{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:02:11Z","timestamp":1790910131151,"version":"4.1.0"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN213522"],"award-info":[{"award-number":["IN213522"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN216922"],"award-info":[{"award-number":["IN216922"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN217822"],"award-info":[{"award-number":["IN217822"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas, M\u00e9xico","award":["CONAHCYT 425859"],"award-info":[{"award-number":["CONAHCYT 425859"]}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas, M\u00e9xico","award":["CF\/2019-40792"],"award-info":[{"award-number":["CF\/2019-40792"]}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas, M\u00e9xico","award":["IFC 2016-2282"],"award-info":[{"award-number":["IFC 2016-2282"]}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas, M\u00e9xico, CONAHCYT","award":["CBF2023-2024-878"],"award-info":[{"award-number":["CBF2023-2024-878"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-025-03426-2","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T03:31:43Z","timestamp":1750303903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer\u2019s disease"],"prefix":"10.1186","volume":"22","author":[{"given":"Bolivar","family":"Arcos-Encarnaci\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eladio","family":"Cortes-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Bar\u00f3n-Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Luis","family":"Almaz\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Valle-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"D\u00edaz de Le\u00f3n-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Hovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla F.","family":"Meza-Sosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nohemi","family":"Camacho-Concha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeovanis","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke Lydia","family":"Kuijjer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliesha","family":"Gonz\u00e1lez-Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Encarnaci\u00f3n-Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Pedraza-Alva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"3426_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","volume":"17","author":"H Kadry","year":"2020","unstructured":"Kadry H, Noorani B, Cucullo L. A blood\u2013brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS. 2020;17:69.","journal-title":"Fluids Barriers CNS"},{"key":"3426_CR2","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1089\/neu.2019.6963","volume":"37","author":"V Chaban","year":"2020","unstructured":"Chaban V, Clarke GJB, Skandsen T, Islam R, Einarsen CE, Vik A, et al. Systemic inflammation persists the first year after mild traumatic brain injury: results from the prospective Trondheim mild traumatic brain injury study. J Neurotrauma. 2020;37:2120\u201330.","journal-title":"J Neurotrauma"},{"key":"3426_CR3","unstructured":"Javaid SF. Data from the United Nations Program on Aging and the US Centers for Disease Control and Prevention project a substantial increase in the global elderly population. 2021."},{"key":"3426_CR4","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/alz.13020","volume":"19","author":"CM Kloske","year":"2023","unstructured":"Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, et al. APOE and immunity: research highlights. Alzheimer\u2019s Dementia. 2023;19:2677\u201396.","journal-title":"Alzheimer\u2019s Dementia"},{"key":"3426_CR5","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00702-010-0438-z","volume":"117","author":"MT Heneka","year":"2010","unstructured":"Heneka MT, O\u2019Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer\u2019s disease. J Neural Transm. 2010;117:919\u201347.","journal-title":"J Neural Transm"},{"key":"3426_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1471-4159.2011.07519.x","volume":"120","author":"H Zhang","year":"2012","unstructured":"Zhang H, Ma Q, Zhang Y, Xu H. Proteolytic processing of Alzheimer\u2019s \u03b2-amyloid precursor protein. J Neurochem. 2012;120:9\u201321.","journal-title":"J Neurochem"},{"key":"3426_CR7","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/jnc.12675","volume":"129","author":"E Dawkins","year":"2014","unstructured":"Dawkins E, Small DH. Insights into the physiological function of the \u03b2-amyloid precursor protein: beyond Alzheimer\u2019s disease. J Neurochem. 2014;129:756\u201369.","journal-title":"J Neurochem"},{"key":"3426_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","volume":"7","author":"DS Knopman","year":"2021","unstructured":"Knopman DS, Amieva H, Petersen RC, Ch\u00e9telat G, Holtzman DM, Hyman BT, et al. Alzheimer disease. Nat Rev Dis Primers. 2021;7:33.","journal-title":"Nat Rev Dis Primers"},{"key":"3426_CR9","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.ygeno.2005.07.001","volume":"86","author":"P Pruunsild","year":"2005","unstructured":"Pruunsild P, Timmusk T. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. Genomics. 2005;86:581\u201393.","journal-title":"Genomics"},{"key":"3426_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/mcne.2000.0913","volume":"17","author":"F Spreafico","year":"2001","unstructured":"Spreafico F, Barski JJ, Farina C, Meyer M. Mouse DREAM\/Calsenilin\/KChIP3: gene structure, coding potential, and expression. Mol Cell Neurosci. 2001;17:1\u201316.","journal-title":"Mol Cell Neurosci"},{"key":"3426_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/35000592","volume":"403","author":"WF An","year":"2000","unstructured":"An WF, Bowlby MR, Betty M, Cao J, Ling H-P, Mendoza G, et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000;403:553\u20136.","journal-title":"Nature"},{"key":"3426_CR12","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1038\/2673","volume":"4","author":"JD Buxbaum","year":"1998","unstructured":"Buxbaum JD, Choi E-K, Luo Y, Lilliehook C, Crowley AC, Merriam DE, et al. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998;4:1177\u201381.","journal-title":"Nat Med"},{"key":"3426_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-011-4196-4","author":"M Rivas","year":"2011","unstructured":"Rivas M, Villar D, Gonz\u00e1lez P, Dopazo XM, Mellstrom B, Naranjo JR. Building the DREAM interactome. Sci China Life Sci. 2011. https:\/\/doi.org\/10.1007\/s11427-011-4196-4.","journal-title":"Sci China Life Sci"},{"key":"3426_CR14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0306-4522(02)00251-8","volume":"114","author":"NF Zaidi","year":"2002","unstructured":"Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, et al. Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience. 2002;114:247\u201363.","journal-title":"Neuroscience"},{"key":"3426_CR15","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/18044","volume":"398","author":"AM Carri\u00f3n","year":"1999","unstructured":"Carri\u00f3n AM, Link WA, Ledo F, Mellstr\u00f6m B, Naranjo JR. DREAM is a Ca2+-regulated transcriptional repressor. Nature. 1999;398:80\u20134.","journal-title":"Nature"},{"key":"3426_CR16","doi-asserted-by":"publisher","first-page":"9120","DOI":"10.1128\/MCB.20.24.9120-9126.2000","volume":"20","author":"F Ledo","year":"2000","unstructured":"Ledo F, Carri\u00f3n AM, Link WA, Mellstr\u00f6m B, Naranjo JR. DREAM-\u03b1CREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. Mol Cell Biol. 2000;20:9120\u20136.","journal-title":"Mol Cell Biol"},{"key":"3426_CR17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1615\/CritRevNeurobiol.v16.i12.40","volume":"16","author":"B Mellstrom","year":"2004","unstructured":"Mellstrom B, Torres B, Link WA, Naranjo JR. The BDNF gene: exemplifying complexity in Ca2+-dependent gene expression. Crit Rev Neurobiol. 2004;16:43\u201350.","journal-title":"Crit Rev Neurobiol"},{"key":"3426_CR18","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.bbamcr.2010.11.001","volume":"1813","author":"M Palczewska","year":"2011","unstructured":"Palczewska M, Casafont I, Ghimire K, Rojas AM, Valencia A, Lafarga M, et al. Sumoylation regulates nuclear localization of repressor DREAM. Biochim Biophys Acta Mol Cell Res. 2011;1813:1050\u20138.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"3426_CR19","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1111\/j.1471-4159.2004.02375.x","volume":"88","author":"DG Jo","year":"2004","unstructured":"Jo DG, Lee JY, Hong YM, Song S, Inhee MJ, Koh JY, et al. Induction of pro-apoptotic calsenilin\/DREAM\/KChIP3 in Alzheimer\u2019s disease and cultured neurons after amyloid-?? exposure. J Neurochem. 2004;88:1570.","journal-title":"J Neurochem"},{"key":"3426_CR20","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1096\/fj.00-0541fje","volume":"15","author":"D Jo","year":"2001","unstructured":"Jo D, Kim M, Choi Y, Kim I, Song Y, Woo H, et al. Pro-apoptotic function of calsenilin\/DREAM\/KChIP3. FASEB J. 2001;15:589\u201391.","journal-title":"FASEB J"},{"key":"3426_CR21","doi-asserted-by":"publisher","first-page":"9097","DOI":"10.1523\/JNEUROSCI.23-27-09097.2003","volume":"23","author":"C Lilliehook","year":"2003","unstructured":"Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, et al. Altered A\u03b2 formation and long-term potentiation in a Calsenilin knock-out. J Neurosci. 2003;23:9097\u2013106.","journal-title":"J Neurosci"},{"key":"3426_CR22","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/jnr.24130","volume":"96","author":"L \u00c1lvarez-Arellano","year":"2018","unstructured":"\u00c1lvarez-Arellano L, Pedraza-Escalona M, Blanco-Ayala T, Camacho-Concha N, Cort\u00e9s-Mendoza J, P\u00e9rez-Mart\u00ednez L, et al. Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to \u03b2-Amyloid peptide accumulation. J Neurosci Res. 2018;96:234\u201346.","journal-title":"J Neurosci Res"},{"key":"3426_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41582-022-00749-z","volume":"19","author":"M Tzioras","year":"2023","unstructured":"Tzioras M, McGeachan RI, Durrant CS, Spires-Jones TL. Synaptic degeneration in Alzheimer disease. Nat Rev Neurol. 2023;19:19\u201338.","journal-title":"Nat Rev Neurol"},{"key":"3426_CR24","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.bbrc.2019.06.134","volume":"516","author":"D Feng","year":"2019","unstructured":"Feng D, Huang A, Yan W, Chen D. CD200 dysfunction in neuron contributes to synaptic deficits and cognitive impairment. Biochem Biophys Res Commun. 2019;516:1053\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"3426_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1101\/lm.1261709","volume":"16","author":"JC Alexander","year":"2009","unstructured":"Alexander JC, McDermott CM, Tunur T, Rands V, Stelly C, Karhson D, et al. The role of calsenilin\/DREAM\/KChIP3 in contextual fear conditioning. Learn Mem. 2009;16:167\u201377.","journal-title":"Learn Mem"},{"key":"3426_CR26","volume-title":"The mouse brain in stereotaxic coordinates. Fourth","author":"P George","year":"2013","unstructured":"George P, Keith F. The mouse brain in stereotaxic coordinates. Fourth. Amsterdam: Elsevier; 2013."},{"key":"3426_CR27","doi-asserted-by":"publisher","first-page":"18129","DOI":"10.1074\/jbc.M117.784546","volume":"292","author":"J Gil","year":"2017","unstructured":"Gil J, Ram\u00edrez-Torres A, Chiappe D, Luna-Pen\u00e3loza J, Fernandez-Reyes FC, Arcos-Encarnaci\u00f3n B, et al. Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells. J Biol Chem. 2017;292:18129.","journal-title":"J Biol Chem"},{"key":"3426_CR28","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1002\/cyto.a.20954","volume":"77A","author":"CG Langhammer","year":"2010","unstructured":"Langhammer CG, Previtera ML, Sweet ES, Sran SS, Chen M, Firestein BL. Automated Sholl analysis of digitized neuronal morphology at multiple scales: Whole cell Sholl analysis versus Sholl analysis of arbor subregions. Cytometry A. 2010;77A:1160\u20138.","journal-title":"Cytometry A"},{"key":"3426_CR29","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1523\/JNEUROSCI.2774-16.2016","volume":"37","author":"GA Prieto","year":"2017","unstructured":"Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, et al. Pharmacological rescue of long-term potentiation in Alzheimer diseased synapses. J Neurosci. 2017;37:1197\u2013212.","journal-title":"J Neurosci"},{"key":"3426_CR30","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1038\/nprot.2013.155","volume":"8","author":"M Leger","year":"2013","unstructured":"Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, et al. Object recognition test in mice. Nat Protoc. 2013;8:2531\u20137.","journal-title":"Nat Protoc"},{"key":"3426_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0092-8674(01)00629-8","volume":"108","author":"H-YM Cheng","year":"2002","unstructured":"Cheng H-YM, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, et al. DREAM is a critical transcriptional repressor for pain modulation. Cell. 2002;108:31\u201343.","journal-title":"Cell"},{"key":"3426_CR32","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/00001756-200504040-00007","volume":"16","author":"J-K Jin","year":"2005","unstructured":"Jin J-K, Choi J-K, Wasco W, Buxbaum JD, Kozlowski PB, Carp RI, et al. Expression of calsenilin in neurons and astrocytes in the Alzheimer??s disease brain. NeuroReport. 2005;16:451\u20135.","journal-title":"NeuroReport"},{"key":"3426_CR33","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, et al. NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature. 2013;493:674\u20138.","journal-title":"Nature"},{"key":"3426_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0006-291X(03)00688-0","volume":"305","author":"D-G Jo","year":"2003","unstructured":"Jo D-G, Chang J-W, Hong H-S, Mook-Jung I, Jung Y-K. Contribution of presenilin\/\u03b3-secretase to calsenilin-mediated apoptosis. Biochem Biophys Res Commun. 2003;305:62\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"3426_CR35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41597-021-01054-y","volume":"8","author":"S Forner","year":"2021","unstructured":"Forner S, Kawauchi S, Balderrama-Gutierrez G, Kram\u00e1r EA, Matheos DP, Phan J, et al. Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer\u2019s disease. Sci Data. 2021;8:270.","journal-title":"Sci Data"},{"key":"3426_CR36","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/ni.2823","volume":"15","author":"C Tiruppathi","year":"2014","unstructured":"Tiruppathi C, Soni D, Wang D-M, Xue J, Singh V, Thippegowda PB, et al. The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nat Immunol. 2014;15:239\u201347.","journal-title":"Nat Immunol"},{"key":"3426_CR37","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","volume":"173","author":"A Deczkowska","year":"2018","unstructured":"Deczkowska A, Keren-Shaul H, Weiner A, Colonna M, Schwartz M, Amit I. Disease-associated microglia: a universal immune sensor of neurodegeneration. Cell. 2018;173:1073\u201381.","journal-title":"Cell"},{"key":"3426_CR38","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1523\/JNEUROSCI.4965-11.2013","volume":"33","author":"DM Taylor","year":"2013","unstructured":"Taylor DM, Moser R, R\u00e9gulier E, Breuillaud L, Dixon M, Beesen AA, et al. MAP kinase phosphatase 1 (MKP-1\/DUSP1) is neuroprotective in Huntington\u2019s disease via additive effects of JNK and p38 inhibition. J Neurosci. 2013;33:2313\u201325.","journal-title":"J Neurosci"},{"key":"3426_CR39","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1128\/MCB.00360-13","volume":"34","author":"B Mellstr\u00f6m","year":"2014","unstructured":"Mellstr\u00f6m B, Sah\u00fan I, Ruiz-Nu\u00f1o A, Murtra P, Gomez-Villafuertes R, Savignac M, et al. DREAM controls the on\/off switch of specific activity-dependent transcription pathways. Mol Cell Biol. 2014;34:877\u201387.","journal-title":"Mol Cell Biol"},{"key":"3426_CR40","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Carson MJ, El KJ, Landreth GE, Brosseron F, Feinstein DL, et al. Neuroinflammation in Alzheimer\u2019s disease. Lancet Neurol. 2015;14:388\u2013405.","journal-title":"Lancet Neurol"},{"key":"3426_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00625","author":"P Edison","year":"2018","unstructured":"Edison P, Donat CK, Sastre M. In vivo imaging of glial activation in Alzheimer\u2019s disease. Front Neurol. 2018. https:\/\/doi.org\/10.3389\/fneur.2018.00625.","journal-title":"Front Neurol"},{"key":"3426_CR42","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.pnpbp.2005.01.018","volume":"29","author":"RHM Salama","year":"2005","unstructured":"Salama RHM, Muramatsu H, Shimizu E, Hashimoto K, Ohgake S, Watanabe H, et al. Increased midkine levels in sera from patients with Alzheimer\u2019s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:611\u20136.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3426_CR43","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.cell.2013.10.037","volume":"155","author":"R Guerreiro","year":"2013","unstructured":"Guerreiro R, Br\u00e1s J, Hardy J. SnapShot: genetics of Alzheimer\u2019s disease. Cell. 2013;155:968-968.e1.","journal-title":"Cell"},{"key":"3426_CR44","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13073-023-01155-w","volume":"15","author":"M Jorfi","year":"2023","unstructured":"Jorfi M, Maaser-Hecker A, Tanzi RE. The neuroimmune axis of Alzheimer\u2019s disease. Genome Med. 2023;15:6.","journal-title":"Genome Med"},{"key":"3426_CR45","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13195-021-00804-9","volume":"13","author":"C Cicognola","year":"2021","unstructured":"Cicognola C, Janelidze S, Hertze J, Zetterberg H, Blennow K, Mattsson-Carlgren N, et al. Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment. Alzheimers Res Ther. 2021;13:68.","journal-title":"Alzheimers Res Ther"},{"key":"3426_CR46","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1172\/JCI7208","volume":"105","author":"M Horiba","year":"2000","unstructured":"Horiba M, Kadomatsu K, Nakamura E, Muramatsu H, Ikematsu S, Sakuma S, et al. Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J Clin Investig. 2000;105:489\u201395.","journal-title":"J Clin Investig"},{"key":"3426_CR47","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1182\/blood-2013-06-510875","volume":"123","author":"LT Weckbach","year":"2014","unstructured":"Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, et al. The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via \u03b22 integrins (CD11\/CD18). Blood. 2014;123:1887\u201396.","journal-title":"Blood"},{"issue":"257","key":"3426_CR48","first-page":"255","volume":"1992","author":"MK Bennett","year":"1979","unstructured":"Bennett MK, Calakos N, Scheller RH. Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science. 1979;1992(257):255\u20139.","journal-title":"Science"},{"key":"3426_CR49","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1093\/bib\/bbr042","volume":"12","author":"P Gaudet","year":"2011","unstructured":"Gaudet P, Livstone MS, Lewis SE, Thomas PD. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011;12:449\u201362.","journal-title":"Brief Bioinform"},{"key":"3426_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2021.661681","author":"A Le\u00f3n","year":"2021","unstructured":"Le\u00f3n A, Aparicio GI, Scorticati C. Neuronal glycoprotein M6a: an emerging molecule in chemical synapse formation and dysfunction. Front Synaptic Neurosci. 2021. https:\/\/doi.org\/10.3389\/fnsyn.2021.661681.","journal-title":"Front Synaptic Neurosci"},{"key":"3426_CR51","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1091\/mbc.e03-07-0493","volume":"15","author":"C Gauthier-Campbell","year":"2004","unstructured":"Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini AE-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004;15:2205\u201317.","journal-title":"Mol Biol Cell"},{"key":"3426_CR52","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.1523\/JNEUROSCI.4814-07.2008","volume":"28","author":"T Bolmont","year":"2008","unstructured":"Bolmont T, Haiss F, Eicke D, Radde R, Mathis CA, Klunk WE, et al. Dynamics of the microglial\/amyloid interaction indicate a role in plaque maintenance. J Neurosci. 2008;28:4283\u201392.","journal-title":"J Neurosci"},{"key":"3426_CR53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ni.1836","volume":"11","author":"CR Stewart","year":"2010","unstructured":"Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155\u201361.","journal-title":"Nat Immunol"},{"key":"3426_CR54","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1016\/j.neurobiolaging.2015.07.027","volume":"36","author":"MM Varnum","year":"2015","unstructured":"Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer\u2019s disease. Neurobiol Aging. 2015;36:2995\u20133007.","journal-title":"Neurobiol Aging"},{"key":"3426_CR55","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/ana.25049","volume":"82","author":"BD Boros","year":"2017","unstructured":"Boros BD, Greathouse KM, Gentry EG, Curtis KA, Birchall EL, Gearing M, et al. Dendritic spines provide cognitive resilience against Alzheimer\u2019s disease. Ann Neurol. 2017;82:602\u201314.","journal-title":"Ann Neurol"},{"key":"3426_CR56","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0006-8993(91)90493-F","volume":"540","author":"SD Hanks","year":"1991","unstructured":"Hanks SD, Flood DG. Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer\u2019s disease. I. CA1 of hippocampus. Brain Res. 1991;540:63\u201382.","journal-title":"Brain Res"},{"key":"3426_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00285","author":"KM O\u2019Neill","year":"2015","unstructured":"O\u2019Neill KM, Akum BF, Dhawan ST, Kwon M, Langhammer CG, Firestein BL. Assessing effects on dendritic arborization using novel Sholl analyses. Front Cell Neurosci. 2015. https:\/\/doi.org\/10.3389\/fncel.2015.00285.","journal-title":"Front Cell Neurosci"},{"key":"3426_CR58","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/1098-1063(2000)10:5<596::AID-HIPO10>3.0.CO;2-Y","volume":"10","author":"D Muller","year":"2000","unstructured":"Muller D, Toni N, Buchs PA. Spine changes associated with long-term potentiation. Hippocampus. 2000;10:596\u2013604.","journal-title":"Hippocampus"},{"key":"3426_CR59","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1126\/science.1128134","volume":"313","author":"JR Whitlock","year":"2006","unstructured":"Whitlock JR, Heynen AJ, Shuler MG, Bear MF. Learning induces long-term potentiation in the hippocampus. Science. 2006;313:1093\u20137.","journal-title":"Science"},{"key":"3426_CR60","doi-asserted-by":"publisher","unstructured":"Marcatti M, Fracassi A, Montalbano M, Natarajan C, Krishnan B, Kayed R, Taglialatela G. A\u03b2\/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer's disease. Cellular and molecular life sciences. 2022;79:4. https:\/\/doi.org\/10.1007\/s00018-022-04255-9.","DOI":"10.1007\/s00018-022-04255-9"},{"key":"3426_CR61","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1098\/rstb.2002.1222","volume":"358","author":"WC Abraham","year":"2003","unstructured":"Abraham WC. How long will long-term potentiation last? Philos Trans R Soc Lond B Biol Sci. 2003;358:735\u201344.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"3426_CR62","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3390\/biomedicines11020599","volume":"11","author":"CQ S\u00e1nchez","year":"2023","unstructured":"S\u00e1nchez CQ, Schmitt FW, Curdt N, Westhoff AC, B\u00e4nfer IWH, Bayer TA, et al. Search strategy analysis of 5xFAD alzheimer mice in the morris water maze reveals sex- and age-specific spatial navigation deficits. Biomedicines. 2023;11:599.","journal-title":"Biomedicines"},{"key":"3426_CR63","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.964336","author":"KC Tsui","year":"2022","unstructured":"Tsui KC, Roy J, Chau SC, Wong KH, Shi L, Poon CH, et al. Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer\u2019s disease. Front Aging Neurosci. 2022. https:\/\/doi.org\/10.3389\/fnagi.2022.964336.","journal-title":"Front Aging Neurosci"},{"key":"3426_CR64","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","volume":"169","author":"H Keren-Shaul","year":"2017","unstructured":"Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, et al. A unique microglia type associated with restricting development of Alzheimer\u2019s disease. Cell. 2017;169:1276-1290.e17.","journal-title":"Cell"},{"key":"3426_CR65","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s40478-022-01356-1","volume":"10","author":"E Drummond","year":"2022","unstructured":"Drummond E, Kavanagh T, Pires G, Marta-Ariza M, Kanshin E, Nayak S, et al. The amyloid plaque proteome in early onset Alzheimer\u2019s disease and down syndrome. Acta Neuropathol Commun. 2022;10:53.","journal-title":"Acta Neuropathol Commun"},{"key":"3426_CR66","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.tins.2011.12.002","volume":"35","author":"H Murakoshi","year":"2012","unstructured":"Murakoshi H, Yasuda R. Postsynaptic signaling during plasticity of dendritic spines. Trends Neurosci. 2012;35:135\u201343.","journal-title":"Trends Neurosci"},{"key":"3426_CR67","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1756-6606-3-3","volume":"3","author":"L-J Wu","year":"2010","unstructured":"Wu L-J, Mellstr\u00f6m B, Wang H, Ren M, Domingo S, Kim SS, et al. DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory. Mol Brain. 2010;3:3.","journal-title":"Mol Brain"},{"key":"3426_CR68","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cub.2008.11.056","volume":"19","author":"\u00c1 Font\u00e1n-Lozano","year":"2009","unstructured":"Font\u00e1n-Lozano \u00c1, Romero-Granados R, Del-Pozo-Mart\u00edn Y, Su\u00e1rez-Pereira I, Delgado-Garc\u00eda JM, Penninger JM, et al. Lack of DREAM protein enhances learning and memory and slows brain aging. Curr Biol. 2009;19:54\u201360.","journal-title":"Curr Biol"},{"key":"3426_CR69","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.neulet.2008.03.084","volume":"438","author":"X Gao","year":"2008","unstructured":"Gao X, Xi G, Niu Y, Zhang S, Fu R, Zheng Z, et al. A study on the correlation between IL1RAPL1 and human cognitive ability. Neurosci Lett. 2008;438:163\u20137.","journal-title":"Neurosci Lett"},{"key":"3426_CR70","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0306-4522(02)00218-X","volume":"114","author":"B Boda","year":"2002","unstructured":"Boda B, Mas C, Muller D. Activity-dependent regulation of genes implicated in X-linked non-specific mental retardation. Neuroscience. 2002;114:13\u20137.","journal-title":"Neuroscience"},{"key":"3426_CR71","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cub.2009.12.030","volume":"20","author":"A Pavlowsky","year":"2010","unstructured":"Pavlowsky A, Gianfelice A, Pallotto M, Zanchi A, Vara H, Khelfaoui M, et al. A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation. Curr Biol. 2010;20:103\u201315.","journal-title":"Curr Biol"},{"key":"3426_CR72","doi-asserted-by":"publisher","first-page":"13485","DOI":"10.1523\/JNEUROSCI.2136-11.2011","volume":"31","author":"T Yoshida","year":"2011","unstructured":"Yoshida T, Yasumura M, Uemura T, Lee S-J, Ra M, Taguchi R, et al. IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase \u03b4. J Neurosci. 2011;31:13485\u201399.","journal-title":"J Neurosci"},{"key":"3426_CR73","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0074-7742(07)82002-2","volume":"82","author":"M Griffiths","year":"2007","unstructured":"Griffiths M, Neal JW, Gasque P. Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins. Int Rev Neurobiol. 2007;82:29\u201355.","journal-title":"Int Rev Neurobiol"},{"key":"3426_CR74","doi-asserted-by":"publisher","first-page":"4707","DOI":"10.2174\/1381612820666140130202911","volume":"20","author":"M Hernang\u00f3mez","year":"2014","unstructured":"Hernang\u00f3mez M, Carrillo-Salinas FJ, Mecha M, Correa F, Mestre L, Lor\u00eda F, et al. Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. Curr Pharm Des. 2014;20:4707\u201322.","journal-title":"Curr Pharm Des"},{"key":"3426_CR75","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.expneurol.2008.09.003","volume":"215","author":"DG Walker","year":"2009","unstructured":"Walker DG, Dalsing-Hernandez JE, Campbell NA, Lue L-F. Decreased expression of CD200 and CD200 receptor in Alzheimer\u2019s disease: a potential mechanism leading to chronic inflammation. Exp Neurol. 2009;215:5\u201319.","journal-title":"Exp Neurol"},{"key":"3426_CR76","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/s43587-022-00281-1","volume":"2","author":"B Dejanovic","year":"2022","unstructured":"Dejanovic B, Wu T, Tsai M-C, Graykowski D, Gandham VD, Rose CM, et al. Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer\u2019s disease mouse models. Nat Aging. 2022;2:837\u201350.","journal-title":"Nat Aging"},{"issue":"352","key":"3426_CR77","first-page":"712","volume":"2016","author":"S Hong","year":"1979","unstructured":"Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 1979;2016(352):712\u20136.","journal-title":"Science"},{"key":"3426_CR78","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1101\/lm.6.5.448","volume":"6","author":"HP Chang","year":"1999","unstructured":"Chang HP, Lindberg FP, Wang HL, Huang AM, Lee EHY. Impaired memory retention and decreased long-term potentiation in integrin-associated protein-deficient mice. Learn Mem. 1999;6:448\u201357.","journal-title":"Learn Mem"},{"key":"3426_CR79","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1007\/s11357-023-01014-x","volume":"46","author":"SA DeVries","year":"2023","unstructured":"DeVries SA, Conner B, Dimovasili C, Moore TL, Medalla M, Mortazavi F, et al. Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment. Geroscience. 2023;46:2503\u201319.","journal-title":"Geroscience"},{"key":"3426_CR80","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21735","author":"R Tomasoni","year":"2017","unstructured":"Tomasoni R, Morini R, Lopez-Atalaya JP, Corradini I, Canzi A, Rasile M, et al. Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects. Elife. 2017. https:\/\/doi.org\/10.7554\/eLife.21735.","journal-title":"Elife"},{"key":"3426_CR81","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2023113796","volume":"42","author":"M Matteoli","year":"2023","unstructured":"Matteoli M, Pozzi D, Fossati M, Menna E. Immune synaptopathies: how maternal immune activation impacts synaptic function during development. EMBO J. 2023;42: e113796.","journal-title":"EMBO J"},{"key":"3426_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105272","volume":"152","author":"F Xue","year":"2021","unstructured":"Xue F, Tian J, Yu C, Du H, Guo L. Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer\u2019s pathology in 5\u00d7FAD mice. Neurobiol Dis. 2021;152: 105272.","journal-title":"Neurobiol Dis"},{"key":"3426_CR83","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41467-017-00769-0","volume":"8","author":"A Deczkowska","year":"2017","unstructured":"Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, et al. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat Commun. 2017;8:717.","journal-title":"Nat Commun"},{"key":"3426_CR84","doi-asserted-by":"publisher","first-page":"L456","DOI":"10.1152\/ajplung.00335.2018","volume":"316","author":"G Momtazi","year":"2019","unstructured":"Momtazi G, Lambrecht BN, Naranjo JR, Schock BC. Regulators of A20 (TNFAIP3): new drug-able targets in inflammation. Am J Physiol Lung Cell Mol Physiol. 2019;316:L456\u201369.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3426_CR85","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13041-018-0359-6","volume":"11","author":"A L\u00f3pez-Hurtado","year":"2018","unstructured":"L\u00f3pez-Hurtado A, Burgos DF, Gonz\u00e1lez P, Dopazo XM, Gonz\u00e1lez V, R\u00e1bano A, et al. Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington\u2019s disease. Mol Brain. 2018;11:13.","journal-title":"Mol Brain"},{"key":"3426_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-017-0713-1","volume":"55","author":"P Larrod\u00e9","year":"2018","unstructured":"Larrod\u00e9 P, Calvo AC, Moreno-Mart\u00ednez L, de la Torre M, Moreno-Garc\u00eda L, Molina N, et al. DREAM-dependent activation of astrocytes in amyotrophic lateral sclerosis. Mol Neurobiol. 2018;55:1\u201312.","journal-title":"Mol Neurobiol"},{"key":"3426_CR87","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/bpa.12013","volume":"23","author":"J Park","year":"2013","unstructured":"Park J, Manzanero S, Chang J, Choi Y, Baik S, Cheng Y, et al. Calsenilin contributes to neuronal cell death in ischemic stroke. Brain Pathol. 2013;23:402\u201312.","journal-title":"Brain Pathol"},{"key":"3426_CR88","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.biopsych.2014.03.023","volume":"77","author":"I Ruiz-DeDiego","year":"2015","unstructured":"Ruiz-DeDiego I, Mellstrom B, Vallejo M, Naranjo JR, Moratalla R. Activation of DREAM (downstream regulatory element antagonistic modulator), a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice. Biol Psychiatry. 2015;77:95\u2013105.","journal-title":"Biol Psychiatry"},{"key":"3426_CR89","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1038\/s41588-020-00721-x","volume":"52","author":"MR Corces","year":"2020","unstructured":"Corces MR, Shcherbina A, Kundu S, Gloudemans MJ, Fr\u00e9sard L, Granja JM, et al. Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer\u2019s and Parkinson\u2019s diseases. Nat Genet. 2020;52:1158\u201368.","journal-title":"Nat Genet"},{"key":"3426_CR90","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41531-022-00293-z","volume":"8","author":"AF Pike","year":"2022","unstructured":"Pike AF, Szab\u00f2 I, Veerhuis R, Bubacco L. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson\u2019s disease. NPJ Parkinsons Dis. 2022;8:32.","journal-title":"NPJ Parkinsons Dis"},{"key":"3426_CR91","doi-asserted-by":"publisher","DOI":"10.2196\/46777","volume":"26","author":"JD Romano","year":"2024","unstructured":"Romano JD, Truong V, Kumar R, Venkatesan M, Graham BE, Hao Y, et al. The Alzheimer\u2019s knowledge base: a knowledge graph for Alzheimer disease research. J Med Internet Res. 2024;26: e46777.","journal-title":"J Med Internet Res"},{"key":"3426_CR92","doi-asserted-by":"publisher","first-page":"6364","DOI":"10.1002\/hbm.26512","volume":"44","author":"H Yu","year":"2023","unstructured":"Yu H, Ding Y, Wei Y, Dyrba M, Wang D, Kang X, et al. Morphological connectivity differences in Alzheimer\u2019s disease correlate with gene transcription and cell-type. Hum Brain Mapp. 2023;44:6364\u201374.","journal-title":"Hum Brain Mapp"},{"key":"3426_CR93","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.3233\/JAD-180678","volume":"70","author":"Z Manji","year":"2019","unstructured":"Manji Z, Rojas A, Wang W, Dingledine R, Varvel NH, Ganesh T. 5xFAD mice display sex-dependent inflammatory gene induction during the prodromal stage of Alzheimer\u2019s disease. J Alzheimer\u2019s Dis. 2019;70:1259\u201374.","journal-title":"J Alzheimer\u2019s Dis"},{"key":"3426_CR94","doi-asserted-by":"publisher","first-page":"105403","DOI":"10.1016\/j.neuint.2022.105403","volume":"159","author":"P Diaz-Amarilla","year":"2022","unstructured":"Diaz-Amarilla P, Arredondo F, Dapueto R, Boix V, Carvalho D, Santi MD, et al. Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer\u2019s disease mice. Neurochem Int. 2022;159:105403.","journal-title":"Neurochem Int"},{"key":"3426_CR95","doi-asserted-by":"publisher","first-page":"6703","DOI":"10.1523\/JNEUROSCI.0215-08.2008","volume":"28","author":"B Cebolla","year":"2008","unstructured":"Cebolla B, Fern\u00e1ndez-P\u00e9rez A, Perea G, Araque A, Vallejo M. DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis. J Neurosci. 2008;28:6703\u201313.","journal-title":"J Neurosci"},{"key":"3426_CR96","doi-asserted-by":"publisher","first-page":"6323","DOI":"10.1021\/bi5008172","volume":"53","author":"K Garai","year":"2014","unstructured":"Garai K, Verghese PB, Baban B, Holtzman DM, Frieden C. The binding of apolipoprotein e to oligomers and fibrils of amyloid-\u03b2 alters the kinetics of amyloid aggregation. Biochemistry. 2014;53:6323\u201331.","journal-title":"Biochemistry"},{"key":"3426_CR97","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.neuron.2017.11.013","volume":"96","author":"C-C Liu","year":"2017","unstructured":"Liu C-C, Zhao N, Fu Y, Wang N, Linares C, Tsai C-W, et al. ApoE4 accelerates early seeding of amyloid pathology. Neuron. 2017;96:1024-1032.e3.","journal-title":"Neuron"},{"key":"3426_CR98","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.neuron.2017.11.014","volume":"96","author":"T-PV Huynh","year":"2017","unstructured":"Huynh T-PV, Liao F, Francis CM, Robinson GO, Serrano JR, Jiang H, et al. Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of \u03b2-amyloidosis. Neuron. 2017;96:1013-1023.e4.","journal-title":"Neuron"},{"key":"3426_CR99","doi-asserted-by":"publisher","first-page":"208.e1","DOI":"10.1016\/j.neurobiolaging.2015.09.009","volume":"37","author":"Y Deming","year":"2016","unstructured":"Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, et al. A potential endophenotype for Alzheimer\u2019s disease: cerebrospinal fluid clusterin. Neurobiol Aging. 2016;37:208.e1-208.e9.","journal-title":"Neurobiol Aging"},{"key":"3426_CR100","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1001\/archgenpsychiatry.2010.78","volume":"67","author":"M Thambisetty","year":"2010","unstructured":"Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, et al. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry. 2010;67:739.","journal-title":"Arch Gen Psychiatry"},{"key":"3426_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101669","volume":"5","author":"Y Levites","year":"2024","unstructured":"Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, et al. Integrative proteomics identifies a conserved A\u03b2 amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer\u2019s disease. Cell Rep Med. 2024;5: 101669.","journal-title":"Cell Rep Med"},{"key":"3426_CR102","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00463","author":"JS Crist\u00f3v\u00e3o","year":"2019","unstructured":"Crist\u00f3v\u00e3o JS, Gomes CM. S100 proteins in Alzheimer\u2019s disease. Front Neurosci. 2019. https:\/\/doi.org\/10.3389\/fnins.2019.00463.","journal-title":"Front Neurosci"},{"key":"3426_CR103","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainres.2018.06.013","volume":"1697","author":"V Matagne","year":"2018","unstructured":"Matagne V, Wondolowski J, Frerking M, Shahidullah M, Delamere NA, Sandau US, et al. Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice. Brain Res. 2018;1697:45\u201352.","journal-title":"Brain Res"},{"key":"3426_CR104","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/s41398-024-03181-7","volume":"14","author":"EM Parker","year":"2024","unstructured":"Parker EM, Kindja NL, DeGiosio RA, Salisbury RB, Krivinko JM, Cheetham CEJ, et al. Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia. Transl Psychiatry. 2024;14:484.","journal-title":"Transl Psychiatry"},{"key":"3426_CR105","doi-asserted-by":"publisher","first-page":"e1008625","DOI":"10.1371\/journal.pgen.1008625","volume":"16","author":"P Coste de Bagneaux","year":"2020","unstructured":"Coste de Bagneaux P, von Elsner L, Bierhals T, Campiglio M, Johannsen J, Obermair GJ, et al. A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions. PLoS Genet. 2020;16:e1008625.","journal-title":"PLoS Genet"},{"key":"3426_CR106","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.1038\/emboj.2012.226","volume":"31","author":"A Tadmouri","year":"2012","unstructured":"Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, et al. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J. 2012;31:3730\u201344.","journal-title":"EMBO J"},{"key":"3426_CR107","doi-asserted-by":"publisher","first-page":"6269","DOI":"10.1007\/s12035-017-0849-z","volume":"55","author":"MV Patel","year":"2018","unstructured":"Patel MV, Swiatkowski P, Kwon M, Rodriguez AR, Campagno K, Firestein BL. A novel short isoform of cytosolic PSD-95 interactor (cypin) regulates neuronal development. Mol Neurobiol. 2018;55:6269\u201381.","journal-title":"Mol Neurobiol"},{"key":"3426_CR108","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s10571-024-01481-6","volume":"44","author":"Z-Y Liu","year":"2024","unstructured":"Liu Z-Y, Tang F, Yang J-Z, Chen X, Wang Z-F, Li Z-Q. The role of Beta2-microglobulin in central nervous system disease. Cell Mol Neurobiol. 2024;44:46.","journal-title":"Cell Mol Neurobiol"},{"key":"3426_CR109","doi-asserted-by":"publisher","first-page":"140428","DOI":"10.1016\/j.bbapap.2020.140428","volume":"1868","author":"V Hook","year":"2020","unstructured":"Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, et al. Cathepsin B in neurodegeneration of Alzheimer\u2019s disease, traumatic brain injury, and related brain disorders. Biochimica et Biophysica Acta (BBA) Proteins Proteomics. 2020;1868:140428.","journal-title":"Biochimica et Biophysica Acta (BBA) Proteins Proteomics"},{"key":"3426_CR110","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3390\/cells10010138","volume":"10","author":"J-W Kim","year":"2021","unstructured":"Kim J-W, Jung S-Y, Kim Y, Heo H, Hong C-H, Seo S-W, et al. Identification of Cathepsin D as a plasma biomarker for Alzheimer\u2019s disease. Cells. 2021;10:138.","journal-title":"Cells"},{"key":"3426_CR111","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3390\/ph15101177","volume":"15","author":"Y Dang","year":"2022","unstructured":"Dang Y, He Q, Yang S, Sun H, Liu Y, Li W, et al. FTH1- and SAT1-induced astrocytic ferroptosis is involved in Alzheimer\u2019s disease: evidence from single-cell transcriptomic analysis. Pharmaceuticals. 2022;15:1177.","journal-title":"Pharmaceuticals"},{"key":"3426_CR112","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13024-022-00588-y","volume":"17","author":"J Hou","year":"2022","unstructured":"Hou J, Chen Y, Grajales-Reyes G, Colonna M. TREM2 dependent and independent functions of microglia in Alzheimer\u2019s disease. Mol Neurodegener. 2022;17:84.","journal-title":"Mol Neurodegener"},{"key":"3426_CR113","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13024-022-00552-w","volume":"17","author":"J-V Haure-Mirande","year":"2022","unstructured":"Haure-Mirande J-V, Audrain M, Ehrlich ME, Gandy S. Microglial TYROBP\/DAP12 in Alzheimer\u2019s disease: transduction of physiological and pathological signals across TREM2. Mol Neurodegener. 2022;17:55.","journal-title":"Mol Neurodegener"},{"key":"3426_CR114","doi-asserted-by":"crossref","unstructured":"Kellogg CM, Pham K, Machalinski AH, Porter HL, Blankenship HE, Tooley K, et al. Microglial MHC-I induction with aging and Alzheimer\u2019s is conserved in mouse models and humans. 2023.","DOI":"10.1101\/2023.03.07.531435"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03426-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-025-03426-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03426-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:02:02Z","timestamp":1750309322000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-025-03426-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":114,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3426"],"URL":"https:\/\/doi.org\/10.1186\/s12974-025-03426-2","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]},"assertion":[{"value":"2 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Bioethical Committee approved all animal experiments described in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"160"}}