author":"H Nishihara","year":"2015","unstructured":"Nishihara H, Shimizu F, Sano Y, Takeshita Y, Maeda T, Abe M, et al. Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis. PLoS ONE. 2015;10(3):e0121488.","journal-title":"PLoS ONE"},{"issue":"2","key":"3321_CR241","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1161\/HYPERTENSIONAHA.117.09088","volume":"70","author":"A Cantalupo","year":"2017","unstructured":"Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (sphingosine-1-phosphate receptor 1) signaling regulates blood flow and pressure. Hypertension. 2017;70(2):426\u201334.","journal-title":"Hypertension"},{"issue":"8","key":"3321_CR242","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(18)30202-3","volume":"17","author":"R Hughes","year":"2018","unstructured":"Hughes R, Dalakas MC, Merkies I, Latov N, L\u00e9ger J-M, Nobile-Orazio E, et al. Oral fingolimod for chronic inflammatory demyelinating polyradiculoneuropathy (FORCIDP Trial): a double-blind, multicentre, randomised controlled trial. Lancet Neurol. 2018;17(8):689\u201398.","journal-title":"Lancet Neurol"},{"issue":"4","key":"3321_CR243","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1152\/physrev.00018.2011","volume":"92","author":"A Schwab","year":"2012","unstructured":"Schwab A, Fabian A, Hanley PJ, Stock C. Role of ion channels and transporters in cell migration. Physiol Rev. 2012;92(4):1865\u2013913.","journal-title":"Physiol Rev"},{"issue":"6","key":"3321_CR244","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/cm.21652","volume":"78","author":"K Tanaka","year":"2021","unstructured":"Tanaka K, Joshi D, Timalsina S, Schwartz MA. Early events in endothelial flow sensing. Cytoskeleton. 2021;78(6):217\u201331.","journal-title":"Cytoskeleton"},{"issue":"18","key":"3321_CR245","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1097\/WNR.0000000000001357","volume":"30","author":"X Ma","year":"2019","unstructured":"Ma X, Liu W. Calcium signaling in brain microvascular endothelial cells and its roles in the function of the blood-brain barrier. NeuroReport. 2019;30(18):1271\u20137.","journal-title":"NeuroReport"},{"issue":"4","key":"3321_CR246","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/10739680701762656","volume":"15","author":"RC Brown","year":"2008","unstructured":"Brown RC, Wu L, Hicks K, O\u2019Neil RG. Regulation of blood-brain barrier permeability by transient receptor potential type C and type v calcium-permeable channels. Microcirculation. 2008;15(4):359\u201371.","journal-title":"Microcirculation"},{"key":"3321_CR247","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2011.11.044","volume":"1436","author":"J Berrout","year":"2012","unstructured":"Berrout J, Jin M, O\u2019Neil RG. Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood-brain barrier endothelial cells. Brain Res. 2012;1436:1\u201312.","journal-title":"Brain Res"},{"issue":"1","key":"3321_CR248","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12974-024-03069-9","volume":"21","author":"CE Hansen","year":"2024","unstructured":"Hansen CE, Kamermans A, Mol K, Berve K, Rodriguez-Mogeda C, Fung WK, et al. Inflammation-induced TRPV4 channels exacerbate blood\u2013brain barrier dysfunction in multiple sclerosis. J Neuroinflammation. 2024;21(1):72.","journal-title":"J Neuroinflammation"},{"issue":"7526","key":"3321_CR249","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nature13701","volume":"515","author":"J Li","year":"2014","unstructured":"Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, et al. Piezo1 integration of vascular architecture with physiological force. Nature. 2014;515(7526):279\u201382.","journal-title":"Nature"},{"issue":"10","key":"3321_CR250","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1161\/CIRCRESAHA.122.320827","volume":"130","author":"OF Harraz","year":"2022","unstructured":"Harraz OF, Klug NR, Senatore AJ, Hill-Eubanks DC, Nelson MT. Piezo1 is a mechanosensor channel in central nervous system capillaries. Circ Res. 2022;130(10):1531\u201346.","journal-title":"Circ Res"},{"issue":"1","key":"3321_CR251","doi-asserted-by":"publisher","first-page":"C92","DOI":"10.1152\/ajpcell.00346.2018","volume":"316","author":"H Kang","year":"2019","unstructured":"Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, et al. Piezo1 mediates angiogenesis through activation of MT1-MMP signaling. Am J Phys Cell Physiol. 2019;316(1):C92\u2013103.","journal-title":"Am J Phys Cell Physiol"},{"issue":"26","key":"3321_CR252","doi-asserted-by":"publisher","first-page":"12980","DOI":"10.1073\/pnas.1902165116","volume":"116","author":"EE Friedrich","year":"2019","unstructured":"Friedrich EE, Hong Z, Xiong S, Zhong M, Di A, Rehman J, et al. Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions. Proc Natl Acad Sci USA. 2019;116(26):12980\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"3321_CR253","doi-asserted-by":"publisher","first-page":"C1010","DOI":"10.1152\/ajpcell.00147.2021","volume":"321","author":"Z Wang","year":"2021","unstructured":"Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, et al. Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. Am J Physiol Cell Physiol. 2021;321(6):C1010\u201327.","journal-title":"Am J Physiol Cell Physiol"},{"key":"3321_CR254","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-021-00600-5","author":"Y Yang","year":"2021","unstructured":"Yang Y, Wang D, Zhang C, Yang W, Li C, Gao Z, et al. Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP\/TAZ activation. Hum Cell. 2021. https:\/\/doi.org\/10.1007\/s13577-021-00600-5.","journal-title":"Hum Cell"},{"issue":"10","key":"3321_CR255","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1084\/jem.20180483","volume":"215","author":"J Albarr\u00e1n-Ju\u00e1rez","year":"2018","unstructured":"Albarr\u00e1n-Ju\u00e1rez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, et al. Piezo1 and Gq\/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018;215(10):2655\u201372.","journal-title":"J Exp Med"},{"issue":"1","key":"3321_CR256","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s42003-023-04706-4","volume":"6","author":"E Chuntharpursat-Bon","year":"2023","unstructured":"Chuntharpursat-Bon E, Povstyan OV, Ludlow MJ, Carrier DJ, Debant M, Shi J, et al. PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing. Commun Biol. 2023;6(1):358.","journal-title":"Commun Biol"},{"issue":"3","key":"3321_CR257","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00281-015-0535-z","volume":"38","author":"S Bertin","year":"2016","unstructured":"Bertin S, Raz E. Transient receptor potential (TRP) channels in T cells. Semin Immunopathol. 2016;38(3):309\u201319.","journal-title":"Semin Immunopathol"},{"key":"3321_CR258","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev-physiol-030222-012349","volume":"85","author":"T Rosenbaum","year":"2023","unstructured":"Rosenbaum T, Islas LD. Molecular physiology of TRPV channels: controversies and future challenges. Annu Rev Physiol. 2023;85:293\u2013316.","journal-title":"Annu Rev Physiol"},{"issue":"23","key":"3321_CR259","doi-asserted-by":"publisher","first-page":"238360","DOI":"10.1242\/jcs.238360","volume":"132","author":"YA Nikolaev","year":"2019","unstructured":"Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, V\u00e1squez V, et al. Mammalian TRP ion channels are insensitive to membrane stretch. J Cell Sci. 2019;132(23):238360.","journal-title":"J Cell Sci"},{"issue":"5","key":"3321_CR260","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1152\/physiol.00009.2014","volume":"29","author":"DC Hill-Eubanks","year":"2014","unstructured":"Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT. Vascular TRP channels: performing under pressure and going with the flow. Physiology. 2014;29(5):343\u201360.","journal-title":"Physiology"},{"issue":"6","key":"3321_CR261","doi-asserted-by":"publisher","first-page":"C846","DOI":"10.1152\/ajpcell.00288.2015","volume":"311","author":"MA Dragovich","year":"2016","unstructured":"Dragovich MA, Chester D, Fu BM, Wu C, Xu Y, Goligorsky MS, Zhang XF. Mechanotransduction of the endothelial glycocalyx mediates nitric oxide production through activation of TRP channels. Am J Physiol Cell Physiol. 2016;311(6):C846\u201353.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"8","key":"3321_CR262","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1161\/CIRCRESAHA.108.189530","volume":"104","author":"S Earley","year":"2009","unstructured":"Earley S, Gonzales AL, Crnich R. Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca 2+ -activated K + channels. Circ Res. 2009;104(8):987\u201394.","journal-title":"Circ Res"},{"issue":"9","key":"3321_CR263","doi-asserted-by":"publisher","first-page":"20191437","DOI":"10.1042\/BSR20191437","volume":"39","author":"A Tiwari","year":"2019","unstructured":"Tiwari A, Acharya T, Saha S, et al. Transient receptor potential ankyrin1 channel is endogenously expressed in T cells and is involved in immune functions. Biosci Rep. 2019;39(9):20191437.","journal-title":"Biosci Rep"},{"issue":"21","key":"3321_CR264","doi-asserted-by":"publisher","first-page":"11460","DOI":"10.3390\/ijms222111460","volume":"22","author":"R Naert","year":"2021","unstructured":"Naert R, L\u00f3pez-Requena A, Talavera K. TRPA1 expression and pathophysiology in immune cells. Int J Mol Sci. 2021;22(21):11460.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"3321_CR265","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.bbamcr.2010.12.022","volume":"1813","author":"AS Wenning","year":"2011","unstructured":"Wenning AS, Neblung K, Strau\u00df B, Wolfs M-J, Sappok A, Hoth M, Schwarz EC. TRP expression pattern and the functional importance of TRPC3 in primary human T-cells. Biochim et Biophys Acta (BBA) - Mol Cell Res. 2011;1813(3):412\u201323.","journal-title":"Biochim et Biophys Acta (BBA) - Mol Cell Res"},{"issue":"6","key":"3321_CR266","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00418-004-0720-y","volume":"122","author":"H Yip","year":"2004","unstructured":"Yip H, Chan W-Y, Leung P-C, Kwan H-Y, Liu C, Huang Y, et al. Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries. Histochem Cell Biol. 2004;122(6):553\u201361.","journal-title":"Histochem Cell Biol"},{"issue":"9","key":"3321_CR267","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1016\/j.bbamcr.2014.12.037","volume":"1853","author":"O Lindemann","year":"2015","unstructured":"Lindemann O, Strodthoff C, Horstmann M, Nielsen N, Jung F, Schimmelpfennig S, et al. TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophil granulocytes. Biochim et Biophys Acta (BBA) - Mol Cell Res. 2015;1853(9):2122\u201330.","journal-title":"Biochim et Biophys Acta (BBA) - Mol Cell Res"},{"key":"3321_CR268","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.isci.2018.09.014","volume":"8","author":"A Chauhan","year":"2018","unstructured":"Chauhan A, Sun Y, Sukumaran P, Quenum Zangbede FO, Jondle CN, Sharma A, et al. M1 macrophage polarization is dependent on TRPC1-mediated calcium entry. iScience. 2018;8:85\u2013102.","journal-title":"iScience"},{"issue":"5","key":"3321_CR269","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.ceca.2008.03.002","volume":"44","author":"S Br\u00e9chard","year":"2008","unstructured":"Br\u00e9chard S, Melchior C, Plan\u00e7on S, Schenten V, Tschirhart EJ. Store-operated Ca2+ channels formed by TRPC1, TRPC6 and orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. Cell Calcium. 2008;44(5):492\u2013506.","journal-title":"Cell Calcium"},{"issue":"1","key":"3321_CR270","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/cvr\/cvt231","volume":"101","author":"JY Tano","year":"2014","unstructured":"Tano JY, Solanki S, Lee RH, Smedlund K, Birnbaumer L, Vazquez G. Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis. Cardiovasc Res. 2014;101(1):138\u201344.","journal-title":"Cardiovasc Res"},{"issue":"Pt 6","key":"3321_CR271","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1242\/jcs.061051","volume":"123","author":"T Numaga","year":"2010","unstructured":"Numaga T, Nishida M, Kiyonaka S, Kato K, Katano M, Mori E, et al. Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells. J Cell Sci. 2010;123(Pt 6):927\u201338.","journal-title":"J Cell Sci"},{"issue":"5","key":"3321_CR272","doi-asserted-by":"publisher","first-page":"120068","DOI":"10.1098\/rsob.120068","volume":"2","author":"K Quick","year":"2012","unstructured":"Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, et al. TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol. 2012;2(5):120068.","journal-title":"Open Biol"},{"issue":"3\u20134","key":"3321_CR273","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000503452","volume":"105","author":"L Tao","year":"2020","unstructured":"Tao L, Guo G, Qi Y, Xiong Y, Ma X, Wu N, et al. Inhibition of canonical transient receptor potential 5 channels polarizes macrophages to an M1 phenotype. Pharmacology. 2020;105(3\u20134):202\u20138.","journal-title":"Pharmacology"},{"issue":"4","key":"3321_CR274","doi-asserted-by":"publisher","first-page":"e0122227","DOI":"10.1371\/journal.pone.0122227","volume":"10","author":"B Shen","year":"2015","unstructured":"Shen B, Wong C-O, Lau O-C, Woo T, Bai S, Huang Y, Yao X. Plasma membrane mechanical stress activates TRPC5 channels. PLoS ONE. 2015;10(4):e0122227.","journal-title":"PLoS ONE"},{"issue":"3","key":"3321_CR275","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00109-020-01872-4","volume":"98","author":"O Lindemann","year":"2020","unstructured":"Lindemann O, Rossaint J, Najder K, Schimmelpfennig S, Hofschr\u00f6er V, W\u00e4lte M, et al. Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels. J Mol Med. 2020;98(3):349\u201360.","journal-title":"J Mol Med"},{"issue":"6","key":"3321_CR276","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ceca.2015.09.001","volume":"58","author":"Z Liu","year":"2015","unstructured":"Liu Z, Yang J, Zhang X, Xu P, Zhang T, Yang Z. Developmental changes in the expression and function of TRPC6 channels related the F-actin organization during differentiation in podocytes. Cell Calcium. 2015;58(6):541\u20138.","journal-title":"Cell Calcium"},{"issue":"47","key":"3321_CR277","doi-asserted-by":"publisher","first-page":"E6486","DOI":"10.1073\/pnas.1518966112","volume":"112","author":"V Riazanski","year":"2015","unstructured":"Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, et al. TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proc Natl Acad Sci. 2015;112(47):E6486\u201395.","journal-title":"Proc Natl Acad Sci"},{"issue":"44","key":"3321_CR278","doi-asserted-by":"publisher","first-page":"16586","DOI":"10.1073\/pnas.0606894103","volume":"103","author":"MA Spassova","year":"2006","unstructured":"Spassova MA, Hewavitharana T, Xu W, Soboloff J, Gill DL. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci. 2006;103(44):16586\u201391.","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"3321_CR279","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.4049\/jimmunol.1102969","volume":"189","author":"N Serafini","year":"2012","unstructured":"Serafini N, Dahdah A, Barbet G, Demion M, Attout T, Gautier G, et al. The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis. J Immunol. 2012;189(7):3689\u201399.","journal-title":"J Immunol"},{"issue":"4","key":"3321_CR280","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1254\/jphs.FP0061332","volume":"103","author":"H Morita","year":"2007","unstructured":"Morita H, Honda A, Inoue R, Ito Y, Abe K, Nelson MT, Brayden JE. Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes. J Pharmacol Sci. 2007;103(4):417\u201326.","journal-title":"J Pharmacol Sci"},{"issue":"4","key":"3321_CR281","doi-asserted-by":"publisher","first-page":"e0195526","DOI":"10.1371\/journal.pone.0195526","volume":"13","author":"V Gerzanich","year":"2018","unstructured":"Gerzanich V, Kwon MS, Woo SK, Ivanov A, Simard JM. SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells. PLoS ONE. 2018;13(4):e0195526.","journal-title":"PLoS ONE"},{"issue":"11","key":"3321_CR282","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1113\/JP270887","volume":"594","author":"M-J Son","year":"2016","unstructured":"Son M-J, Kim J-C, Kim SW, Chidipi B, Muniyandi J, Singh TD, et al. Shear stress activates monovalent cation channel transient receptor potential melastatin subfamily 4 in rat atrial myocytes via type 2 inositol 1,4,5-trisphosphate receptors and Ca2+release. J Physiol. 2016;594(11):2985\u20133004.","journal-title":"J Physiol"},{"issue":"4","key":"3321_CR283","doi-asserted-by":"publisher","first-page":"C308","DOI":"10.1152\/ajpcell.00275.2013","volume":"308","author":"Z Zeng","year":"2015","unstructured":"Zeng Z, Inoue K, Sun H, Leng T, Feng X, Zhu L, Xiong Z-G. TRPM7 regulates vascular endothelial cell adhesion and tube formation. Am J Physiol Cell Physiol. 2015;308(4):C308\u201318.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"3321_CR284","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1161\/CIRCULATIONAHA.107.710111","volume":"117","author":"SM Nauli","year":"2008","unstructured":"Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J. Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation. 2008;117(9):1161\u201371.","journal-title":"Circulation"},{"issue":"14","key":"3321_CR285","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1111\/febs.13306","volume":"282","author":"RK Majhi","year":"2015","unstructured":"Majhi RK, Sahoo SS, Yadav M, Pratheek BM, Chattopadhyay S, Goswami C. Functional expression of TRPV channels in T cells and their implications in immune regulation. FEBS J. 2015;282(14):2661\u201381.","journal-title":"FEBS J"},{"key":"3321_CR286","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.578514","author":"H Luo","year":"2020","unstructured":"Luo H, Saubamea B, Chasseigneaux S, Cochois V, Smirnova M, Glacial F, et al. Molecular and functional study of transient receptor potential vanilloid 1\u20134 at the rat and human blood-brain barrier reveals interspecies differences. Front Cell Dev Biol. 2020. https:\/\/doi.org\/10.3389\/fcell.2020.578514.","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"3321_CR287","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/ni.3009","volume":"15","author":"S Bertin","year":"2014","unstructured":"Bertin S, Aoki-Nonaka Y, De Jong PR, Nohara LL, Xu H, Stanwood SR, et al. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells. Nat Immunol. 2014;15(11):1055\u201363.","journal-title":"Nat Immunol"},{"issue":"3","key":"3321_CR288","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1042\/bj20021975","volume":"371","author":"I Heiner","year":"2003","unstructured":"Heiner I, Eisfeld J, Halaszovich CR, Wehage E, J\u00fcngling E, Zitt C, L\u00fcckhoff A. Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. Biochem J. 2003;371(3):1045\u201353.","journal-title":"Biochem J"},{"issue":"1","key":"3321_CR289","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.bbamem.2014.09.008","volume":"1848","author":"I Pottosin","year":"2015","unstructured":"Pottosin I, Delgado-Enciso I, Bonales-Alatorre E, Nieto-Pescador MG, Moreno-Galindo EG, Dobrovinskaya O. Mechanosensitive Ca2+-permeable channels in human leukemic cells: pharmacological and molecular evidence for TRPV2. Biochim Biophys Acta (BBA) - Biomembranes. 2015;1848(1):51\u20139.","journal-title":"Biochim Biophys Acta (BBA) - Biomembranes"},{"key":"3321_CR290","doi-asserted-by":"publisher","DOI":"10.1481\/phy2.12296","author":"M Nagasawa","year":"2015","unstructured":"Nagasawa M, Kojima I. Translocation of TRPV2 channel induced by focal administration of mechanical stress. Physiol Rep. 2015. https:\/\/doi.org\/10.1481\/phy2.12296.","journal-title":"Physiol Rep"},{"issue":"3","key":"3321_CR291","doi-asserted-by":"publisher","first-page":"H1390","DOI":"10.1152\/ajpheart.01006.2006","volume":"292","author":"SP Marrelli","year":"2007","unstructured":"Marrelli SP, O\u2019Neil RG, Brown RC, Bryan RM. PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries. Am J Physiol-Heart Circ Physiol. 2007;292(3):H1390\u20137.","journal-title":"Am J Physiol-Heart Circ Physiol"},{"issue":"9","key":"3321_CR292","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1039\/c0ib00034e","volume":"2","author":"BD Matthews","year":"2010","unstructured":"Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DE. Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface \u03b21 integrins. Integr Biol. 2010;2(9):435.","journal-title":"Integr Biol"},{"issue":"1","key":"3321_CR293","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1073\/pnas.0303329101","volume":"101","author":"J Vriens","year":"2004","unstructured":"Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B. Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci. 2004;101(1):396\u2013401.","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"3321_CR294","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1165\/rcmb.2014-0225OC","volume":"54","author":"J Yin","year":"2016","unstructured":"Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, et al. Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol. 2016;54(3):370\u201383.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"3321_CR295","doi-asserted-by":"publisher","first-page":"L353","DOI":"10.1152\/ajplung.00315.2009","volume":"299","author":"K Hamanaka","year":"2010","unstructured":"Hamanaka K, Jian M-Y, Townsley MI, King JA, Liedtke W, Weber DS, et al. TRPV4 channels augment macrophage activation and ventilator-induced lung injury. Am J Physiol-Lung Cell Mol Physiol. 2010;299(3):L353\u201362.","journal-title":"Am J Physiol-Lung Cell Mol Physiol"},{"issue":"6","key":"3321_CR296","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1134\/S1990519X08060047","volume":"2","author":"IO Vassilieva","year":"2008","unstructured":"Vassilieva IO, Negulyaev YA, Marakhova II, Semenova SB. TRPV5 and TRPV6 calcium channels in human T cells. Cell Tissue Biol. 2008;2(6):584\u20139.","journal-title":"Cell Tissue Biol"},{"issue":"2","key":"3321_CR297","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00232-012-9511-x","volume":"246","author":"IO Vassilieva","year":"2013","unstructured":"Vassilieva IO, Tomilin VN, Marakhova II, Shatrova AN, Negulyaev YA, Semenova SB. Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in human blood lymphocytes and jurkat leukemia T cells. J Membr Biol. 2013;246(2):131\u201340.","journal-title":"J Membr Biol"},{"key":"3321_CR298","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00413\/full","author":"L Michalick","year":"2020","unstructured":"Michalick L, Kuebler WM. TRPV4\u2014a missing link between mechanosensation and immunity. Front Immunol. 2020. https:\/\/doi.org\/10.3389\/fimmu.2020.00413\/full.","journal-title":"Front Immunol"},{"issue":"9","key":"3321_CR299","doi-asserted-by":"publisher","first-page":"e827","DOI":"10.1371\/journal.pone.0000827","volume":"2","author":"V Hartmannsgruber","year":"2007","unstructured":"Hartmannsgruber V, Heyken W-T, Kacik M, Kaistha A, Grgic I, Harteneck C, et al. Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS ONE. 2007;2(9):e827.","journal-title":"PLoS ONE"},{"issue":"1","key":"3321_CR300","doi-asserted-by":"publisher","first-page":"15942","DOI":"10.1038\/s41598-017-16276-7","volume":"7","author":"S Baratchi","year":"2017","unstructured":"Baratchi S, Knoerzer M, Khoshmanesh K, Mitchell A, McIntyre P. Shear stress regulates TRPV4 channel clustering and translocation from adherens junctions to the basal membrane. Sci Rep. 2017;7(1):15942.","journal-title":"Sci Rep"},{"key":"3321_CR301","doi-asserted-by":"crossref","unstructured":"Swain SM, Liddle RA. Shear stress-induced pathological changes in endothelial cells occur through Piezo1 activation of TRPV4. 2020.","DOI":"10.1101\/2020.07.01.182212"},{"issue":"2","key":"3321_CR302","doi-asserted-by":"publisher","first-page":"H466","DOI":"10.1152\/ajpheart.00854.2009","volume":"298","author":"SA Mendoza","year":"2010","unstructured":"Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, et al. TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol. 2010;298(2):H466\u201376.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3321_CR303","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/bs.apha.2017.03.002","volume":"79","author":"P Rajasekhar","year":"2017","unstructured":"Rajasekhar P, Poole DP, Veldhuis NA. Role of nonneuronal TRPV4 signaling in inflammatory processes. Adv Pharmacol. 2017;79:117\u201339.","journal-title":"Adv Pharmacol"},{"issue":"9","key":"3321_CR304","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCRESAHA.108.192930","volume":"104","author":"CK Thodeti","year":"2009","unstructured":"Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res. 2009;104(9):1123\u201330.","journal-title":"Circ Res"},{"key":"3321_CR305","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.actbio.2019.10.013","volume":"100","author":"X Song","year":"2019","unstructured":"Song X, Sun Z, Chen G, Shang P, You G, Zhao J, et al. Matrix stiffening induces endothelial dysfunction via the TRPV4\/microRNA-6740\/endothelin-1 mechanotransduction pathway. Acta Biomater. 2019;100:52\u201360.","journal-title":"Acta Biomater"},{"key":"3321_CR306","doi-asserted-by":"publisher","first-page":"570195","DOI":"10.3389\/fimmu.2020.570195","volume":"11","author":"B Dutta","year":"2020","unstructured":"Dutta B, Goswami R, Rahaman SO. TRPV4 plays a role in matrix stiffness-induced macrophage polarization. Front Immunol. 2020;11:570195.","journal-title":"Front Immunol"},{"issue":"3","key":"3321_CR307","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.pharmthera.2009.05.009","volume":"123","author":"R Inoue","year":"2009","unstructured":"Inoue R, Jian Z, Kawarabayashi Y. Mechanosensitive TRP channels in cardiovascular pathophysiology. Pharmacol Ther. 2009;123(3):371\u201385.","journal-title":"Pharmacol Ther"},{"issue":"6","key":"3321_CR308","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1096\/fj.14-261396","volume":"29","author":"K Narita","year":"2015","unstructured":"Narita K, Sasamoto S, Koizumi S, Okazaki S, Nakamura H, Inoue T, Takeda S. TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport. FASEB J. 2015;29(6):2247\u201359.","journal-title":"FASEB J"},{"key":"3321_CR309","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3389\/fcell.2020.00849","volume":"8","author":"SC Rosenkranz","year":"2020","unstructured":"Rosenkranz SC, Shaposhnykov A, Schnapauff O, Epping L, Vieira V, Heidermann K, et al. TRPV4-mediated regulation of the blood brain barrier is abolished during inflammation. Front Cell Dev Biol. 2020;8:849.","journal-title":"Front Cell Dev Biol"},{"key":"3321_CR310","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.248823","author":"R Potla","year":"2020","unstructured":"Potla R, Hirano-Kobayashi M, Wu H, Chen H, Mammoto A, Matthews BD, Ingber DE. Molecular mapping of transmembrane mechanotransduction through the \u03b21 integrin-CD98hc-TRPV4 axis. J Cell Sci. 2020. https:\/\/doi.org\/10.1242\/jcs.248823.","journal-title":"J Cell Sci"},{"issue":"29","key":"3321_CR311","doi-asserted-by":"publisher","first-page":"26541","DOI":"10.1074\/jbc.M302590200","volume":"278","author":"R Strotmann","year":"2003","unstructured":"Strotmann R, Schultz G, Plant TD. Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a c-terminal calmodulin binding site. J Biol Chem. 2003;278(29):26541\u20139.","journal-title":"J Biol Chem"},{"key":"3321_CR312","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00097","author":"H Zhao","year":"2018","unstructured":"Zhao H, Zhang K, Tang R, Meng H, Zou Y, Wu P, et al. TRPV4 blockade preserves the blood-brain barrier by inhibiting stress fiber formation in a rat model of intracerebral hemorrhage. Front Mol Neurosci. 2018. https:\/\/doi.org\/10.3389\/fnmol.2018.00097.","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"3321_CR313","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s00424-012-1169-9","volume":"464","author":"A Fabian","year":"2012","unstructured":"Fabian A, Bertrand J, Lindemann O, Pap T, Schwab A. Transient receptor potential canonical channel 1 impacts on mechanosignaling during cell migration. Pfl\u00fcgers Arch Eur J Physiol. 2012;464(6):623\u201330.","journal-title":"Pfl\u00fcgers Arch Eur J Physiol"},{"key":"3321_CR314","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev-neuro-062012-170412","volume":"36","author":"N Eijkelkamp","year":"2013","unstructured":"Eijkelkamp N, Quick K, Wood JN. Transient receptor potential channels and mechanosensation. Annu Rev Neurosci. 2013;36:519\u201346.","journal-title":"Annu Rev Neurosci"},{"issue":"9","key":"3321_CR315","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1161\/01.RES.0000187473.85419.3e","volume":"97","author":"X Yao","year":"2005","unstructured":"Yao X, Garland CJ. Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res. 2005;97(9):853\u201363.","journal-title":"Circ Res"},{"issue":"6","key":"3321_CR316","doi-asserted-by":"publisher","first-page":"C1583","DOI":"10.1152\/ajpcell.00458.2009","volume":"298","author":"K Hicks","year":"2010","unstructured":"Hicks K, O\u2019Neil RG, Dubinsky WS, Brown RC. TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress. Am J Physiol Cell Physiol. 2010;298(6):C1583\u201393.","journal-title":"Am J Physiol Cell Physiol"},{"key":"3321_CR317","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/978-3-540-34891-7_35","volume":"179","author":"M Trebak","year":"2007","unstructured":"Trebak M, Lemonnier L, Smyth JT, Vazquez G, Putney JW Jr. Phospholipase C-coupled receptors and activation of TRPC channels. Handb Exp Pharmacol. 2007;179:593\u2013614.","journal-title":"Handb Exp Pharmacol"},{"key":"3321_CR318","doi-asserted-by":"publisher","first-page":"100726","DOI":"10.1016\/j.jbc.2021.100726","volume":"296","author":"M Ningoo","year":"2021","unstructured":"Ningoo M, Plant LD, Greka A, Logothetis DE. PIP(2) regulation of TRPC5 channel activation and desensitization. J Biol Chem. 2021;296:100726.","journal-title":"J Biol Chem"},{"issue":"5","key":"3321_CR319","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1161\/HYPERTENSIONAHA.112.198820","volume":"60","author":"A Adebiyi","year":"2012","unstructured":"Adebiyi A, Thomas-Gatewood CM, Leo MD, Kidd MW, Neeb ZP, Jaggar JH. An elevation in physical coupling of type 1 inositol 1,4,5-trisphosphate (IP 3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension. Hypertension. 2012;60(5):1213\u20139.","journal-title":"Hypertension"},{"issue":"Pt 1","key":"3321_CR320","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1113\/jphysiol.2005.092999","volume":"567","author":"M Freichel","year":"2005","unstructured":"Freichel M, Vennekens R, Olausson J, Stolz S, Philipp SE, Weissgerber P, Flockerzi V. Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies. J Physiol. 2005;567(Pt 1):59\u201366.","journal-title":"J Physiol"},{"issue":"11","key":"3321_CR321","doi-asserted-by":"publisher","first-page":"7833","DOI":"10.1074\/jbc.M608288200","volume":"282","author":"I Singh","year":"2007","unstructured":"Singh I, Knezevic N, Ahmmed GU, Kini V, Malik AB, Mehta D. G\u03b1q-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin. J Biol Chem. 2007;282(11):7833\u201343.","journal-title":"J Biol Chem"},{"issue":"6","key":"3321_CR322","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1161\/HYPERTENSIONAHA.111.183608","volume":"59","author":"F Thilo","year":"2012","unstructured":"Thilo F, Vorderw\u00fclbecke BJ, Marki A, Krueger K, Liu Y, Baumunk D, et al. Pulsatile atheroprone shear stress affects the expression of transient receptor potential channels in human endothelial cells. Hypertension. 2012;59(6):1232\u201340.","journal-title":"Hypertension"},{"issue":"1","key":"3321_CR323","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/aps.2015.126","volume":"37","author":"J Du","year":"2016","unstructured":"Du J, Fu J, Xia XM, Shen B. The functions of TRPP2 in the vascular system. Acta Pharmacol Sin. 2016;37(1):13\u20138.","journal-title":"Acta Pharmacol Sin"},{"issue":"4","key":"3321_CR324","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.3892\/mmr.2017.7164","volume":"16","author":"Y-Y Qu","year":"2017","unstructured":"Qu Y-Y, Wang L-M, Zhong H, Liu Y-M, Tang N, Zhu L-P, et al. TRPC1 stimulates calcium-sensing receptor-induced store-operated Ca2+ entry and nitric oxide production in endothelial cells. Mol Med Rep. 2017;16(4):4613\u20139.","journal-title":"Mol Med Rep"},{"issue":"3","key":"3321_CR325","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.cell.2009.08.045","volume":"139","author":"R Sharif-Naeini","year":"2009","unstructured":"Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, et al. Polycystin-1 and -2 dosage regulates pressure sensing. Cell. 2009;139(3):587\u201396.","journal-title":"Cell"},{"issue":"7","key":"3321_CR326","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1161\/CIRCRESAHA.108.192765","volume":"104","author":"WA Aboualaiwi","year":"2009","unstructured":"Aboualaiwi WA, Takahashi M, Mell BR, Jones TJ, Ratnam S, Kolb RJ, Nauli SM. Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ Res. 2009;104(7):860\u20139.","journal-title":"Circ Res"},{"issue":"12","key":"3321_CR327","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.1016\/j.bbamcr.2013.08.017","volume":"1833","author":"S-K Cha","year":"2013","unstructured":"Cha S-K, Kim J-H, Huang C-L. Flow-induced activation of TRPV5 and TRPV6 channels stimulates Ca(2+)-activated K(+) channel causing membrane hyperpolarization. Biochem Biophys Acta. 2013;1833(12):3046\u201353.","journal-title":"Biochem Biophys Acta"},{"key":"3321_CR328","doi-asserted-by":"publisher","first-page":"241","DOI":"10.17691\/stm2016.8.4.29","volume":"8","author":"A Shuvaev","year":"2016","unstructured":"Shuvaev A, Kuvacheva NV, Morgun A, Khilazheva E, Salmina AB. The role of ion channels expressed in cerebral endothelial cells in the functional integrity of the blood-brain barrier (review). Sovremennye tehnologii v medicine. 2016;8:241\u201350.","journal-title":"Sovremennye tehnologii v medicine"},{"issue":"28","key":"3321_CR329","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.1126\/sciadv.abh3457","volume":"7","author":"CL Yankaskas","year":"2021","unstructured":"Yankaskas CL, Bera K, Stoletov K, Serra SA, Carrillo-Garcia J, Tuntithavornwat S, et al. The fluid shear stress sensor TRPM7 regulates tumor cell intravasation. Sci Adv. 2021;7(28):3457.","journal-title":"Sci Adv"},{"issue":"1\u20134","key":"3321_CR330","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000099187","volume":"19","author":"T Numata","year":"2007","unstructured":"Numata T, Shimizu T, Okada Y. Direct mechano-stress sensitivity of TRPM7 channel. Cell Physiol Biochem. 2007;19(1\u20134):1\u20138.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"3321_CR331","doi-asserted-by":"publisher","first-page":"16522","DOI":"10.1038\/srep16522","volume":"5","author":"Y-S Liu","year":"2015","unstructured":"Liu Y-S, Liu Y-A, Huang C-J, Yen M-H, Tseng C-T, Chien S, Lee OK. Mechanosensitive TRPM7 mediates shear stress and modulates osteogenic differentiation of mesenchymal stromal cells through osterix pathway. Sci Rep. 2015;5(1):16522.","journal-title":"Sci Rep"},{"key":"3321_CR332","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051167","author":"MG Alvarado","year":"2021","unstructured":"Alvarado MG, Thakore P, Earley S. Transient receptor potential channel ankyrin 1: a unique regulator of vascular function. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10051167.","journal-title":"Cells"},{"key":"3321_CR333","doi-asserted-by":"publisher","first-page":"102255","DOI":"10.1016\/j.ceca.2020.102255","volume":"91","author":"L Moparthi","year":"2020","unstructured":"Moparthi L, Zygmunt PM. Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel. Cell Calcium. 2020;91:102255.","journal-title":"Cell Calcium"},{"issue":"1\u20132","key":"3321_CR334","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jns.2013.03.002","volume":"333","author":"A Rostami","year":"2013","unstructured":"Rostami A, Ciric B. Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination. J Neurol Sci. 2013;333(1\u20132):76\u201387.","journal-title":"J Neurol Sci"},{"issue":"9","key":"3321_CR335","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1002\/eji.201546251","volume":"46","author":"H Rudolph","year":"2016","unstructured":"Rudolph H, Klopstein A, Gruber I, Blatti C, Lyck R, Engelhardt B. Postarrest stalling rather than crawling favors CD8 + over CD4 + T-cell migration across the blood\u2013brain barrier under flow in vitro. Eur J Immunol. 2016;46(9):2187\u2013203.","journal-title":"Eur J Immunol"},{"issue":"13","key":"3321_CR336","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1016\/j.celrep.2017.11.099","volume":"21","author":"M Abadier","year":"2017","unstructured":"Abadier M, Pramod AB, McArdle S, Marki A, Fan Z, Gutierrez E, et al. Effector and regulatory T cells roll at high shear stress by inducible tether and sling formation. Cell Rep. 2017;21(13):3885\u201399.","journal-title":"Cell Rep"},{"issue":"7411","key":"3321_CR337","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nature11248","volume":"488","author":"P Sundd","year":"2012","unstructured":"Sundd P, Gutierrez E, Koltsova EK, Kuwano Y, Fukuda S, Pospieszalska MK, et al. \u2018Slings\u2019 enable neutrophil rolling at high shear. Nature. 2012;488(7411):399\u2013403.","journal-title":"Nature"},{"key":"3321_CR338","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.3389\/fimmu.2019.02436","volume":"10","author":"S Dusi","year":"2019","unstructured":"Dusi S, Angiari S, Pietronigro EC, Lopez N, Angelini G, Zenaro E, et al. LFA-1 controls Th1 and Th17 motility behavior in the inflamed central nervous system. Front Immunol. 2019;10:2436.","journal-title":"Front Immunol"},{"issue":"12","key":"3321_CR339","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1161\/ATVBAHA.107.151456","volume":"27","author":"A Woodfin","year":"2007","unstructured":"Woodfin A, Voisin M-B, Nourshargh S. PECAM-1: a multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol. 2007;27(12):2514\u201323.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"3321_CR340","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1111\/j.1468-1331.2006.01640.x","volume":"13","author":"A Kalinowska","year":"2006","unstructured":"Kalinowska A, Losy J. PECAM-1, a key player in neuroinflammation. Eur J Neurol. 2006;13(12):1284\u201390.","journal-title":"Eur J Neurol"},{"issue":"4","key":"3321_CR341","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1007\/s10439-007-9426-3","volume":"36","author":"S Chien","year":"2008","unstructured":"Chien S. Effects of disturbed flow on endothelial cells. Ann Biomed Eng. 2008;36(4):554\u201362.","journal-title":"Ann Biomed Eng"},{"issue":"2","key":"3321_CR342","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1023\/A:1007025325451","volume":"24","author":"JS Alexander","year":"2000","unstructured":"Alexander JS, Alexander BC, Eppihimer LA, Goodyear N, Haque R, Davis CP, et al. Inflammatory mediators induce sequestration of VE-cadherin in cultured human endothelial cells. Inflammation. 2000;24(2):99\u2013113.","journal-title":"Inflammation"},{"key":"3321_CR343","doi-asserted-by":"crossref","unstructured":"Koivisto A-P, Belvisi MG, Gaudet R, Szallasi A. Advances in TRP channel drug discovery: from target validation to clinical studies. Nature Reviews Drug Discovery. 2021.","DOI":"10.1038\/s41573-021-00268-4"},{"issue":"2","key":"3321_CR344","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.cct.2013.12.007","volume":"37","author":"F Miller","year":"2014","unstructured":"Miller F, Bj\u00f6rnsson M, Svensson O, Karlsten R. Experiences with an adaptive design for a dose-finding study in patients with osteoarthritis. Contemp Clin Trials. 2014;37(2):189\u201399.","journal-title":"Contemp Clin Trials"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03321-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-024-03321-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-024-03321-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T15:14:36Z","timestamp":1734534876000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-024-03321-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":344,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3321"],"URL":"https:\/\/doi.org\/10.1186\/s12974-024-03321-2","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"7 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"325"}}