{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:29:44Z","timestamp":1793716184029,"version":"4.6.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-025-03466-8","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T07:59:35Z","timestamp":1747814375000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine"],"prefix":"10.1186","volume":"22","author":[{"given":"Yanjie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanbin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheman","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"3466_CR1","doi-asserted-by":"publisher","unstructured":"Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018;38:1\u2013211. https:\/\/doi.org\/10.1177\/0333102417738202","DOI":"10.1177\/0333102417738202"},{"key":"3466_CR2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s10194-024-01798-z","volume":"25","author":"J Cen","year":"2024","unstructured":"Cen J, Wang Q, Cheng L, Gao Q, Wang H, Sun F. Global, regional, and National burden and trends of migraine among women of childbearing age from 1990 to 2021: insights from the global burden of disease study 2021. J Headache Pain. 2024;25:96. https:\/\/doi.org\/10.1186\/s10194-024-01798-z.","journal-title":"J Headache Pain"},{"key":"3466_CR3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","volume":"23","author":"GBD 2021 Nervous System Disorders Collaborators","year":"2024","unstructured":"GBD 2021 Nervous System Disorders Collaborators. Global, regional, and National burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the global burden of disease study 2021. Lancet Neurol. 2024;23:344\u201381. https:\/\/doi.org\/10.1016\/S1474-4422(24)00038-3.","journal-title":"Lancet Neurol"},{"key":"3466_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/head.14827","author":"A de Dios","year":"2024","unstructured":"de Dios A, Pag\u00e8s-Puigdemont N, Ojeda S, Riera P, Pelegr\u00edn R, Morollon N, et al. Persistence, effectiveness, and tolerability of anti-calcitonin gene-related peptide monoclonal antibodies in patients with chronic migraine. Headache. 2024. https:\/\/doi.org\/10.1111\/head.14827.","journal-title":"Headache"},{"key":"3466_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/head.14788","author":"R Ornello","year":"2024","unstructured":"Ornello R, Baldini F, Onofri A, Rosignoli C, De Santis F, Burgalassi A, et al. Impact of duration of chronic migraine on long-term effectiveness of monoclonal antibodies targeting the calcitonin gene-related peptide pathway-A real-world study. Headache. 2024. https:\/\/doi.org\/10.1111\/head.14788.","journal-title":"Headache"},{"key":"3466_CR6","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1210\/en.2011-1459","volume":"153","author":"SC Egea","year":"2012","unstructured":"Egea SC, Dickerson IM. Direct interactions between Calcitonin-Like receptor (CLR) and CGRP-Receptor component protein (RCP) regulate CGRP receptor signaling. Endocrinology. 2012;153:1850\u201360. https:\/\/doi.org\/10.1210\/en.2011-1459.","journal-title":"Endocrinology"},{"key":"3466_CR7","unstructured":"CGRP as the target of. new migraine therapies \u2014 successful translation from bench to clinic| Nature Reviews Neurology n.d. https:\/\/www.nature.com\/articles\/s41582-018-0003-1 (accessed December 14, 2023)."},{"key":"3466_CR8","doi-asserted-by":"publisher","first-page":"12260","DOI":"10.1074\/jbc.M606338200","volume":"282","author":"GS Cottrell","year":"2007","unstructured":"Cottrell GS, Padilla B, Pikios S, Roosterman D, Steinhoff M, Grady EF, et al. Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. J Biol Chem. 2007;282:12260\u201371. https:\/\/doi.org\/10.1074\/jbc.M606338200.","journal-title":"J Biol Chem"},{"key":"3466_CR9","doi-asserted-by":"publisher","first-page":"42182","DOI":"10.1074\/jbc.M107323200","volume":"276","author":"S Hilairet","year":"2001","unstructured":"Hilairet S, B\u00e9langer C, Bertrand J, Laperri\u00e8re A, Foord SM, Bouvier M. Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. J Biol Chem. 2001;276:42182\u201390. https:\/\/doi.org\/10.1074\/jbc.M107323200.","journal-title":"J Biol Chem"},{"key":"3466_CR10","unstructured":"Mode and site of action of therapies targeting CGRP signaling - PubMed. n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/37691118\/ (accessed February 15, 2025)."},{"key":"3466_CR11","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1042\/BST20231570","volume":"52","author":"JE Lim","year":"2024","unstructured":"Lim JE, Bernatchez P, Nabi IR. Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling. Biochem Soc Trans. 2024;52:947\u201359. https:\/\/doi.org\/10.1042\/BST20231570.","journal-title":"Biochem Soc Trans"},{"key":"3466_CR12","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1186\/s12974-018-1387-y","volume":"15","author":"Q Huang","year":"2018","unstructured":"Huang Q, Zhong W, Hu Z, Tang X. A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke. J Neuroinflammation. 2018;15:348. https:\/\/doi.org\/10.1186\/s12974-018-1387-y.","journal-title":"J Neuroinflammation"},{"key":"3466_CR13","unstructured":"Potential of caveolae. in the therapy of cardiovascular and neurological diseases - PubMed n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/25324780\/ (accessed September 30, 2024)."},{"key":"3466_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/sj.bjp.0705930","volume":"143","author":"RS Ostrom","year":"2004","unstructured":"Ostrom RS, Insel PA. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular Pharmacology. Br J Pharmacol. 2004;143:235\u201345. https:\/\/doi.org\/10.1038\/sj.bjp.0705930.","journal-title":"Br J Pharmacol"},{"key":"3466_CR15","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.lfs.2005.05.040","volume":"77","author":"J Barnett-Norris","year":"2005","unstructured":"Barnett-Norris J, Lynch D, Reggio PH. Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system. Life Sci. 2005;77:1625\u201339. https:\/\/doi.org\/10.1016\/j.lfs.2005.05.040.","journal-title":"Life Sci"},{"key":"3466_CR16","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/S0026-895X(24)12593-X","volume":"59","author":"S Gin\u00e9s","year":"2001","unstructured":"Gin\u00e9s S, Ciruela F, Burgue\u00f1o J, Casad\u00f3 V, Canela EI, Mallol J, et al. Involvement of Caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 2001;59:1314\u201323.","journal-title":"Mol Pharmacol"},{"key":"3466_CR17","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s10555-020-09890-x","volume":"39","author":"L Sim\u00f3n","year":"2020","unstructured":"Sim\u00f3n L, Campos A, Leyton L, Quest AFG. Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer. Cancer Metastasis Rev. 2020;39:435\u201353. https:\/\/doi.org\/10.1007\/s10555-020-09890-x.","journal-title":"Cancer Metastasis Rev"},{"key":"3466_CR18","doi-asserted-by":"publisher","first-page":"11930","DOI":"10.1074\/jbc.271.20.11930","volume":"271","author":"C Mineo","year":"1996","unstructured":"Mineo C, James GL, Smart EJ, Anderson RG. Localization of epidermal growth factor-stimulated Ras\/Raf-1 interaction to caveolae membrane. J Biol Chem. 1996;271:11930\u20135. https:\/\/doi.org\/10.1074\/jbc.271.20.11930.","journal-title":"J Biol Chem"},{"key":"3466_CR19","doi-asserted-by":"publisher","first-page":"6867","DOI":"10.1038\/ncomms7867","volume":"6","author":"E Shvets","year":"2015","unstructured":"Shvets E, Bitsikas V, Howard G, Hansen CG, Nichols BJ. Dynamic caveolae exclude bulk membrane proteins and are required for sorting of excess glycosphingolipids. Nat Commun. 2015;6:6867. https:\/\/doi.org\/10.1038\/ncomms7867.","journal-title":"Nat Commun"},{"key":"3466_CR20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s10194-022-01416-w","volume":"23","author":"Y Zhou","year":"2022","unstructured":"Zhou Y, Zhang L, Hao Y, Yang L, Fan S, Xiao Z. FKN\/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats. J Headache Pain. 2022;23:42. https:\/\/doi.org\/10.1186\/s10194-022-01416-w.","journal-title":"J Headache Pain"},{"key":"3466_CR21","doi-asserted-by":"publisher","first-page":"1115318","DOI":"10.3389\/fneur.2023.1115318","volume":"14","author":"T Qiu","year":"2023","unstructured":"Qiu T, Zhou Y, Hu L, Shan Z, Zhang Y, Fang Y, et al. 2-Deoxyglucose alleviates migraine-related behaviors by modulating microglial inflammatory factors in experimental model of migraine. Front Neurol. 2023;14:1115318. https:\/\/doi.org\/10.3389\/fneur.2023.1115318.","journal-title":"Front Neurol"},{"key":"3466_CR22","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.tins.2024.06.003","volume":"47","author":"J Badaut","year":"2024","unstructured":"Badaut J, Blochet C, Obenaus A, Hirt L. Physiological and pathological roles of Caveolins in the central nervous system. Trends Neurosci. 2024;47:651\u201364. https:\/\/doi.org\/10.1016\/j.tins.2024.06.003.","journal-title":"Trends Neurosci"},{"key":"3466_CR23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1742-2094-11-39","volume":"11","author":"IR Niesman","year":"2014","unstructured":"Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, et al. Traumatic brain injury enhances neuroinflammation and lesion volume in Caveolin deficient mice. J Neuroinflamm. 2014;11:39. https:\/\/doi.org\/10.1186\/1742-2094-11-39.","journal-title":"J Neuroinflamm"},{"key":"3466_CR24","unstructured":"Cellular prion protein acts. as mediator of amyloid beta uptake by caveolin-1 causing cellular dysfunctions in vitro and in vivo - da Silva Correia - Alzheimer\u2019s & Dementia - Wiley Online Library n.d. https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14120 (accessed October 4, 2024)."},{"key":"3466_CR25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s10194-023-01600-6","volume":"24","author":"Z Shan","year":"2023","unstructured":"Shan Z, Wang Y, Qiu T, Zhou Y, Zhang Y, Hu L, et al. SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3\/Pgc-1\u03b1 positive feedback loop. J Headache Pain. 2023;24:65. https:\/\/doi.org\/10.1186\/s10194-023-01600-6.","journal-title":"J Headache Pain"},{"key":"3466_CR26","doi-asserted-by":"publisher","first-page":"654761","DOI":"10.3389\/fnagi.2021.654761","volume":"13","author":"H Cui","year":"2021","unstructured":"Cui H, Su W, Cao Y, Ma L, Xu G, Mou W, et al. Lack of spinal neuropeptide Y is involved in mechanical itch in aged mice. Front Aging Neurosci. 2021;13:654761. https:\/\/doi.org\/10.3389\/fnagi.2021.654761.","journal-title":"Front Aging Neurosci"},{"key":"3466_CR27","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/ana.21537","volume":"65","author":"RM Edelmayer","year":"2009","unstructured":"Edelmayer RM, Vanderah TW, Majuta L, Zhang E-T, Fioravanti B, De Felice M, et al. Medullary pain facilitating neurons mediate allodynia in headache-related pain. Ann Neurol. 2009;65:184\u201393. https:\/\/doi.org\/10.1002\/ana.21537.","journal-title":"Ann Neurol"},{"key":"3466_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13041-022-00985-w","volume":"15","author":"C Pi","year":"2022","unstructured":"Pi C, Tang W, Li Z, Liu Y, Jing Q, Dai W, et al. Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping. Mol Brain. 2022;15:99. https:\/\/doi.org\/10.1186\/s13041-022-00985-w.","journal-title":"Mol Brain"},{"key":"3466_CR29","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3945\/jn.113.177980","volume":"143","author":"G Chugh","year":"2013","unstructured":"Chugh G, Asghar M, Patki G, Bohat R, Jafri F, Allam F, et al. A High-Salt diet further impairs Age-Associated declines in cognitive, behavioral, and cardiovascular functions in male Fischer brown Norway Rats123. J Nutr. 2013;143:1406\u201313. https:\/\/doi.org\/10.3945\/jn.113.177980.","journal-title":"J Nutr"},{"key":"3466_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-025-01078-8","author":"L-Q Xie","year":"2025","unstructured":"Xie L-Q, Hu B, Lu R-B, Cheng Y-L, Chen X, Wen J, et al. Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity. Cell Res. 2025. https:\/\/doi.org\/10.1038\/s41422-025-01078-8.","journal-title":"Cell Res"},{"key":"3466_CR31","unstructured":"M\u03b2CD inhibits SFTSV entry. by disrupting lipid raft structure of the host cells - PubMed n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/39265655\/ (accessed February 17, 2025)."},{"key":"3466_CR32","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1091\/mbc.11.12.4205","volume":"11","author":"S Grimmer","year":"2000","unstructured":"Grimmer S, Iversen T-G, van Deurs B, Sandvig K. Endosome to golgi transport of ricin is regulated by cholesterol. Mol Biol Cell. 2000;11:4205\u201316.","journal-title":"Mol Biol Cell"},{"key":"3466_CR33","unstructured":"Long-term safety. of zavegepant nasal spray for the acute treatment of migraine: A phase 2\/3 open-label study - PubMed n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/39210835\/ (accessed September 29, 2024)."},{"key":"3466_CR34","doi-asserted-by":"publisher","first-page":"887","DOI":"10.2174\/1567201816666191029122740","volume":"16","author":"K Kashyap","year":"2019","unstructured":"Kashyap K, Shukla R. Drug delivery and targeting to the brain through nasal route: mechanisms, applications and challenges. Curr Drug Deliv. 2019;16:887\u2013901. https:\/\/doi.org\/10.2174\/1567201816666191029122740.","journal-title":"Curr Drug Deliv"},{"key":"3466_CR35","unstructured":"Inhibiting PAC1 receptor internalization and endosomal ERK pathway activation may ameliorate hyperalgesia in a chronic migraine rat model - Lily Zhang, Yanjie Zhou, Yajuan Wang, Liu Yang, Yue Wang, Zhengming Shan, Jingjing Liang, Zheman Xiao. 2023 n.d. https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024231163131 (accessed September 29, 2024)."},{"key":"3466_CR36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s10194-022-01403-1","volume":"23","author":"R Tian","year":"2022","unstructured":"Tian R, Zhang Y, Pan Q, Wang Y, Wen Q, Fan X, et al. Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC\/ERK\/CREB pathway in an experimental chronic migraine rat model. J Headache Pain. 2022;23:35. https:\/\/doi.org\/10.1186\/s10194-022-01403-1.","journal-title":"J Headache Pain"},{"key":"3466_CR37","doi-asserted-by":"publisher","first-page":"e005424","DOI":"10.1136\/jitc-2022-005424","volume":"10","author":"RD Vavolizza","year":"2022","unstructured":"Vavolizza RD, Petroni GR, Mauldin IS, Chianese-Bullock KA, Olson WC, Smith KT, et al. Phase I\/II clinical trial of a helper peptide vaccine plus PD-1 Blockade in PD-1 antibody-na\u00efve and PD-1 antibody-experienced patients with melanoma (MEL64). J Immunother Cancer. 2022;10:e005424. https:\/\/doi.org\/10.1136\/jitc-2022-005424.","journal-title":"J Immunother Cancer"},{"key":"3466_CR38","doi-asserted-by":"publisher","first-page":"C202","DOI":"10.1152\/ajpcell.00124.2017","volume":"314","author":"H Yu","year":"2018","unstructured":"Yu H, Cui X, Zhang J, Xie JX, Banerjee M, Pierre SV, et al. Heterogeneity of signal transduction by Na-K-ATPase \u03b1-isoforms: role of Src interaction. Am J Physiol Cell Physiol. 2018;314:C202\u201310. https:\/\/doi.org\/10.1152\/ajpcell.00124.2017.","journal-title":"Am J Physiol Cell Physiol"},{"key":"3466_CR39","doi-asserted-by":"publisher","first-page":"C933","DOI":"10.1152\/ajpcell.00151.2020","volume":"319","author":"V Sudhahar","year":"2020","unstructured":"Sudhahar V, Okur MN, O\u2019Bryan JP, Minshall RD, Fulton D, Ushio-Fukai M, et al. Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function. Am J Physiol Cell Physiol. 2020;319:C933\u201344. https:\/\/doi.org\/10.1152\/ajpcell.00151.2020.","journal-title":"Am J Physiol Cell Physiol"},{"key":"3466_CR40","doi-asserted-by":"publisher","first-page":"e2025846118","DOI":"10.1073\/pnas.2025846118","volume":"118","author":"SC Wright","year":"2021","unstructured":"Wright SC, Lukasheva V, Le Gouill C, Kobayashi H, Breton B, Mailhot-Larouche S, et al. BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes. Proc Natl Acad Sci U S A. 2021;118:e2025846118. https:\/\/doi.org\/10.1073\/pnas.2025846118.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3466_CR41","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/cvr\/cvv218","volume":"108","author":"SM Armstrong","year":"2015","unstructured":"Armstrong SM, Sugiyama MG, Fung KYY, Gao Y, Wang C, Levy AS, et al. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. Cardiovasc Res. 2015;108:268\u201377. https:\/\/doi.org\/10.1093\/cvr\/cvv218.","journal-title":"Cardiovasc Res"},{"key":"3466_CR42","doi-asserted-by":"publisher","first-page":"8244","DOI":"10.1038\/ncomms9244","volume":"6","author":"S Lim","year":"2015","unstructured":"Lim S, Kim W-J, Kim Y-H, Lee S, Koo J-H, Lee J-A, et al. dNP2 is a blood\u2013brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis. Nat Commun. 2015;6:8244. https:\/\/doi.org\/10.1038\/ncomms9244.","journal-title":"Nat Commun"},{"key":"3466_CR43","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neuroscience.2023.07.027","volume":"528","author":"W Huang","year":"2023","unstructured":"Huang W, Zhang Y, Zhou Y, Zong J, Qiu T, Hu L, et al. Glymphatic dysfunction in migraine mice model. Neuroscience. 2023;528:64\u201374. https:\/\/doi.org\/10.1016\/j.neuroscience.2023.07.027.","journal-title":"Neuroscience"},{"key":"3466_CR44","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.canlet.2019.02.013","volume":"449","author":"S Codenotti","year":"2019","unstructured":"Codenotti S, Faggi F, Ronca R, Chiodelli P, Grillo E, Guescini M, et al. Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling Cooperation. Cancer Lett. 2019;449:135\u201344. https:\/\/doi.org\/10.1016\/j.canlet.2019.02.013.","journal-title":"Cancer Lett"},{"issue":"Suppl 2","key":"3466_CR45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/head.13081","volume":"57","author":"L Edvinsson","year":"2017","unstructured":"Edvinsson L. The trigeminovascular pathway: role of CGRP and CGRP receptors in migraine. Headache. 2017;57(Suppl 2):47\u201355. https:\/\/doi.org\/10.1111\/head.13081.","journal-title":"Headache"},{"key":"3466_CR46","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/head.13529","volume":"59","author":"S Iyengar","year":"2019","unstructured":"Iyengar S, Johnson KW, Ossipov MH, Aurora SK. CGRP and the trigeminal system in migraine. Headache: J Head Face Pain. 2019;59:659\u201381. https:\/\/doi.org\/10.1111\/head.13529.","journal-title":"Headache: J Head Face Pain"},{"key":"3466_CR47","doi-asserted-by":"publisher","first-page":"e17360","DOI":"10.1371\/journal.pone.0017360","volume":"6","author":"L Neeb","year":"2011","unstructured":"Neeb L, Hellen P, Boehnke C, Hoffmann J, Schuh-Hofer S, Dirnagl U, et al. IL-1\u03b2 stimulates COX-2 dependent PGE2 synthesis and CGRP release in rat trigeminal ganglia cells. PLoS ONE. 2011;6:e17360. https:\/\/doi.org\/10.1371\/journal.pone.0017360.","journal-title":"PLoS ONE"},{"key":"3466_CR48","doi-asserted-by":"publisher","first-page":"21226","DOI":"10.1038\/srep21226","volume":"6","author":"J Meng","year":"2016","unstructured":"Meng J, Wang J, Steinhoff M, Dolly JO. TNF\u03b1 induces co-trafficking of TRPV1\/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1\/syntaxin1\/SNAP-25 mediated fusion. Sci Rep. 2016;6:21226. https:\/\/doi.org\/10.1038\/srep21226.","journal-title":"Sci Rep"},{"key":"3466_CR49","doi-asserted-by":"publisher","first-page":"12309","DOI":"10.1073\/pnas.1706656114","volume":"114","author":"RE Yarwood","year":"2017","unstructured":"Yarwood RE, Imlach WL, Lieu T, Veldhuis NA, Jensen DD, Klein Herenbrink C, et al. Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission. Proc Natl Acad Sci U S A. 2017;114:12309\u201314. https:\/\/doi.org\/10.1073\/pnas.1706656114.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3466_CR50","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1177\/0333102417691762","volume":"38","author":"CS Walker","year":"2018","unstructured":"Walker CS, Raddant AC, Woolley MJ, Russo AF, Hay DL. CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured. Cephalalgia. 2018;38:437\u201351. https:\/\/doi.org\/10.1177\/0333102417691762.","journal-title":"Cephalalgia"},{"key":"3466_CR51","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.3390\/biology12111402","volume":"12","author":"CM Dalton","year":"2023","unstructured":"Dalton CM, Schlegel C, Hunter CJ. Caveolin-1: A review of intracellular functions, tissue-specific roles, and epithelial tight junction regulation. Biology (Basel). 2023;12:1402. https:\/\/doi.org\/10.3390\/biology12111402.","journal-title":"Biology (Basel)"},{"key":"3466_CR52","doi-asserted-by":"publisher","first-page":"108849","DOI":"10.1016\/j.isci.2024.108849","volume":"27","author":"M \u0160tefl","year":"2024","unstructured":"\u0160tefl M, Takamiya M, Middel V, Tekp\u0131nar M, Nienhaus K, Beil T, et al. Caveolae disassemble upon membrane lesioning and foster cell survival. iScience. 2024;27:108849. https:\/\/doi.org\/10.1016\/j.isci.2024.108849.","journal-title":"iScience"},{"key":"3466_CR53","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrm1571","volume":"6","author":"C Le Roy","year":"2005","unstructured":"Le Roy C, Wrana JL. Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol. 2005;6:112\u201326. https:\/\/doi.org\/10.1038\/nrm1571.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3466_CR54","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1139\/bcb-2013-0020","volume":"91","author":"JQ Tang","year":"2013","unstructured":"Tang JQ, Sun F, Wang YH, Chen LX, Yao CH, Fu XQ, et al. The role of caveolae in regulating calcitonin receptor-like receptor subcellular distribution in vascular smooth muscle cells. Biochem Cell Biol. 2013;91:357\u201360. https:\/\/doi.org\/10.1139\/bcb-2013-0020.","journal-title":"Biochem Cell Biol"},{"key":"3466_CR55","doi-asserted-by":"publisher","first-page":"29602","DOI":"10.1074\/jbc.M004534200","volume":"275","author":"K Kuwasako","year":"2000","unstructured":"Kuwasako K, Shimekake Y, Masuda M, Nakahara K, Yoshida T, Kitaura M, et al. Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. J Biol Chem. 2000;275:29602\u20139. https:\/\/doi.org\/10.1074\/jbc.M004534200.","journal-title":"J Biol Chem"},{"key":"3466_CR56","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/cr.2008.315","volume":"19","author":"Y-G Chen","year":"2009","unstructured":"Chen Y-G. Endocytic regulation of TGF-beta signaling. Cell Res. 2009;19:58\u201370. https:\/\/doi.org\/10.1038\/cr.2008.315.","journal-title":"Cell Res"},{"key":"3466_CR57","doi-asserted-by":"publisher","first-page":"105675","DOI":"10.1016\/j.archoralbio.2023.105675","volume":"150","author":"RB Nascimento","year":"2023","unstructured":"Nascimento RB, Risteli M, Paiva KBS, Juurikka K, Rodrigues MFSD, Salo TA, et al. Cholesterol depletion affects caveolin-1 expression, migration and invasion of oral tongue squamous cell carcinoma cell lines. Arch Oral Biol. 2023;150:105675. https:\/\/doi.org\/10.1016\/j.archoralbio.2023.105675.","journal-title":"Arch Oral Biol"},{"key":"3466_CR58","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/v14030496","volume":"14","author":"S Li","year":"2022","unstructured":"Li S, Xiao D, Zhao Y, Zhang L, Chen R, Liu W, et al. Porcine deltacoronavirus (PDCoV) entry into PK-15 cells by caveolae-mediated endocytosis. Viruses. 2022;14:496. https:\/\/doi.org\/10.3390\/v14030496.","journal-title":"Viruses"},{"key":"3466_CR59","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.neuroscience.2008.06.052","volume":"158","author":"CT Ekdahl","year":"2009","unstructured":"Ekdahl CT, Kokaia Z, Lindvall O. Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience. 2009;158:1021\u20139. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.06.052.","journal-title":"Neuroscience"},{"key":"3466_CR60","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","volume":"131","author":"B Stevens","year":"2007","unstructured":"Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, et al. The classical complement cascade mediates CNS synapse elimination. Cell. 2007;131:1164\u201378. https:\/\/doi.org\/10.1016\/j.cell.2007.10.036.","journal-title":"Cell"},{"key":"3466_CR61","doi-asserted-by":"publisher","first-page":"102636","DOI":"10.1016\/j.arr.2024.102636","volume":"104","author":"H Zhao","year":"2025","unstructured":"Zhao H, Lv Y, Xu J, Song X, Wang Q, Zhai X, et al. The activation of microglia by the complement system in neurodegenerative diseases. Ageing Res Rev. 2025;104:102636. https:\/\/doi.org\/10.1016\/j.arr.2024.102636.","journal-title":"Ageing Res Rev"},{"key":"3466_CR62","doi-asserted-by":"publisher","first-page":"114508","DOI":"10.1016\/j.expneurol.2023.114508","volume":"368","author":"D Cao","year":"2023","unstructured":"Cao D, Li B, Cao C, Zhang J, Li X, Li H, et al. Caveolin-1 aggravates neurological deficits by activating neuroinflammation following experimental intracerebral hemorrhage in rats. Exp Neurol. 2023;368:114508. https:\/\/doi.org\/10.1016\/j.expneurol.2023.114508.","journal-title":"Exp Neurol"},{"key":"3466_CR63","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.7150\/ijbs.57774","volume":"17","author":"W Zhang","year":"2021","unstructured":"Zhang W, Wang H, Yuan Z, Chu G, Sun H, Yu Z, et al. Moderate mechanical stimulation rescues degenerative annulus fibrosus by suppressing caveolin-1 mediated pro-inflammatory signaling pathway. Int J Biol Sci. 2021;17:1395\u2013412. https:\/\/doi.org\/10.7150\/ijbs.57774.","journal-title":"Int J Biol Sci"},{"key":"3466_CR64","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.freeradbiomed.2022.12.095","volume":"195","author":"D Fu","year":"2023","unstructured":"Fu D, Wu S, Jiang X, You T, Li Y, Xin J, et al. Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease. Free Radic Biol Med. 2023;195:245\u201357. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.12.095.","journal-title":"Free Radic Biol Med"},{"key":"3466_CR65","unstructured":"Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation - PubMed n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/38520693\/ (accessed February 23, 2025)."},{"key":"3466_CR66","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jare.2024.01.006","volume":"66","author":"Y Hu","year":"2024","unstructured":"Hu Y, Tao W. Current perspectives on microglia-neuron communication in the central nervous system: direct and indirect modes of interaction. J Adv Res. 2024;66:251\u201365. https:\/\/doi.org\/10.1016\/j.jare.2024.01.006.","journal-title":"J Adv Res"},{"key":"3466_CR67","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1177\/0269881116689257","volume":"31","author":"AA Altarifi","year":"2017","unstructured":"Altarifi AA, David B, Muchhala KH, Blough BE, Akbarali H, Negus SS. Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, Gastrointestinal function, and abuse liability in rodents. J Psychopharmacol. 2017;31:730\u20139. https:\/\/doi.org\/10.1177\/0269881116689257.","journal-title":"J Psychopharmacol"},{"key":"3466_CR68","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41388-024-03241-8","volume":"44","author":"H Wang","year":"2025","unstructured":"Wang H, Wang H, Wang R, Li Y, Wang Z, Zhou W, et al. Discovery of a molecular glue for EGFR degradation. Oncogene. 2025;44:545\u201356. https:\/\/doi.org\/10.1038\/s41388-024-03241-8.","journal-title":"Oncogene"},{"key":"3466_CR69","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1007\/s12031-020-01493-z","volume":"70","author":"L Edvinsson","year":"2020","unstructured":"Edvinsson L, Grell A-S, Warfvinge K. Expression of the CGRP family of neuropeptides and their receptors in the trigeminal ganglion. J Mol Neurosci. 2020;70:930\u201344. https:\/\/doi.org\/10.1007\/s12031-020-01493-z.","journal-title":"J Mol Neurosci"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03466-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-025-03466-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03466-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T07:59:42Z","timestamp":1747814382000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-025-03466-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3466"],"URL":"https:\/\/doi.org\/10.1186\/s12974-025-03466-8","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"19 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Experimental procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of Renmin Hospital of Wuhan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"134"}}