{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:41:43Z","timestamp":1788907303050,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Tai-Shan scholar program","award":["ts20190979"],"award-info":[{"award-number":["ts20190979"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["U2202211"],"award-info":[{"award-number":["U2202211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-025-03539-8","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:26:16Z","timestamp":1758738376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition of Ephrin receptor signaling in the paraventricular nucleus attenuates psoriasis-like dermatitis via synaptic plasticity and immune homeostasis modulation"],"prefix":"10.1186","volume":"22","author":[{"given":"Qingyu","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanpeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikai","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijia","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"issue":"10275","key":"3539_CR1","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","volume":"397","author":"K Ghoreschi","year":"2021","unstructured":"Ghoreschi K, Balato A, Enerb\u00e4ck C, Sabat R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet (London England). 2021;397(10275):754\u201366.","journal-title":"Lancet (London England)"},{"key":"3539_CR2","doi-asserted-by":"crossref","unstructured":"Germ\u00e1n B, Wei R, Hener P, Martins C, Ye T, Gottwick C et al. Disrupting the IL-36 and IL-23\/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis. JCI Insight. 2019;4(2):e123390.","DOI":"10.1172\/jci.insight.123390"},{"issue":"3","key":"3539_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/1346-8138.14139","volume":"45","author":"E Ogawa","year":"2018","unstructured":"Ogawa E, Sato Y, Minagawa A, Okuyama R. Pathogenesis of psoriasis and development of treatment. J Dermatol. 2018;45(3):264\u201372.","journal-title":"J Dermatol"},{"key":"3539_CR4","doi-asserted-by":"crossref","unstructured":"Marek-Jozefowicz L, Czajkowski R, Borkowska A, Nedoszytko B, \u017bmijewski MA, Cuba\u0142a WJ et al. The Brain-Skin axis in Psoriasis-Psychological, psychiatric, hormonal, and dermatological aspects. Int J Mol Sci. 2022;23(2):669.","DOI":"10.3390\/ijms23020669"},{"issue":"1","key":"3539_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s12974-021-02317-6","volume":"18","author":"S Talley","year":"2021","unstructured":"Talley S, Valiauga R, Anderson L, Cannon AR, Choudhry MA, Campbell EM. DSS-induced inflammation in the colon drives a Proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod. J Neuroinflamm. 2021;18(1):263.","journal-title":"J Neuroinflamm"},{"issue":"12","key":"3539_CR6","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1016\/j.celrep.2020.02.109","volume":"30","author":"P S\u00fc\u00df","year":"2020","unstructured":"S\u00fc\u00df P, Hoffmann A, Rothe T, Ouyang Z, Baum W, Staszewski O, et al. Chronic peripheral inflammation causes a Region-Specific myeloid response in the central nervous system. Cell Rep. 2020;30(12):4082\u2013e956.","journal-title":"Cell Rep"},{"key":"3539_CR7","doi-asserted-by":"publisher","first-page":"102540","DOI":"10.1016\/j.coi.2025.102540","volume":"93","author":"H Xu","year":"2025","unstructured":"Xu H, Hehnly C, Lehtinen MK. The choroid plexus: a command center for brain-body communication during inflammation. Curr Opin Immunol. 2025;93:102540.","journal-title":"Curr Opin Immunol"},{"key":"3539_CR8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neubiorev.2018.07.013","volume":"94","author":"TE Kraynak","year":"2018","unstructured":"Kraynak TE, Marsland AL, Wager TD, Gianaros PJ. Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies. Neurosci Biobehav Rev. 2018;94:76\u201392.","journal-title":"Neurosci Biobehav Rev"},{"issue":"7","key":"3539_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s11906-022-01187-4","volume":"24","author":"H Zheng","year":"2022","unstructured":"Zheng H, Katsurada K, Nandi S, Li Y, Patel KP. A critical role for the paraventricular nucleus of the hypothalamus in the regulation of the volume reflex in normal and various cardiovascular disease States. Curr Hypertens Rep. 2022;24(7):235\u201346.","journal-title":"Curr Hypertens Rep"},{"issue":"5","key":"3539_CR10","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.clinthera.2020.03.008","volume":"42","author":"N Pondeljak","year":"2020","unstructured":"Pondeljak N, Lugovi\u0107-Mihi\u0107 L. Stress-induced interaction of skin immune cells, hormones, and neurotransmitters. Clin Ther. 2020;42(5):757\u201370.","journal-title":"Clin Ther"},{"key":"3539_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.lfs.2017.11.019","volume":"192","author":"AH de Mello","year":"2018","unstructured":"de Mello AH, Costa AB, Engel JDG, Rezin GT. Mitochondrial dysfunction in obesity. Life Sci. 2018;192:26\u201332.","journal-title":"Life Sci"},{"issue":"5","key":"3539_CR12","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/jnc.13842","volume":"139","author":"OM Ogundele","year":"2016","unstructured":"Ogundele OM, Lee CC, Francis J. Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor as a possible link between sympathoexcitation and inflammation. J Neurochem. 2016;139(5):706\u201321.","journal-title":"J Neurochem"},{"key":"3539_CR13","doi-asserted-by":"crossref","unstructured":"Pham GS, Mathis KW. Lipopolysaccharide challenge reveals Hypothalamic-Pituitary-Adrenal axis dysfunction in murine systemic lupus erythematosus. Brain Sci. 2018;8(10):184.","DOI":"10.3390\/brainsci8100184"},{"issue":"11","key":"3539_CR14","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1093\/cvr\/cvx084","volume":"113","author":"K Garrott","year":"2017","unstructured":"Garrott K, Dyavanapalli J, Cauley E, Dwyer MK, Kuzmiak-Glancy S, Wang X, et al. Chronic activation of hypothalamic Oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure. Cardiovascular Res. 2017;113(11):1318\u201328.","journal-title":"Cardiovascular Res"},{"issue":"1\u20132","key":"3539_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cellimm.2007.09.005","volume":"252","author":"DL Bellinger","year":"2008","unstructured":"Bellinger DL, Millar BA, Perez S, Carter J, Wood C, ThyagaRajan S, et al. Sympathetic modulation of immunity: relevance to disease. Cell Immunol. 2008;252(1\u20132):27\u201356.","journal-title":"Cell Immunol"},{"issue":"1","key":"3539_CR16","doi-asserted-by":"publisher","first-page":"7526","DOI":"10.1038\/s41598-019-43899-9","volume":"9","author":"SC Furiati","year":"2019","unstructured":"Furiati SC, Catarino JS, Silva MV, Silva RF, Estevam RB, Teodoro RB, et al. Th1, Th17, and Treg responses are differently modulated by TNF-\u03b1 inhibitors and methotrexate in psoriasis patients. Sci Rep. 2019;9(1):7526.","journal-title":"Sci Rep"},{"issue":"12","key":"3539_CR17","doi-asserted-by":"publisher","first-page":"e734","DOI":"10.1002\/iid3.734","volume":"10","author":"X Li","year":"2022","unstructured":"Li X, Jiang M, Chen X, Sun W. Etanercept alleviates psoriasis by reducing the Th17\/Treg ratio and promoting M2 polarization of macrophages. Immun Inflamm Dis. 2022;10(12):e734.","journal-title":"Immun Inflamm Dis"},{"issue":"3","key":"3539_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrn3677","volume":"15","author":"DM Bannerman","year":"2014","unstructured":"Bannerman DM, Sprengel R, Sanderson DJ, McHugh SB, Rawlins JN, Monyer H, et al. Hippocampal synaptic plasticity, Spatial memory and anxiety. Nat Rev Neurosci. 2014;15(3):181\u201392.","journal-title":"Nat Rev Neurosci"},{"key":"3539_CR19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","volume":"91","author":"ZH Zheng","year":"2021","unstructured":"Zheng ZH, Tu JL, Li XH, Hua Q, Liu WZ, Liu Y, et al. Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behav Immun. 2021;91:505\u201318.","journal-title":"Brain Behav Immun"},{"issue":"6","key":"3539_CR20","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1080\/00207454.2018.1545771","volume":"129","author":"J Fares","year":"2019","unstructured":"Fares J, Bou Diab Z, Nabha S, Fares Y. Neurogenesis in the adult hippocampus: history, regulation, and prospective roles. Int J Neurosci. 2019;129(6):598\u2013611.","journal-title":"Int J Neurosci"},{"issue":"7","key":"3539_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nrn3881","volume":"16","author":"JS Bains","year":"2015","unstructured":"Bains JS, Wamsteeker Cusulin JI, Inoue W. Stress-related synaptic plasticity in the hypothalamus. Nat Rev Neurosci. 2015;16(7):377\u201388.","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"3539_CR22","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuron.2017.06.028","volume":"95","author":"E Favuzzi","year":"2017","unstructured":"Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, S\u00e1nchez-Aguilera A, Mantoan L, et al. Activity-Dependent gating of parvalbumin interneuron function by the perineuronal net protein Brevican. Neuron. 2017;95(3):639\u2013e5510.","journal-title":"Neuron"},{"issue":"6","key":"3539_CR23","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.neuron.2017.02.031","volume":"93","author":"SL Chiu","year":"2017","unstructured":"Chiu SL, Diering GH, Ye B, Takamiya K, Chen CM, Jiang Y, et al. GRASP1 regulates synaptic plasticity and learning through endosomal recycling of AMPA receptors. Neuron. 2017;93(6):1405\u2013e198.","journal-title":"Neuron"},{"issue":"1","key":"3539_CR24","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1038\/s41467-020-16884-4","volume":"11","author":"Y Joo","year":"2020","unstructured":"Joo Y, Xue Y, Wang Y, McDevitt RA, Sah N, Bossi S, et al. Topoisomerase 3\u03b2 knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity. Nat Commun. 2020;11(1):3143.","journal-title":"Nat Commun"},{"issue":"4","key":"3539_CR25","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.2337\/db12-0982","volume":"62","author":"B Szepietowska","year":"2013","unstructured":"Szepietowska B, Zhu W, Czyzyk J, Eid T, Sherwin RS. EphA5-EphrinA5 interactions within the ventromedial hypothalamus influence counterregulatory hormone release and local glutamine\/glutamate balance during hypoglycemia. Diabetes. 2013;62(4):1282\u20138.","journal-title":"Diabetes"},{"issue":"3","key":"3539_CR26","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.2337\/db13-1259","volume":"63","author":"B Szepietowska","year":"2014","unstructured":"Szepietowska B, Horvath TL, Sherwin RS. Role of synaptic plasticity and EphA5-ephrinA5 interaction within the ventromedial hypothalamus in response to recurrent hypoglycemia. Diabetes. 2014;63(3):1140\u20137.","journal-title":"Diabetes"},{"issue":"3","key":"3539_CR27","doi-asserted-by":"publisher","first-page":"613","DOI":"10.5665\/sleep.5538","volume":"39","author":"M Freyburger","year":"2016","unstructured":"Freyburger M, Pierre A, Paquette G, B\u00e9langer-Nelson E, Bedont J, Gaudreault PO, et al. EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation. Sleep. 2016;39(3):613\u201324.","journal-title":"Sleep"},{"issue":"10","key":"3539_CR28","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1158\/0008-5472.CAN-18-3257","volume":"79","author":"S Bhatia","year":"2019","unstructured":"Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, et al. Inhibition of EphB4-Ephrin-B2 signaling reprograms the tumor immune microenvironment in head and neck cancers. Cancer Res. 2019;79(10):2722\u201335.","journal-title":"Cancer Res"},{"issue":"2","key":"3539_CR29","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nn.2477","volume":"13","author":"D Nie","year":"2010","unstructured":"Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, et al. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci. 2010;13(2):163\u201372.","journal-title":"Nat Neurosci"},{"issue":"6","key":"3539_CR30","doi-asserted-by":"publisher","first-page":"e13006","DOI":"10.1111\/jpi.13006","volume":"76","author":"Q Ren","year":"2024","unstructured":"Ren Q, Han W, Yue Y, Tang Y, Yue Q, Comai S, et al. Melatonin regulates neuronal synaptic plasticity in the supramammillary nucleus and attenuates Methamphetamine-Induced conditioned place preference and sensitization in mice. J Pineal Res. 2024;76(6):e13006.","journal-title":"J Pineal Res"},{"issue":"1","key":"3539_CR31","doi-asserted-by":"publisher","first-page":"6923","DOI":"10.1038\/s41467-023-42814-1","volume":"14","author":"DD Shi","year":"2023","unstructured":"Shi DD, Zhang YD, Zhang S, Liao BB, Chu MY, Su S, et al. Stress-induced red nucleus Attenuation induces anxiety-like behavior and lymph node CCL5 secretion. Nat Commun. 2023;14(1):6923.","journal-title":"Nat Commun"},{"issue":"6381","key":"3539_CR32","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1126\/science.aal3589","volume":"359","author":"ID Vainchtein","year":"2018","unstructured":"Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, et al. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Sci (New York NY). 2018;359(6381):1269\u201373.","journal-title":"Sci (New York NY)"},{"key":"3539_CR33","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/1742-2094-9-155","volume":"9","author":"L Tian","year":"2012","unstructured":"Tian L, Ma L, Kaarela T, Li Z. Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases. J Neuroinflamm. 2012;9:155.","journal-title":"J Neuroinflamm"},{"issue":"8","key":"3539_CR34","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.neuron.2022.01.010","volume":"110","author":"J Yu","year":"2022","unstructured":"Yu J, Xiao K, Chen X, Deng L, Zhang L, Li Y, et al. Neuron-derived neuropeptide Y fine-tunes the Splenic immune responses. Neuron. 2022;110(8):1327\u2013e396.","journal-title":"Neuron"},{"issue":"9","key":"3539_CR35","doi-asserted-by":"publisher","first-page":"6806","DOI":"10.1007\/s12035-016-0170-2","volume":"54","author":"G Morris","year":"2017","unstructured":"Morris G, Anderson G. Hypothalamic-Pituitary-Adrenal hypofunction in myalgic encephalomyelitis (ME)\/Chronic fatigue syndrome (CFS) as a consequence of activated Immune-Inflammatory and oxidative and nitrosative pathways. Mol Neurobiol. 2017;54(9):6806\u201319.","journal-title":"Mol Neurobiol"},{"issue":"24","key":"3539_CR36","doi-asserted-by":"publisher","first-page":"5902","DOI":"10.1016\/j.cell.2021.10.013","volume":"184","author":"T Koren","year":"2021","unstructured":"Koren T, Yifa R, Amer M, Krot M, Boshnak N, Ben-Shaanan TL, et al. Insular cortex neurons encode and retrieve specific immune responses. Cell. 2021;184(24):5902\u2013e1517.","journal-title":"Cell"},{"issue":"12","key":"3539_CR37","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1111\/j.1365-2826.2011.02217.x","volume":"23","author":"MJ Weiser","year":"2011","unstructured":"Weiser MJ, Osterlund C, Spencer RL. Inhibitory effects of corticosterone in the hypothalamic paraventricular nucleus (PVN) on stress-induced adrenocorticotrophic hormone secretion and gene expression in the PVN and anterior pituitary. J Neuroendocrinol. 2011;23(12):1231\u201340.","journal-title":"J Neuroendocrinol"},{"key":"3539_CR38","doi-asserted-by":"crossref","unstructured":"Chaves T, Fazekas CL, Horv\u00e1th K, Correia P, Szab\u00f3 A, T\u00f6r\u00f6k B et al. Stress adaptation and the brainstem with focus on Corticotropin-Releasing hormone. Int J Mol Sci. 2021;22(16):9090.","DOI":"10.3390\/ijms22169090"},{"issue":"1","key":"3539_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00395-023-01013-1","volume":"118","author":"KJ Schunke","year":"2023","unstructured":"Schunke KJ, Rodriguez J, Dyavanapalli J, Schloen J, Wang X, Escobar J, et al. Outcomes of hypothalamic Oxytocin neuron-driven cardioprotection after acute myocardial infarction. Basic Res Cardiol. 2023;118(1):43.","journal-title":"Basic Res Cardiol"},{"issue":"2\u20133","key":"3539_CR40","first-page":"75","volume":"27","author":"DE Itzev","year":"2003","unstructured":"Itzev DE, Lolov SR, Usunoff KG. Aging and synaptic changes in the paraventricular hypothalamic nucleus of the rat. Acta Physiol Pharmacol Bulg. 2003;27(2\u20133):75\u201382.","journal-title":"Acta Physiol Pharmacol Bulg"},{"issue":"17","key":"3539_CR41","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1113\/JP275669","volume":"596","author":"EW Salter","year":"2018","unstructured":"Salter EW, Sunstrum JK, Matovic S, Inoue W. Chronic stress dampens excitatory synaptic gain in the paraventricular nucleus of the hypothalamus. J Physiol. 2018;596(17):4157\u201372.","journal-title":"J Physiol"},{"issue":"6","key":"3539_CR42","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s00401-021-02371-7","volume":"142","author":"XY Qin","year":"2021","unstructured":"Qin XY, Shan QH, Fang H, Wang Y, Chen P, Xiong ZQ, et al. PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression. Acta Neuropathol. 2021;142(6):1045\u201364.","journal-title":"Acta Neuropathol"},{"issue":"1","key":"3539_CR43","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13195-019-0554-4","volume":"11","author":"L Poppe","year":"2019","unstructured":"Poppe L, Ru\u00e9 L, Timmers M, Lenaerts A, Storm A, Callaerts-Vegh Z, et al. EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of alzheimer\u2019s disease. Alzheimers Res Ther. 2019;11(1):102.","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"3539_CR44","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/s41419-025-07512-4","volume":"16","author":"W Zhang","year":"2025","unstructured":"Zhang W, Zhao J, Fan X, Chen S, Wang R. Targeted demethylation of the EphA7 promoter inhibits tumorigenesis via the SP1\/DNMT1 and PI3K\/AKT axes and improves the response to multiple therapies in cervical cancer. Cell Death Dis. 2025;16(1):324.","journal-title":"Cell Death Dis"},{"issue":"11","key":"3539_CR45","doi-asserted-by":"publisher","first-page":"e11343","DOI":"10.1016\/j.heliyon.2022.e11343","volume":"8","author":"Y Wang","year":"2022","unstructured":"Wang Y, Cheng H, Zeng T, Chen S, Xing Q, Zhu B. A novel 17 apoptosis-related genes signature could predict overall survival for bladder cancer and its associations with immune infiltration. Heliyon. 2022;8(11):e11343.","journal-title":"Heliyon"},{"key":"3539_CR46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13045-015-0202-9","volume":"8","author":"S Bhatia","year":"2015","unstructured":"Bhatia S, Hirsch K, Baig NA, Rodriguez O, Timofeeva O, Kavanagh K, et al. Effects of altered ephrin-A5 and EphA4\/EphA7 expression on tumor growth in a Medulloblastoma mouse model. J Hematol Oncol. 2015;8:105.","journal-title":"J Hematol Oncol"},{"issue":"4","key":"3539_CR47","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/1096-9861(20010319)431:4<405::AID-CNE1079>3.0.CO;2-D","volume":"431","author":"RM Buijs","year":"2001","unstructured":"Buijs RM, Chun SJ, Niijima A, Romijn HJ, Nagai K. Parasympathetic and sympathetic control of the pancreas: a role for the Suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake. J Comp Neurol. 2001;431(4):405\u201323.","journal-title":"J Comp Neurol"},{"issue":"1","key":"3539_CR48","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s43440-019-00025-w","volume":"72","author":"MIO Milanez","year":"2020","unstructured":"Milanez MIO, Silva AM, Perry JC, Faber J, Nishi EE, Bergamaschi CT, et al. Pattern of sympathetic vasomotor activity induced by GABAergic Inhibition in the brain and spinal cord. Pharmacol Rep. 2020;72(1):67\u201379.","journal-title":"Pharmacol Rep"},{"key":"3539_CR49","doi-asserted-by":"crossref","unstructured":"Xu XY, Wang JX, Chen JL, Dai M, Wang YM, Chen Q et al. GLP-1 in the hypothalamic paraventricular nucleus promotes sympathetic activation and hypertension. J Neuroscience: Official J Soc Neurosci. 2024;44(21):e2032232024.","DOI":"10.1523\/JNEUROSCI.2032-23.2024"},{"issue":"7876","key":"3539_CR50","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s41586-021-03830-7","volume":"597","author":"F Cardoso","year":"2021","unstructured":"Cardoso F, Klein Wolterink RGJ, Godinho-Silva C, Domingues RG, Ribeiro H, da Silva JA, et al. Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit. Nature. 2021;597(7876):410\u20134.","journal-title":"Nature"},{"issue":"12","key":"3539_CR51","doi-asserted-by":"publisher","first-page":"e57176","DOI":"10.15252\/embr.202357176","volume":"24","author":"J Wang","year":"2023","unstructured":"Wang J, Sun L, You J, Peng H, Yan H, Wang J, et al. Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress. EMBO Rep. 2023;24(12):e57176.","journal-title":"EMBO Rep"},{"issue":"8","key":"3539_CR52","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/gene.2014.45","volume":"15","author":"O Palomares","year":"2014","unstructured":"Palomares O, Mart\u00edn-Fontecha M, Lauener R, Traidl-Hoffmann C, Cavkaytar O, Akdis M, et al. Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-\u03b2. Genes Immun. 2014;15(8):511\u201320.","journal-title":"Genes Immun"},{"issue":"6","key":"3539_CR53","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1007\/s10753-024-02023-4","volume":"47","author":"Z Shen","year":"2024","unstructured":"Shen Z, Jiang J, Zhou X, Tan Q, Yan S, Wu X, et al. Melatonin attenuates Imiquimod-Induced Psoriasis-Like inflammation and restores the Th17\/Treg immune balance. Inflammation. 2024;47(6):2027\u201340.","journal-title":"Inflammation"},{"issue":"3","key":"3539_CR54","doi-asserted-by":"publisher","first-page":"103735","DOI":"10.1016\/j.autrev.2024.103735","volume":"24","author":"A Ram\u00f3n-V\u00e1zquez","year":"2025","unstructured":"Ram\u00f3n-V\u00e1zquez A, Flood P, Cashman TL, Patil P, Ghosh S. T lymphocyte plasticity in chronic inflammatory diseases: the emerging role of the Ikaros family as a key Th17-Treg switch. Autoimmun Rev. 2025;24(3):103735.","journal-title":"Autoimmun Rev"},{"issue":"7","key":"3539_CR55","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nm.3589","volume":"20","author":"T Heidt","year":"2014","unstructured":"Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, et al. Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014;20(7):754\u20138.","journal-title":"Nat Med"},{"key":"3539_CR56","doi-asserted-by":"crossref","unstructured":"Liu D, Xu X, Dai Y, Zhao X, Bao S, Ma W et al. Blockade of AIM2 inflammasome or \u03b11-AR ameliorates IL-1\u03b2 release and macrophage-mediated immunosuppression induced by CAR-T treatment. J Immunother Cancer 2021;9(1):e001466.","DOI":"10.1136\/jitc-2020-001466"},{"issue":"1","key":"3539_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000471828","volume":"29","author":"XQ Wang","year":"2021","unstructured":"Wang XQ, Wang TT, Fang XX, Shen WX, Peng YP, Qiu YH. Intervention of tyrosine hydroxylase expression alters joint inflammation and Th17\/Treg imbalance in Collagen-Induced arthritis. Neuro-Signals. 2021;29(1):1\u201313.","journal-title":"Neuro-Signals"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03539-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-025-03539-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03539-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T20:05:27Z","timestamp":1758744327000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-025-03539-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3539"],"URL":"https:\/\/doi.org\/10.1186\/s12974-025-03539-8","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,24]]},"assertion":[{"value":"16 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments in this study were approved by the Institutional Animal Care and Use Committee at the Shandong University (No. ECSBMSSDU2024-2-005).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All listed authors consent to the submission, and all data are used with the consent of the person generating the data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"211"}}