{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:35:20Z","timestamp":1793676920589,"version":"4.5.1"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220030, 2023A1515110505, 2021A1515110231"],"award-info":[{"award-number":["2023A1515220030, 2023A1515110505, 2021A1515110231"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M720061"],"award-info":[{"award-number":["2022M720061"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374193\uff0c81873158"],"award-info":[{"award-number":["82374193\uff0c81873158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The second national famous Traditional Chinese Medicine Inheritance Studio","award":["G724290126"],"award-info":[{"award-number":["G724290126"]}]},{"name":"Key Discipline Construction Project of Traditional Chinese Medicine of Guangdong Province","award":["20220105"],"award-info":[{"award-number":["20220105"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-025-03367-w","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T08:51:35Z","timestamp":1739868695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning"],"prefix":"10.1186","volume":"22","author":[{"given":"Jiao","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Juan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"3367_CR1","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38.","DOI":"10.1177\/0333102417738202"},{"key":"3367_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41572-021-00328-4","volume":"8","author":"MD Ferrari","year":"2022","unstructured":"Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A, Ashina M, van den Maagdenberg AMJM, Dodick DW, Migraine. Nat Rev Dis Primers. 2022;8:2.","journal-title":"Nat Rev Dis Primers"},{"key":"3367_CR3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","volume":"23","author":"regional Global","year":"2024","unstructured":"Global regional. National burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the global burden of Disease Study 2021. Lancet Neurol. 2024;23:344\u201381.","journal-title":"Lancet Neurol"},{"key":"3367_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ncl.2019.06.001","volume":"37","author":"RC Burch","year":"2019","unstructured":"Burch RC, Buse DC, Lipton RB. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37:631\u201349.","journal-title":"Neurol Clin"},{"key":"3367_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s10194-017-0742-1","volume":"18","author":"MFP Peres","year":"2017","unstructured":"Peres MFP, Mercante JPP, Tobo PR, Kamei H, Bigal ME. Anxiety and depression symptoms and migraine: a symptom-based approach research. J Headache Pain. 2017;18:37.","journal-title":"J Headache Pain"},{"key":"3367_CR6","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1007\/s00415-012-6725-x","volume":"260","author":"DC Buse","year":"2013","unstructured":"Buse DC, Silberstein SD, Manack AN, Papapetropoulos S, Lipton RB. Psychiatric comorbidities of episodic and chronic migraine. J Neurol. 2013;260:1960\u20139.","journal-title":"J Neurol"},{"key":"3367_CR7","doi-asserted-by":"crossref","unstructured":"Della Pietra A, Mikhailov N, Giniatullin R. FM1-43 dye memorizes Piezo1 activation in the trigeminal nociceptive system implicated in Migraine Pain. Int J Mol Sci. 2023; 24.","DOI":"10.3390\/ijms24021688"},{"key":"3367_CR8","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s13311-020-00951-1","volume":"18","author":"H Tzeng","year":"2021","unstructured":"Tzeng H, Lee MT, Fan P, Knutson DE, Lai T, Sieghart W, Cook J, Chiou L. \u03b16GABAA receptor positive modulators alleviate migraine-like grimaces in mice via compensating GABAergic deficits in trigeminal ganglia. Neurotherapeutics. 2021;18:569\u201385.","journal-title":"Neurotherapeutics"},{"key":"3367_CR9","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41401-022-00941-3","volume":"44","author":"DG Yang","year":"2023","unstructured":"Yang DG, Gao YY, Yin ZQ, Wang XR, Meng XS, Zou TF, Duan YJ, Chen YL, Liao CZ, Xie ZL, et al. Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1\u03b1\/NF-\u03baB\/inflammation pathway. Acta Pharmacol Sin. 2023;44:308\u201320.","journal-title":"Acta Pharmacol Sin"},{"key":"3367_CR10","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12974-019-1603-4","volume":"16","author":"F Jing","year":"2019","unstructured":"Jing F, Zhang YX, Long T, He W, Qin GC, Zhang DK, Chen LX, Zhou JY. P2Y12 receptor mediates microglial activation via RhoA\/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine. J Neuroinflamm. 2019;16:217.","journal-title":"J Neuroinflamm"},{"key":"3367_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrn3516","volume":"14","author":"MC Bushnell","year":"2013","unstructured":"Bushnell MC, Ceko M, Low LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci. 2013;14:502\u201311.","journal-title":"Nat Rev Neurosci"},{"key":"3367_CR12","doi-asserted-by":"publisher","first-page":"e209305","DOI":"10.1212\/WNL.0000000000209305","volume":"102","author":"RH Christensen","year":"2024","unstructured":"Christensen RH, Ashina H, Al-Khazali HM, Zhang Y, Tolnai D, Poulsen AH, Cagol A, Hadjikhani N, Granziera C, Amin FM, et al. Differences in cortical morphology in people with and without migraine: a Registry for Migraine (REFORM) MRI study. Neurology. 2024;102:e209305.","journal-title":"Neurology"},{"key":"3367_CR13","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.nicl.2016.02.007","volume":"11","author":"A Hougaard","year":"2016","unstructured":"Hougaard A, Amin FM, Arngrim N, Vlachou M, Larsen VA, Larsson HBW, Ashina M. Sensory migraine aura is not associated with structural grey matter abnormalities. NeuroImage Clin. 2016;11:322\u20137.","journal-title":"NeuroImage Clin"},{"key":"3367_CR14","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1523\/ENEURO.0006-14.2014","volume":"1","author":"CS Hubbard","year":"2014","unstructured":"Hubbard CS, Khan SA, Keaser ML, Mathur VA, Goyal M, Seminowicz DA. Altered brain structure and function correlate with Disease Severity and Pain Catastrophizing in Migraine patients. eNeuro. 2014;1:e14\u201320.","journal-title":"eNeuro"},{"key":"3367_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s10194-016-0638-5","volume":"17","author":"M Curto","year":"2015","unstructured":"Curto M, Lionetto L, Negro A, Capi M, Fazio F, Giamberardino MA, Simmaco M, Nicoletti F, Martelletti P. Altered kynurenine pathway metabolites in serum of chronic migraine patients. J Headache Pain. 2015;17:47.","journal-title":"J Headache Pain"},{"key":"3367_CR16","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s10194-021-01239-1","volume":"22","author":"B Tuka","year":"2021","unstructured":"Tuka B, Ny\u00e1ri A, Cseh EK, K\u00f6rt\u00e9si T, Ver\u00e9b D, T\u00f6m\u00f6si F, Kecskem\u00e9ti G, Jan\u00e1ky T, Tajti J, V\u00e9csei L. Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period. J Headache Pain. 2021;22:60.","journal-title":"J Headache Pain"},{"key":"3367_CR17","doi-asserted-by":"publisher","first-page":"6099","DOI":"10.1111\/febs.16086","volume":"289","author":"MT Pallotta","year":"2022","unstructured":"Pallotta MT, Rossini S, Suvieri C, Coletti A, Orabona C, Macchiarulo A, Volpi C, Grohmann U. Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme. FEBS J. 2022;289:6099\u2013118.","journal-title":"FEBS J"},{"key":"3367_CR18","doi-asserted-by":"crossref","unstructured":"Jovanovic F, Candido KD, Knezevic NN. The role of the Kynurenine Signaling Pathway in different Chronic Pain conditions and potential use of Therapeutic agents. Int J Mol Sci. 2020; 21.","DOI":"10.3390\/ijms21176045"},{"key":"3367_CR19","doi-asserted-by":"crossref","unstructured":"Palego L, Betti L, Rossi A, Giannaccini G. Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and Medical Aspects in Humans. J Amino Acids. 2016; 2016: 8952520.","DOI":"10.1155\/2016\/8952520"},{"key":"3367_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuro.2021.03.009","volume":"84","author":"RK Sodhi","year":"2021","unstructured":"Sodhi RK, Bansal Y, Singh R, Saroj P, Bhandari R, Kumar B, Kuhad A. IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson\u2019s disease. Neurotoxicology. 2021;84:184\u201397.","journal-title":"Neurotoxicology"},{"key":"3367_CR21","doi-asserted-by":"publisher","first-page":"250574093","DOI":"10.1177\/15333175231214861","volume":"38","author":"ZZ Duan","year":"2023","unstructured":"Duan ZZ, Shi L, He ZNT, Kuang CX, Han TX, Yang Q. The protective effect of IDO1 inhibition in A\u03b2-Treated neurons and APP\/PS1 mice. Am J Alzheimers Dis Other Dement. 2023;38:250574093.","journal-title":"Am J Alzheimers Dis Other Dement"},{"key":"3367_CR22","doi-asserted-by":"publisher","first-page":"638854","DOI":"10.3389\/fncel.2021.638854","volume":"15","author":"N Deng","year":"2021","unstructured":"Deng N, Hu J, Hong Y, Ding YW, Xiong YF, Wu ZY, Xie W. Indoleamine-2,3-Dioxygenase 1 Deficiency suppresses seizures in Epilepsy. Front Cell Neurosci. 2021;15:638854.","journal-title":"Front Cell Neurosci"},{"key":"3367_CR23","doi-asserted-by":"crossref","unstructured":"Maganin AG, Souza GR, Fonseca MD, Lopes AH, Guimar\u00e3es RM, Dagostin A, Cecilio NT, Mendes AS, Gon\u00e7alves WA, Silva CE et al. Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice. J Clin Invest. 2022; 132.","DOI":"10.1172\/JCI153805"},{"key":"3367_CR24","doi-asserted-by":"publisher","first-page":"113926","DOI":"10.1016\/j.bcp.2020.113926","volume":"177","author":"Y Wang","year":"2020","unstructured":"Wang Y, Li CM, Han R, Wang ZZ, Gao YL, Zhu XY, Yu X, Du GY, Wang HB, Tian JW, et al. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem Pharmacol. 2020;177:113926.","journal-title":"Biochem Pharmacol"},{"key":"3367_CR25","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3389\/fphar.2018.00724","volume":"9","author":"E Rojewska","year":"2018","unstructured":"Rojewska E, Ciapa\u0142a K, Piotrowska A, Makuch W, Mika J. Pharmacological inhibition of indoleamine 2,3-Dioxygenase-2 and kynurenine 3-Monooxygenase, enzymes of the Kynurenine Pathway, significantly diminishes Neuropathic Pain in a rat model. Front Pharmacol. 2018;9:724.","journal-title":"Front Pharmacol"},{"key":"3367_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1742-2094-11-41","volume":"11","author":"W Xie","year":"2014","unstructured":"Xie W, Cai L, Yu YH, Gao L, Xiao LM, He QC, Ren ZJ, Liu YZ. Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy. J Neuroinflamm. 2014;11:41.","journal-title":"J Neuroinflamm"},{"key":"3367_CR27","doi-asserted-by":"crossref","unstructured":"Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O\u2019Loughlin K, Harutyunyan A, Mcfarlane C, Green CE, Madrid PB. Efficacy of Tilorone Dihydrochloride against Ebola Virus infection. Antimicrob Agents Chemother. 2018; 62.","DOI":"10.1128\/AAC.01711-17"},{"key":"3367_CR28","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.pain.2013.10.004","volume":"155","author":"AA Pradhan","year":"2014","unstructured":"Pradhan AA, Smith ML, Mcguire B, Tarash I, Evans CJ, Charles A. Characterization of a novel model of chronic migraine. Pain. 2014;155:269\u201374.","journal-title":"Pain"},{"key":"3367_CR29","doi-asserted-by":"publisher","first-page":"12793","DOI":"10.1038\/s41598-020-69669-6","volume":"10","author":"B Donmez-Demir","year":"2020","unstructured":"Donmez-Demir B, Erdener SE, Karatas H, Kaya Z, Ulusoy I, Dalkara T. KCl-induced cortical spreading depression waves more heterogeneously propagate than optogenetically-induced waves in lissencephalic brain: an analysis with optical flow tools. Sci Rep. 2020;10:12793.","journal-title":"Sci Rep"},{"key":"3367_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.brainres.2010.10.059","volume":"1368","author":"Z Dong","year":"2011","unstructured":"Dong Z, Jiang L, Wang XH, Wang XL, Yu SY. Nociceptive behaviors were induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats and reduced by morphine and rizatriptan benzoate. Brain Res. 2011;1368:151\u20138.","journal-title":"Brain Res"},{"key":"3367_CR31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jep.2019.03.026","volume":"237","author":"ZH Pu","year":"2019","unstructured":"Pu ZH, Peng C, Xie XF, Luo M, Zhu H, Feng R, Xiong L. Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun. J Ethnopharmacol. 2019;237:39\u201346.","journal-title":"J Ethnopharmacol"},{"key":"3367_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55\u201363.","journal-title":"J Neurosci Methods"},{"key":"3367_CR33","doi-asserted-by":"publisher","first-page":"114992","DOI":"10.1016\/j.jep.2022.114992","volume":"288","author":"CT Vong","year":"2022","unstructured":"Vong CT, Chen YL, Chen ZJ, Gao CF, Yang FQ, Wang SP, Wang YT. Classical prescription Dachuanxiong Formula delays nitroglycerin-induced pain response in migraine mice through reducing endothelin-1 level and regulating fatty acid biosynthesis. J Ethnopharmacol. 2022;288:114992.","journal-title":"J Ethnopharmacol"},{"key":"3367_CR34","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s13311-021-01168-6","volume":"19","author":"XH Su","year":"2022","unstructured":"Su XH, Li WP, Wang YJ, Liu J, Liu JY, Jiang Y, Peng FH. Chronic administration of 13-cis-retinoic acid induces Depression-Like Behavior by altering the activity of Dentate Granule cells. Neurotherapeutics. 2022;19:421\u201333.","journal-title":"Neurotherapeutics"},{"key":"3367_CR35","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.biopsych.2022.04.019","volume":"92","author":"WP Li","year":"2022","unstructured":"Li WP, Su XH, Hu NY, Hu J, Li XW, Yang JM, Gao TM. Astrocytes mediate cholinergic regulation of adult hippocampal neurogenesis and memory through M1 muscarinic receptor. Biol Psychiatry. 2022;92:984\u201398.","journal-title":"Biol Psychiatry"},{"key":"3367_CR36","doi-asserted-by":"crossref","unstructured":"Schafer DP, Lehrman EK, Heller CT, Stevens B. An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. J Vis Exp. 2014.","DOI":"10.3791\/51482"},{"key":"3367_CR37","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1515\/revneuro-2023-0037","volume":"34","author":"DD Yao","year":"2023","unstructured":"Yao DD, Chen YR, Chen G. The role of pain modulation pathway and related brain regions in pain. Rev Neurosci. 2023;34:899\u2013914.","journal-title":"Rev Neurosci"},{"key":"3367_CR38","doi-asserted-by":"publisher","first-page":"578180","DOI":"10.1016\/j.jneuroim.2023.578180","volume":"383","author":"K Biswas","year":"2023","unstructured":"Biswas K. Microglia mediated neuroinflammation in neurodegenerative diseases: a review on the cell signaling pathways involved in microglial activation. J Neuroimmunol. 2023;383:578180.","journal-title":"J Neuroimmunol"},{"key":"3367_CR39","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.it.2015.08.008","volume":"36","author":"YW Wu","year":"2015","unstructured":"Wu YW, Dissing-Olesen L, Macvicar BA, Stevens B, Microglia. Dynamic mediators of Synapse Development and Plasticity. Trends Immunol. 2015;36:605\u201313.","journal-title":"Trends Immunol"},{"key":"3367_CR40","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","volume":"352","author":"S Hong","year":"2016","unstructured":"Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016;352:712\u20136.","journal-title":"Science"},{"key":"3367_CR41","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3389\/fimmu.2017.00873","volume":"8","author":"N Kopitar-Jerala","year":"2017","unstructured":"Kopitar-Jerala N. The role of interferons in inflammation and inflammasome activation. Front Immunol. 2017;8:873.","journal-title":"Front Immunol"},{"key":"3367_CR42","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.biopsych.2014.08.004","volume":"77","author":"F Barthas","year":"2015","unstructured":"Barthas F, Sellmeijer J, Hugel S, Waltisperger E, Barrot M, Yalcin I. The anterior cingulate cortex is a critical hub for pain-induced depression. Biol Psychiatry. 2015;77:236\u201345.","journal-title":"Biol Psychiatry"},{"key":"3367_CR43","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neuron.2014.12.021","volume":"85","author":"K Koga","year":"2015","unstructured":"Koga K, Descalzi G, Chen T, Ko HG, Lu JS, Li S, Son JH, Kim T, Kwak C, Huganir RL, et al. Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron. 2015;85:377\u201389.","journal-title":"Neuron"},{"key":"3367_CR44","doi-asserted-by":"crossref","unstructured":"Caston RM, Smith EH, Davis TS, Singh H, Rahimpour S, Rolston JD. Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulation. medRxiv [Preprint]; 2023.","DOI":"10.1101\/2023.03.18.23287266"},{"key":"3367_CR45","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/pm\/pnac135","volume":"24","author":"HY Xiong","year":"2023","unstructured":"Xiong HY, Cao YQ, Du SH, Yang QH, He SY, Wang XQ. Effects of High-Definition Transcranial Direct Current Stimulation Targeting the Anterior Cingulate Cortex on the Pain thresholds: a Randomized Controlled Trial. Pain Med. 2023;24:89\u201398.","journal-title":"Pain Med"},{"key":"3367_CR46","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1097\/j.pain.0000000000000951","volume":"158","author":"Y Wang","year":"2017","unstructured":"Wang Y, Cao DY, Remeniuk B, Krimmel S, Seminowicz DA, Zhang M. Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia. Pain. 2017;158:1561\u201370.","journal-title":"Pain"},{"key":"3367_CR47","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s10194-016-0698-6","volume":"17","author":"B Chen","year":"2016","unstructured":"Chen B, He Y, Xia L, Guo LL, Zheng JL. Cortical plasticity between the pain and pain-free phases in patients with episodic tension-type headache. J Headache Pain. 2016;17:105.","journal-title":"J Headache Pain"},{"key":"3367_CR48","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1744-8069-6-62","volume":"6","author":"K Koga","year":"2010","unstructured":"Koga K, Li XY, Chen T, Steenland HW, Descalzi G, Zhuo M. In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice. Mol Pain. 2010;6:62.","journal-title":"Mol Pain"},{"key":"3367_CR49","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13041-015-0170-6","volume":"8","author":"SJ Kang","year":"2015","unstructured":"Kang SJ, Kwak C, Lee J, Sim S, Shim J, Choi T, Collingridge GL, Zhuo M, Kaang B. Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACC. Mol Brain. 2015;8:81.","journal-title":"Mol Brain"},{"key":"3367_CR50","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1126\/science.1191792","volume":"330","author":"XY Li","year":"2010","unstructured":"Li XY, Ko HG, Chen T, Descalzi G, Koga K, Wang HS, Kim SS, Shang YZ, Kwak C, Park SW, et al. Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science. 2010;330:1400\u20134.","journal-title":"Science"},{"key":"3367_CR51","doi-asserted-by":"publisher","first-page":"20130146","DOI":"10.1098\/rstb.2013.0146","volume":"369","author":"M Zhuo","year":"2014","unstructured":"Zhuo M. Long-term potentiation in the anterior cingulate cortex and chronic pain. Philos Trans R Soc B Biol Sci. 2014;369:20130146.","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"3367_CR52","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1038\/s42255-022-00688-5","volume":"4","author":"HD Tang","year":"2022","unstructured":"Tang HD, Dong WY, Hu R, Huang JY, Huang ZH, Xiong W, Xue T, Liu J, Yu JM, Zhu X, et al. A neural circuit for the suppression of feeding under persistent pain. Nat Metab. 2022;4:1746\u201355.","journal-title":"Nat Metab"},{"key":"3367_CR53","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nrd3793","volume":"12","author":"L V\u00e9csei","year":"2013","unstructured":"V\u00e9csei L, Szal\u00e1rdy L, F\u00fcl\u00f6p F, Toldi J. Kynurenines in the CNS: recent advances and new questions. Nat Rev Drug Discov. 2013;12:64\u201382.","journal-title":"Nat Rev Drug Discov"},{"key":"3367_CR54","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1172\/JCI61884","volume":"122","author":"H Kim","year":"2012","unstructured":"Kim H, Chen L, Lim G, Sung B, Wang SX, Mccabe MF, Rusanescu G, Yang LL, Tian YH, Mao JR. Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. J Clin Invest. 2012;122:2940\u201354.","journal-title":"J Clin Invest"},{"key":"3367_CR55","doi-asserted-by":"publisher","first-page":"100105","DOI":"10.1016\/j.ynpai.2022.100105","volume":"12","author":"P Sureda-Gibert","year":"2022","unstructured":"Sureda-Gibert P, Romero-Reyes M, Akerman S. Nitroglycerin as a model of migraine: clinical and preclinical review. Neurobiol Pain. 2022;12:100105.","journal-title":"Neurobiol Pain"},{"key":"3367_CR56","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1111\/bph.12591","volume":"171","author":"AA Pradhan","year":"2014","unstructured":"Pradhan AA, Smith ML, Zyuzin J, Charles A. \u03b4-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. Br J Pharmacol. 2014;171:2375\u201384.","journal-title":"Br J Pharmacol"},{"key":"3367_CR57","doi-asserted-by":"crossref","unstructured":"Kitamura E, Imai N. Molecular and Cellular Neurobiology of spreading Depolarization\/Depression and migraine: a narrative review. Int J Mol Sci. 2024; 25.","DOI":"10.3390\/ijms252011163"},{"key":"3367_CR58","doi-asserted-by":"publisher","first-page":"11408","DOI":"10.1038\/s41598-020-67948-w","volume":"10","author":"C Tang","year":"2020","unstructured":"Tang C, Unekawa M, Kitagawa S, Takizawa T, Kayama Y, Nakahara J, Shibata M. Cortical spreading depolarisation-induced facial hyperalgesia, photophobia and hypomotility are ameliorated by sumatriptan and olcegepant. Sci Rep. 2020;10:11408.","journal-title":"Sci Rep"},{"key":"3367_CR59","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0143-4179(90)90114-E","volume":"16","author":"AS Zagami","year":"1990","unstructured":"Zagami AS, Goadsby PJ, Edvinsson L. Stimulation of the superior sagittal sinus in the cat causes release of vasoactive peptides. Neuropeptides. 1990;16:69\u201375.","journal-title":"Neuropeptides"},{"key":"3367_CR60","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s10194-023-01582-5","volume":"24","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Wang H, Sun YF, Huang ZT, Tao Y, Wang YR, Jiang XH, Tao J. Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors. J Headache Pain. 2023;24:49.","journal-title":"J Headache Pain"},{"key":"3367_CR61","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.neuron.2018.11.009","volume":"100","author":"G Chen","year":"2018","unstructured":"Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR. Microglia in Pain: detrimental and protective roles in Pathogenesis and Resolution of Pain. Neuron. 2018;100:1292\u2013311.","journal-title":"Neuron"},{"key":"3367_CR62","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/bja\/aex006","volume":"118","author":"H Zhao","year":"2017","unstructured":"Zhao H, Alam A, Chen Q, A Eusman M, Pal A, Eguchi S, Wu L, Ma D. The role of microglia in the pathobiology of neuropathic pain development: what do we know? Br J Anaesth. 2017;118:504\u201316.","journal-title":"Br J Anaesth"},{"key":"3367_CR63","doi-asserted-by":"publisher","first-page":"578118","DOI":"10.1016\/j.jneuroim.2023.578118","volume":"381","author":"W He","year":"2023","unstructured":"He W, Wang YY, Zhang YX, Zhang YN, Zhou JY. The status of knowledge on migraines: the role of microglia. J Neuroimmunol. 2023;381:578118.","journal-title":"J Neuroimmunol"},{"key":"3367_CR64","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jphs.2017.05.010","volume":"134","author":"K Miyamoto","year":"2017","unstructured":"Miyamoto K, Kume K, Ohsawa M. Role of microglia in mechanical allodynia in the anterior cingulate cortex. J Pharmacol Sci. 2017;134:158\u201365.","journal-title":"J Pharmacol Sci"},{"key":"3367_CR65","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bbi.2022.12.019","volume":"109","author":"J Wang","year":"2023","unstructured":"Wang J, Chen HS, Li HH, Wang HJ, Zou RS, Lu XJ, Wang J, Nie BB, Wu JF, Li S, et al. Microglia-dependent excessive synaptic pruning leads to cortical underconnectivity and behavioral abnormality following chronic social defeat stress in mice. Brain Behav Immun. 2023;109:23\u201336.","journal-title":"Brain Behav Immun"},{"key":"3367_CR66","doi-asserted-by":"crossref","unstructured":"Cao P, Chen CM, Liu A, Shan QH, Zhu X, Jia CH, Peng XQ, Zhang M, Farzinpour Z, Zhou WJ et al. Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. Neuron. 2021; 109.","DOI":"10.1016\/j.neuron.2021.06.012"},{"key":"3367_CR67","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.7150\/thno.65427","volume":"12","author":"K Sundaram","year":"2022","unstructured":"Sundaram K, Mu JY, Kumar A, Behera J, Lei C, Sriwastva MK, Xu FY, Dryden GW, Zhang LF, Chen SY, et al. Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut\/brain axis. Theranostics. 2022;12:1220\u201346.","journal-title":"Theranostics"},{"key":"3367_CR68","doi-asserted-by":"publisher","first-page":"339","DOI":"10.7150\/ijbs.51241","volume":"17","author":"SL Yang","year":"2021","unstructured":"Yang SL, Tan HX, Niu TT, Liu YK, Gu CJ, Li DJ, Li MQ, Wang HY. The IFN-\u03b3-IDO1-kynureine pathway-induced autophagy in cervical cancer cell promotes phagocytosis of macrophage. Int J Biol Sci. 2021;17:339\u201352.","journal-title":"Int J Biol Sci"},{"key":"3367_CR69","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.tins.2022.10.007","volume":"45","author":"O Kann","year":"2022","unstructured":"Kann O, Almouhanna F, Chausse B. Interferon \u03b3: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration. Trends Neurosci. 2022;45:913\u201327.","journal-title":"Trends Neurosci"},{"key":"3367_CR70","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.tins.2023.08.008","volume":"46","author":"LM Wangler","year":"2023","unstructured":"Wangler LM, Godbout JP. Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity. Trends Neurosci. 2023;46:926\u201340.","journal-title":"Trends Neurosci"},{"key":"3367_CR71","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1136\/jnnp-2015-312233","volume":"87","author":"MT Minen","year":"2016","unstructured":"Minen MT, De Begasse O, Van Kroon A, Powers S, Schwedt TJ, Lipton R, Silbersweig D. Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry. 2016;87:741\u20139.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3367_CR72","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1177\/014107689408700613","volume":"87","author":"J Devlen","year":"1994","unstructured":"Devlen J. Anxiety and depression in migraine. J R Soc Med. 1994;87:338\u201341.","journal-title":"J R Soc Med"},{"key":"3367_CR73","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s12264-021-00800-x","volume":"38","author":"D Ren","year":"2022","unstructured":"Ren D, Li JN, Qiu XT, Wan FP, Wu ZY, Fan BY, Zhang MM, Chen T, Li H, Bai Y, et al. Anterior cingulate cortex mediates hyperalgesia and anxiety Induced by Chronic Pancreatitis in rats. Neurosci Bull. 2022;38:342\u201358.","journal-title":"Neurosci Bull"},{"key":"3367_CR74","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jneuroim.2017.10.016","volume":"313","author":"SW Jeon","year":"2017","unstructured":"Jeon SW, Kim Y. Inflammation-induced depression: its pathophysiology and therapeutic implications. J Neuroimmunol. 2017;313:92\u20138.","journal-title":"J Neuroimmunol"},{"key":"3367_CR75","doi-asserted-by":"publisher","first-page":"571","DOI":"10.2174\/13894501113149990154","volume":"14","author":"M Catena-Dell\u2019Osso","year":"2013","unstructured":"Catena-Dell\u2019Osso M, Rotella F, Dell\u2019Osso A, Fagiolini A, Marazziti D. Inflammation, serotonin and major depression. Curr Drug Targets. 2013;14:571\u20137.","journal-title":"Curr Drug Targets"},{"key":"3367_CR76","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0166-4328(01)00452-1","volume":"134","author":"V Carola","year":"2002","unstructured":"Carola V, D\u2019Olimpio F, Brunamonti E, Mangia F, Renzi P. Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav Brain Res. 2002;134:49\u201357.","journal-title":"Behav Brain Res"},{"key":"3367_CR77","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1001\/jama.2023.5536","volume":"329","author":"R Marcus","year":"2023","unstructured":"Marcus R. Study provides New Insight into Female Sex hormones and migraines. JAMA. 2023;329:1439\u201340.","journal-title":"JAMA"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03367-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-025-03367-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03367-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T08:51:46Z","timestamp":1739868706000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-025-03367-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3367"],"URL":"https:\/\/doi.org\/10.1186\/s12974-025-03367-w","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]},"assertion":[{"value":"4 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental procedures were approved by the Institutional Animal Care and Use Committee of Southern Medical University (L-2019-071, Guangdong, China).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"42"}}